genotypic and phenotypic data representation in biological systems

... clinicopathological parameters including TNM staging, grade, histological subtype and intrinsic phenotype Results: Compared to the general population, MBC incidence was higher in all subgroups In contrast to ... 2009.Clinical parameters, including TNM staging, tumour re-currence, occurrence of non-breast primary tumours and death were obtained from referring clinical centres, kConFab questionnaires and ... subtypes in male breast cancer: a) invasive ductal carcinoma of no special type, b) & c) invasive lobular carcinoma, d) & e) invasive papillary carcinoma, f) invasive micropapillary carcinoma.

Ngày tải lên: 05/11/2020, 07:42

... CCAAT/enhancer-binding protein(C/EBP),alpha(Cebp˛);CCAAT/enhancer-bindingprotein (C/EBP),beta(Cebpˇ);sterolregulatoryelementbinding transcrip-tionfactor 1 (Srebf1)and retinoidX receptor andalpha (Rxr˛) ... afterstartingdifferentiation,themediumwasdiscardedandthe cellswereairdriedfor20minandfixedatroomtemperatureby adding10%formalininPBSfor15min.Afterfixation,thecellswere airdriedagainandstainedwithafilteredoil-red-Oworking solu-tionfor1hontheorbitalshaker.Fortheworkingsolution,the0.5% ... with DMI in the presence and absenceof3␮MATRA(SigmaAldrich,Taufkirchen,Germany).After 96h, DMIwasreplacedbygrowthmedium(±3␮MATRA) con-taining10%FBS,1%penicillin–streptomycinand1␮g/mlinsulin in500mlDMEM.Themediumwasrenewedevery2days

Ngày tải lên: 04/12/2022, 15:03

... buffer proteins, including Troponin C, that drives the tropomyosin complex off the actin binding site allowing the binding of myosin and producing a shortening in the actin filaments and the contraction ... The instabilities arising in the different enzymatic kinetics models as well as their spatial considerations help in understanding the complex dynamics in protein activation and in developing ... Publishing AG Switzerland Preface Many biological systems, such as circadian rhythms, calcium signaling in cells, the beating of the heart and the dynamics of protein folding, are inherently nonlinear

Ngày tải lên: 14/05/2018, 15:37

... 2,4dinitrophenyl (DNP) and 3-nitro-l-tyrosine (NT), loaded on human serum albumin (HSA) and bovine serum albumin (BSA), respectively, was used to analyze the input signals of the corresponding ... processes in biological systems / edited by Andrzej Lewenstam, Lo Gorton pages cm – (Wiley series on electrocatalysis and electrochemistry) Includes bibliographical references and index ISBN ... system resulted in the inactivation of the biofuel cell (operating as the inverter producing output for input 1, and vice versa), the system modeled an NOR logic gate (Fig 10.12b, inset) After the

Ngày tải lên: 15/05/2019, 16:56

... mi-crosomes containing recombinant CYP79A61 and CPR1 were incubated with the potential amino acid substrates L-phenylalanine, L-tyrosine, L-tryptophan, L-isoleucine, and L-leucine in the presence ... converted into indole glucosinolates and camalexin in Arabidopsis [8, 9] The aldoxime intermediates produced by CYP79 enzymes do not accumulate in the plant but are channeled within a large protein ... L-tyrosine, L-isoleucine, and L-leucine The pH optima for the formation of phenylacetaldoxime and indole-3-acetaldoxime were 7.0 and 7.2, respectively, and the substrate affinity for L-phenylalanine

Ngày tải lên: 26/05/2020, 21:22

... distinguished invited speakers Shay Kutten, Kirk Pruhs and Paolo Santi In light of the continuously increasing interaction between computing andother areas, there arise a number of interesting and ... contains the 25 papers presented at the First International ICSTConference on Theory and Practice of Algorithms in (Computer) Systems(TAPAS 2011), held in Rome during April 18-20 2011, including ... Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Ngày tải lên: 29/08/2020, 23:31

... partnership, and supply chain network design Sharing information in an organization's supply chain promotes resilience by reducing uncertainty and risk Li et al [38], confirms this point by demonstrating ... important competencies discovered in the analysis for promoting resilience in the manufacturing system are related to maintaining monitoring and anticipating impacts and threats, particularly from ... material [14] In health and medicine, resilience is defined as the ability to maintain or recover mental health following adversity According to the authors, the definition of resilience in this context

Ngày tải lên: 13/10/2022, 15:50

... the protein-protein interactionand gene regulatory networks uncovered in our study are consistent with our biologicalintuition about the complexity of living organisms The main findings of this ... be studied in the context of integrated systems of interacting components, and asparts of the systems, they do not function in isolation, but in cooperation That is theunderlying principle of ... direct binary interactions, affinity Trang 21pu-Figure 1.1: Protein-protein interaction network of Saccharomyces cerevisiae Thereare 2018 nodes (proteins) and 2930 links (interactions) Data from

Ngày tải lên: 10/09/2015, 09:06

... Partitioning and Consistency Data Partitioning for Minimizing Transferred Data in MapReduce Miguel Liroz-Gistau, Reza Akbarinia, Divyakant Agrawal, Esther Pacitti, and Patrick Valduriez Incremental ... the basis of the datastore information and the host name included in the deploy instructions The hypervisor deploys a virtual desktop in an appointed datastore and host name and outputs a deploy ... contained herein Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper Springer is part of Springer Science+Business

