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Plant Health Care: Focus on Plant Response Elicitors Technology, Boost Company's Rapid DevelopmentSeipasa: Focus on the American Market, Develop Biotechnology Products New Registrations

2020 Biologicals Special 1

INTERVIEW

2020 Biologicals Special 2020 Biologicals Special

Getting your biorationals on the fast track to international market success

• Basic and low-risk substances

• Biostimulants and fertilisers – soil aids, soil conditioners or plant aids

• Organic/precision farming and IPM Our knowledge is the key to your success.

2020 Biologicals Special 2020 Biologicals Special

Plant Health Care: Focus on Plant Response Elicitors Technology, Boost Company's Rapid Development

Seipasa: Focus on the American Market, Develop Biotechnology Products

New Registrations of Microbial Pesticides in US from 2015 to 2018Botanical Pesticides Approved/Launched in Europe, US in Spring 2020Regev™ – A Broad-spectrum Hybrid Fungicide for Plant Disease ControlBiorational Developments in Open Field Crops

Ingevity: Enhance the Efficiency of Micronutrients with Pine-based Kraft Lignin

Azotic’s Natural Nitrogen Fixing Technology Is A Must for AgricultureKwizda Agro: Driving Innovation in Biologicals

Complementary Approach to BiostimulationHow to Achieve Constant Quality in HorticultureAgri Star is Positioned as the Leader in the Bio-Inputs Market in Argentina

Biopesticide in Latin America: The Market Is Changing, Where Are the Future Opportunities?

Viral Insecticides: Technological Innovation, A New Blue Ocean of Future Pesticides

Timing, One the Keys to Maximise Results When Using BiostimulantsRNAi Opens A New Vista for Pest Control

France: Reducing Chemical Pesticide Use And Developing Biological Control

Biopesticides – A Fast-growing Multibillion Market

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Advertiser Index

Advanced Biological Marketing (ABM)Agri Star

AgriThorityAzotic TechnologiesBeijing Kingbo Biotech Co.,Ltd Beijing Multigrass FormulationBESTAR

Biolchim Certis USACompliance Services International (CSI)CropTrials GmbH

DOGALEurofins Agroscience Services GroupGrupo Vigna Brasil

Hangzhou Pulan BiotechnologyIngevity

INTERMAG Sp z o.o

IPL Biologicals LimitedLeili Marine BioIndustry INC

Kwizda Agro GmbH LOMON CORPORATIONM2i Biocontrol

Plant Health CareScientific Consulting Company (SCC)Seipasa

Shan Dong Peng Bo Bio Technology Staphyt

STKTradecorpVerdesian Life Sciences U.S LLC

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CONTENTS

2020 Biologicals Special 2020 Biologicals Special

Opportunities or Challenges?

- Changes in EU Registration Regulation in 2019

CC – Scientific Consulting Company – was founded in 1989 by Dr Friedbert Pistel

Since then, it has become one of Europe’s largest privately owned and independent regulatory consulting companies, supporting its global customers with all their registration needs for agrochemicals and biorationals, including biostimulants and fertilisers and other industries

What kind of company is SCC? What has happened to the EU's registration policy for biopesticides and biostimulants in 2019? What are the points to note when registering biopesticides or biostimulants in the EU? Taking this opportunity, AgroPages interviewed Dr Lars Huber, Head of Biorationals, Fertilisers and IPM of SCC

In the field of Agrochemicals and

Biorationals, after more than

30 years of development, SCC

has become a leading consulting

company in this field What

do you think is the distinctive

service of SCC compared with

other companies? Why do many

companies choose to cooperate

with SCC?

Lars: According to the feedback from our

clients as well as cooperation partners, CROs

and authorities, one of the most distinctive

features of SCC is our independence As we

have no own labs for example we are able

always to choose the lab or CRO most suited

to conduct a specific study in regards to its

scientific experience as well as in regards

to economic suitability or timing of studies

This feature also emphasises the quality and

neutrality of data monitored or provided by

SCC in dossiers in the eyes of evaluators and

authorities Furthermore, this independence

ensures high flexibility and enables us to offer

all different types of projects according to the

needs of the client

Another important fact, especially in case

of the quite new and constantly changing field

of the registration of biorationals is the

long-term experience of SCC with all different

types of natural substances under plant protection as well as fertiliser/biostimulant regulatory frameworks This includes not only the work in regards to registration projects but also in R&D as well as academia research projects These different activities provide for in-depth knowledge, scientifically and regulatory, and synergies allow for the development of innovative and future-oriented testing and registration strategies for all types of biorationals and regulatory frameworks

At present, SCC has operations in overseas countries such as Japan and China Please summarize the global development of SCC, especially in the core market?

Lars: In the case of plant protection

products and especially biorationals requests from clients from Asian countries for registrations in Europe increased in recent years This is partly due to the changes brought on by the new plant protection and sustainability goals, regulations and guidelines in EU SCC responded to these increasing demands from Asian customers by intensifying or establishing a SCC presence

in certain Asian countries to be able to attend

General topics and trends are given by the technical progress in regards to agrochemical practices such as Integrated Pest Management (IPM), Sustainability or Precision Farming

as well as testing methods to be used for study conduct Overall, requirements for the registration of plant protection products become more and more complex but also more individualised, specifically considering the characteristics of the individual active substance and/or product This allows for very specific, substance-orientated approaches

in regards to requirements, studies and scientific justifications for study waivers for biorationals Thus, dossiers in general get more complex and scientifically demanding but, on the other hand, increased acceptance

of scientific argumentation and use of public literature offers possibilities to reduce study requirements and thus registration costs at least for biorationals

What does a typical SCC global customer look like? Who are your target customers? What are your plans for future development and expansion into new markets / regions?

Lars: Due to SCCs mode of operation,

especially the already mentioned independent character, there is no typical global customer

SCC cooperates, and is able to cooperate, with the full scale of customers interested

in or in need of regulatory and scientific services for plant protection products, biostimulants, fertilisers and other related products Of course, in cooperation with our other departments, biocides or REACH projects for example can also be handled

Some of our clients conduct much of the relevant work themselves Other clients work with cooperation or distribution partners or even split forces between active substances and products Still, other clients require the full SCC service from R&D issues, study monitoring, dossier writing, applications, defence and follow-up Thus, there is no typical SCC customer or even a target customer

The fact that SCC has not established offices in additional countries does not

mean that we are not actively working in registration projects also outside EU such

as in US, Australia or Southern American

or Asian countries Although, normally we cover all this work via our global network of cooperation partners, all of them having in-depth knowledge of the national requirements and authorities Thus, we are already acting on

a global scale with international registration projects but of course we will expand further

if our clients require respective services

Regarding the registration

of biopesticides, is there any change in the EU's biopesticide registration policy in 2019? How

do you think the EU's biopesticide registration policy should be changed to drive the rapid development of biopesticides?

Lars: This is a very complex issue

and involves many different areas of the registration process On the one hand, there are the data requirements itself which clearly are not or only partially suitable for biopesticides, i.e natural substances and especially microorganisms These have to

be revised and adapted Respective scientific work dates already back more than two decades but has not been included in the regulatory process This implementation

is currently ongoing on authority level and, after a delay of many years, hopefully will lead to significant improvements in the near future On the other hand, the specifics of biopesticides have to be considered more detailed in the regulatory process For one, the Modes of Action of many biopesticides require not a curative but a preventive use

Others do not act directly on target organisms but have an indirect Mode of Action acting via the defence systems of plants This requires not only their IPM use in the agricultural practise but also the incorporation and acceptance of IPM in the regulatory process

In spite of the fact that IPM is mandatory

in EU since 2014 for all professional users, the regulatory process and the requirements

do not reflect this This applies especially

to active substances and products with a very narrow range of applications and niche

Asian customers as best as possible On the other hand this enables us to offer our other clients services in Asian countries and at least partially use synergies, knowledge and data produced for registrations in Europe or US for example for registrations in Asia

Could you describe the status and some trends of the agrochemical consulting industry? What do you think is the biggest challenge in the consulting industry?

