2 transients mediated by ryrs see notes 2 and 13
Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest
... cancers such as colon [20–23], pancreatic [24], hepatocel-lular [25], breast [26], prostate [26] and leukemia [27] However, the molecular mechanisms for the growth inhib-ition and cytotoxicity of ... condensation and DNA fragmentation [20] These effects of HES are mediated through regula-tion of the B-cell lymphoma-2 (Bcl-2) family [24, 28], acti-vation of caspase-9 and -3 [24], induction ... [26], elevation of the levels of reactive oxygen spe-cies (ROS) [22, 23], and decreased levels of nuclear factor-κB (NF-factor-κB) [25–27] HES was also found to inhibit cyclooxygenase-2 (COX-2),
Ngày tải lên: 22/09/2020, 23:44
Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: An effect mediated by EGFR inhibition, p53 acetylation and oxidative stress
... MDA-MB 231 (ER-, PR-, HER2/Neu-, EGFR+, and p53 mutant R280K), BT-20 ( ER-, PR-, HER2/Neu-, EGFR++, and p53 mutant K132G), and MDA-MB-468 (ER-, PR-, HER2/Neu-, EGFR++, and p53 mutant R2073H) ... p21 0 1 2 3 x IC50 p53 A MDA-MB-231 cells MDA-MB-231 SC xenografts p53 0 1 2 x IC50 BT-20 cells BT-20 cells PA-2 0 1 2 4 β-actin p21 0 1 2 4 h 1.5 xIC50 B IB (MDM2) MDA-MB-231 ... 1 7 14 18 21 25 28 Treatment, days Vehicle PA-2 300 mg/kg * * * Vehicle PA-2 0 5 10 15 20 25 * * Vehicle PA-2 0 1 2 3 4 A Vehicle PA-2 Aspirin Figure 2 Phospho-aspirin-2 inhibits the
Ngày tải lên: 05/11/2020, 01:26
Perceptions towards the use of TFLAT dictionary in english vocabulary learning by first year major english students at faculty of foreign languages, hanoi pedagogical university 2 and suggestions for users
... vocabulary 5 1.2 Aspects of Vocabulary Knowledge 5 1.2.1 Meaning 5 1.2.2 Pronunciation 6 1.2.3 Grammar 6 1.2.4 Word Formation 6 1.2.5 Collocations 7 1.2.6 Idioms 7 1.2.7 Connotation 7 1.2.8 Register ... Participants 16 Trang 92 Data collection instruments 162.1 Questionnaire 16 2.1.1 Reasons for using Questionnaire: 16 2.1.2 Description of questionnaire 16 2.2 Interview 17 2.2.1 Reasons for using ... 1.3.2 Academic vocabulary 8 1.3.3 Technical words 8 1.3.4 Low frequency words 9 2 Vocabulary learning strategies 9 2.1 Using Context Clues 9 2.2 Mnemonics 9 2.3 Word Part Analysis 9 2.4
Ngày tải lên: 16/08/2018, 09:35
Enhanced expression of sodium hydrogen exchanger (NHE)-1, 2 and 4 in the cervix of ovariectomised rats by phytoestrogen genistein
... biology 2002; 190(2): 117-125 21 Gholami K, Muniandy S, Salleh N In-Vivo Functional Study on the In-volvement of CFTR, SLC26A6, NHE-1 and CA Isoenzymes II and XII in Uterine Fluid pH, Volume and ... Physiology 248.1985; 6(): F821-F829 12 Gholami K, Muniandy S, Salleh N Differential expression of Na+/H+-exchanger (NHE-1, 2, and 4) proteins and mRNA in rodent's uterus under sex steroid effect and ... research international 2013 (2013) 13 Chinigarzadeh A, Kasim NF, Muniandy S, Kassim NM, Salleh N Genistein Induces Increase in Fluid pH, Na+ and HCO3− Concentration, SLC26A6 and SLC4A4 (NBCe1)-B
