... Acceleration of the cis–trans isomerization of the peptide results in the collapse of these resonances into a single set of peaks (D) Binding, but not isomerization, of the N-terminal peptide of PPWD1 ... interactions between the backbone nitrogen of Glu485 with the oxygen of Gly551, the side-chain of Glu485 is nestled in a deep pocket of the enzyme (Fig 3B) An oxygen of the c-carboxyl group forms ... amongst the Cyps may play In summary, the interactions seen between the QAEGPKR peptide and PPWD1 active site in the cur-rent structure might be a product of an inability of the Fig 1 Structure of
Ngày tải lên: 23/03/2014, 07:20
... B Fig 1 The topology of Glut1 and alignment of the deduced amino acid sequences of Glut1 and Glut3 (A) The predicted structure of Glut1 [1] The position of the single endogenous site of N-linked ... line [25] The differential distribution of these isoforms seems to be independent of cell type or the amount of protein expressed To clarify the molecular basis for the con-trol of the differential ... through these FLAG-tagged proteins Neither the N-terminus nor the C-terminus of Glut1 is needed for the DRM distribution To determine the functional domains responsible for the DRM distribution of
Ngày tải lên: 23/03/2014, 09:20
Báo cáo khoa học: The crystal structure of the ring-hydroxylating dioxygenase from Sphingomonas CHY-1 pot
... in the center of the domain with the active site of the enzyme on one side and the Rieske center on the other side of the sheet (Fig 3) Covering one side of the sheet are two Fig 2 Crystal structure ... following the sequence.) Together with the extended loop, which extends 20 A˚ from the center of the funnel, they form the base of the b subunit (Fig 3) The last four resi-dues in the C-terminal ... for each of the three a subunits LI, on the other hand, could only be partially modeled for one of the three a subunits, the high flexibility of the loop precluded modeling for the two other chains
Ngày tải lên: 23/03/2014, 09:21
Báo cáo khoa học: The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima pdf
... structure of the dimeric apo form of TmIDH at 2.2 A˚ The R-factor of the refined model was 18.5% (Rfree22.4%) The conformation of the TmIDH structure was open and showed a domain rotation of 25– ... used to solve the structure Quality and description of the model The crystal structure of TmIDH was solved by molecu-lar replacement at 2.2 A˚ and represents the apo form of the enzyme The atomic ... Super-position of the small domains showed an rmsd of 0.27 A˚ for the Ca-atoms, whereas the rmsd between the large domains was 0.32 A˚ The relative difference in the rotation of the large domain between the
Ngày tải lên: 23/03/2014, 10:21
The Organisational Structure of Banking Supervision ppt
... few miles furthereast The same people continued to do the same job What then their work had meant that their offices in the Bank had ously been sealed off internally from the rest of the Bank (Chinese ... responsibilities.’ And yet the current tide is running now quite strongly in the opposite direction.7The Wallis Report in Australia, the establish-ment of the FSA in the UK, much of the advice of the IMF to ... their good offices Moreover the strength of reaction was testimony to the efficacy of the instrument. Trang 26lege’ of national regulators, i.e self-regulation for the tors But, at the time of
Ngày tải lên: 29/03/2014, 08:20
Báo cáo khoa học: Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase pptx
... (see the next section) Impact of Zn2+and K+ions on the refolding of HDAH The crystal structure of HDAH contains one Zn2+ion at the bottom of the active site and two K+ ions in the neighbourhood of ... stabilization of the the major part of the conformational structure of HDAH [13] The meq value of free and complexed HDAH is about )11 kJÆ mol)1Æm)1 This is consistent with the assumption that the intermediate, ... conformational stability of HDAH, DDG u , upon inhibitor binding is the difference between the free energy of unfolding of HDAH in the absence of inhibitor and in the presence of 100 l M of the noted inhibitor
Ngày tải lên: 30/03/2014, 08:20
Báo cáo khoa học: The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis Implications for the substrate activation mechanism of this enzyme ppt
... space-filling mode The closed and open sides of the tetramers are indicated. Trang 6Structure of the active siteThe general architecture of the active site of KlPDC corresponds to that of other ThDP-dependent ... in the final model, and the position of the residues adjacent to the loop are labeled The orientation of the sub-unit is the same as that of subsub-unit B in Fig 1. Trang 5domains contains the ... located at the solvent-exposed surface of the tetramer and it connects the middle and the C-ter-minal domains (Fig 2) In the crystal structure of pyruvamide-activated ScPDC, the cleft between these
