dipole moments of aromatic heterocycles

... of any developed human society The majority of pharmaceuticals and biologically active agrochemicals are heterocycles The importance of heterocycles provides a new basis for the development of ... of a catalytic amount of tetra-alkylammonium salts or cation complexing agents 1.6 Application of Microwave Activation in Heterocyclic Chemistry The importance of heterocycles in many fields of ... effectiveness or rate of microwave heating of an ionic solution is a function of the concentration of ions in solution When a reaction mixture is subjected to microwave irradiation, the transfer of microwave...

Ngày tải lên: 29/05/2014, 17:31

... (ASA) of individual residues in the API variants were calculated with the INSIGHT II/DISCOVER software The radius of the solvent ˚ probe was 1.4 A Measurement of 1H-NMR The pH-dependent 1H-NMR of ... effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig 3C) When the accessibility of the side-chain of His210 increased, ... the side-chain of residue 210 Molecular mechanism of aromatic stacking for the optimum pH shift Fig shows the charged state of key residues involved in the catalytic activity of API For wild-type...

Ngày tải lên: 21/02/2014, 03:20

... influence of smoking on internal exposure by measurement of cotinine in the urine of the workers In view of the explanatory nature of our data, we used the RIE index to compare the values of external ... internal exposure of about the last months in accordance with the lifetime of the erythrocytes – is a powerful tool for the surveillance of occupationally exposed workers Only the approach of biological ... Supplement, Cincinnati; 1998 Weiss T, Angerer J: Simultaneous determination of various aromatic amines and metabolites of aromatic nitro compounds in urine for low level exposure using gas chromatography-mass...

Ngày tải lên: 20/06/2014, 00:20

... spacing of 1.886 nm Data indicate that stiff and long chain structure of oligomer leads to the greater d-spacing of montmorillonite helping for the intercalation of polyamide into interlayers of clay ... Temperature (°C) Fig TGA curves of aromatic aliphatic polyamide/oligomer-MMT nanocomposites obtained at a heating rate of 10 °C min-1 in nitrogen Table Mechanical data of aromatic aliphatic polyamide/oligomer-MMT ... illustrates the formation of aromatic aliphatic polyamide chains Na-MMT Synthesis of Nanocomposite Films - + NH3 H H N O O N H C O N H C O C O N H C O N H O Appropriate amounts of polyamide solution...

Ngày tải lên: 22/06/2014, 01:20

... interpretation of moments of the characteristic polynomials enables an explicit formula to be obtained for the total number of two-rowed lexicographic arrays constructed from the letters of an alphabet of ... the number of arrays of an arbitrary size that include weakly increasing subsequences of N elements or less By the Robinson-Schensted-Knuth correspondence, the number of ordered pairs of semi-standard ... interpretation of the Keating and Snaith conjecture, the above considerations raise a question of how the moments of the Riemann zeta function are related to the representation theory of finite groups...

Ngày tải lên: 07/08/2014, 07:21

Ngày tải lên: 14/11/2014, 06:18

Ngày tải lên: 14/11/2014, 08:23

... Infrared spectrum of ortho-diethylbenzene Infrared spectrum of meta-diethlbenzene Infrared spectrum of ortho-diethylbenzene Infrared spectrum of para-diethylbenzene Infrared spectrum of styrene The ... conjugate on the side of the single-bonded oxygen: Apparently this form of conjugation interferes with resonance of the carbonyl group, hence increasing the arbsorption frequency of the C=O bond α-keto ... bending of CH2 Methylene groups often absorb stronger when attached to a cabonyl Crotoaldehyde Benzaldehyde The reason the C-H splits into two peaks is due to fermi-resonance, from a coupling of the...

Ngày tải lên: 19/12/2014, 07:14

... Since then, biofilm reactors have become a focus of interest in the field of bioremediation Lots of studies have been performed in using biofilm reactors for bioremediation of aromatic pollutants ... Major groups of anaerobic bacteria in aromatic biodegradation 11  Table 2-6 Bacterial utilization of aromatic compounds 14  Table 2-7 Enzymes associated with biodegradation of aromatic compounds ... and objectives of this thesis Published research in biodegradation of aromatic compounds and the current status of the state -of- the-art techniques in proteomics and the applications of proteomics...

Ngày tải lên: 12/09/2015, 08:19

... reduction of benzoquinones xiv List of Tables Table 2-1 Synthesis of 2-1-8 24 Table 2-2 Synthesis of 2-1-13 26 Table 2-3 Synthesis of 2-1-7b 26 Table 2-4 Synthesis of 2-2-11a 33 Table 3-1 Synthesis of ... family members i Table of Contents Acknowledgements i Table of Contents ii Summary xiii List of Tables xv List of Figures and Schemes xvi List of Abbreviations xix List of Publications xxiii Part ... 5.4.3 Synthesis of monomer 5-4 130 5.4.4 Synthesis of polymer 5-18 130 5.4.5 Synthesis of polymer 5-19 131 5.4.6 Synthesis of polymer 5-20 131 5.4.7 General procedure for reduction of α,β-unsaturated...

Ngày tải lên: 14/09/2015, 13:37

... conjugation of GSH to a variety of endogenous and exogenous electrophilic compounds Evidence suggests that the level of expression of GST is a crucial factor in determining the sensitivity of cells ... membrane-cytoplasmic interface of the most COOH-proximal TM segment of MRP1 The data indicated that substitution of Trp with Cys reduced the affinity of MRP1 for LTC4, but the transport capacities of the mutant ... examined the effects of replacing the analogous tryptophan residue at position of 1254 of MRP2 Nonconservative (Ala, Cys) substitutions of MRP2-Trp1254 eliminated the transport of E217ßG similar...

