... within the preceding 12 months Respondents selected from a list of settings all those settings in which they learned a specific competency or skill They then indicated the single “best” learning ... a range of potential developmental activities RESEARCH QUESTION DAL staff members raised questions pertaining to the nature and extent of airmen development occurring within the Training, Exercise, ... as a setting for skill broadening and competency development In doing so, this research addresses the larger issue of whether the learning that occurs during deployments merits tracking This
Ngày tải lên: 23/03/2014, 01:20
... The Role of Government in Economic DevelopmentThere have been three phases in the dominant view concerning the optimal role ofgovernment in development The Government as Prime Mover Phase: In ... spread of the Industrial Revolution duringthe nineteenth century; and the development of developing countries during the Goldenera of economic development between the end of World War II and the ... favoring the influx of unskilled labor Where the country was too poorto finance the banks required to finance industry, the state promoted the establishment offinancial intermediaries, invested in
Ngày tải lên: 31/03/2014, 05:21
Evaluation of the role of autophagy in fungal development and pathogenesis 2
... Atg24 bind PtdIns(3)P and belong to the sorting nexin family that functions in protein trafficking from the Golgi to the endosome (Hettema et al., 2003); and are involved in the Cvt pathway in S. ... XcaI) in one step, so that the newly created plasmid contained an in- frame insertion of RFP ORF at the translational start site within the ATG8 coding sequence while retaining the ... conidiation in atg8∆. More interestingly, ectopic expression of Sga1, the vacuolar glucoamylase that acts following autophagy-based delivery of glycogen into the vacuole, in the cytosol, could bypass the
Ngày tải lên: 11/09/2015, 10:01
Evaluation of the role of autophagy in fungal development and pathogenesis 3
... OP-2 strains. The indicated strains were initially grown in the dark for days and then subjected to constant illumination to induce conidiation. At the specified time-points post induction, the fungal ... regulation of conidiation, and to elucidate the exact physiological role of autophagy in the process of asexual development in Magnaporthe. A key finding was the remarkable suppression of atg8Δ ... breakdown in the cytoplasm instead of the vacuole, thus bypassing the requirement of autophagic machinery for glycogen transport to the vacuoles. To verify if the increased conidiation in the atg8∆
Ngày tải lên: 11/09/2015, 10:01
Evaluation of the role of autophagy in fungal development and pathogenesis
... processing and Atg8p targeting to autophagosomes in Magnaporthe 53 3.2.5 Induction and subcellular localization of RFP-Atg8 in Magnaporthe 56 3.2.6 Suppression of conidiation defects in atg8∆ ... characterization of an atg20∆ mutant in Magnaporthe 90 4.2.2 Subcellular localization of Atg20 90 4.2.3 Investigation of non-selective autophagy and the Cvt pathway in the atg20∆ mutant 98 4.2.4 Investigation ... required for Magnaporthe conidiogenesis and pathogenesis 105 4.2.5 Investigation of retrieval trafficking pathway in the atg20∆ mutant 112 4.2.6 Investigation of vacuolar morphology in atg20∆ 116
Ngày tải lên: 11/09/2015, 10:01
The role of entrepreneurs in economic development
... Trang 1VIỆN NC QUẢN LÝ KINH TẾ TW TRUNG TÂM THÔNG TIN – TƯ LIỆU THÔNG TIN CHUYÊN ĐỀ VAI TRÒ CỦA DOANH NHÂN TRONG PHÁT TRIỂN KINH TẾ THE ROLE OF ENTREPRENEURS IN ECONOMIC DEVELOPMENT 9 Trang ... 2VIỆN NC QUẢN LÝ KINH TẾ TW TRUNG TÂM THÔNG TIN – TƯ LIỆU VAI TRÒ CỦA DOANH NHÂN TRONG PHÁT TRIỂN KINH TẾ THE ROLE OF ENTREPRENEURS IN ECONOMIC DEVELOPMENT TRUNG TÂM THÔNG TIN – TƯ LIỆU Tel ... tiếp thu những kiến thức kinh tế mới nhất, những kinh nghiệm quản trị kinh doanh tốt nhất từ các giáo sư, chuyên gia kinh tế, các nhà kinh doanh thành đạt Cung cấp thông tin cho doanh nhân, DN cũng
Ngày tải lên: 23/01/2021, 11:32
Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 2
... change Within the linear range of the assay (~5-25μg/mL), the more protein present, the more the Coomassie Blue binds changing the absorbance of the sample After getting cell lysates from the CHO ... requirement of Graduate Program in BioEngineering, investigations of the synthetic compounds were more on their applications in tissue engineering, which is in stem cells differentiation, in this ... D-erythro-sphingosine (Figure 2.1a) is a natural substrate for SPHKs The design of the compounds was based on investigations of: 1) changing the fatty acid carbon chain length; 2) converting the existing