Lars: Status and challenges differ

according to the countries in which registrations are envisaged e.g EU and US

Differences in regards to rules, regulatory frameworks and procedures as well as data requirements between countries are one of the biggest challenges Simultaneously, this results in a quite different, country-specific status quo in regards to active substance and product registrations One of the most recent examples is the establishment of a new legal and regulatory framework for biostimulants in EU, clearly differentiating between biostimulants and biopesticides In other countries, such a strict differentiation

or definitions are missing or only under development

products Sale revenues for such products often do not justify the investments necessary for a registration There are some support schemes in place in certain countries but they are still too few and they have to be expanded But it’s not always the financial investment itself that detain companies from the registration Often, the reasons are the uncertainties and the lack of harmonisation

in regards to data requirements, requests for post-submissions during the registration procedure or the timelines Thus, a regulatory harmonisation and a fast track procedure,

at least in regards to the admissibility of an application, would be required Participation

of EFSA in pre-submission meeting is a necessary first step to be welcomed but additional improvements in the regulatory registration process are also be necessary

Regarding biostimulant registration, is there any change

in EU biostimulant registration policy in 2019? In the biostimulant registration section, what services can SCC provide to help customers obtain registration quickly?

Lars: In 2019 the new EU regulation on

fertilisers entered into force This regulation also includes biostimulants and plant aids for example This of course changed registration possibilities significantly as the regulation introduces EU-harmonised rules Regrettably, applicability of the regulation will be in 2022 only as the respective guidelines and guidance have to be developed in the meantime Until then, respective products still have to be registered on a national level if applicable National registrations can be a good basis for

a subsequent registration as an EU-fertilising product Thus, SCC can assist clients to achieve national registrations in important target markets and evaluate the possible registrability of individual products or product portfolios according to the upcoming

EU rules Thus, SCC can support clients in attaining national registrations and allow for an early entry into core markets and for core products and prepare for the subsequent EU-wide registration of the products after applicability of the EU harmonised rules

S

2020 Biologicals Special 2020 Biologicals Special

Adjust Strategy Under 2019-nCoV,

Break Through the Encirclement and Lead Again

What is the impact of the

outbreak of 2019-nCoV in 2020

on Biolchim's overall business? In

this particular situation, how did

Biolchim carry out related work?

Marco: The impact was very strong, in

the sense that we had to reorganize ourselves

from the point of view of managing suppliers,

supplies and sales activities very quickly

The company has been and is strong, and

therefore we managed to handle the impact

fairly well, in terms of production, in the

acquisition of raw materials, which obviously

suffered enormous delays, and also from the

point of view of the sales We managed to

keep the connection alive with our customers,

with our network, with our end users and

also to maintain the connections within the

group in the various areas, in the various

departments This is due to the great sense

of responsibility, a great motivation, a great

desire to overcome this terrible crisis that we

and our collaborators have In this moment

of crisis, we continue to guarantee the three

fundamental characteristics that we have

always had as a group The focus on concrete

results, the great capacity for innovation

and finally the ability to provide continuous

technical support We expect this model to still be rewarded by the market even after the crisis We all remain united and work in the same direction to get out of this situation and become stronger than we were before, when all this started

The first half of 2020 has passed

For the second half of the year, what is Biolchim's plan to increase product sales? What are the new product launch plans?

Marco: In the second half of the year,

not being sure of being able to work as before the crisis and travel we will continue with online technical / marketing support activities and with online customer management We will be present in a different way but we’ll

be always effectively close to our customers

The product launch plan for us is always

at the beginning of the year, so there will

a consolidation of what was launched in January, therefore the products Vhera, Vhera Life and Kriss Bio

Vhera and Vhera Life are part of the strategy of supporting crop productivity even

in difficult environments, such as in soils

where there is the presence of nematodes that create an important stress on the plant

Kriss Bio is an organic product for increasing fruit size

Therefore, in the second half of 2020 we will continue to develop what was launched and planned in January

Nowadays growers in Latin America are increasingly accepting biostimulants and specialty fertilizers Could you share with

us some of Biolchim’s experience

in developing the Latin American market?

Marco: Yes, this is true Farming

practices in several Latin-American Countries are today more focused to export markets

Chile and Peru, for instance, as well as Brazil and Colombia nowadays are among the biggest exporters of fruits to the US, Europe and Asian markets Farmers to keep competitiveness need often to improve fruit qualities, or to maintain a certain yield even under stress conditions and/or to concentrate harvest to catch the proper time window for exporting In those particular conditions

our bio-stimulants can play a crucial role, becoming year after year “standard practice”

for the farmers A history of success is our product (BLUPRINS) for improving sprouting and uniformity in cherries in Chile, which is today a consolidated solution which many farmers apply to produce quality cherries even in areas with high temperatures

Another example is the application of two of our star products like Folicist and Fylloton, which in Peru are widely used by blueberry producers to enhance the productivity of this crop of which the cultivated area is increasing year by year

At present, there are many types

of special fertilizers on the market

What do you think is the biggest competitive advantage of special fertilizers from Biolchim? From the perspective of dealers or growers, how do you think they should choose an excellent special fertilizer product?

Marco: Our products are developed

through the WIN platform which ensures the development close to where there are

agronomic problems and needs So, growers choose our products because they know that when we launch a product, we have tested it in situations, even in geographical environments where their problem occurs We solve the problem close to the farmers, not in the laboratory

Could you share with us the performance of Biolchim in new product development, product launch and sales performance in 2019? In terms of international market development, what level of Biolchim's international business is currently at? What plans does Biolchim have in the future for international market development?

Marco: In 2019 the important

growth curve continued in national and international markets, and special products and biostimulants saw a relevant increase

Biolchim's plan for the future is certainly linked to the very important activities of the subsidiaries present at an international level, therefore we would strengthen the

iolchim is a leader in the production and commercialization of special fertilizers in Italy and in the world Biolchim today is a synonym for biostimulants: innovative products in all aspects, in the raw materials they contain as well as in the agronomic performances that characterize them Biolchim operates in more than 75 countries worldwide, and is a company where Research and Development represent the main gear that drives the whole business activity

Affected by the 2019-nCoV in 2020, most companies in the world will be affected to varying degrees

in their construction and sales As a leader in the specialty fertilizer industry, how does the epidemic affect Biolchim? In this difficult environment, how does Biolchim break through itself and adjust the follow-up plan? Taking this opportunity, AGROPAGES interviewed Marco Civitareale, Product Manager of Biolchim

support to our subsidiaries and continue to develop products through the WIN platform with the help of local partners, distributors, universities, international research centres This is to position our products in the best possible way and be close to the needs of farmers all over the world

At present, special fertilizers are developing towards functional fertilizers Do you agree with this theory? In your opinion, if special fertilizers want to break through the bottleneck in the future, what aspects of attention and research should be paid attention to?

Marco: In our opinion, special fertilizers,

in particular biostimulants are much more than functional fertilizers, in the sense that the part that is functional is only a feature of the biostimulant Biostimulants have a root,

an application, that is much deeper and wider The peculiarity of marketing these products

is that they have to relate to the application

in the individual areas of use Biostimulants have to be developed, studied and applied where they arrive on the market

Biolchim:

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2020 Biologicals Special 2020 Biologicals Special

Why should the company focus on Plant Response Elicitors research? What products does the company currently have and how does the specific market perform? What are the plans for the future? With these questions, we interviewed Christopher Richards, the CEO of Plant Health Care

Could you share with us what kind

of company Plant Health Care is?

Plant Health Care® is a leading provider

of proprietary agricultural biological products and technology solutions focused on improving crop performance We offer products to improve the health, vigour and yield of major field crops such as corn, soybeans, cotton and rice, as well as speciality crops such as fruits and vegetables We operate globally through subsidiaries, distributors and supply agreements with major industry partners

Our innovative, patent-protected biological products help growers to protect their crops from stress and diseases, and to produce higher quality fruit and vegetables, with a favourable environmental profile

What are the products which Plant Health Care sells today?

Plant Health Care’s Commercial business is driven by sales of Harpin αß,

a recombinant protein which acts as a powerful biostimulant, promoting the yield and quality of crops Plant Health Care also sells the proprietary soil treatment Myconate

in selected countries Plant Health Care sells Harpin αß and Myconate through specialist distributors around the world In Mexico, Plant Health Care also distributes third-party biological products in addition to our Harpin αß business

Where is Plant Health Care active around the world with current sales?

Plant Health Care has outstanding market access, through strong relationships with well-established distributors in a range of countries; we are also seeking additional distributors in some areas In the USA, we sell through two of the five largest ag input distributors, which gives

us outstanding market coverage In Brazil,

we are currently selling into sugar cane and seeking distributors for sales into other crops In Mexico, we sell a broad range

of products to retailers across the entire

country Current distribution elsewhere is patchy, with sales building in countries such

as Spain, UK, Turkey and S Africa, but with many other countries where we have limited

or no presence

We know that Plant Health Care’s R&D effort is now focusing on its next-generation plant response elicitor technology (PREtec) Could you tell us what is PREtec? Why should companies focus on this area?