Ngày tải lên: 12/03/2019, 15:50

... Flavonoid Hesperidin in Chemical and Biological Systems Scientific seminar - Lam Thu Huyen Trang 2I.Background: General about hesperidinHesperidin Trang 3I.Background: properties of hesperidin antimicrobial ... hesperidinMethod: in vitro Trang 7In vivo Trang 8hesperidin & trolox(diluted in DMSO) 250 µM of DPPH (radical) dissolved in ethanol + Tris-HCl buffer ( difference concentration) maintained in ... & results: using yeast cells incubated in YPD medium 6h, 28°C, 130 rpm diluted in 0.9% (w/v) NaCl, plated onto YPD agar incubated 72h, 28°C compare with control plates (beginning) Trang 13III

Ngày tải lên: 10/06/2022, 21:23

... carbohydrate) removal and fouling reduction were investigated by conducting batch and long-term MBR experiments The main goals of adding such modified coagulants were to increase particle size, and to enhance ... Environmental Systems Engineering, Faculty of Science and Engineering, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Japan ABSTRACT The mixture of polysilicate and Fe(III), and commercial ... Environmental Systems Engineering, Faculty of Science and Engineering, Ritsumeikan University, Email: jnt07778@se.ritsumei.ac.jp Received May 7, 2010, Accepted July 7, 2010 - 203 - increase of

Ngày tải lên: 05/09/2013, 10:15

... vector, bPLATFORM, included three terms: a year effect, an overall linear trend in time for the three months in 2008 and two months in 2009, and the interaction of year and linear trend in time Three ... μmol/m2s during the seedling growth and the hardening process, whereas the freezing cycle was carried out in dark The experiment in 2008 contained 139 S families The experiment in 2009 contained 201 ... 0.01) Linear decreasing trends were observed during each year which was expected since those were longitudinal data and thus the damaged portions of plants increased during the progression of winter...

Ngày tải lên: 11/08/2014, 11:21

... long-standing reductionist bias in the study of biological systems Concluding Remarks Understanding how biological systems can be complex, robust and evolvable is germane to our understanding of ... ability to find subsequent adaptations Complexity, in the context of multi-scaled evolving systems, clearly demands evolvability to form such systems and robustness to maintain such systems at ... requires a matching realization of redundancies This simplicity in structure (and inefficiency) is encouraged in most human planning activities Degeneracy and Evolvability (Link 3) For systems to...

Ngày tải lên: 13/08/2014, 16:20

... each demand site and flow requirement Runoff and infiltration from catchments, assuming no irrigation inflow Inflows and outflows of water for every node and link in the system This includes ... demand and those months for which there is no water demand Demand intakes Transmission links (the equivalent of demand intakes in AQUATOOL) are elements that supply water to demand sites A demand ... subsystems: (1) a GUI, (2) model management, and (3), information management [4] A DSS also has the following architecture: (1) data measurement: data gathering tasks, (2) data processing: data...

Ngày tải lên: 05/09/2013, 14:58

... Secure Information Systems George Mason University jajodia@gmu.edu Introduction Access control is the process of mediating every request to resources and data maintained by a system and determining ... include micro data release and k-anonymity In Part V, we include two essays, which are about challenges in the database-as-a-service model and database watermarking The audience of this book includes ... there is an explicit information flow from B and C into D since the information in B and C is transferred into D However, there is another implicit information flow from A into D because the future...

Ngày tải lên: 25/03/2014, 12:06

... systems In Proceedings of the 21st ACM SIGACT-SIGMOD-SIGART Symposium on Principles of Database Systems ACM, New York, 1–16 BERRY, M AND LINOFF, M 1996 Data Mining Techniques for Marketing, Sales, and ... Discovery and Data Mining (PAKDD) (Hong Kong, China) WANG, H AND ZANIOLO, C 2000 Using SQL to build new aggregates and extenders for objectrelational systems In Proceedings of 26th International ... last 15 minutes before the closing, and we place an offer as soon as ACM Transactions on Database Systems, Vol 29, No 2, June 2004 Expressing and Optimizing Sequence Queries in Database Systems...

Ngày tải lên: 30/03/2014, 22:20

... potentially involving both intra- and extracellular inflammatory reactions Inorganic and nonbiodegradable nanoparticles have been found in liver, kidney, and colon, leading to the definition of ... School of Medicine and all of the graduate students in the School of Engineering at Stanford whose work has been an inspiration to the editors, in the laboratory, the clinic and in the preparation ... dimensions, help in observing oxidation–reduction reactions not only in fuel cells but also in biological cells The RPL studies mass transport within and between lipid bilayers to gain insights into the...

Ngày tải lên: 04/06/2014, 14:39

... Advances in Signal Processing and its inverse IN is the N × N identity matrix and 0M ×N is the M × N all zero matrix Operators !, · and ÷ denote factorial component-wise vector multiplication and ... [l] and hence Dtot [l] is accurately known, we can obtain Stot [l] as in (12) This is the principle behind the joint compensation scheme in [11, 17] It should be noted that (14) is also valid in ... these lead to ill-conditioning in (45) N p shows that as the number of training symbols is increased, we also have additional tone pairs that can be included in (45), leading to an improved estimation...

Ngày tải lên: 21/06/2014, 08:20

... matrix Λ contains singular values in descending order, the (M −d)×L matrix U and Q×L matrix V consist of left and right singular vectors, respectively U p (V p ) and Ur (Vr ) are the left and right ... estimation is mainly in uenced by the SNR, and the dimension of the matrices Y1 and Y2 Then the sampling period is the key parameter in both the complexity and performance since the main computation ... pulse, and this sampling rate is already above the Nyquist rate in terms of the −10 dB bandwidth To reduce the sampling rate without introducing aliasing, similar to [3], a low-pass filter with bandwidth...

Ngày tải lên: 21/06/2014, 23:20