Ngày tải lên: 11/09/2015, 16:06
Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 3
... Staining 3.1.3.1 Alizarin Red S Staining Alizarin Red S staining is widely used to evaluate the calcium-rich deposits generated by cells In this study, the staining was used to detect the mineralization ... days of culture, the cells grown in the presence of either 1μM of DMS, 0.5μM of CP6, 1μM of CP6, or 5μM of CP6, showed more lipid droplets staining than that from the cells cultured without the inhibitors ... staining in each sample was quantified by dissolving the staining with 100% of isopropanol and detecting the absorbance at 500nm 3.1.3.3 Fluorescence Immunostaining Fluorescence immunostaining
Ngày tải lên: 11/09/2015, 16:06
Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 4
... Cells cultured in S1P-supplemented media were then measured for their stemness maintenance by checking their morphology change, the cell surface markers expression profile, and their osteogenic ... were aliquoted into tubes, and the methanol was evaporated by a stream of nitrogen A suitable amount of 0.1% fat-acid free bovine serum albumin (FAF-BSA) was then added into the tubes to make ... washed twice with 1x PBS and starved in serum-free DMEM for half an hour 1μM S1P was then added into the wells and incubated at 37°C for 5min, 10min, 30min, and 60min to look for ERK activation Human
Ngày tải lên: 11/09/2015, 16:06
Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 6
... "Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase." ... et al (1998) “N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide.” ... “Characterization of N, N-dimethyl-d-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.” Prostaglandins & Other Lipid Mediators 86(1-4):18-25
Ngày tải lên: 11/09/2015, 16:06
Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation
... Geoffroy et al., 2004) Figure 1.1 Structure of Sphingosine, D-erythro Sphingomyelin, the major membrane sphingolipid, is the precursor of the bioactive ceramide, sphingosine and S1P When sphingomyelin ... activation, while HDL could inhibit all of these, by inhibiting the SPHK activity triggered by TNFα These findings suggested an atherogenic role for SPHK activation Interestingly, Nofer et al (2004) reported ... immunosuppressive effects of S1P by inhibiting proliferation and secretion of cytokines, while enhancing secretion of the suppressive cytokine Interleukin-10 (IL-10) S1PR5 is the most recent member in S1PRs family
Ngày tải lên: 11/09/2015, 16:06
The role of microRNAs in embryonic stem cell development and differentiation
... for indefinite self-renewal in culture 1.1.3 Maintaining Pluripotency: LIF, BMP & Wnt Signalling One of the major breakthroughs in ESC maintenance was reported in 1988, when leukemia inhibitory ... noncoding RNAs similar to the siRNAs involved in RNA silencing, originate from stem-loop precursors in the genome They have been shown to play important roles in diverse processes including apoptosis, ... microRNAs in animals However, it is interesting to note that other components of the post-transcriptional machinery, the RNA-binding proteins (RBPs), are known to bind all along mRNAs and regulate their
Ngày tải lên: 12/09/2015, 08:16
The role of language integration in english teaching and learning
... opinion, Frank Smith (1985:102) added that “reading isunderstanding the author’s thought” In conclusion, all of the definitions involve the recognition of words and theproduction of meaning They ... meaning They are the basic elements of reading process 2 Types of reading 2.1 Skimming and scanning Skimming is the technique of reading for general sense or the gist of the text The reader wants ... only in the detail comprehension of short texts but also in the interpretation of the writer’s intention In general, intensivereading is often less encouraging because it is expected that the
Ngày tải lên: 24/04/2017, 00:12
The role of people training and development in delivering service quality in uk based thai restaurants
... training for some employees (Hospitality Training Foundation, 1999) Bearing in mind the importance skill staffs in providing service quality in the hospitality sector, impacts of training in development ... Regarding to ethnic food history in the UK, Chinese and Indian cuisines have become dominant since the end of the 19th century with the first arrival of Chinese and Indian immigrants (Mintel, ... quality The following part declares the necessity of people training and development to improve staff skill in a context of less training practise in the hospitality due to unawareness of training