PREtec – Plant Response Elicitors technology – are peptides (short chains

of amino acids) derived originally from naturally occurring harpin proteins PREtec peptides act by initiating a complex defense mechanism in plants, analogous in some ways

to a broad spectrum immune response in animals This protective response makes the plant resistant to a wide range of fungal and bacterial diseases during the growing season

In addition to protecting against various diseases, PREtec peptides enhance tolerance

to abiotic stress such as drought, leading

to enhanced plant growth and yield The company has three distinct PREtec platforms, focused either on disease control, nematode control, or biostimulants

What do you think are the significant advantages of plant immune proteins products?

Where are the future market opportunities for plant immune proteins?

Unlike the action of most chemical pesticides, PREtec peptides are environmentally friendly and do not interact directly with disease pests Consequently, these pests are not expected to develop resistance Because of their unique mode of action, PREtec peptides complement and are

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2020 Biologicals Special 2020 Biologicals Special

Christopher Richards

CEO of Plant Health Care

compatible with existing chemical fungicides and can be deployed as part of an IPM strategy As concerns about the environmental footprint of large-scale agriculture continue

to grow, farmers and consumers will increasingly demand ‘greener’ products such

of the most pressing problems facing farmers are under development and we are very optimistic about the ability of PREtec to bring added value to growers In the near-term, we are excited about the potential of our lead PREtec peptide, PHC279, as a seed treatment for the management of Asian soybean rust

in Brazil, as well as in the US to enhance the activity of foliar fungicides in corn, soy and vegetable crops In the medium-term, our PREtec peptide for nematode control is delivering impressive results from multi-state field testing in soy and specialty crops and

is expected to be embraced by growers after receiving regulatory approval

Compared with other companies that do plant immune proteins

on the market, what do you think

is the biggest advantage of Plant Health Care?

This is a great question There are very few products currently on the market that claim to work via stimulating plants’ immune

technology we call PREtec Plant Health Care has filed for the first PREtec product registrations in the US and Brazil and

we expect registrations in 2021 with first potential sales in 2022 Plant Health Care is finalizing the scale up of the manufacturing and will be looking to produce on a full-scale basis to meet the product launch dates In parallel, we are looking for complementary products to sell through our strong network of distribution relationships

What are Plant Health Care's requirements for partners in choosing a distribution partner? Does the company have plans to explore new markets such as Brazil and China?

It is a great question Plant Health Care is

a small biological company so when choosing our distribution partner first we are looking for leading distributors who have a strong presence in the row crop and specialty crop markets Next we are looking for partners who have strong technical and marketing skills with a presence in the market to reach the grower Lastly, we look for partners who want to add new technology to their portfolio and extract value from the market that is meaningful for both parties This alignment with large distributors is what sets us apart from other biological companies and gives

us confidence in our growth plans for the business We are currently open to inquiries from distributors interested in exploring opportunities for Harpin αβ in crops where we have demonstrated compelling performance, such as soy, corn, cane, and citrus in Brazil, South Asia, China and East Asia

response and those that do are known to have formulation limitations, to cause a drag on crop yield, or to act via poorly understood mechanisms PREtec peptides have none of these shortcomings Rather, PREtec is based

on cutting-edge science built up over years

of research and development to develop a new class of products that are stable, can be formulated as liquids or dry granules, and deliver dependable results

Which market areas is Plant Health Care focusing on now? What are the future market development plans?

Currently, Plant Health Care has commercial operations in the US, Mexico, Brazil, Chile, Peru, Spain, UK, Italy, Greece, Morocco, Turkey, Portugal and South Africa

Our plans are to expand into Argentina and Taiwan when we receive regulatory approvals

Plant Health Care products are focused into the specialty and row crops markets delivering yield and quality improvements to those crops which give the grower a greater return for their crop

In terms of product line, does Plant Health Care plan to expand the existing product line? If

so, could you share with us the company's existing product line and R & D pipeline?

Absolutely Today we market and sell Harpin ab and Myconate into the row crop and specialty crop markets We are excited about the launch of our next generation

Infuse Your Yield with

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promoter that offers reduction of cracking of

cherries, improvement of coloring and fruit

sizing of tree fruit, and increased overall yield

of certain crops This is because it contains

the 2nd generation of the Harpin protein, a

naturally occurring compound produced by

pathogenic bacteria that signals plants’ growth

and pathogen pathways.

• Improve fruit size for tree fruit

• Improve fruit color

• Improve yields for certain crops

• Even fruit ripening

2020 Biologicals Special 2020 Biologicals Special

or bradcustis@ABM1st.com ABM1st.com | P.O Box 222 | Van Wert, OH 45891

A Complete Line of Biological Seed Treatments for All Crops.

2020 Biologicals Special 2020 Biologicals Special

Seipasa: Focus on the American Market,

Develop Biotechnology Products

he Americas region, especially Latin

America, has become one of the

most attractive regions for crop protection

companies With more and more fruits and

vegetables produced in the Americas imported

into high-end markets such as Europe in

recent years, local requirements for pesticides

and fertilizers have also risen to a new level

The demand for green, environmentally

friendly, residue-free biopesticides and

biostimulant products in the Americas has

increased significantly Focusing on the

American market has become an important

strategic layout for many European

companies The Seipasa company we

analyzed for you today is one such company

In January 2020, Seipasa signs a

strategic cooperation agreement with French multinational company Suez, Suez will sell four products of Seipasa in Chile, including Bryosei, Kynetic4, Seiland and Sweetsei

In September 2019, Seipasa signed an

agreement with Ecuador distributor Ecuador S.A, a company with 41 years

QSI-of experience, providing various types QSI-of solutions for different industrial sectors and agriculture

In July 2019, Seipasa signed a

distribution agreement with Peru’s Agritop (a company specializing in plant nutrition)

Agritop is responsible for providing biological solutions that meet the current market requirements in Peru according to customer needs, that is, no residues and high efficiency for pests and diseases controlled products

In May 2019, Seipasa signed an

agreement with Summit Agro USA, which distributes Seican biological pesticides in the United States Seican has a dual action mode of insecticide and acaricide Seican is developed from a formula based on plant-derived substances, with low dosage and high efficacy

In September 2018, Seipasa signed

a strategic cooperation agreement with Innovak Global, Mexico's leading biological solution development and sales company

The latter is responsible for the launch of two new Seipasa products, Biocinnafol (natural plant-derived acaricides / fungicides for the prevention of mites and powdery mildew) and Biocrifol (insecticides containing natural pyrethrins, for the prevention of thorns) on the Mexican market Sucking pests)

In July 2017, Seipasa reached a

long-term cooperative relationship with Israeli biopesticide company STK, which will jointly develop and exclusively distribute Seipasa's patented bacterial agent Bacillus subtilis in the United States This patented strain can quickly form a probiotic community around the plant roots and leaves, prevent pathogens from entering the plant through the roots and plant surface, and block the development of pathogens by plant induced SAR (system acquired resistance)

In order to better understand the company's strategic intention to focus on the American market, we also took the opportunity to interview the CEO of Seipasa Pedro Peleato

We have noticed that Seipasa has selected partners in the Americas, Mexico, Peru, Chile and other Americas Why does Seipasa set strategic markets in the Americas?

The agri-food industry is a global market with numerous points of connection between all countries and continents Seipasa is a fully

innovation and research applied to active principles of botanical and microbiological origin It is clear that the Latin American market emulates all that is happening in Europe and that, furthermore, Europe is a major importer of agri-food products grown

in Latin America This strategic connection and continuous exchange between both markets is the reason why we are reinforcing our position in the American market

Can you disclose which markets Seipasa will focus on in the next phase?