Ngày tải lên: 16/01/2020, 03:05
Increase the profitability by improving supervisor’s management and leadership skills – the case of pomina 2 steel JSC
... 488,26 523,47 452,22 -9,3% 7,2% -13,6% Original price 1.995,25 2.021,28 2.029,49 2.036,03 1,3% 0,4% 0,3% Accumulated depreciation (1.457,09) (1.497,81) (1.541,23) (1.583,80) 2,8% 2,9% 2,8% ... 2016 2017 2018 30/06/2019 Original price 1.995,25 2.021,28 2.029,49 2.036,03 % Tangible fixed assets/ Original price 27,0% 24,2% 25,8% 22,2% The author would like to find out more about ... 4.656 6.228 2.962 3.547 91,4% 93,7% 90,3% 98,9% Operating cost 15,78 17,56 23,59 10,46 9,98 0,3% 0,4% 0,3% 0,3% Net operating profit 388 323 299 261 (42) 6,3% 4,5% 8,0% -1,2% Net
Ngày tải lên: 16/07/2020, 23:31
Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism
... that GNF-2 is active in inhibiting p185 Bcr-Abl auto-phosphorylation (Figure 3A and 3B) 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 GNF-2 Imatinib (0.2 µM) Dasatinib (2 nM) 0 5 10 15 20 25 30 GNF-2 Imatinib ... 5µM 25µM 100µM GNF-2 5µM 25µM 100µM GNF-2 + Imatinib 0.1µM 5µM 25µM 100µM GNF-2 + Imatinib 1µM A Ba/F3 p185 Bcr-Abl T315 I Imatinib DMSO Nilotinib0.1µM Nilotinib1µM 5µM 25µM 100µM GNF-2 5µM 25µM ... 25µM 100µM GNF-2 + Dasatinib 0.1µM 5µM 25µM 100µM GNF-2 + Dasatinib 1µM C Ba/F3 p185 Bcr-Abl T315I Dasatinib D GNF-2 GNF-2 GNF-2 GNF-2 GNF-2 GNF-2 GNF-2 AKIs Imatinib (0.1µM) Nilotinib (0.1µM)
Ngày tải lên: 05/11/2020, 07:55
2019 CFA level 2 finquiz notes alternatives and portfolio
... T = 1, and ST = 90.Assuming the underlying will distribute 2.9277 at Time t = 0.5: γt = 2.9277 The time until the distribution of 2.9277 is t, and hence, the present value is γ0 = 2.9277/(1 + ... PV1,2[πc+– + (1 – π)c– –] = 0.974627[0.5(0.000042) + (1 – 0.5)0.0] = 0.00002 p+ = PV1,2[πp++ + (1 – π)p+–] = 0.962386[0.5(0.0) + (1 – 0.5)0.0] = 0.0 p– = PV1,2[πp+– + (1 – π)p– –] = 0.974627[0.5(0.0) ... 6, Reading 40, Curriculum Trang 20Ø At Time 0, the present value of the US$3 dividend payment is US$2.970297 (= 3/1.01) Therefore, 118.7644 = (100 – 2.970297)1.224 is the stock value without dividends
Ngày tải lên: 18/10/2021, 20:35
THE ANALYSIS OF THE SUGGESTED TRANSLATION OF CHAPTER 1,2 AND 3 FROM THE BOOK “HOW TO GET WHAT YOU WANT AND WANT WHAT YOU HAVE” BY JOHN GRAY,1999
... TRANSLATION 5 2.2 TYPES OF TRANSLATION 6 2.2.1 Full and Partial Translation 7 2.2.2 Total vs Restricted Translation 7 2.2.3 Phonological Translation 8 2.2.4 Transliteration 8 2.2.5 Free, Literal, and Word-for-word ... 2.3.2.1 Meaning 11 2.3.2.2 Form 12 2.3.2.3 Register 12 2.3.2.4 Idiom 12 2.3.2.5 Style and Clarity 12 2.3.3 Rules of Translation 13 2.3.3.1 The Rule of Proximity 13 CHAPTER III SUGGESTED TRANSLATION ... translation 102.3.1.4 Sematic translation 10 2.3.1.5 Adaptation 10 2.3.1.6 Idiomatic translation 11 2.3.1.7 Communicative translation 11 2.3.2 Principles of Translation 11 2.3.2.1 Meaning 11 2.3.2.2 Form
Ngày tải lên: 29/03/2022, 16:09
Increase the profitability by improving supervisor’s management and leadership skills – the case of pomina 2 steel JSC