Ngày tải lên: 24/03/2021, 17:39
English major students perceptions of the role of culture in english language learning and their levels of intercultural communicative competence a case study
... Additionally, Hinkel (1999) emphasizes the importance of addressing the culture of the community in which the language is used in foreign language teaching.In the Vietnamese context, selecting the appropriate ... perceptions of the role of culture in English language learning and their levels of ICC in terms of levels of academic study? If yes, how?Significance of the StudyThis study aims to support English language ... culture in English language instruction, encouraging teachers to integrate cultural elements into their practices Additionally, the findings highlight the essential role of culture in language
Ngày tải lên: 12/01/2022, 23:19
Globalization and Language Learning in Rural Japan: The Role of English in the Local Linguistic Ecology
... Technical Internship Program in the early 1990s allowedthese industrial trainees to stay and engage in training in Japan for up to3 years A majority of these trainees in Japan are from China Wandering ... residents The communitysurvey report provides insight into the general public’s views of localdiversity and the role of English, whereas the interviews offer an in-depthaccount of the experiences ... processes of defining and describing the language system anduse, and yet they invoke realistic or contingent discursive representa-tions He states, This understanding of construction … points to the
Ngày tải lên: 22/10/2022, 20:56
Teachers beliefs about the role of culture in english language teaching and their classroom practices a case study m a 60 14 10
... explore the role of culture as well as the importance of incorporating culture in language teaching 2.2.1 Definition of culture There have been a great number of definitions of culture so far In ... toward the role of culture in their ELT……… ………… 71 4.3.1.2 EL teachers’ beliefs about the role of culture in their ELT……… …… …… 72 4.3.2 EL teachers’ defining objectives of culture teaching in the ... is inseparable, and the integration of culture teaching in language teaching has been widely recognized as an indispensable component in language education However, the perception of the role of
Ngày tải lên: 01/07/2023, 20:29
AUSTRIAN PRE-SERVICE TEACHERS’ ATTITUDES TOWARDS THE ROLE OF ELF IN THE LANGUAGE CLASSROOM – EXPLORING MOTIVATIONAL POTENTIALS
... ELF-sensitive approach in their own teaching in order to check their readiness regarding adopting an ELF- informed way of teaching as their degree of readiness might affect their answers in the third topic ... discussion of the principles of CLT throughout their teacher training has influenced the participants’ views as all of them put an elevated emphasis on meaning-focused language teaching Fluency and intelligibility ... some indicated skepticism concerning the feasibility of the task of incorporating the concept in the actual teaching context Interviewees explained that they liked the ELF-sensitive approach for
Ngày tải lên: 17/05/2024, 14:29
Tài liệu Research " THE ROLE OF EDUCATION IN ECONOMIC TRANSITION AND POLITICAL TRANSFORMATION IN POST-COMMUNIST COUNTRIES " ppt
... p 33) Another striking feature of the transition was that the fall in the official GDP coincided with the rise of an informal economy If the latter were included into the accounting of GDP that ... investment in education in these post-communist countries The first chapter analyzes the determinants of economic growth in these countries and focuses on the role of investment in education in the ... communist ideology In order to fulfill these goals, the communist leadership early on recognized the important role of education in the process of indoctrination and in the formation of these new communist
Ngày tải lên: 18/02/2014, 11:20
Circuit theory of finance and the role of incentives in financial sector reform
... capital profitability is declining. The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing. The ... placing money with investment financial institutions in the capital market, and hold the remaining share in non- interest bearing, short-term bank deposits (eq. 7). The share of savings going ... Banks thus increase lending to the point where the marginal revenue from lending equals the marginal default risk. The amount lent determines the amount of inputs that firms can purchase in the factor...
Ngày tải lên: 24/10/2012, 09:33