Seipasa is commercially present in

4 continents and in over 25 countries worldwide We currently have a catalogue of

45 products with phytosanitary registrations and our aim is to reinforce and broaden our presence in the USA and Latin America This process will come about via new phytosanitary registrations, once all the applications that are currently under way are approved Our international growth project also includes Africa where we already have

a business unit in operation We are focusing

on developing this market and are laying down the foundations for extremely strong growth in this area We are also currently carrying out an in-depth, strategic analysis of the Asian market to define the advantages and opportunities this region can offer us

Seipasa is a pioneer in the development of natural plant protection products, biostimulants and nutrition products in Spain Over the past two decades, high-value solutions produced and registered by the company have been used in most agricultural systems worldwide

Currently, Seipasa has carried out business in more than 20 countries

After sorting out the trajectory of Seipasa's development in the Americas in the past three years, it can be found that Seipasa's market development in the Americas has selected strong local distributors for cooperation These distributors may become potential partners of domestic companies interested in exploring the American market

integrated actor in the agri-food production chain and, as such, interacts with the main players in the market from the point of view

of regulation, production, distribution or consumption The market is calling out for Seipasa’s natural technology solutions and the American continent is no different The same widespread trend we see throughout Europe for the consumption of healthy, residue-free fruit and vegetables has also grown strongly in Latin America To respond

to this demand, producers need solutions that can fight off pests and diseases and improve crop health from a sustainable, efficient and cost-effective point of view This is Seipasa’s goal in developing its natural technology model, backed by its strong commitment to

T

Pedro Peleato, CEO of Seipasa

2020 Biologicals Special 19

PRODUCT FOCUS INTERVIEW

We know Seipasa and Suez

signed an alliance for the distribution

of biostimulants in Chile Why choose

Suez? Do you have any requirements in

choosing a distribution partner?

The key aspect is the alignment of strategic

values within the context of a clear commitment to

transforming the agricultural system into a much

more sustainable and efficient model Suez is a

multinational with more than 160 years’ experience

in the sustainable management of natural resources

Its innovation and research policy is geared towards

managing water, an essential and increasingly

scarce resource in agriculture

Seipasa and Suez share a series of strategic

values that align us totally Our natural technology

model, the development of innovative and highly

technical solutions for residue-free fruit and

vegetable growing mean that we align perfectly

with Suez’s commitment to sustainable management

of the resources needed for agriculture On this

solid base we have built our alliance which, at this

initial stage, is focused on the Chilean market of

which Suez has ample knowledge and expertise

What is the current Seipasa product line?

Seipasa is a company that specialises in the development of biopesticide and biostimulant solutions based on substances of botanical and microbiological origin Our competitive edge

is that we are capable of identifying and selecting the most efficient materials and applying technology to obtain the best from these active principles We use the raw materials provided

by nature while but employing the most advanced technology that science provides At Seipasa we develop solutions that adapt to the needs of each country and type of agriculture and continue to advance in the development of new biocontrol solutions

New Registrations of Microbial Pesticides in US from 2015 to 2018

By Paul Zheng, Editor of AgroPages

iopesticide has been highly recognized due to its small side effect, high safety and environment-friendly property, having become

a new trend of pesticide development worldwide Biopesticides in Europe have development rapidly in the last few years, but unfortunately Europe is not developed into the world’s largest biopesticide market because of the restraint from the regulatory procedures in the EU Today

I would like to talk about the world's most mature and also the largest biopesticide market – the U.S market

Simplified biopesticide registration process, having greatly promoted the development of biopesticides

According to the report of MarketsandMarkets, the global sales of biopesticides exceeded $3.3 billion in 2017, which is expected to reach

$9.5 billion by 2025, at a compound annual growth rate of as high as 13.9% As the world's largest biopesticide sales country, in 2017 the sales of biopesticides in the United States accounted for 1 / 3 of the total global sales of biopesticides, of which the microbial biopesticides accounted for 67% of the total sales of biopesticides in the United States

The rapid development of biopesticides in the United States is attributed mainly to the demand from organic product market and the strong support of the US Environmental Protection Agency (EPA)

According to statistics, by the end of 2019 the U.S Environmental Protection Agency approved about 1,401 biopesticide registrations, involving nearly 400 active ingredients, in which biochemical pesticides accounted for 57.5%, microbial pesticides accounted for 36% and other miscellaneous accounted for 6.5% The simplified biopesticide registration process of EPA has greatly improved the efficiency of registration, having much reduced the time and cost associated with registration We can say that EPA has pioneered simplification of the process of biopesticide registration, which is a good reference and worth learning by other countries

A Summary of New Registrations of Active Ingredients of Microbial Pesticides in the United States from 2015 to 2018

As mentioned above, the sales of microbial pesticides accounted for 2 / 3 of the total sales of biopesticides in the United States, which indicates that microbial pesticide is currently the main trend of development of biopesticides In this paper, we are presenting the active ingredients of microbial biopesticides newly registered in the United States from 2015

to 2018 Many of them have been the first-time registration in the world, which we hope can provide a reference to our biopesticide counterparts

in China

Pseudomonas chlororaphis AFS009

In August 2017, the American biopesticide company AgBiome obtained EPA’s approval of registration of the biopesticide Howler™

It is the first product developed by AgBiome and launched to market

by AgBiome Innovations, which is used for prevention and control of

a series of fungi and oomycetes diseases AgBiome declares that the activity of the fungicide is 20 times higher than the existing biological solutions It also says that the product can completely supplant chemical pesticides in respect of control effect This is a rare statement, as biological product manufacturers generally acknowledge that their products can reduce the use of conventional chemical pesticides rather than complete replacement of chemical pesticides

Muscodor albus SA-13

In November 2016, the biological fumigant MBI-601 EP of Marrone Bio Innovations was granted registration in the United States According

to information, MBI-601 EP can be used for treatment of agricultural and horticultural soils, which can control and inhibit plant parasitic nematodes, soil pests and soil borne diseases Its active ingredient,

B

2020 Biologicals Special 2020 Biologicals Special

The first choice for synergism in the post-plant conditioning era

Ultra low cost

0.03 yuan(RMB)/15 liters of water Flush: 1.6 yuan(RMB)/666.7 square meters

g

Address: No.1, North Tianmen street,

Tai'an City, Shandong Province

E-mail: pbsw15610341616@163.com Tel: 15610341616

The main functions :

Muscodor albus, can produce a variety of chemical substances, which not only can kill or inhibit the growth of some destructive nematodes and pests, but also can control specific plant diseases such

as root rot, damping off, blight and greensickness

In addition to soil treatment, the novel microbial pesticide is expected to have more applications

to lawn, forestry seedling, post-harvest and seed treatment

Table 1: 2015 – 2018 New Registrations of Microbial Pesticides in US

Bio-fungicides

Active IngredientsBacillus subtilis FMCH002Bacillus subtilis BU1814

Bacillus mycoides AFS009

Muscodor albus strain SA-13Bacillus mycoides isolate J

Bacillus amyloliquefaciens PTA-4838

Bacillus subtilis IAB/BS03Bacillus licheniformis FMCH001

Bacillus thuringiensis subsp SA-10

Cotton armyworm nucleopolyhedro virus BV-0003Spodoptera frugiperda nucleopolyhedro virus 3AP2

Papaya ringspot viral proteinBeet armyworm nucleopolyhedro virus BV-0004

Bacillus thuringiensis Kurstaki EVB-113-19Bacillus thuringiensis subsp Israelensis SUM-6218

First-Time Registration 20182017

2017

201620162016

20152018

2016

2015201620162015

2016

2016

Owner FMCBASF

AgBiome Innovations

Marrone Bio InnovationsCERTIS USA

Valent USALIDOCHEM

SEIPASAIBERFOLINVESTIGACIONES Y APLICACIONES

BIOTECNOLOGICASQUIMICAS MERISTEM

FMC

CERTIS USA

CERTIS USAAGBITECHUNIVERSITY OF FLORIDAAndermatt Biocontrol

AEF Global

SUMMIT CHEMICAL CO DBA SUMMIT RESPONSIBLE SOLUTIONS

Trade Name-VELONDIS

Howler

ENNOBLELIFEGARD

VBC-90052VARNIMO IF

FungiseiMilagrum PlusMildoreBACIXAVODA

Btt SDTC

SPOD-X LCFAWLIGENX17-2 PapayaSPEXIT

BIOPROTEC

DUNKS

Bio-nematocides

Bio insecticides

Bacillus mycoides isolate J

In 2016, the LifeGard WG of the US Certis, Mitsui Chemical, was granted registration

in the United States, with the active ingredient being Bacillus mycoides, which is the first biopesticide in the world to act via induced resistance against fungal and viral diseases In that year, the product won the world's best biological innovation award LifeGard WG is registered mainly for control of potato early blight, late blight and powdery mildew So far, the product has been sold in most of the regions of the United States and Canada, with a good market response

2020 Biologicals Special 2020 Biologicals Special

Botanical Pesticides Approved/Launched

in Europe, US in Spring 2020

By Joyce Wang

Editor of AgroPages

joyce@agropages.com

Product from ORO AGRI

Oro Agri is a global market-oriented business company, developing and providing biological products for crop protection and yield increase Its products are sold to more than 85 countries across five continents, with

