contribution of advances in immunology to vaccine development

... quantity) of lymphocytes directed against HPV epitopes has been examined with the goal of providing insights into the clinical outcomes of HPV-positive patients To this end, analyses of cytokines ... circulating or secreted cytokines can be useful indicators of immune response, but the best indications may come Cytokines and Markers of Immune Response to HPV Infection 13 from the actual site of interaction ... polarization, using a single cytokine (or small group of cytokines) to characterize the T-helper phenotype However, advances in immunology have led to the shift of the TH1/TH2 paradigm to the TH1/TH2/TH17/T-reg...

Ngày tải lên: 07/03/2014, 20:20

... fibroblasts lacking p15INK4b are resistant to the growth-inhibitory effects of gefitinib As the level of p15INK4b is increased by MEK inhibitors, but not by Akt inhibitors, the induction of Fig The cell-cycle ... is involved in gefitinib-induced growth inhibition in HNSCC [58] Another group of cell-cycle regulatory molecules – those of the INK4 family – has also been implicated in gefitinib-induced inhibition ... in promoting the G1 -to- S phase transition of the cell-cycle by phosphorylating the retinoblastoma (RB) protein Activation of cyclin–CDK complexes is counterbalanced by CDK inhibitors, including...

Ngày tải lên: 16/02/2014, 09:20

... determined the variation of amount of glycoprotein in cells As shown in Fig 5E, although the total amount of protein in cells decreased to 87% after 48 h of incubation, the amount of glycoprotein ... 2-aminopyridine and analyzed using HPLC according to the method described in Experimental procedures Ten per cent volume of the product of each sample was injected into the column The arrows indicate ... This distinction may be due to differences in the mechanism of action of swainsonine and bafilomycin A1 Swainsonine inhibits both lysosomal and nonlysosomal mannosidases, whereas bafilomycin A1 blocks...

Ngày tải lên: 30/03/2014, 04:20

... cycle [11–15] Certain transacting proteins such as HuR were proposed as regulators of changes in mRNA stability during the cell cycle [15] In this context it is of interest that during vertebrate ... thymidine ⁄ amphidicolin block, the half-life of cyclin B1 mRNA measured after actinomycin D addition increased from 1.2 h in early G1 to 12 h in G2 ⁄ M phase [11] With the same method the cyclin ... reported to change from 1.6 h in early G1 to 12 h in late G1 and h in S and G2 ⁄ M phase [12] Similarly, cyclin A and B1 mRNA half-lives increased in RKO cells from about 2.5 h in G1 to 18 h in S...

Ngày tải lên: 30/03/2014, 20:20

... Nominals Case Singular Plural Nominative Genitive Dative Accusative Vocative Ablative a king king’s, of a king to a king a king ´ o king! with, from, or by a king kings of kings to kings kings ... of It is tempting to suggest that this orientation is a symptom of the hearing status of the investigators However, such ‘‘blinders’’ may be less the consequence of a hearing– speaking chauvinism ... field is now leaving behind much of the wishful-thinking simplicity of its youth and gaining Preface vii a deeper understanding of the process and content of sign language development in deaf children...

Ngày tải lên: 11/06/2014, 06:49

... doing on-the-job training and bedside teaching; ▪ Strong management (including infrastructure) capacity of certain expatriates; ▪ Improved quality of teaching in educational institutions Most informants ... even stopping to send any altogether This is influenced by several factors First, changes in thinking about development, where establishing long-term relations with partners, capacity building ... regarding the role of international health volunteers Finally, we identify factors of successful contribution of international health volunteers to health services in the south Methods In this...

Ngày tải lên: 18/06/2014, 17:20

... to differ in postural sway of infants with typical development, as compared to infants with motor development pathologies such as cerebral palsy The application of the concept of entropy to information ... comparing the values, with similarity of the vectors being defined as one vector having values within a specified range of those in the comparison vector However, comparison of the vectors can ... give insight into the motor control pathology in cerebral palsy, as it has in other motor control studies, including concussion [1], grip force in Parkinson's disease [2], stereotypical rocking in...

Ngày tải lên: 19/06/2014, 08:20

... leaching of arsenic in AIRU The leaching of arsenic and iron in the presence of organic matter in AIRU feed water was investigated under dosage-response observations in multiple sets of laboratory ... reduced in the bioleaching process, re-oxidized to insoluble ferric form due to the intrusion of supernatant aerobic water into the sand-filter bed and was trapped by the mechanical straining mechanism, ... contamination is even used in drinking water treatment in the rural areas of Bangladesh Moreover, the concentration of organic matter is sometimes unnoticed in the installation process of the...

Ngày tải lên: 05/09/2013, 09:38

... summary of the possible barriers and obstacles to knowledge management initiatives in software engineering 4.1 Needs in software engineering The field of software engineering have some interesting ... Ubiquitous computing The ease of access to almost any kind of information at any time in any place increases the value of cognitive skills of individuals Choosing the right information to process ... Jonson School of Engineering Blekinge Institute of Technology Box 520 SE - 372 25 Ronneby Sweden This thesis is submitted to the School of Engineering at Blekinge Institute of Technology in partial...

