... adenylate cyclase convert-ing ATP to cAMP Intracellular cAMP was measured usconvert-ing a colorimetric direct immunoassay in accordance with the manufacturer’s instructions Briefly, 5 × 105monocytes/ ... inhibitor, reduced the clinical and histological severity of collagen-induced arthritis (CIA) [4,5] These studies APC = antigen-presenting cell; ATF-1 = activating transcription factor-1; CIA = collagen-induced ... transduced via three known recep-tors, VPAC1, VPAC2, and PAC1, all of which are coupled to adenylate cyclase via heterotrimeric G proteins In vivo, VIP has a therapeutic effect in the CIA mouse
Ngày tải lên: 09/08/2014, 01:23
... Trang 1Open AccessR796 Vol 7 No 4 Research article Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score Daniel ... erythrocyte sedimentation rate; 0–10 mg/dl for C-reactive protein (CRP) CDAI, Clinical Disease Activity Index; DAS, Disease Activity Score; SDAI, Simplified Disease Activity Index. Figure 2 Cross-sectional ... Cross-sectional correlation of composite scores and correlation with HAQ scores Cross-sectional correlation of composite scores and correlation with HAQ scores Matrix displaying Spearman rank coefficients
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx
... expressed in cells of the myelomonocytic lineage; both proteins are present at high concentrations in the cytoplasm of AA = arachidonic acid; CBA = cytometric beads array; CRP = C-reactive protein; ... electro- phoretic mobility shift assay; esRAGE = endogenous secretory receptor for advanced glycation endproducts; FCS = fetal calf serum; FITC = fluo- rescein isothiocyanate; GM-CSF = granulocyte-macrophage ... peripheral blood mononuclear cell; PDTC = 1-pyrrolidinecarbodithioic acid; PE = phycoerythrin; RA = rheumatoid arthritis; RAGE = receptor for advanced glycation endproducts; SD = standard deviation;
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Validation of the International Classification of Functioning, Disability and Health (ICF) Core Set for rheumatoid arthritis from the patient perspective using focus group" pdf
... each concept to the ICF category representing this concept most precisely One concept could be linked to one or more ICF categories, depending on the number of themes contained in the concept Consensus ... previous focus groups Saturation was checked separately for the two approaches Confirmation of the ICF categories contained in the Comprehensive ICF Core Set for RA An ICF category of the Comprehensive ... ICF categories according to established linking rules Forty-nine patients participated in ten focus groups (five in each approach) Of the 76 ICF categories contained in the Comprehensive ICF Core
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis" pdf
... ENA-78), Cxcl1 (KC/human Gro-α), Cxcl13 (BLC), Ccl8 (MCP-2), Ccl7 (MCP-3), Ccl2 (MCP-1), Cxcl14 (MIP-2γ), Ccl5 (RANTES), Cxcl16 (SR-PSOX), Ccl9 (Mip-1γ), Ccl6 (C10), and Cxcl12 (SDF-1) Genes encoding ... Ccr6, Ccr1,Ccr2, and Ccr5 are specifically expressed by immature dendritic cells (DCs) Cxcl16, a T-cell chemoattractant, is expressed by both DCs and macrophages Ccl9, Ccl6, and Cxcl13 are produced ... Figure 5, included 11 genes in a 2-Mb scale Hierarchical clustering and visualization of these genes, including CC chemokine ligand genes (Ccl2, Ccl6, Ccl7, Ccl8, Ccl9, and Ccl5) and schlafen genes
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis" docx
... production induced by Ttcr cells We found that AdIκBα inhibits the production of CC chemokines induced by contact with Ttcr cells but has no effect on CXC chemokine induction MIP-1α production ... rheu-matoid arthritis; Tck cells = cytokine-activated T cells; TCR = T-cell receptor; Ttcr cells = anti-CD3-activated T cells; TNF α = tumour necrosis factor alpha. Trang 2T cells were recently shown ... investigated whether activated T cells can also induce macrophage CC or CXC chemokine secretion in a contact-dependent manner We found that, upon coculture, T cells activated with anti-CD3 antibody are
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... cohort) A collection kit was sent to par-ticipants, consisting of instructions for the buccal cell collection and the necessary supplies (a small bottle of mouth-wash, a plastic cup with a screwtop ... detailed medical record review for American College of Rheu-matology (ACR) classification criteria for RA [43], in order to identify and validate incident cases of RA The presence or absence of rheumatoid ... among Caucasian women in these cohorts We found both additive and multiplicative interactions between PTPN22 and heavy cigarette smoking ACR = American College of Rheumatology; CCP = cyclic citrullinated