180 employers in more than 23 countries

The company has production plants in Brazil, South Africa and North America, as well as

a contract manufacturer in Spain The orange oil products from Oro Agri are biological pesticides which provide multi-functions of insecticide, acaricide and fungicide, of which PREV-AM® has been applied successfully in South Europe for more than three years, and has also been launched in the Chinese market

In February 2020, Oro Agri launched a new version of PREV-AM – Oroganic, in the Netherlands It is a novel insecticide/

acaricide/fungicide based on the active substance of the natural orange oil, with built-

in adjuvant The product has been approved

by the Dutch Board for the Authorization

of Plant Protection Products (CTGB), for application on tomatoes, bell peppers, chilies, Cucurbitaceae (like cucumbers) and ornamentals (such as cut-flowers) Oroganic can be used to control spider mite, whitefly, thrips, aphid, scaly insect and mealybug, as well as diseases such as botrytis, powdery mildew and downy mildew

According to the company, Oroganic is quick and effective in controlling targeted insect pests without leaving harmful residues, and there is no requirement for pre-harvest and post-harvest intervals Oroganic's mode

of action reduces the risk of pest becoming resistant to the active ingredients The product has a low impact on beneficial insect and mite, being an ideal choice for Integrated Pest Management (IPM)

Oroganic can be used with a combination

of other biological control solutions, or

tank-symptoms disappear Moreover, the product can inhibit the growth of fungal mycelium, hinder the germination of the fruiting body, disrupt the disease life cycle and prevent its further spread

In terms of harmful mites and insects, Cinnerate asphyxiates them by sealing their spiracles Cinnerate can also disturb the nervous system, and inhibit glucose uptake and use This leads to effective control of all mite life stages, including the eggs

Cinnerate has little to no impact on the beneficial insect population The product

is compatible with most of the biological control products and can be used with chemical fungicides and acaricide to create

a synergistic effect In addition to hemp, Cinnerate is approved for the application to most of the crop varieties

AzaPro is an insect growth regulator, which controls various insect species, and is a nematicide as well With the highly bioactive

azadirachtin, the product has dual modes of action It primarily regulates the growth of insects, with a repellent effect The product controls more than 300 different insect species, including aphid, thrips, leafminer, leafhopper, beetle, mealybug, weevil, Lepidoptera and pear psylla, etc

AzaPro kills the insect larvae and nymphs

by interfering with ecdysone, thereby making

it impossible for them to become reproducing adults The product is lethal to sucking and chewing pests with minimal effect on non-target beneficial insects Although it is difficult to control with sprays to kill insects that feed on the undersides of the leaves, AzaPro is able to penetrate the leaves to control these pests Repeated application of the product forms a protective barrier within the plants to prevent the growth of pest populations

Furthermore, AzaPro contains 75% fewer oil carriers than competing products The product can thus reduce the oil accumulation

on crops, and leave no visible oil residue on the produce

otanical pesticides, as a substitution for

chemical pesticide, mitigate the problem

of harmful residues and pesticide resistance,

as many botanical pesticides have shown an

ideal efficacy to control agricultural pests

These products have multiple modes

of action and are harmless to non-target

organisms In the past years, research has

shown constant improvement in the control

effect of botanical pesticides Pyrethrum,

azadirachtin and plant essential oil are

commonly active ingredients in these products

Such products make a great contribution

to organic farming in developed countries

and play an important role in agricultural

production and post-harvest preservation in

developing countries

Today, there are mainly four types

of botanical pesticides for pest control:

pyrethrum, rotenone, azadirachtin and plant

essential oil Some vegetable extracts, such

as garlic-derived ingredient, are relatively

less used worldwide The desired safety and

efficacy of botanical pesticides enable them to

be alternatives to chemical products

This article present four botanical

pesticides approved or launched in Europe and

the United States in spring 2020

mixed with many other crop protection products Regular use in the irrigation system will not cause chemical residue deposition or nozzle-plugging Oroganic is not easily affected by the pH of the tank-mix formulations Moreover, the product is both hydrophilic and lipophilic, which is good for tank-mix formulations to penetrate into insect pest and the plant’s superficial wax coat

Oro Agri is working on research, registration and label extension for the product’s other uses Now the company has registrations pending in more than 20 countries

Products from Sym Agro

In order to effectively control the common insect pests and diseases such as powdery mildew, botrytis, mite and worm for hemp growers, Sym Agro has assembled

a suite of broad-spectrum biopesticides to improve the control efficacy This assemblage includes four biological control products, three of which are vegetal pesticides, granted the organic certification In addition to hemp, these products can be applied to various crops

Cinnerate is a fast-acting acaricide/

fungicide/insecticide, based on cinnamon aldehyde, emulsified with potassium oleate

The innovative formulation enables the product to be effective with low application rates It has an eradicative effect against various diseases such as powdery mildew, botrytis and rust Cinnerate can control most mite and other insect species

Cinnerate provides multiple modes of action and is an ideal product for resistance management Cinnerate affects the oxidation

of fungal mitochondria, which interferes with the enzyme activity of the cell membrane, causing quick dehydration and making

Alluma contains 15% refined garlic oil (Allyl polysulfides+Allicin), which is a stable and long-lasting formulation It acts as an insecticide, insect repellent and miticide, as well as a feeding and oviposition deterrent After insect uptakes Alluma, the product inhibits its chitin Alluma also acts on the pest’s sensing faculties, disguising the odor signal emitted by crops and thus preventing females from laying eggs The product controls various Lepidoptera, thrip, weevil, soft-bodied insect species and mites Alluma can be used either alone or tank-mixed with other pesticides enhancing overall pest control The experimental result has revealed a high synergistic effect when Alluma is applied with Cinnerate

or azadirachtin The product is of great help in the control of tough insect pests Besides hemp, Alluma can be used on fruits, vegetables, herbs and field crops

More biopesticides approved/launched worldwide in spring 2020 are as below:

Company Product Ingredient Target Pest Target Crop Country

Oro AgriBayer

Kenogard

Valent BioSciences

AzaPro

Orange oilEndophyteQST713

Saccharomyces cerevisiae cell

wall

Bacillus thuringiensis subspecies aizawai (ABTS-1857), insecticidal proteins

Streptomyces griseochromogenes K61

Hydrogen peroxide

Trichoderma asperellum TV1

Extract of Melaluca alternifolia

Garlic oilCinnamon oilNovel bacillus subtilis IAB/BS03Azadirachtin

NetherlandsChina

Various fungal diseases

Box tree moths, cabbage loopers, corn earworm, leafrollers, tomato leafminers

Damping off, root and crown rot, wilt

Over 300 kinds of insect pests, mites,

nematodes

Greenhouse tomato, pimento, chili, cucurbitaceae, ornamental plantTomato, potato

Grape, tomato, eggplant, cucurbitaceae, strawberry, lettuce

Fruiting vegetables, tree nuts, herbs and spices, grape, etc

Various crops

Fruit and vegetable crops

Greenhouse ornamentals, vegetables,

2020 Biologicals Special 2020 Biologicals Special

PRODUCT FOCUS

Regev™ – A Broad-spectrum Hybrid Fungicide for Plant Disease Control

By Prof Moshe Reuveni

Chief Scientist, STK bio-ag technologies, Israel

Introduction

The global search for plant-protection solutions that

are both environmentally safe and efficacious is driven by

the need to supply food to the ever-growing population

The call for chemical load reduction is an important aspect

of sustainable agriculture Recently, documented issues of

widespread environmental contamination, toxicity to

non-target organisms and negative effects on human health by

synthetic agrochemicals have led to a resurgence of interest

in "natural" means of pest and pathogen controls, including

an intensified search for new sources of biopesticides and

botanical pesticides The latest solutions are generally used in

crop protection and contain secondary metabolites, which can

be (but are not always) involved in plant defense Among the

latest solutions, essential oils are considered to be attractive

for plant protection

Tea tree oil (TTO) is a valuable essential oil extracted

by the steam distillation of Melaleuca alternifolia leaves

(belonging to family Myrtaceae) It contains many

components of terpenes, sesquiterpenes, and their respective

alcohol The oil has proven to be an effective antiseptic,

fungicide and bactericide In the recent decade, it was found

to be effective against a broad range of plant-pathogenic

fungi in numerous crops, including vegetables, herbs, coffee,

rice, grapevines, bananas, and fruit trees

New effective alternatives that can provide different

and multiple modes of action with a lower risk for fungicide

resistance, and which place a smaller chemical load on the

environment, concomitantly with consistent disease control,

are required to increase options for controlling plant diseases The newly developed Regev EC by the Israeli bio-tech company, STK Bio-Ag Technologies, is a hybrid formulation: it contains 200 g/L of the systemic triazole fungicide difenoconazole plus 400 g/L of TTO This unique prepacked formulation provides various mechanisms of action against a broad spectrum of plant pathogens with improved efficacy

