Knowledge of post‐COVID conditions is likely to change rapidly with ongoing research • With extensive research underway, it is likely that evidence‐based treatment practices will evolve
Trang 1Sequelae of COVID‐19
Asso. Prf. Nguyen Van Tri
HoChiMinh City
Trang 2TẠI SAO NGƯỜI CAO TUỔI THUỘC NHÓM NGUY CƠ CAO SAU NHIỄM SARC‐CoV‐2 ?
Trang 3là quá trình tự nhiên của tích tuổi không liên quan đến đa bệnh
Am J Med 2009 Jul;122(7):605‐13.doi: 10.1016/j.amjmed.2009.01.030.
Trang 5Knowledge of post‐COVID conditions is likely to change rapidly with ongoing research
• With extensive research underway, it is likely that evidence‐based treatment practices will evolve over time
Trang 7‘’Signs and symptoms that develop during or following
an infection consistent with COVID 19 which continue for more than 12 weeks and are not explained by an alternative diagnosis’’
‘’it usually presents with clusters of symptoms, often overlapping, which can fluctuate and change over time and can affect any system of the body’’
NICE/SIGN/RCGP
Post COVID‐19 as defined:
Trang 9Post-traumatic stress disorder (PTSD)
Trang 10The predominant pathophysiologic mechanisms of acute COVID‐19 include the following:
• Direct viral toxicity
• Endothelial damage
• Microvascular injury
Trang 12• Potential mechanisms contributing to the pathophysiology of post‐acute COVID‐19 include:
Trang 13• Increased arterial and venous thrombosis in severe and non severe disease
• Microthrombi seen in lungs, heart, liver and kidney
LANCET
Trang 15Listen to and validate patients’ experiences and partner with patients to identify achievable health goals
• Most post‐COVID conditions can be diagnosed and managed by
primary care
• Consider referral to multidisciplinary post‐COVID care centers
• Many post‐COVID conditions may be diagnosed based on history and physical exam
– Potential harms could arise from excessive testing
• Consider conservative diagnostic approach in the first 4 to 12 weeks
• Symptoms persisting beyond three months should prompt further evaluation
Trang 16Commonly reported symptoms include dyspnea, fatigue, post‐exertional malaise, and brain fog
Trang 17consider broad range of possible post‐COVID conditions
Trang 19At this time, no laboratory test can definitively distinguish post‐COVID conditions from other etiologies
• Lab testing should be guided by clinical findings
• A basic panel of lab tests might be considered between 4 and 12
weeks
• Consider additional testing if symptoms persist for 12 weeks or longer
Trang 21More evidence is needed to support the utility of specific imaging tests for evaluation of post‐COVID conditions
• Some imaging tests may have low yield
– CT chest with normal chest x‐rays and normal oxygen saturation – CT pulmonary angiogram without an elevated D‐dimer and
compatible symptoms
– Brain MRI with brain fog
• More specialized imaging studies (e.g., cardiac MRI) might merit consultation with specialists
Trang 23For most patients, the goal of medical management is to optimize function and quality of life
• Creating a comprehensive rehabilitation plan may be helpful for some patients
• Many post‐COVID conditions can be improved through already
established symptom management approaches
Individual approach