General principles GP set 04 immuno heme onc a

List the different regions in the lymph node and the spleen and the cell types found in those regions.. Describe the development of T cells from the pre-thymic stage to the mature T cell

GENERAL PRINCIPLES SET 4: IMMUNOLOGY, HEMATOLOGY, AND ONCOLOGY, PART A

1 List the different regions in the lymph node and the spleen and the cell types found in those regions

2 Compare and contrast eosinophils, neutrophils, and basophils based on identification and function

3 Describe the development of T cells from the pre-thymic stage to the mature T cell stage Include in your answer, regions of the thymus and cell surface markers present

4 Label the Ab with Fab fragment and Fc fragment List the functions of each fragment

5 Draw the cell surface interactions between a TH cell and a macrophage

6 Compare and contrast the TH1 vs TH2 response including type of immunity elicited and major cytokines secreted

7 List the autoantigens for the following diseases:

• Graves disease:

• Systemic lupus erythematosus:

• Rheumatoid arthritis:

• Goodpasture syndrome:

8 Compare and contrast the type II and type III hypersensitivity reactions based on immune mechanisms and mechanisms of tissue destruction

9 A 15-year-old male develops itchy eyes, post-nasal drip and is sneezing while visiting a friend with several cats and dogs Discuss this type of hypersensitivity reaction including:

• How it begins:

• Different mediators involved (both cellular and secreted mediators):

10 Identify the drug that is a prodrug of 6-mercaptopurine and used as an immunosuppressant

11 What is the primary purpose for giving a patient erythropoietin, filgrastim (G-CSF), and thrombopoietin?

12 A patient is started on multiple immunosuppressant drugs following an organ transplant For one drug the patient is cautioned to maintain good dental hygiene and watch for increased hair growth Identify this

particular drug

13 Define the following and give examples of each

• Autograft

• Isograft

• Allograft

• Xenograft

14 A 17-year-old male presents to an infectious disease specialist due to multiple infections with various bacteria including Staphylococcus, Aspergillus, and Pseudomonas Describe the diagnosis including genetic mutation and what cell types are affected

15 Compare and contrast the 3 major causes of severe combined immunodeficiency disease based on genetics

16 What is the difference between leukemia and lymphoma?

17 What oncologic disorders can produce monoclonal spikes on serum electrophoresis?

18 What percentage of patients with monoclonal gammopathy of undetermined significance eventually develop myeloma, lymphoma, amyloidosis, or Waldenstrom macroglobulinemia?

19 A child has a white blood cell count of 100,000/mm3, almost entirely composed of lymphoblasts What is the most likely diagnosis?

20 Which disorders are included among the chronic myeloproliferative disorders?

21 What is the characteristic fusion protein for chronic myelogenous leukemia?

These question sets are intended to be completed before viewing the High Yield course lectures

Video explanations can be found on the Warm-up Questions page within the online High Yield course For further review of the topics covered in this set, refer to the following lectures:

Immunology, Hematology, Oncology:

• Blood Cells and Lymphoid Structures

• T-cell and B-cell Function