Hybrid solutions can be the "bridge" between conventional agrochemical farming and sustainable farming That’s because it is a "pre-mix", so it is easy-to-use, in the exact same way as the grower’s current chemical pesticide To the best

of our knowledge, this is the first bio and chemical-based hybrid product

Modes of action

As a Hybrid, Regev combines the modes of action of the botanical extract with

a synthetic chemical molecule The fungicidal and antimicrobial activities of TTO against fungal pathogens, as documented, are derived from its ability to inhibit respiration and disrupt the permeability barrier presented by the membrane structures

of living organisms Our recents studies showed that TTO is effective against spore germination and significantly inhibited lesion development and the sporulation of fungal pathogens TTO was found to disrupt the fungal cell membrane and cell wall

in plant tissues infected with pathogenic fungi [see Figure 1], which explains why

it exhibited a strong curative activity against fungal pathogens, making it a unique product and enabling growers to use it even when the disease was already visible on the tissue In addition, TTO was found to be an activator of defense mechanisms and systemically induce resistance in plants

The sterol biosynthesis inhibitors, including difenoconazole, affect the fungal cell membrane by inhibiting the C-14 demethylation of lanosterol or 24-methylenedihydrolanosterol, a biosynthesis step that occurs during the conversion

of lanosterol to ergosterol, the final product of fungal cell membrane sterol synthesis

The different modes of action of TTO and difenoconazole, i.e a combination of

a natural product with broad-spectrum activity (TTO) and a traditional site-specific chemical, make Regev an effective and unique tool for resistance management, which is suitable for Integrated Pest Management programs This combination results

in a reduced synthetic chemical load on the environment compared to other mixtures based on two traditional chemicals

Field trials

Regev is currently used for controlling a broad range of diseases on arable crops, cereals, fruits and vegetables Diseases effectively controlled by Regev include powdery mildews, apple scab (Venturia inaequalis), Black Sigatoka (Mycosphaerella fijiensis) in bananas, species of Alternaria, Cercospora, Botrytis, Rhizoctonia, Pyricularia, Helminthosporium, Sclerotium and more Numerous trials have been conducted with various crops and in different countries Here, we present an example

of Regev's activity against apple scab caused by Venturia inaequalis

A field trial was undertaken in Northern Israel in a major apple growing region and the efficacy of Regev was examined, compared to the systemic fungicide, difenoconazole Untreated trees served as controls Six foliar sprays of each fungicide were applied, starting from the green tip at 6-10-day intervals Treatments were arranged in a randomized complete block design The results given in Figs 2 and 3 show that difenoconazole inhibited scab development on apple trees compared

to untreated control trees However, Regev (TTO + difenoconazole) was significantly more effective in controlling apple scab

Resistance management

Regev has a unique multiple functional activity and presents a very low probability for the development of resistance or cross-resistance in plant pathogens, so it could be an important tool in preventing the development

Figure 2 Efficacy of Regev (TT+Difenoconazole) and difenoconazole in controlling apple scab Different letters on bars indicate a significant difference (P < 0.05)

Figure 3 Efficacy of Regev (TTO+Difenoconazole, lower)

in controlling apple scab on fruits and leaves compared to untreated (upper)

Figure 1 A section of fungal hyphae in the intracellular space of the mesophyll tissue of TTO-treated leaves: (a) at low magnification (x20,000=a) and (b) at high magnification (x50,000) Note the destruction and breakdown of the cell wall, causing leakage of cell content

2020 Biologicals Special 2020 Biologicals Special

Biorational Developments in Open Field Crops

By Jan Mostert

Head of Biorationals Innovation Team, Certis Europe

he current focus on the ‘greening’

of agriculture and horticulture crop protection in Europe is not new, nor is it likely

to go away Considerable progress has been made in some sectors already, but there is still a lot of work to be done to meet the ever-increasing demands of governments, the value chain and consumers for more sustainable and environmentally friendly production

Certis Europe has a long history of providing growers with Biorational crop protection solutions for sustainable production and is at the forefront of new innovative product developments, continuing to extend its footprint in the market Biorationals are defined as “registered plant protection products generally derived from the natural environment, offering improved benefits for plants, people and the planet, which are increasingly important factors for Integrated Crop Production to satisfy requirements of the value chain and consumers.”

The biorationals portfolio of Certis includes many products for use in protected cropping, as well as several that are already registered and used effectively in open field crops* Whilst the production of protected crops such as tomatoes, cucumbers, peppers and strawberries using biorational control products in effective Integrated Pest Management programmes is now quite normal, the successful transfer of such techniques to open field crops is clearly not just a matter of ‘copy and paste’

However, work on open field crops is well underway and much has already been learnt It is vital to adjust both the products used and the application techniques to achieve more reliable and more effective control in an open field cropping situation

For example, in open field crops, elements such as rainfastness can become critical and a spraying technique that targets pests correctly, for example if they are found on the underside

of leaves, is vital Since most Biorational products are not systemic, control is only effective if they can be applied on the spots where the pest or disease has been detected at

an early infestation level, so preferably even before damage to the crop occurs Aphids who hide on the underside of the leaves for example, can only adequately be controlled with a Biorational product, if the product

is applied to the underside of the leaves

Many open field crops are sprayed by tractor mounted booms, whose nozzles spray mainly downwards This application technology does not really support the efficacy of a Biorational aphicide Work is moving forward and researchers are encouraged by the improvements seen, as progress is made

In protected cropping situations new technology, such as drones and robots for monitoring the crop to detect and identify pests and diseases early on, are being tested or even in use already If such developments continue to be successful and their use becomes accepted and economically

justifiable, this could offer improved opportunities for early detection of pests and diseases even in open field crops Such new technologies could bring a definite advantage for more optimal use and so performance

of Biorational products in outdoor cropping situations too

New products are in the Certis development pipeline, while others such as Eradicoat Max and Neudosan®** are already registered or in the registration process of different countries and coming to the market soon Certis aims to have over 30% of sales coming from Biorationals by 2025 The major challenge is to create innovative production and application technology to facilitate the effective use of Biorationals in open field crops Without such innovation the use of Biorationals in field crops will not advance very quickly

* Examples include slug pellets based on ferric-phosphate, a salt (potassium bicarbonate)

to control powdery mildew, as well as Bacillus thuringiensis and pheromone products for pest control solutions in fruit and vegetables and Trichodermas as a microbial solution against soil diseases

** Neudosan® is a registered trademark

of Neudorff and is based on fatty acid-based potassium salt with insecticidal and acaricidal activity It is already EU approved and currently sold in Germany on both greenhouse and open field crops It has approval for use on organic crops in Germany Registrations in other EU countries are anticipated via Mutual Recognition procedures according to Regulation 1107/2009.+

of cross-resistance during the season Its application

can be rotated with products that exhibit differing

modes of action and to which populations of fungal

pathogens have shown a loss of sensitivity, so that the

population of individuals less sensitive to chemical

products can be reduced Studies showed that Regev

(TTO plus difenoconazole) improved the sensitivity

of difenoconazole against fungal isolates, which

exhibited a lower sensitivity to difenoconazole, and

subsequently, delayed the emergence of resistance to

this fungicide

Registration

Regev has already been registered in the USA,

Israel, the Philippines, Serbia and various Latin

American countries for various crops and diseases It

is currently in the process of being registered in Brazil

and the EU

Summary

The different modes of action of TTO and difenoconazole, created by the combination

of a natural product (TTO) with broad-spectrum activity and a traditional site-specific chemical, make Regev an effective and unique tool for resistance management It presents multiple modes of action (FRAC Groups F7 and G1) to help prevent the development

of resistance This combination results in a reduced chemical load on the environment compared to other mixtures based on two traditional chemicals, leading to reduced residual potential

The preventive and curative activity of Regev, related to its efficiency of contact, mesosystemic plus systemic activity by a single application, together with the indirect activity via the host plant by systemic resistance, leaving little residue and providing significant added value to growers, make Regev an important component in the control

of plant diseases Regev has an expanded spectrum over either component alone and has demonstrated activity over a wide range of plant diseases It can therefore be an efficacious and easy-to-use "bridge" solution for controlling various diseases