Ngày tải lên: 05/10/2015, 13:53

... of electron donative S heteroatom in the structure of thiophene The influences of dipole moment, the orientation at the carbon cloth surface and the size of the compound as well as the type of ... aqueous solutions having a range of pH onto high area activated carbon cloth by means of in situ UV spectroscopy The examination of the effect of ionization of these aromatic acids on their adsorption ... examine the effects of both the surface charge of the carbon cloth and the ionization of organic acids on adsorption The initial concentrations of organic acids and the amount of carbon cloth were...

Ngày tải lên: 01/12/2016, 16:24

... moneyness of options 5.1 Description of the Option Data The sample of market option quotes covers the period of June 19, 1997 through August 18, 1997, which overlaps with the last part of the sample of ... biases of the model option prices, while the MARE statistic measures the dispersion of relative biases of the model prices The difference between MARE and MRE suggests the direction of the bias of ... practical advantage of this technique is its flexibility, a property it inherits of other momentbased techniques Once the moments are chosen one may estimate a whole class of SV models In addition,...

Ngày tải lên: 21/12/2013, 01:20

... mechanism of action of those two classes of substituted benzoheterocycles, the kinetic parameters of inhibition were measured Compounds 1c and 2b were chosen as being representative of each class ... inhibitors, a molecular model of the methyltetrahydrofolate-binding domain of the rat liver MetS was constructed In the absence of a high-resolution structure of the methyltetrahydrofolate-binding site ... Figure shows the superimposed structures of DHPS and 5-methyltetrahydrofolate The model of the methyltetrahydrofolate-binding site of MetS with one molecule of the substrate included was further...

Ngày tải lên: 19/02/2014, 05:20

... studies of the reductive half-reaction (Table 2) Stopped-flow studies of the reductive half-reaction of AADH Studies of the reductive half-reaction were performed to allow comparison of kinetic ... studies of the pH dependence of TTQ reduction by benzylamine have indicated that a single kinetically influential ionization of pKa 6.0 controls the rate of TTQ reduction The crystal structure of AADH ... native enzyme The migration of both subunits is consistent with the predicted masses of the mature form of the subunits (14 472 and 40 421 Da 5896 Fig Purification of recombinant AADH from P denitrificans...

Ngày tải lên: 19/02/2014, 07:20

... terms of assembly of fragments is discussed Results CD spectra Secondary structure of SNase and its mutants was determined by CD with spectrapolorimetry measurements The approximate fraction of ... the sum of fractional multiples of the reference spectra for each structural type Figure 1A shows the CD spectra of W140A, E142O and K133A There are no significant differences from that of the ... the secondary structure of the protein disintegrated Using the peak at 222 nm of the wild-type protein as an index of helical conformational stability, this CD spectrum of W140O suggests a decrease...

Ngày tải lên: 20/02/2014, 01:20

... 711–738 10 Harrison EH (2005) Mechanisms of digestion and absorption of dietry vitamin A Annu Rev Nutr 25, 87– 103 11 Blomhoff R & Blomhoff HK (2005) Overview of retinoid metabolism and function J ... amounts of 3-OH-retinal (C20) Similarly, the relative amounts of the C18 and C22 products resulting from the cleavage of C13-C14 (or C13¢-C14¢) in b-carotene were much higher than those of the ... the decolorization indicated a high conversion of the substrate, HPLC analyses of the cells showed only traces of two products (Fig 7) On the basis of UV-visible spectra and elution pattern, the...

Ngày tải lên: 15/03/2014, 23:20

... specificity of this isoform The aim of this study was to identify amino acid residues that are involved in substrate specificity of UGTs 2B4 and 2B7 in order to better understand the molecular basis of ... two-fold of that of the blank sample Kinetic analysis of the data Kinetic parameters were evaluated from initial velocity values of the reaction performed as described above Varying concentrations of ... critical importance of an aromatic amino acid at position 33 for the activity and substrate specificity of both UGT2B4 and UGT2B7 Results The phenylalanine residue at position 33 of UGT2B4 is important...

Ngày tải lên: 23/03/2014, 09:21

... Defects in several of the enzymes of aromatic amino acid biosynthesis therefore hypersensitize yeast to weak organic acid stress We also investigated the growth of this same series of strains after ... studies of growth kinetics for any full characterization of the effects of a mutation on growth in the presence of a stress agent (Fig 8) Importantly, this and other studies [18] strike a note of ... findings of a decreased acetate resistance with the loss of Pdr12p in the trp1-D63 genetic background We therefore investigated Fig The effects of Pdr12p overexpression on growth in the presence of...

Ngày tải lên: 23/03/2014, 21:20

... Gifts of Silence Forms of Silence Reflections on the Dialogue of Silence 79 chapter four: Mutual Touch Mutual Touch Defined The Importance of Touch in Health Care The Nature of Touch Types of Touch ... understanding of me, of oncology nursing, and ultimately of exemplary nursing practice 25 more moments in time : images of exempl ary nursing The first part of the “My Memories” section of this chapter ... used to illustrate each of the three themes: the dialogue of silence, mutual touch, and sharing the lighter side of life In Chapter I describe the essence of the experience of exemplary 22 chap...

Ngày tải lên: 29/03/2014, 09:20