Ngày tải lên: 30/03/2014, 10:20
Báo cáo khoa học: The crystal structure of the tryptophan synthase b2 subunit from the hyperthermophile Pyrococcus furiosus Investigation of stabilization factors pot
... on the basis of its X-ray structure [17] In this report, the stabilization mechanism of the hyperthermophilc b2 subunit will be discussed on the basis of the crystal structures, compared with the ... than the structure of the a and/or b subunits in the complex form reported Discussion Structure ofPf b2and mutual activation Since the first report in 1988 [3], the crystal structures of the a2b2 ... 7Stabilization mechanism ofPf b2on the basisof the structure In order to elucidate the stabilization mechanism, the structure of a protein should be analysed in detail, because the conformation of a protein
Ngày tải lên: 30/03/2014, 14:20
Báo cáo khoa học: Tracking interactions that stabilize the dimer structure of starch phosphorylase from Corynebacterium callunae Roles of Arg234 and Arg242 revealed by sequence analysis and site-directed mutagenesis doc
... through analysis of the StP primary structure The results have revealed clearly that Arg234 and Arg242 of the TOWER interface region of StP partially destabilize the dimer structure of the unligated ... elements of rmGP [4] and EcMalP [3] onto the linear sequence of StP and thus measures the extent of conservation of the respective sites in StP As in other GPs, the catalytic site and the PLP ... bp downstream of the stop codon of the StP gene The entire open reading frame for StP consisted of 2388 bp encoding a protein of 796 amino acids The calculated molecular mass of the StP subunit
Ngày tải lên: 31/03/2014, 01:20
the basic practice of statistics 3rd ed. - d. s. moore
... observations. 2 The first quartile Q1 is the median of the observations whose position in the ordered list is to the left of the location of the overallmedian 3 The third quartile Q3is the median of the ... location of the median with n= 7: location of Q1=n+ 1 2 = 7+ 1 The third quartile is the median of the 7 observations to the right of the median, Q3= 55 The overall median is left out of the calculation ... have marked the location of the median by | The first quartile is the median of the first 8 observations, because these are the observations to the left of the location of the median Check that
Ngày tải lên: 31/03/2014, 16:25
THE SOUND STRUCTURE OF ENGLISH
... the railway timetable represents the underlying structure of the running of trains, it doesn’t tell us whether the trains are red or yellow These are part of the physical characteristics of the ... furthermore, both tures are comprised of a cover and some inside leaves of paper, but thefunction of the manila folder is to hold the final draft of a pamphlet ofpoems, while the function of the ... palate, softpalate … all of these places of articulation are crucially involved in theproduction of many speech sounds of English Notice too the size and shapeof the nasal cavity, and the size
Ngày tải lên: 07/04/2014, 01:09
university of texas press the teotihuacan trinity the sociopolitical structure of an ancient mesoamerican city dec 2007
... emerging from a goddess on theTeocalli, Tenochtitlan 157 8.12 Southerly view of the Plaza of theMoon 159 8.13 Plan of the Building of the Altars 1608.14 Calendrical page of the Codex Féjérvary-Mayer ... on Cerro Gordo at the end of the avenue The sensation of containment is further am-plified by the manner in which the Avenue of the Dead was built Although the overall effect is of one long road ... it.Furthermore, these courtyards work in tandemwith another feature of the avenue The walk isnot only a directional one, but a vertical climb as well The southern section of the Avenue ofthe Dead
Ngày tải lên: 11/06/2014, 15:57
Báo cáo toán học: "On the combinatorial structure of arrangements of oriented pseudocircles" ppsx
... vertex. 2 The initial vertex of the next edge is v(j, ∓k). 3 Determine the direction of the next edge by the sign of the entry ∓k in list j and the direction of the preceding edge according to the ... information about the direction of the first edge with the corresponding crossing yields a rule for the direction of the second edge If the entry in list k has negative sign (or the entry in list ... made in the proof of Theorem 4.2 (cf also Figure 3) it follows that if a vertex v is incident with the edges e1, e2, e3, e4 (in clockwise order), then the edges e1, e3 are in the same list of A,
Ngày tải lên: 07/08/2014, 08:20
The Market Structure of the Health Insurance Industry