... Unit:BillionVND 2016 2017 2018 30/06/2019 2017- 2016 2017 2018-30/06/2019– 30/06/2018 Tangiblefixedassets 538,16 488,26 523,47 452,22 -9,3% 7,2% -13,6% Originalprice 1.995,25 2.021,28 2.029,49 2.036,03 ... Anotheraspectofthecompany’sHR,thenumberofmanagersisonlyasmallpercentagecomparedwiththenumberoftotalemployees.Accordingtothecompanyinternalinformation,i n t h e year2019therewere718employeesworkingin thePomina2 factory: Vice director 2 2 2 Supervisor 26 3,15% 23 3,19% 23 3,2%Skilledworker/Engineer 226 27% 158 22% 158 22%Unskilledworker ... 74% 534 74% Wecanseethereductionof thenumbersofskilledworkersfrom 226 people in 2017 to158i n theyear2018and2019,27%downto22%,andthenumberofsupervisorsalsoreducesfrom2 6to23.Notes:engineersmusthaveatleast3yearsofexperienceandforasupervisoratleast5yearsof
Ngày tải lên: 24/10/2022, 20:31
ginseng and its active components ginsenosides inhibit adipogenesis in 3t3 l1 cells by regulating mmp 2 and mmp 9
... proMMP-2 and proMMP-9 activities by 25 and 26%, respectively Moreover, GE, TGSs, and Rb1 reduced active MMP-2 levels by 13, 31, and 19%, respectively 3.5 GE and GSs Reduce PMA-Induced 2 and MMP-9 ... respectively, and GS decreased their mRNA levels by 24 and 24%, respectively (Figure 3) By contrast, GE increased the mRNA levels of TIMP-1 and TIMP-2 by 135 and 77%, respectively, and TGSs increased ... levels by 123 and 43%, respectively In particular, Rb1 also decreased the mRNA levels of MMP-2 and MMP-9 by 46 and 4MMP-2%, respectively, whereas Rb1 increased TIMP-1 and TIMP-2 mRNA levels by 70 and
Ngày tải lên: 02/11/2022, 10:43
ledgf p75 independent hiv 1 replication demonstrates a role for hrp 2 and remains sensitive to inhibition by ledgins
... 78.8** 5.0 Nalm 2/2 cl 1 404 52.2** 11.1** Nalm 2/2 cl 2 395 51.4** 8.6** MRC sites Nalm +/+ 3225 39.8 2.8 (HIV) Nalm +/c 1983 39.8 3.3 Nalm 2/2 cl 1 1212 40.8 3.6 Nalm2/2cl 2 1185 37.4 3.1 Abbreviations: ... Nalm+/+miR HRP-2, Nalm+/cmiR HRP-2and Nalm2/2miR HRP-2and matched controls Nalm+/+control, Nalm+/ccontroland Nalm2/2control HRP-2 KD cells showed 65, 75 and 80% depletion of HRP-2, respectively, ... doi:10.1371/journal.ppat.1002558.g001 Trang 4replication All selected transgenic cell lines (Nalm+/+, Nalm+/cand Nalm2/2cl 1 and cl 2) showed similar growth rates (Figure S6A and S6C) and CD4 and
Ngày tải lên: 02/11/2022, 14:25
melatonin protects the esophageal epithelial barrier by suppressing the transcription expression and activity of myosin light chain kinase through erk1 2 signal transduction
... 2013;54:282-291. 9 Yuan X, Li B, Li H, Xiu R: Melatonin inhibits il-1β-induced monolayer permeability of human umbilical vein endothelial cells via rac activation J Pineal Res 2011;51:220-225. ... patients (27 NERD and 32 RE) and 23 controls The patients who had completed a questionnaire survey and undergone upper gastrointestinal endoscopy were enrolled between February 2014 and May 2014 ... Acknowledgments This work was supported by the Natural Science Funds of China (No 81270462) and the Postgraduates’ Innovation Program of Jiangsu Province (No Jx22013279) Disclosure Statement The authors
