gait and balance disorders

... between gait and balance variables Relationships between gait variables and balance, as assessed by BESTest were explored (Table 2) A significant large positive relationship between fast gait speed ... frequency The GAITRite® is valid and reliable in measuring gait in people with neurological conditions and normative comparison groups [19, 20] Measures of gait speed, stride length (right and left ... prediction of falls and falls risk This study examined the relationship between gait variables, balance performance and falls history in ambulant adults with CP, and demonstrated slow gait speeds, short

Ngày tải lên: 25/08/2016, 21:39

... 41 Susan Lindquist and Karen L Allendoerfer Tau and Intracellular Transport in Neurons 59 E.-M Mandelkow, E Thies, S Konzack, and E Mandelkow Signaling Between Synapse and Nucleus During Synaptic ... neurodegenerative disorders, isthat protein misfolding plays a defining role This was the focus of work reported byLindquist, in studies of Parkinson and Huntington disease models, and Mandelkowand colleagues ... Aβgeneration; and (4) sorting of APP and/or itsα- and β-carboxyl-terminal fragments (C83 and C99, respectively) toward the trans-Golgi network is under the influence of presenilins and the VPS35/retromer

Ngày tải lên: 14/02/2014, 17:20

... an ‘‘understandable’’ consequence of the illness On theother hand, behavioral problems such as delusions and hallucinationsdramatically aVect both patients’ and caregivers’ lives, and treatment ... clinical features and treatment of Parkinson’s disease, followed by discussion of associated depressive disorders, anxiety, phobias, apathy, hallucinations, delusions and sleep disorders Speci ... are also discussed, and the mechanisms for these disorders explored In addition, the book addresses the psychiatric and cognitive side-eVects of antiparkinsonian medications and new surgical treatments.

Ngày tải lên: 28/03/2014, 22:21

... 1Somatoform and Factitious DisordersTrang 2Review of Psychiatry SeriesJohn M Oldham, M.D.Michelle B Riba, M.D., M.S Series Editors Trang 3No 3Washington, DC London, England Somatoform and Factitious Disorders ... drug dosages, schedules, and routes of administration is accurate asof the time of publication and consistent with standards set by the U.S Food and Drug Administration and the general medical ... many mysteries of these disorders Despite the consistent richness of their historical and clinicaltradition, somatoform and factitious disorders have receivedvariable, and in some cases limited,

Ngày tải lên: 11/04/2014, 07:11

... Trang 2Psychological DisordersChild Abuse and Stress Disorders Trang 3Addiction Alzheimer’s Disease and Other Dementias Trang 4Foreword byPat Levitt, Ph.D. Vanderbilt Kennedy Center for ... psychological disorders later in life func-Those who study the relationship between brain ture and function, and the diseases that affect this bond, areneuroscientists Those who study and treat the disorders ... brain controls our feelings,fears, and emotions; our ability to learn and store new infor-mation; and how well we recall old information The braindoes all this, and more, by building, during development,

Ngày tải lên: 03/05/2014, 18:12

... obsessive-compulsive disorder (OCD) and obsessive-compulsive related disorders (OCRDs) and their clinical management via literature review, critical analysis and synthesis Information on OCD and OCRD current nosography, ... gambling, skin picking and others) and the tic disorders (for exam-ple, Tourette's syndrome) but others, including drug-induced and non-psychiatric disorders, could overlap and show similar clinical pictures ... symptom clusters for OCD and OCRDs: a 'somatic' cluster for BDD and hypocondriasis, a 'reward deficiency' cluster for TTM and other impulse control disorders (ICDs), and an 'impulsivity' one

Ngày tải lên: 08/08/2014, 23:21

... 12 As this patient repetitively clenches and unclenches his fists, a paucity of movement is apparent in his left hand Figure 13 Power-spectrum (upper) and accelerometer (lower) tracings taken ... normal) arcuate zone (white arrow), and rarefied pale-staining deep white matter, containing thick-walled arteriosclerotic blood vessels lying in dilated and fibrotic perivascular spaces (black ... lacunar infarct (pale area) with an irregular cavity lined by reactive cells (astrocytes and macrophages). Debris and a few vascular channels can be seen (Luxol fast blue–H & E) ©2004 CRC Press