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis" pdf
... receptors PCR conditions were 35 cycles of 95°C for 45 seconds, 60°C for 50 seconds, and 72°C for 5 minutes The reaction was terminated with an elongation step of 72°C for 10 minutes PCR products ... 30 cycles of 95°C for 45 seconds, 60°C for 50 sec-onds, and 72°C for 1 minute The reaction was terminated with an elongation step of 72°C for 10 minutes For quantitative RT-PCR, gene-specific ... quantitative RT-PCR Amplification of each target sequence was performed across 29 distinct normal tissues as well as cancer tissues including two cancer cell lines For PCR amplification of ASV,
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx
... rheumatoid arthritis. ACR: American Colleage Rheumatology; ACPA: anti-citrullinated protein antibody; BSA: bovine serum albumin; CCP: cyclic citrullinated peptide; CRP: C-reactive protein; CS: ... Glc (a1-4) Glc (b); Glc (b); Glc (b1-4) Glc (b); Glc (b1-4) Glc (b1-4) Glc (b); GlcNAc (a); GlcNAc (b); GlcNAc (b1-3) GalNAc (a); Glc- NAc (b1-4) GalNAc (b); GlcNAc (b1-6) GalNAc (a); L-Rha (a); ... inverse correlation both with the Disease Activity Score (DAS) 28 scores and C-reactive protein (CRP) levels in rheumatoid arthritis. Conclusion The highly abundant and cross-reactive, GAG- specific
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: " Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein" doc
... and cardiovascular disease: clinical applications of C-reactive protein determination Am J Cardiovasc Drugs 2009, 9(Suppl 1):3-7. 20 Ridker PM: Clinical application of C-reactive protein for cardiovascular ... A R C H Open AccessDiscovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein Shu-Lin Liu1, Chun-Chia Cheng2,3, Chun-Chao Chang4, Fu-Der Mai2,5,6, Chia-Chi Wang7, ... Hirschfield GM: C-reactive protein: a critical update J Clin Invest 2003, 111:1805-1812. 23 Das T, Sen AK, Kempf T, Pramanik SR, Mandal C, Mandal C: Induction of glycosylation in human C-reactive
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx
... receptor, thereby allowing regulation of IL-1 activity Subcutaneous injection daily Rituximab (Rituxan, 2006) Chimeric monoclonal antibody that binds to the cell surface protein CD20 and selectively ... erythrocyte sedimentation rate, pain scale and functional questionnaire The ACR50 and ACR70 categories adhere to the same criteria, but for 50% and 70% improvement, respectively ACR, American College ... reported ACR response rates according to whether the reason for discontinuation was related to efficacy, which did not fit with the classification defined above A fifth study [47] was excluded because
Ngày tải lên: 12/08/2014, 15:22
Báo cáo khoa học: "Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients" pdf
... day of maximum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in multiple-trauma patients. Figure 2 Serum levels of procalcitonin (PCT) and C-reactive protein (CRP) in patients ... data collected each day for 7 days, and on days 14 and 21 of treatment in the ICU: PCT, CRP, clinical evi-dence and laboratory data of infection, microbiological find-ings, clinical suspicion ... the various stages of sepsis according to American College of Chest Physicians/Society of Critical Care Medicine criteria [13], and the occurrence of organ dysfunction The final data analyzed
Ngày tải lên: 12/08/2014, 23:20
Báo cáo y học: "High systemic levels of interleukin-10, interleukin22 and C-reactive protein in Indian patients are associated with low in vitro replication of HIV-1 subtype C viruses" docx
... Surveillance Definition for Adolescents and Adults Based on 3 clinical categories; category C includes the clinical conditions listed in the AIDS surveillance case definition. 2 CDC Classification ... CCR5 or CXCR4 chemokine receptors as described before [28] Additionally, syncytial characteri-zation was determined by the MT-2 syncytium-forming assay For this, 1 × 106 fresh PBMCs were co-cultivated ... replication capacity in healthy-donor PBMC HIV-1C usage of CXCR4 co-receptor was rare; therefore, it did not account for the differences in replication potential observed There was also no correlation
