olfactory pathway and olfactory sensor specificity

... to review and evaluate associations between genes in the NER pathway and lung cancer risk, focusing on genes encoding five key enzymes in this pathway: XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG ... gene causes CS)) and XPV have been identified [6] XPA, ERCC3/XPB, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG have a defect in TCR and GGR, while XPC and XPE have a defect in GGR only ERCC6 and ERCC8 are ... cases and controls ** Crude odds ratio and 95% confidence interval † Based on random effects model ‡ P for heterogeneity (Cochran Q test) Table Genetic polymorphisms in the NER pathway and lung...

Ngày tải lên: 31/10/2012, 14:59

... book The first one, "Sensor- Referenced Control and Planning: Theory and Applications," was held at the IEEE International Conference on Decision and Control, New Orleans, 1995 and the second one, ... that the sensor- guided planning and control problems introduced in this book involve state-of-the-art knowledge in the field of sensor- guided automation and robotics Contributors R Anderson, ... The real challenge is to develop a planning and control scheme that is able to detect and recognize both discrete and continuous events and adjust and modify the original plan at a high rate...

Ngày tải lên: 01/01/2014, 20:12

... phosphatidylinositol 3-kinase (PI3K) pathway and its downstream effectors [23] This pathway is a key signal transducer of many growth factors and cytokines and has been implicated in the regulation ... Insulin is a polypeptide hormone that regulates glucose, lipid and protein metabolism and promotes cell growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates ... inhibition and Nrf2 gene silencing The fold-increase in both HO-1 protein and mRNA in response to insulin was consistent, as well as being time and concentration dependent The role of the PI3K ⁄ Akt pathway...

Ngày tải lên: 07/03/2014, 12:20

... efficiencies of different siRNAs and related RNA molecules in inducing MMB defects asGFP, antisense strand of GFP; dsGFP, double-stranded GFP without 3¢-overhangs; sGFP, sense strand of GFP Embryos analyzed ... GFP sequence Singlestranded and double-stranded molecules without the characteristic features of siRNA did not affect the level of miR-430b, as compared to non-injected (WT) and buffer-injected ... levels of processed miRNAs and lethality Experimental procedures Isolation and analysis of genomic DNA and cDNA Two zebrafish eri1 expressed sequence tags (BQ285328 and BI888174), reported previously...

Ngày tải lên: 16/03/2014, 06:20

... Catabolism of L-proline and L-arginine does not lead to induction of the alc genes L-Proline and L-arginine can serve as sole carbon and nitrogen sources for A nidulans and both are catabolized ... conditions, RNA isolation and Northern blots were as described in Materials and methods Membranes were hybridized with 32P-labelled probes specific for the alcA, alcR, facA, facB and c-actin (acnA) genes ... glycerol, six amino acids, putrescine, c-aminobutyric acid (GABA) and small carboxylic esters Materials and methods Strains, media and growth conditions Aspergillus nidulans strains used in this...

Ngày tải lên: 17/03/2014, 10:20

... Fig (a) Sensor response to H2S and NO2 of gas sensors based on 400 and 700 8C-annealed WO3 as functions of working temperature, (b) Sensor response to H2S (200 8C) and NO2 (225 8C) of gas sensors ... ethanol and deposited on amorphous holey carbon membranes Results and discussion 3.1 Gas sensor response Fig 1a shows sensor response to ppm of NO2 and 20 ppm of H2S in synthetic dry air of gas sensors ... capacitive humidity sensor Gas sensor response was calculated as the resistance ratio Rgas/Rair for both gases Operating temperature of the sensor devices was varied between 200 and 300 8C Sensor response...

Ngày tải lên: 19/03/2014, 16:47

... magnication 15 600ã) taken from random observations and found that the surface corresponding to mitochondria represents 11.2 2.3% and 18.8* 2.5% (*P < 0.05) for L929 and rho-L929 cells, respectively ... and activity of NRF-1 and Tfam in mtDNA-depleted cells A B C D E 5038 L Mercy et al Activity of YY1, Sp1, PPARc, MyoD, MEF2 and CREB in mtDNA-depleted cells Beside the crucial role of NRF-1 and ... activity and protein abundance analysed by western blotting and immunostaining (supplementary Fig S2) Fig Effect of mtDNA-depletion on Sp1, PPARc, MyoD and MEF2 DNA-binding activity and transactivation...