Ngày tải lên: 09/08/2014, 16:21

... sym- metrical atrophy and discoloration of the putamen Figure 32 11 C-raclopride binding in a normal subject (left) compared with that in Parkinson's disease (middle) and in progressive supranuclear ... striatonigral degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) ©2004 CRC Press LLC Figure 36 Axial (upper) and coronal (lower) T 2 -weighted MRIs showing putaminal hypointensity ... middle cere- bellar peduncles and the cerebellum. The axial proton-density MRI (lower) shows hyperintensity of the transverse pontine fibers, middle cerebellar peduncles and cerebellum in olivopontocerebellar

Ngày tải lên: 09/08/2014, 16:21

... degeneration shows severe gliosis and an achromatic neuron (H & E) Trang 3Figure 48 Dorsal (left) and palmar (right) views of dystonic posturing of the lefthand of a patient with corticobasal ... This patient with corticobasal degener-ation shows ideomotor apraxia of the left hand When asked to copy three hand postures (A–C, lower), in each instance, the patient's version was defective ... Dystonic postur-ing of the hand consequent to perinatal hypoxia Figure 58 Dystonic postur-ing of the foot consequent to perinatal hypoxia There is inversion of the foot and relative dorsiflexion

Ngày tải lên: 09/08/2014, 16:21

... nucleus (white arrow) and putamen (black arrow) ©2004 CRC Press LLC Figure 73 PETscans showing integrated 11 C-raclopride and 11 C-SCH 23390 activity in a normal subject (left) and choreic patient ... trinucleo- tide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 69 Histological section of brain in Huntington's disease shows atrophy with loss of neurons and astrocytic gliosis (immunocytochem- ... section of brain in Huntington's disease shows symmetrical atrophy and brown discoloration (arrowed) of the caudate and putamen together with dilatation of the lateral vent- ricles ©2004

Ngày tải lên: 09/08/2014, 16:21

... NeuschwanderTetri BA Non-alcoholic steatohepatitis: an expanded clinical entity Gastroenterology 19 94; 10 7: 11 03–9 11 Marchesini G, Forlani G NASH: From liver diseases to metabolic disorders ... emerging identity and importance J Hepatol 19 98; 2 9: 495–5 01 10 15 Matteoni CA, Younossi ZM, Gramlich T et al Nonalcoholic fatty liver disease: a spectrum of clinical and pathological ... 11 36–43 15 Cairns SR, Peters T Biochemical analysis of hepatic lipid in alcoholic and diabetic and control... Non-alcoholic fatty liver disease N Engl J Med 2002; 1 6: 12

Ngày tải lên: 10/08/2014, 15:20

... glucose and lipid metabolism,which explains the link with the associated metabolicdisorders In the scenario of metabolic and liver dis-ease, NAFLD looks very much like type 2 diabetes and obesity, ... associations will greatly enhance our understand-ing of disease pathogenesis and, accordunderstand-ingly, our abil-ity to design effective therapies Introduction Obesity and insulin resistance are undoubtedly ... production, TNF-α expression and insulin resist-ance, and ultimately to hepatocyte death and associ-ated inflammation The upregulation of uncouplingprotein-2 (UCP-2) by ROS, FFA and TNF-α alongwith dicarboxylic

Ngày tải lên: 10/08/2014, 15:20

... upregulated CYP2E1 and 4A MCD fed rats and mice Oxidative stress; upregulated CYP2E1 and/or 4A; ?secondary mitochondrial injury Fibrogenesis MCD fed rats and mice Roles of oxidative stress and stellate ... metabolism and the mechanisms of steatosis and lipotoxicity 2 The concept of fatty acid overload and the molecular and biochemical adaptive responses in the liver to fatty acid overload 3 The value and ... hypertriglyceri-daemia, increased FFA and steatosis [64] Among several other ko mice created in attempts to under-stand the pathogenesis and pathobiology of insulinresistance and type 2 diabetes (reviewed

Ngày tải lên: 10/08/2014, 15:20

... (see Chapters 7, 8 and 10) 3 Dysregulation of leptin expression and signalling 4 PPARα and γ expression and signalling 5 Inflammation and release of cytokine and other fibrogenic ... CYP2E1 and 4A or from other sources, dysregulation of leptin expression and signalling, peroxisome proliferator-activated receptor-α and - expression and signalling, inflammation and ... NASH and Related Disorders Edited by Geoffrey C. Farrell, Jacob George, Pauline de la M. Hall, Arthur J. McCullough Copyright © 2005 Blackwell Publishing Ltd MITOCHONDRIAL INJURY AND NASH 133 and