Ngày tải lên: 12/08/2014, 23:23
Báo cáo y học: "Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study" docx
... 0.05) Receiver-operating characteristic (ROC) curves comparing procalci-tonin (pct), lipopolysaccharide-binding protein (lbp), C-reactive protein (crp), IL-6 (il6), white blood cell (wbc) and ... 0.01) Receiver-operating char-acteristic (ROC) curves comparing procalcitonin (pct), lipopolysaccha-ride-binding protein (lbp), C-reactive protein (crp), IL-6 (il6), white blood cell (wbc) and ... Receiver-operat-ing characteristic (ROC) curves comparReceiver-operat-ing procalcitonin (pct), lipopolysaccharide-binding protein (lbp), C-reactive protein (crp), IL-6 (il6), white blood cell (wbc) and
Ngày tải lên: 12/08/2014, 23:23
Báo cáo khoa học: "Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to
... diagnostic characteristics Trial registration NCT00389337 AUC = area under the receiver operating characteristic curve; CI = confidence interval; CRP = C-reactive protein; ICU = intensive care unit; ... Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee Ameri-can College of Chest Physicians/Society of Critical ... and specificity of C-reactive protein (CRP), procalcitonin (PCT) and neutrophil count were computed using the predefined cutoff values of 60 mg/l, 0.25 μg/l and 7.5 × 10 9 cells/l, respectively
Ngày tải lên: 13/08/2014, 03:20
Báo cáo y học: " Effect of cardiopulmonary bypass on activated partial thromboplastin time waveform analysis, serum procalcitonin and C-reactive protein concentrations" docx
... American College of Chest Physicians/Society of Criti-cal Care Medicine Consensus Conference Committee to define a non-specific generalized inflammatory process inde-pendently from any causative ... of the CPB circuits aPTT: activated partial thromboplastin time; BPW: biphasic waveform; CPB: cardiopulmonary bypass; CRP: C-reactive protein; EuroSCORE: Euro-pean System for Cardiac Operative ... American Society of Anesthesiology; BPW = biphasic waveform; CABG = coronary artery bypass grafting; CPB = cardiopulmonary bypass; CRP = C-reactive protein; EuroSCORE = European system for cardiac
Ngày tải lên: 13/08/2014, 19:20
nghiên cứu nồng độ hs.c-reactive protein huyết tương ở bênh nhân có hội chứng mạch vành cấp tại bệnh viện đa khoa trung ươngcần thơ từ 09 2009-10 2010
... Việt Nam, các công trình nghiên cứu về HCMVC chủ yếu làNMCT có ST chênh lên, còn các công trình nghiên cứu về đau thắt ngựckhông ổn định và nhồi máu cơ tim không ST chênh lên chưa có nhiều hiệnnay ... Nhiều nghiờn cứu khác còn cho thấy có sự tương quan giữa nồng độCRP với kích thước của vùng NMCTC ,mức độ tử vong trongNMCTC[25][39] và có giá trị tiên đoán các biến chứng sau NMCTC, nhất là rối ... LDLc được coi là một tác nhân kích thích viờm, cỏc TBNMcũng nhanh chóng bị thay đổi sau khi bị kích thích bởi các sản phẩm của vitrùng như Herpes virus, Chlamydia Pneumonia hoặc bởi các YTNC nhưthuốc
Ngày tải lên: 17/11/2014, 22:35
Drugs for rheumatoid arthritis
... on Certification of Physician Assistants (NCCPA) accepts AMA PRA Category 1 Credit(s)™ from organiza-tions accredited by ACCME NCCPA also accepts AAFP Prescribed credits for recertification Treatment ... to 2 credits/exam $12/exam. ACCREDITATION INFORMATION: ACCME: The Medical Letter is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education ... ACCME. AOA: This activity, being ACCME (AMA) approved, is acceptable for Category 2-B credit by the American Osteopathic Association (AOA). Physician Assistants: The National Commission on Certification
Ngày tải lên: 12/04/2017, 22:58
LATS Y HỌC -Bệnh phổi tắc nghẽn mạn tính trên bệnh nhân suy tim - tần suất, đặc điểm cytokine và C-Reactive Protein trong máu, tiên lượng (FULL TEXT)
... Long-Acting Muscarinic Antagonist Đối vận muscarinic tác dụng kéo dài TLC Total Lung Capacity Tổng dung lượng phổi KTC Khoảng tin cậy NMCT Nhồi máu cơ tim UCMC Ức chế men chuyển UCTT Ức chế thụ thể angiotensin ... TIẾN SĨ Y HỌC THÀNH PHỐ HỒ CHÍ MINH – NĂM 2018 Trang 2MỤC LỤCTRANG PHỤ BÌA LỜI CAM ĐOAN MỤC LỤC DANH MỤC CÁC CHỮ VIẾT TẮT DANH MỤC THUẬT NGỮ ANH VIỆT DANH MỤC CÁC BẢNG DANH MỤC CÁC HÌNH, BIỂU ... đoán của IL-6 cho các kết cục bất lợi của bệnh nhân suy tim có thể độc lập vớicác dấu ấn viêm khác [112], [130] - IL-8, còn được gọi là yếu tố hóa hướng động bạch cầu, là một cytokine có liên
Ngày tải lên: 16/05/2018, 16:29