Ngày tải lên: 23/03/2014, 15:21

... numbers and positions of Fnu4H1 ⁄ BstX1 restriction sites All four isoforms comprise BstX1 and Fnu4H1 sites at positions 34 and 598 bp Plf1 and Mrp3 show BstX1 sites at position 352, and Plf2 and ... candidate genes were compared in C57MG ⁄ Wnt-1 cells and in C57MG ⁄ PLNCx cells by northern blot: the up-regulated candidates Lcn2, Fos, Gnb1, Fabp5, Slc7a2, Osf2, Sdc4, Ccl2, Pedf and Fas and ... type and on the level of interference with the Wnt pathway We conclude that the type of the trigger and the regulation level within the Wnt pathway decide about the gene expression pattern and...

Ngày tải lên: 30/03/2014, 16:20

... Measuring and analyzing tissue specificity of human genes and protein complexes EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:5 Submit your manuscript to a journal and benefit ... Atlas and RNA-sequencing as well as the Gene Atlas and the Exon Array, the average correlation is 0.31 in both cases, with a minimum of 0.23 (muscle) and a maximum of 0.39 (cerebellum), and a ... tissue-specific proteins and interactions However, these earlier findings were likely biased towards highly expressed genes and thus could not provide accurate insight into tissue specificity and its functional...

Ngày tải lên: 21/06/2014, 01:20

... (IgM, IgG and IgA) and HLA-SE gene carriage in individuals who had donated blood before development of RA The predictive effects of the genes and antibodies were then evaluated Materials and methods ... registers and matched for sex, age at the time of blood sampling and rural or urban residence A total of 368 controls (276 women and 92 men) were selected The mean age of the prepatients and of ... DRB1*0404 and DRB1*0401 Two controls were randomly selected for each pre-patient The HLA-DRB1 typing was successful for 90 pre-patients and 173 controls Anti-CCP antibodies (n = 89 for pre-patients and...

Ngày tải lên: 09/08/2014, 07:20

... this equation, (Dx)1 and (Dx)2 represent the doses Dx of compounds and alone required to produce an effect, and (D)1 and (D)2 represent isoeffective doses D when compounds and are given simultaneously ... Bcl-2 and Bcl-XL are important inhibitors of apoptosis and frequently overexpressed in a variety of human tumors [2-7] Increased levels of Bcl-2 and Bcl-XL have been associated with radioand chemoresistance ... destruction and represents an important regulatory mechanism for removing abundant and unwanted cells during embryonic development, growth, differentiation and normal cell turnover Radiation and most...

Ngày tải lên: 09/08/2014, 10:20

... examined in this system, and the involvement of a mechano-transduction pathway via the integrin/mitogen-activated protein kinase (MAPK) pathway and of another signaling pathway via β-catenin was ... cut into smaller pieces, and the cartilage specimens were washed well in PBS (pH 7.4) and digested with 0.25% trypsin–ethylenediamine tetraacetic acid (Gibco, Grand Island, NY, USA) for 20 minutes ... tissues and their supernatant medium were harvested at days 3, 7, 10 and 14 Cell counting The cartilage tissues were harvested 1, 3, 7, 10 and 14 days after culture (2 hours after the last LIPUS) and...

Ngày tải lên: 09/08/2014, 10:23

... the catheter and its stiffness We elected to use RF energy and minimized the number of catheters used and the number, power, and duration of the lesions By using this approach, safe and successful ... infancy [3-6], the risk of damage to the coronary arteries and intra-cardiac structures, and technical reasons (patient and catheter size and curves) [7] A large multi-center study by the Pediatric ... analyzed and interpreted the data from our patient and participated in the EP study MF was the cardiac surgeon who performed the operation and implanted the LCA into the aortic annulus TC suspected and...