Ngày tải lên: 10/08/2014, 15:20

... aggressively and perform a liver biopsy, or take a more conservative approach and defer the liver biopsy and treat with current standard therapy for the associated comorbid associated metabolic disorders ... polyunsaturated fatty acids, fibre and the antioxidant vitamins C and E. Inter- estingly, this study also showed that the NASH cohort had higher postprandial total triglyceride and very- low-density lipoprotein ... tion; and types 3 and 4 characterized by steatosis, inflammation and fibrosis, balloon cells or Mallory bodies. A recent paper [9] has shown a high degree of correlation between types 3 and 4,

Ngày tải lên: 10/08/2014, 15:20

... were enrolled and randomized to UDCA (13–15 g /kg /day) or identical placebo and treated for 2 years The study has recently been completed and the results will soon be analysed and reported (see ... resulting from weight loss deter-The National Heart, Lung and Blood Institute(NHLBI) and National Institute of Diabetes andDigestive and Kidney Diseases (NIDDK) expert panelclinical guidelines ... have distinctly different pathogeneses and outcomes; these disorders are listed in Chapter 1 (Table 1.2) and dis-cussed in Chapter 21 The terms ‘NAFLD’ and ‘NASH’ are currently reserved for those

Ngày tải lên: 10/08/2014, 15:20

... clearance Curcumin increases CD11c in phagocytes and faciliates clearance Synapse and neuron dysfunction and loss Curcumin suppresses A␤-induced loss of NR2B and PSD-95, synaptic markers essential for ... Frautschy SA: Estrogen (E 2 ) and glucocorticoid (Gc) effects on microglia and A␤ clearance in vitro and in vivo. Neurochem Int 2001;39:435–448. 80 Hussain MS, Chandrasekhara N: Effect on curcumin ... antibody and anti-HMGA1, followed by staining with Cy3- and FITC-conjugated secondary antibodies, respectively, and analyzed by immunofluo- rescence microscopy. Endogenous HMGA1 (green) and SC35...

Ngày tải lên: 14/02/2014, 17:20

... the alpha- and beta frequency bands. For instance, in parkinso- nian monkeys and patients, oscillatory burst- ing typically emerges in both the 3–8 Hz band, and a power spectral band around 10 ... honour outstanding scient ists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders) , Saskia Biskup, Germany and Andrew ... to practice and treatment strategies. The guided poster tours allowed exchange of scientific ideas and shed light on new findings in etiology, diagnosis and treatment of PD and related disorders. A...

Ngày tải lên: 14/02/2014, 17:20

... distribution, and reproduction in any medium, provided the original work is properly cited. Photoreceptor Sensory Cilium and Associated Disorders Linjing Li, Ozge Yildiz, Manisha Anand and Hemant ... diseases, and photoreceptor degeneration and blindness [6-7, 16-18]. 2. Photoreceptor sensory cilium and its components In photoreceptors (rods and cones), cilia are highly specialized and modified ... blindness and loss of peripheral vision (due to rod death) in the Photoreceptor Sensory Cilium and Associated Disorders 55 [22] Insinna, C. and Besharse, J. C. Intraflagellar transport and the...

Ngày tải lên: 19/02/2014, 22:20

... RELEVANT TO MOVEMENT DISORDERS CENTRAL NERVOUS SYSTEM SIGNS HYPER KINETIC DISORDERS FINAL COMMENTS SELECTED READING 1 3 From: Parkinson’s Disease and Movement Disorders: Diagnosis and Treatment Guidelines ... ground (steppage gait) resembles certain dystonic gaits with dystonic exaggeration of knee and hip flexion Proprioceptive deficits affecting gait • Resembles cerebellar ataxic gait Tremor (occurs ... Practice: Application and Interpretation, by S YDNEY LOU BONNICK, 1998 Diseases of the Liver and Bile Ducts: Diagnosis and Treatment, edited by GEORGE Y. WU AND JONATHAN ISRAEL, 1998 The Pain Management Handbook:...

Ngày tải lên: 05/03/2014, 23:20