Ngày tải lên: 24/01/2014, 00:20

... then bind to these adaptors to initiate multiple signalling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase ⁄ AKT and the signal transducer and activator of transcription ... stimulates intrinsic tyrosine kinase activity of the receptors and triggers autophosphorylation of specific tyrosine residues within the cytoplasmic regulatory domain These phosphorylated tyrosines ... receptor tyrosine kinase All ERBB proteins have four functional domains: an extracellular ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal...

Ngày tải lên: 16/02/2014, 09:20

... (EGFR-TKIs), gefitinib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig ... tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs, leading to an increase of  100-fold in sensitivity to inhibition by EGFR-TKIs compared with that of ... Okamoto The position of the T790M mutation within the EGFR is analogous to the positions of mutations in other tyrosine kinases known to result in resistance to imatinib (T315I in ABL, T764I in...

Ngày tải lên: 16/02/2014, 09:20

... beneficial to the growth of rubber trees Intensive intercropping of young rubber with banana may result in an increase in growth and yield of rubber trees, and to a reduction in the length of the ... reported four main integrated rubber farming systems in the South of Thailand emerging during the financial crisis in the late 19 1990's The major systems included 1) Rubber intercrop farming, 2) Rubber-rice ... individual volumes of trees in relation to plantation age have not been done In order to contribute to improving the productivity of rubber cultivation in Thailand, this kind of information is needed...

Ngày tải lên: 21/02/2014, 04:20

Ngày tải lên: 23/02/2014, 08:20

... expenditures of libraries, construction spending to build and maintain facilities, and the spending of visitors • A second form of economic contribution is the value of library services offered to businesses ... spending of staff, operating expenses of libraries, construction spending to build and maintain facilities, and the spending of visitors • A second form of economic contribution is the value of library ... contributions of public libraries to overall literacy, to helping people with special needs, to supporting the efforts of pK-12 schools, to providing community gathering space, and to supplying...

Ngày tải lên: 08/03/2014, 08:20

... investigators, since apparently ~he training for coding interpreted many more statements as representing some sort of analysis or opinion than "should" be there, according to the distributions obtained ... difficulty of CC groups in reaching total consensus DISCUSSION OF THE RESULTS The twelve categories in Bales Interaction Process Analysis can be combined into four main zhlnctional areas Categories ... varieties of "asking questions" in the task oriented area h "Gives SUggestion, direction, implying autonom~ for other" Includes giving suggestions about the task or sUggesting concrete actions in the...

Ngày tải lên: 24/03/2014, 01:21

... of endogenous histone mRNA (Fig 5) Stabilization of ARE-containing reporter mRNAs was also insensitive to the inhibitor, as well as to coexpression of inhibitory mutants of the p38 and MK2 kinases ... 4A) This indicates that UV light can induce stabilization of a much broader spectrum of mRNAs including species containing and lacking AREs in their 3¢-UTR Of note, the mRNAs devoid of AU-rich ... described in (A) UV light but not activation of p38 MAP kinase increases cytoplasmic HuR-binding activity Analysis of protein–RNA binding showed that several complexes were formed when GM-CSF ARE is incubated...

Ngày tải lên: 31/03/2014, 08:20

... learning cycle does not only apply to when we are studying but also when we are in work It will help me in developing my career in the future too 1.5 Belbin Team Role Inventory Test Belbin Team ... According to E-belbin (2011), Belbin Self-Perception Inventory is “a behavior-based questionnaire” This test analyzes the personality of users into nine team-role contributions (E-Belbin, 2011) ... found in the definitions, social media is then defined in this study: “Social media is a set of web-based media tools, similar to offline media that allow people to interact by generating and...

Ngày tải lên: 03/04/2014, 09:20

... the private sector came ahead of avoiding paying back years of training with years of work in the public sector Interestingly, married nurses were less likely to prefer working in urban areas ... existing possibilities in the labour market For example in Indonesia, the authors delinked the opportunity to specialize from the obligation to so in the public sector Synthesis of findings Studies ... married doctors valued a job in Addis Ababa more, and that younger doctors were more impatient in wanting to be freed from their obligation towards the public sector after their training In the same...

Ngày tải lên: 18/06/2014, 17:20

... exercise was divided into two major categories: any form of exercise, excluding walking, lasting a minimum of 30 minutes per day, and walking alone, again for a minimum period of 30 minutes Both groups ... factors leading to increased body weight and obesity and, consequently, to the impairment of health-related quality of life Competing interests The authors declare that they have no competing interests ... quality of life in adults 65 years and older Obesity Res 2004, 12:69-76 Borowiak E, Kostka T: Predictors of quality of life in older people living at home and in institutions Aging Clin Exp Res...

Ngày tải lên: 18/06/2014, 19:20

... come to know her state They don't have to be told You have to let them grow up to a certain age They will have to be told when they have a sense of understanding and wisdom giving such information ... other literature on disclosure of HIV status to infected minors in similar settings [10] This is an important finding for supporting disclosure to youth participating in HIV-related research that ... it was better to be informed These findings provide some support for incorporating disclosure or planning for disclosure into assent or research participation procedures Taking into consideration...

Ngày tải lên: 20/06/2014, 08:20