Ngày tải lên: 02/11/2022, 14:28
β1 and β2 adrenergic stimulation induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications
... ± 18.6% (from 12.2 ± 2.7 μ A/cm2 to 1.7 ± 2.8 μ A/cm2, p = 0.002) for type B trans-epithelial current, and 104.3 ± 12.9% as a whole (from 13.1 ± 2.0 μ A/cm2 to 1.1 ± 2.0 μ A/cm2, p < 0.001) ... ± 2.1 μ A/cm2 to 0.2 ± 2.1 μ A/cm2, n = 4, p = 0.01) or 80.1 ± 26.6% (from 5.8 ± 1.3 μ A/cm2 to 0.6 ± 1.7 μ A/cm2, n = 3, p = 0.04), respectively, and by 88.8 ± 16.6% (from 10.1 ± 2.2 μ A/cm2 ... current by 55.3 ± 12.0% (from 26.4 ± 18.7 μ A/cm2 to 15.8 ± 12.6 μ A/cm2, p = 0.001, n = 4) in which type A cur-rent was reduced by 56.4 ± 20.8% (from 33.6 ± 30.0 μ A/cm2 to 20.9 ± 20.0 μ A/cm2, n
Ngày tải lên: 19/11/2022, 11:34
nuclear drosha enhances cell invasion via an egfr erk1 2 mmp7 signaling pathway induced by dysregulated mirna 622 197 and their targets lamc2 and cd82 in gastric cancer
... LAMC2 is a direct target of miR-622 and CD82 is a target of miR-197 (a) The predicted binding sites of miR-622 and miR-197 in LAMC2 and CD82 3 ′-UTRs (b) Luciferase activities of LAMC2 and CD82 ... miR-622, miR-197, miR-199b-5p, miR-146a, miR-129 and miR-130-5p, may be the regulators ofLAMC2 and CD82 Of these, miR-622 and miR-197 have a high score to bind to the 3′-UTR of LAMC2 or CD82, respectively ... con-firmed that LAMC2 was a miR-622 target, and CD82, a miR-197 target.LAMC2 (laminin γ2) is the only monomeric chain that was secreted from laminin 332, consisting of the α3, β3 and γ2 chains Higher
Ngày tải lên: 04/12/2022, 15:52
Tissue specific mitochondrial decoding of cytoplasmic ca 2 signals is controlled by the stoichiometry of micu1 2 and mcu
... changed by increasing the MICU1 expression. See also Figures S2 and S3 Cell Reports 18, 2291–2300, March 7, 2017 2295 Trang 7(A) mRNA level of human MICU1 (hMICU1) and mouse MICU1, MICU2, and MCU ... 2012a; Perocchi et al., 2010; Wang et al., 2014) and MICU2 (Kamer and Mootha, 2014; Patron et al., 2014; Plovanich et al., 2013) To date, a MICU complex (a hetero/homo-dimer of MICU1 and MICU2) ... both the threshold and cooperative activation of the mtCU by Ca2+(Csorda´s et al., 2013; Hung et al., 2014; Patron et al., 2014; Perocchi et al., 2010; Plovanich et al., 2013) MCU and MICU1 both
Ngày tải lên: 19/03/2023, 15:08
giao án toán 2 tuần 13
... học 2.Hướng dẫn làm bài tập : 2.1.Bài tập 1 : - ( Có thể viết trước vào vở nháp ,vở BT GVmời một số HS viết lên bảng VD : quét nhà trông em,dọn dẹp nhà cửa , cho gà ăn vv 2.2Bài tập 2 : ... phút -Nêu yêu câu 1.Giới thiệu bài : 2 Luyện đọc : 2.1.Giáo viên đọc mẫu toàn bài Lời người kể thongthả , lời Chi cầu khẩn,lời cô giáo dịu dàng,trìu mến 2.2.Hướng dẫn luyện đọc kết hợp giải ... bài tập 1,2,3,4vở BTToán.)64 - HS viết phép tínhtheo cột rồi trừ từphải sang trái , vừa nóivừa viết : 34trừ được 8 ,lấy 14 trừ 8 được 6 ,viết 6 nhớ 1 8 * 3 trừ 1 bằng 2,viết 2 26 -HS đặt