Ngày tải lên: 10/08/2014, 23:20

... transcriptional factors, including NF-κB, CREB, C/EBPβ and AP-1, through the activation of multiple signaling pathways; for example, NF-κB, MAPK ERK1/2, p38 and PI3K pathways (reviewed in [1]) Materials RIAA ... the inhibition of GSK3 pathway (A) GSK-3α was incubated with RIAA (0, 5, 25 and 50 μg/ml) and the kinase activity was determined Data represent representative experiment and are expressed as % ... 25 and 50 μg/ml) and the kinase activity was determined Data represent representative experiment and are expressed as % activity (C) RAW 264.7 cells were incubated with RIAA (0, 1, 5, 10 and...

Ngày tải lên: 11/08/2014, 08:22

... cytokines and inhibit iNOS expression and NO release in LPS-stimulated RAW264.7 macrophages by targeting the NFB activation pathway Materials And Methods Cell Culture and Sample Treatment The RAW264.7 ... phosphorylation and degradation (Fig 2D-F) and inhibited NFkB nuclear translocation (Fig 3C-D) The molecular pathways involved in the regulation of iNOS expression occur largely at a transcriptional level and ... curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages Biochem Pharmacol 2000, 60:1665-76 Kabe Y, Ando K, Hirao S, Yoshida M, Handa...

Ngày tải lên: 11/08/2014, 08:22

... activation pathway, maximal activation of this pathway via K13 relies on cooperative interaction between IKK1, IKK2 and NEMO The transcription of cellular and viral genes is regulated by structural and ... Unlike the classical NF-κB pathway, which involves IKK2 and NEMO, activation of the alternative NF-κB pathway by TNF family receptors is critically dependent on NIK and IKK1 [9,10] Kaposi's sarcoma ... the classical and the alternate NF-κB pathways [21-24] Several recent studies suggest that binding of NF-κB to HIV-1 LTR may not be sufficient and interaction with additional viral and cellular...

Ngày tải lên: 13/08/2014, 13:20

... data and drafted the manuscript WL performed the experiments and analyzed the data YG collected the background materials and drafted the manuscript YT, PCWF and LT interpreted the results and ... EGb761, quecertin and bilobalide were 1, 10 and 100 μg/ml respectively These representative data were obtained from five independent experiments twenty-four hours and low glucose and low serum; ... care and application of experimental procedures were all in accordance with the institutional guidelines and approved by the University Committee on the Use of Live Animals in Teaching and Research...

Ngày tải lên: 13/08/2014, 14:20

... lines (rows) and the columns are 290 gene sets and pathways The order of pathways on both axes was determined by standard two-dimensional hierarchical clustering of the Z score results, and is the ... cell lines) and in axoplasmic transport (and thus highly expressed in neural tissue) Sodium and potassium transport pathways are also expressed in gut Non-uniform expression of pathways and gene ... Wilcoxon, KS, and Z score metrics, and the divergence of the PCA and hypergeometric metrics from the others It is also clear from these examples and others in our analysis that few gene sets and pathways...

Ngày tải lên: 14/08/2014, 17:22

... dependent pathway; and/ or the non-canonical SMAD independent pathway to bring about a change at the gene transcriptional level (Baker and Harland, 1997, Derynck and Zhang, 2003, Herpin and Cunningham, ... cells first, followed by horizontal cells and cones and lastly amacrine cells, bipolar cells, rods and muller glial cells (development of retina and optic pathway paper) They arise following terminal ... I and type II receptors The BMP type I receptors act downstream of the type II receptors and determine the specificity of the signal (Conidi et al., 2011) Three type I (Alk -2, -3 and -6) and...

Ngày tải lên: 24/08/2014, 13:27

... diacylglycerol and Ca2+ [29-33] The unconventional isoforms, δ, ε, η, and θ, require phosphatidylserine and diacylglycerol but not require Ca2+ The ζ and λ isoforms are called atypical and require ... through mathematical modeling and simulation is known as pathway simulation Pathway simulation is therefore a quantitative prediction of complex biological pathways [96-101] Pathway simulation will ... were used for signaling pathways and Boolean networks were used for gene expressions [218] Each method has got its own strength and limitation and choosing the method to pathway simulation often...

Ngày tải lên: 09/09/2015, 10:14