... risk At the other extreme, the employer may self-insure and handle the plan itself, thus bearing all of the insurance risk and the administrative burden of the plan Often the extent of employer ... a discussion 90 The law of large numbers is a mathematical theorem stating that the average of a randomly drawn sample of observations will converge to the true value of the underlying probability ... providers on the payments for health services Consequently, policies affecting health insurers will likely affect the other parts of the health care sector The market structure of the U.S health
Ngày tải lên: 30/10/2014, 22:00
Property rights as investment incentives the contractual structure of rd activities in biopharmaceutical industry
... (1998) provided the first systematic comparison of the TCE and the PRT They contended that there are certainly points of similarity between these two theories, but the detailed logic of them is different, ... Research Setting In view of the wealth of theoretical literatures of the PRT, it is surprising that only a small number of empirical research study the formal structures of transactions from this ... collaborations These observations are explicitly at odds with the predictions of the TCE In contrast to the TCE, the PRT suggests that the governance structure of a transaction is about to balance the benefits
Ngày tải lên: 11/09/2015, 16:05
Two patterns of culture in xunzi the basic character of xunzis thought and an interpretation in the scope of intellectual history 1
... n t he p r e -Qi n peri od Th e pu rpos e of t hi s t hes i s i s t o i nt er pr et t he b as i c ch ar act e r of hi s phi l o s oph y Fi r s t of al l , i t a r gu es t h at l i k e M o h ... om ent of c om pl et i n g m y M A t he s i s i s t h at without m y parents’ unceasing encouragement , I would have never com pl et e d m y g rad uat e edu c at i on and t hus n on e of m y ... r i c al ch ar act e r of Xun Zi ’ s t ho u gh t ex em pl i fi ed t he hi s t o ri c al com p et i t i on and re c onci l i at i on o f t w o p art i cul ar p at t er ns of cul t u res — t he
Ngày tải lên: 16/10/2015, 15:35
Using the method of presentation towards promoting positive student learning in subjects the basic principles of marxism leninism in the colleges and universities of thai nguyen province
... subjects the basic principles of Marxism - Leninism in the colleges and universities of Thai Nguyen province 1.2.2 These issues need further thesis solved First, the theoretical system on the use of ... measures proposed in the thesis feasible pedagogical experimentally Trang 68 New contributions of the thesis In theory, system theory of opinions and give their views of methods of presentation; ... the role of mentor with the promotion of an active role of the learner ? Therefore, the research, find out the principles and measures to effectively use methods to promote the presentation of
Ngày tải lên: 06/10/2016, 19:16
The Crystal Structure of the [NiFe] Hydrogenase
... S1andS2) The comparison of the structures from the A vinosum and D vulgaris MF hydrogenases bears striking homolo-gy (Fig 2c) The electrostatic potential of the contact surface of the dimer with the ... and the diatomic ligand (CO) of the Fe atom The three meshed spheres show the electron density of the bridging ligand assigned as an oxygen, the diatomic ligand (CO), and the modification of the ... of them also bridge the two metals One of the bridging cysteines (Cys64) exhibits a modified thiolate in part of the sample A mono-oxo bridging ligand was assigned between the metal ions of the
Ngày tải lên: 21/12/2016, 10:50
Tài liệu Đề tài " The causal structure of microlocalized rough Einstein metrics " pptx
... take the use of the special structure of the Einstein equations one step further by deriving unexpected regularity properties of optical functions which are essential in the proof of the Main Theorem ... fundamental for the proof of Theorem 2.5 In Section we obtain some crucial properties of the components of the Riemann curvature tensor Rαβγδ The remaining sections are occupied with the proof of the Asymptotics ... derivatives of the traceless part of χ A similar observation holds for another null component of the Hessian of the optical function, η The role of the Raychaudhuri equation is taken by the transport...
Ngày tải lên: 16/02/2014, 05:20
Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... reported X-ray structure of bovine SOD [32] The structure is also similar to the solution structure of the monomeric mutants with the exception of the significantly better definition of the first part ... percent of the backbone 13C resonances were assigned and about 86% of the 13C side-chain resonances All the ring protons of the histidines of the active site and of His43 were assigned through the ... respectively, for the backbone of the two subunits The difference between rmsd of monomeric and dimeric species is due to the indetermination of the reciprocal orientation of the two subunits The average...
Ngày tải lên: 21/02/2014, 03:20