Ngày tải lên: 27/06/2013, 11:45
báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... 20 00, 28 7:6 02- 604 22 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Hittinger G, Poggi C, Delbeke E, Profizi N, Lafeuillade A: Correlation between plasma levels of cytokines and HIV-1 RNA copy ... U0 126 (MEK1 /2 inhibitor), SB203580 (p38 MAPK inhibitor), and SP600 125 (JNK inhibitor) (Fig 5) U0 126 and SB203580 inhibited the LPS-enhanced release of IL-6 and GM-CSF by BMECs In the SP600 125 -treated ... (96.5 ± 3 .2, 110 .2 ± 3.6, and 99.6 ± 5.0 % of control) Luminal treatment with IL-6 (1, 10, and 100 ng/mL) significantly decreased TEER (Fig 2B) from 72. 1 ± 1 .2 to 64 .2 ± 2. 8, 58.3 ± 2. 0, and 56.4...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: "Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK" doc
... Hcy + LY2940 02 Hcy + SB203580 Figure Homocysteine-induced MIP- is mediated by p38MAPK and PI3 kinase Homocysteine-induced MIP- is mediated by p38MAPK and PI3 kinase MCs were incubated (24 hours; ... hepatocytes mediated via activator protein-1 activation J Biol Chem 20 08, 28 3: 128 2- 129 2 Page of 10 (page number not for citation purposes) Journal of Inflammation 20 09, 6 :27 30 31 32 33 34 35 ... expression induced by Hcy Hcy-induced MIP -2 was significantly attenuated (p < 0.05) by a PI-3 Kinase inhibitor (LY2940 02) and by an inhibitor of a p38MAPK (SB203580) In contrast, use of a p 42/ 44 MAPK...
Ngày tải lên: 11/08/2014, 08:22
Electronic communications mediated by metal clusters and pi conjugated systems 2
... Cu(1)-Cu(3)-Cu (2) 59 .13 (2) Cu(1)-P(1) 2. 291 (2) Cu(1)-C(1)-Cu (2) 74.8 (2) Cu (2) -P(3) 2. 2861 (2) Cu(1)-C(1)-Cu(3) 69.1 (2) Cu(3)-P(5) 2. 2 828 (2) Cu (2) -C(1)-Cu(3) 72. 9 (2) Cu(1)-C(1) 2. 184(5) Cu(1)-C(3)-Cu (2) 70.8 (2) ... 28 26 24 22 20 18 16 14 12 10 -2 -4 -6 -8 -10 - 12 -14 -16 -18 -20 -22 -24 -26 -28 (ppm) 60 50 40 30 20 10 -10 -20 -30 -40 -50 -60 -70 -80 -90 -100 -110 - 120 -130 -140 -154.5114 -148.7 028 -1 42. 8943 ... 80 23 26 b -47±10 43±10 90±10 35 27 b -29 7±10 -77±10 22 0±10 6100 25 00 27 a-c -330 -45 28 5 1 .2 105 27 f (C≡CFc )2} Trans-[Pt(PMePh2 )2 (C≡CFc )2] trans-[Ru(PBu3 )2( CO )2 (C≡CFc )2] trans- 70 [Ru(dppm )2( C≡CFc )2] ...
Ngày tải lên: 17/09/2015, 17:17
Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
... 64, 113 122 Webb JL, Ravikumar B, Atkins J, Skepper JN & Rubinsztein DC (20 03) Alpha-synuclein is degraded by both autophagy and the proteasome J Biol Chem 27 8, 25 009 25 013 FEBS Journal 27 4 (20 07) ... Nature 4 02, 6 72 676 13 Oberstein A, Jeffrey P & Shi Y (20 07) Crystal structure of the BCL–XL–beclin peptide complex: beclin is a 12 novel BH3-only protein J Biol Chem 28 2, 13 123 131 32 14 Pattingre ... Gene Med 2, 326 –333 Rizo J & Sudhof TC (1998) C2-domains, structure and function of a universal Ca2+-binding domain J Biol Chem 27 3, 15879–158 82 FEBS Journal 27 4 (20 07) 3184–3197 ª 20 07 The Authors...
Ngày tải lên: 07/03/2014, 09:20