Please contact Julia.levy@stk-ag.com with any questions about this article or Regev hybrid fungicide

T

2020 Biologicals Special 2020 Biologicals Special

Ingevity: Enhance the Efficiency of Micronutrients with Pine-based Kraft Lignin

ccording to recent United Nations estimates, the

world’s population is projected to grow to nearly

10 billion by 2050, which will require boosting agricultural

demand by an estimated 50% to meet this global food

challenge1 To support this need, farmers worldwide must

increase crop production by enhancing productivity on

existing agricultural land through innovative methods like

precision farming and plant nutrition management Proper

plant health maintenance, such as soil and foliar applications

of micronutrients and fertilizers, is crucial to optimize nutrient

uptake and support growing crop yield

Micronutrients are essential for plant growth and play

an important role in balanced crop nutrition Commonly

composed of minerals like iron, zinc, manganese, boron

and copper, micronutrient solutions can be applied in soil

or by foliar application as soluble metal salts, insoluble

metal carbonate or metal oxides Organic carriers such as

ethylenediaminetetraacetic acid (ETDA), amino acid, humic

acid and kraft lignosulfonates (kraft lignin) play a prominent

role in the dissolution of micronutrients and their transport to

plant roots

Specialty chemical producer Ingevity is the world’s largest

producer of kraft lignin, and as such offers an array of

high-quality, sustainable lignosulfonates These bio-based

lignosulfonates protect micronutrients from oxidization or

precipitation, remediate leaf burn, and extend the absorption

time on the crop With a low molecular weight, kraft lignin

contributes to low viscosity formulations without threatening

Compared to the commonly used chelating agent EDTA, kraft lignin’s level complexation structure adapts to a wider pH range, allowing application compatibility with various soil properties Its weaker complexation strength offers easier release of metals into soils and plant leaves Also, the hydrophilic sulfonate groups make kraft lignin a natural humectant, ensuring prolonged absorption time of the agricultural chemical Lastly, when formulated with insoluble metal oxides, Ingevity’s kraft lignin can serve as an excellent dispersant by providing impressive surface coverage and steric stabilization Table 1 includes Ingevity’s most frequently used products in micronutrition applications

multi-Crop friendliness without sacrificing performance

Kraft lignin’s inherent functionalities (phenolic hydroxyl, carboxylate) form much weaker complexation with metal ions when compared to those from EDTA Figure 1 compares the complexation stability constants (Log K, where K is the equilibrium constant)

of several model phenolic compounds and aromatic carboxylic acids with different divalent cations, using EDTA as a reference

The weaker complexation stability is advantageous for ions to be released from the complex and absorbed by the plant rooting or foliar system In turn, the regenerated lignosulfonates can complex with the remaining micronutrients

Property Reax ® 260 Reax 88A Reax 100M

Degree of sulfonation

pH

Ammonium sulfate tolerance*

* Based on a 2.5% lignosulfonate and 3.79% zinc sulfate formula.

0.550.55

1.510.74

5.86.10

7.305.15

16.3118.62

18.8016.50

7.267.84

8.607.99

Figure 1 Complexation stability constants (Log K) of model phenolic and aromatic carboxylic acid compounds with divalent cations compared to EDTA

Figure 2 Moisture uptake study of ZnSO4 and ZnSO4-KLS complex

Table 2 University of Florida tomato greenhouse study of Ingevity’s kraft

lignin micronutrient formulations

1 Nikos Alexandratos and Jelle Bruinsma, “World Agriculture Towards 2030/2050: the 2012 Revision,” Food and Agriculture Organization of the United Nations,

June 2012, http://www.fao.org/3/ap106e/ap106e.pdf

As a natural humectant, kraft lignin provides improved wetting and prolonged foliar absorption As shown in Figure 2, zinc-kraft lignin (ZnSO4-KLS) complexes can absorb 8% moisture, while zinc sulfate (ZnSO4) only absorbs 1% Formulations with kraft lignin dry more slowly than sulfate solutions and EDTA complexes, allowing longer uptake time for foliar applications A naturally derived product, kraft lignin does not cause phytotoxicity, remediating leaf burn if nutrient overdose occurs

Demonstrated plant health and crop height in the field

Ingevity collaborated with The University of Florida on a tomato greenhouse study of kraft lignin-based micronutrient products (Table 1)

to determine the efficiency plant health and crop yield A blend of various uncomplexed inorganics, including sodium borate (Na2B4O7); copper sulfate (CuSO4); iron sulfate (FeSO4); magnesium sulfate (MnSO4); sodium molybdate (NaMoO4); and ZnSO4, was used as the control group to compare to a blank study group excluding inorganics In the experimental groups, one inorganic salt was replaced by the kraft lignin complexed product and applied to soil types with pH levels of 6.0 and 7.5 Crop height was measured after 16 days of the application, and plant yield was represented by fresh weight and dry weight provided in Table 2 All lignin-based experiment groups demonstrated increased crop height and plant yield For example, more than a 20% crop height and yield increase was observed when using complexed zinc or magnesium

A

Table 1 Ingevity kraft lignin products designed for micronutrient applications

Crop Location and soil type

Reax product and application rate

Method of application Comments

Rice Sorghum Kansas, pH 6.6 Reax Zinc - 11lbs/acre Knifed in soil

Soybean

NC Muck - nearly drained - deficient

in all metals, pH 4.5

Reax Copper - 0.75 lbs/acre;

Reax Manganese - 1.50lbs/acre; Reax lron - 1.00lbs/acre

Broadcast in 8-22 suspension, banded at planting in 10- 34-0, banded at planting in10- 34-0

18-Control 4lbs/acre copper and 4lbs/ acre manganese as sulfates 12%yield increase

Carrots Florida - Muck Reax Manganese 2lbs/100 gals

200gpa Foliar spray

Complete greening

of leaves within one week of application 30% increase in yield over control

Texas, wet, pH 7.5 Reax Zinc - 14.8lbs/acre Chlorosis correction,61% yield increase

Chlorosis correction, 37% yield increase Soil

Table 3 Third-party field trials of Ingevity’s kraft lignin micronutrient

formulations

Test Experiment LS-Metal Complex

Increase in Height after 16 Days, mm Plant Yield Soil

pH 6.0 pH 7.5 Soil Fresh wt., g Dry wt., g

123

54

6

23.3164

2592

15.3122

1287

-All Inorganics* -Except Fe Fe

93

2020 Biologicals Special 2020 Biologicals Special

Ingevity also conducted additional

third-party field trials for rice, sorghum, soybean

and carrots among different soil conditions

(Table 3) The application of zinc complexes

with Ingevity’s kraft lignin corrected

chlorosis and increased the yield by 61%

for rice and 37% for sorghum For soybeans

tested on a nearly drained and metal-deficient

soil, 12% crop yield was observed with a

60% lower application rate of the KLS-metal

complexes Following the foliar application

of complexed magnesium, carrots showed

complete greening of leaves within one week

of application and a 30% yield increase

Easier formulation and reduced

costs

Since lignosulfonate-based micronutrient

products are typically delivered in liquid

form, the formulation viscosity and stability

are key considerations in the process of

production, storage and field application

Common undesirable formulation

performances include high product viscosity

and formation of precipitates With high-solid

Figure 4 Stability for aqueous suspension of metal oxides and carbonates in the presence

of Ingevity’s kraft lignin products

Achieve the highest crop yield with pine-based technology

As the world's largest producer of kraft lignosulfonates, Ingevity is committed to quality,

loading, low viscosity and long-term solution stability, Ingevity’s kraft lignin products provide farmers with formulation flexibility, reduced shipping cost and improved user friendliness

Ingevity’s Reax® 100M is specifically designed for micronutrients complexation, offering a high degree of functionality for optimal metal complexation and aqueous solubility, and a low molecular weight decreasing solution viscosity For example,

a solution with 40% Reax 100M can be easily prepared by simple mixing to achieve

a readily flowable solution viscosity of approximately 30 centipoises A nearly saturated ZnSO4 solution with 15% of zinc and a MnSO4 solution with 12% of magnesium were prepared in deionized water

Stable KLS-metal complexation solutions can be prepared from any given ratio between the 40% Reax 100M solution and the metal solutions, indicating formulation flexibility with the use of a wide range of concentrations

For illustration, solutions with a weight ratio of 1:2 between Reax 100M solution and

