RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER

DENDRIMERS • most size-controlled macromolecules • geometrically restricted structures • well-defined and highly branched structure with a high degree of control over their size and shap

RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER

Laboratory of organic and polymer chemistry, Institute of Chemical Technology, VAST

1 Mac Dinh Chi, Dist.1, Ho Chi Minh City

Email: hoangthikimdung@gmail.com

Ha Noi - 2009

INTRODUCTION

DENDRITIC POLYMER

Dendritic architecture class

dendrons and dendrimers

dendrigraft or dendronized polymers randomly hyperbranched polymers and star polymers

DENDRIMERS

• most size-controlled macromolecules

• geometrically restricted structures

• well-defined and highly branched structure with a high degree

of control over their size and shape in three dimensions

• very low polydispersities

• a wide variety of functionalization on their multiple functional groups on the exterior as well as interior

Structure of Dendrimers

Figure 1 Structure of a dendrimer includes core, branched interior layers

known as ‘generation’ and periphery (surface group)

Characteristic features of dendrimers

• isolated as a monodisperse single compound

• the properties of dendrimers (e.g., solubility, chemical reactivity, glass transition temperature) are dominated by the nature of the end groups

• dendritic growth is mathematically limited linear polymer

growth that theoretically can continue ad infinitum

generation after a maxima is reached

APPLICATION OF DENDRIMERS

Dendrimers are application in many fields such as catalysis, materials, biological (delivery devices)…

Figure 2 Dendrimer as drug carrier agent

Drug molecules can be loaded both in the interior of the dendrimers as

well as attached to the surface groups by covalently or non-covalently

bounds

OUR LAB’S RESULTS

1 Synthesis PAMAM (polyamidoamine)

PAMAM: a popular dendrimer

By using ethylenediamine (EDA) and amonia as cores, we synthesized 2 kind

of PAMAM

 PAMAM using ethylenediamine (EDA) core: up to G(3,0)

Figure 3 Structure and TEM image of PAMAM G(2,0) core EDA

Figure 4: Structure and TEM image of PAMAM G(2,5) core EDA

 PAMAM using NH 3 core:

Figure 5 Structrure and TEM images of PAMAM

generations (NH3 core)

G(1,0) G(2,0) G(3,0)

 Initial applied research: making silver nanoparticle in dendrimer:

Figure 6 TEM images of Ag-PAMAM generations (EDA core)

Figure 7 UV-vis spectrum of Ag-PAMAM

The absorption spectra of the obtained silver particles system were measured at different shelf time so as to investigate its stability The result shown that the silver nanoparticles could remain stable at least 3 month

 Forthcoming plan

synthesize

PEG-PAMAM as 5-flourouracil carrier agent

PAMAM - cis-platin

complex

Test biological activities

2 Hyperbranched polyester

 their properties are similar to those of dendrimers

 synthesized via one-step reactions

Hyperbranched polyester: 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (TMP)

as a core, interior branching: 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)

 Initial applied research:

• Substituting the terminal hydroxy groups with benzoyl chloride, propionyl chloride, stearic acid

• Researching about influence of dendrimer on vitamine C preserve

The initial result shown that polyester can make to increase the time of vitamine C preserve about 10%

Figure 9 TEM images of

vitamine C in stearate-modified hyperbranched polymer

Figure 8 TEM images of

benzoyl-modified hyperbranched polymer

THANK YOU FOR YOUR

ATTENTION!