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the metal solutions are demonstrated in Figure

3 A sulfite lignin product with 30% solid is also used for the comparison study Solutions prepared with Reax 100M exhibit impressive stability with no precipitations Solutions containing sulfite lignin were initially cloudy after blending and separation was observed after three days

Metal oxides or carbonates, such

as copper oxide (Cu2O) and manganese carbonate (MnCO3), are insoluble, meaning the settling of these particles over time will negatively impact the formulation’s application efficiency Ingevity’s kraft lignin products have proven valuable in dispersing insoluble metals and challenging pesticides due to their steric stabilization abilities A formula was created with the ratio given in Table 4, and the average particle size in the suspension was 3-4 micrometers (μm) Figure

4 below shows no precipitation from the suspension after testing the formulation at 45

℃ for one week Even after nine weeks of storage at 45 ℃ , the formulation has minimal particle growth and good suspensibility

Figure 3 Photo of lignosulfonate metal complexation solutions as observed after three days

Solution A: 7 grams (g) of Reax 100M solution (40% solid) and 14 g of ZnSO4 solution (15%

element Zn); Solution B: 7 g of Reax 100M solution and 14 g of MnSO4 solution (12% element

Mn); Solution C: 7 g of sulfite lignin solution (30% solid) and 14 g of ZnSO4 solution; Solution D:

7 g of sulfite lignin solution and 14 g of MnSO4 solution

Table 4 Aqueous suspension of metal oxides and metal carbonates with Ingevity’s kraft

Ingevity also introduced a bio-based line of sticker adjuvants under the name AltaHance®that are beneficial for micronutrient applications AltaHance products provide tunable rainfastness, accelerated spreading, increased penetration, and high performance under challenging conditions Learn more about these products in the recent ArgoPages feature “Bio-based adjuvants: The future

of sustainable agriculture.”

2020 Biologicals Special 2020 Biologicals Special

Azotic’s Natural Nitrogen Fixing Technology

Is A Must for Agriculture

zotic Technologies, a UK-based

global ag-tech company, was

established in January 2012 to develop and

commercialise a natural nitrogen-fixing

technology (N-Fix®) N-Fix® is a disruptive

technology which has the potential to totally

transform agriculture and is unique to

Azotic A marketable product is now being

commercialised with positive benefits to

growers

Agriculture accounts for 80 percent of

total nitrous oxide (N2O) emissions, mainly

from the application of fertilisers, and 20

per cent of greenhouse gas discharges which

impacts on climate change¹ Agriculture must

change in order to reduce nitrogen pollution

which is damaging to human health It will

be essential to improve biodiversity in order

to future proof agriculture for subsequent

generations Azotic’s natural nitrogen fixing

technology provides a sustainable solution to

fertiliser overuse and nitrogen pollution

It is estimated that the world population

will grow to 10 billion in 2050 Increasing food production sufficiently to meet future demand whilst reducing pollution will be

a major challenge for agriculture Also, soil degradation and the reduction of arable land compounds this issue Azotic’s natural nitrogen fixing technology, which is environmentally friendly, will boost plant efficiency and increase crop yields

Humanity depends on fixed nitrogen to fertilise crops and boost food production

Although nitrates are added in vast quantities

to increase crop productivity, this is a very inefficient process with up to 30% of nitrates applied on the land ending up in coastal waters and leached into the atmosphere This has adversely affected the earth’s nitrogen balance therefore agriculture needs to change

N-Fix® is a novel technology which is derived from a naturally occurring beneficial food grade bacterium Gluconacetobacter diazotrophicus (Gd) This is neither genetic modification (GM) nor bio-engineering This

enables plants to fix nitrogen from the air and replace up to 50 per cent of their nitrogen needs as an alternative to fertiliser This is a patented innovative technology which will have a huge impact on agriculture – Azotic’s strain of Gd is unique in its ability to colonise plant cells intracellularly Azotic is the only company offering an “intracellular” strain of

Gd in non-legumes The bacterium Gd does not persist as a free-living soil bacterium, it has been found only when associated with plant material, most notably sugar-cane

Azotic’s N-Fix® technology is a new way to deliver nitrogen to plants; it is applied to plants via the seed in order to create a symbiotic relationship within the plant enabling it to substitute the nitrogen

it normally takes up from the soil with atmospheric nitrogen – thus reducing dependency on nitrogen fertilisers It works from within plant cells to fix nitrogen from root to leaf all season long It contains no toxins, is environmentally friendly and helps reduce nitrogen pollution It has proven efficacy in strategic crops which include corn, soybean, rice, wheat and others

Market demand for food is changing with the emphasis on greater food security

Consumers require good quality food and supermarkets realise the need for more sustainable produce Agriculture has to change; it must reduce emissions

of greenhouse gases, nitrates and other contaminants into the environment as well

as increasing food supply Sustainability

is critical, unless the footprint of the food system on the environment is reduced, the capacity of the earth to produce food for humankind will be compromised with grave implications for future food security

The continued production and use of synthetic nitrogen-based fertilisers is no longer sustainable and growers are being

encouraged to adopt more sustainable farming practices The movement towards climate smart agriculture has encouraged the use of biologicals, bio-fertilisers and seed treatments Agriculture must progress and adopt new innovative technologies and practices Transparency will be important

in all aspects of the food chain especially farming N-Fix® is an ideal fit; it is a world first organic technology providing sustainable nitrogen which will boost agriculture

Biological nitrogen fixation will improve modern agriculture at a time when more food

is needed to feed an increasing population without damaging the ecosystem

Azotic's N-Fix® technology won the AgroPages Awards for Novel Fertilisers

in 2018 and judged to having great market potential in China Azotic Technologies was awarded Frost and Sullivan’s 2015 Technology Innovation Award for the European Alternative Fertiliser Industry

Analysts independently evaluated the technology’s attributes and future business value to recognise the Company as having strong overall performance, highlighting the importance of a ground-breaking agricultural solution that allows plants to extract nitrogen from the air rather than from polluting fertilisers

This ground-breaking nitrogen technology has achieved positive results in the USA through a Grower Partner Programme It is now registered and officially available in all

50 US states Commercial sales on corn and soybean in the US has reduced the need for applied nitrogen fertiliser on average by 27%

without impacting yield On corn, applied furrow, it delivers on average between 5-13%

in-yield increase and in some cases up to 20%

In addition, observations have indicated:

▪ Early tillering

▪ Improved rooting with more fine roots and a more robust root system as the plant matures

▪ Better plant vigour with advanced growth stages throughout the life cycle

▪ Plant tissue tests revealed more nitrogen

in the plant up through mid-vegetative stages

Rice trials in Asia have shown very positive results In three Vietnamese rice trials the overall response was a mean average 20% (825 kg/ha) yield increase across all the field trials (2017) Further rice trials in Thailand and the Philippines showed that there was a positive effect on yield at all of the trials; the N-Fix® treated plots yielded 17% (645 kg/ha) more than the untreated, with a 1 t/ha (29%) increase being seen at 50% of the recommended fertiliser N (2018)

Also, when N-Fix® was applied with the full recommended level of N there was a significant increase in yield of 7% equivalent

to 300 kg/ha

This technology generates high yield production in agriculture combined with nitrogen sustainability It is ubiquitous to all crops and provides a cost benefit to the grower through reduced fertiliser costs and increased yields Another benefit is cleaner and superior quality food for the consumer.Peter Blezard, CEO of Azotic, said:

“Agriculture requires more efficient and sustainable farming practices in order

to increase food supply and maintain biodiversity Positive results highlight the efficacy of our revolutionary technology in making crops nitrogen-fixing and with the resulting increased yields This technology

is a must for commercial agriculture where yield, cost and pollution needs can be optimised”

Azotic’s progression is quite remarkable The company has developed its own strain of Gluconacetobacter diazotrophicus (Gd) and transformed that into a marketable product The scale up and production of an inoculant via the development of a specific fermentation process has resulted in the first commercial product of its kind Azotic is delivering this technology to market and continues to add value with new IP Through its development work on N-Fix, Azotic has identified a new platform nitrogen technology; It will commercialise technologies based on this platform through appropriate partnerships in R&D and routes to market There is a pipeline

of products under development and these include a dry formulation and a foliar spray.Azotic’s nitrogen fixing technology is a must for agriculture and will certainly change current farming practices New technologies including N-Fix will play a pivotal role in propelling sustainable agriculture forward

¹Agriculture and climate change, McKinsey

& Company 2020

A