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Patient Evaluation Because many of the conditions that affect the sternoclavicular joint are systemic, a careful history, including systemic complaints, family history of arthritis, and

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Thomas O Higginbotham, MD, and John E Kuhn, MD

Abstract

The sternoclavicular joint, a

saddle-shaped synovial joint, is the only bony

articulation between the axial and

ap-pendicular skeletons (Fig 1, A) The

large medial clavicle articulates

some-what incongruently with a shallow

socket formed by the superomedial

manubrium and the first costal

car-tilage, creating a joint with little

in-herent bony stability Between the two

articular surfaces is a dense

fibrocar-tilaginous articular disk separating the

joint into two distinct synovial

cav-ities An intra-articular disk ligament

originates from the junction of the first

rib and sternum, passes through the

sternoclavicular joint, and attaches on

the posterior and superior medial

clav-icle That ligament contributes to joint

stability and prevents medial

displace-ment of the clavicle It is contiguous

with the anterior and posterior

ster-noclavicular ligaments, which are

thickenings of the fibrous joint

cap-sule that function as the primary

re-straints to anterior and posterior

trans-lation of the medial clavicle.1The joint

capsule extends laterally to include

the epiphysis of the clavicle The

ster-noclavicular joint also is reinforced

superiorly by the interclavicular

lig-ament, which connects the superome-dial margins of each clavicle The ex-tracapsular costoclavicular (rhomboid) ligament, extending from the first rib and costal cartilage to the inferome-dial margin of the clavicle, further sta-bilizes the sternoclavicular articula-tion (Fig 1, A) Articular branches of the internal thoracic and suprascapu-lar arteries provide the blood supply

to the sternoclavicular joint Innerva-tion is provided by branches of the medial suprascapular nerve and the nerve to the subclavius muscle

The great vessels of the brachio-cephalic trunk, the common carotid artery, and the internal jugular vein lie directly posterior to the sterno-clavicular joint (Fig 1, B) The sur-geon must be knowledgeable about the relationship of these vascular structures to the sternoclavicular joint and plan the surgical approach accordingly

Patient Evaluation

Because many of the conditions that affect the sternoclavicular joint are systemic, a careful history, including

systemic complaints, family history

of arthritis, and drug use should be done for all patients who present with sternoclavicular joint complaints The physician should pay careful atttion to warmth, fluctuance, bony en-largement, and sternoclavicular joint translation

Plain radiographs are indicated in the initial evaluation of sternoclavic-ular joint disorders, but other imag-ing modalities typically are required Computed tomography (CT) scans are indicated for disease processes in which bony destruction or ossifica-tion may occur Magnetic resonance imaging (MRI) provides more de-tailed and useful information when evaluating suspected pathology in-volving inflammation, a soft-tissue mass, or osteonecrosis of the medial clavicle (ie, Friedrich’s disease) Bone scans can help correlate active inflam-mation of the sternoclavicular joint

Dr Higginbotham is Resident, Department of Or-thopaedics, University of Michigan, Ann Arbor,

MI Dr Kuhn is Chief of Shoulder Surgery, Vanderbilt Sports Medicine and Shoulder Surgery, Nashville, TN.

None of the following authors or the departments with which they are affiliated has received anything

of value from or owns stock in a commercial com-pany or institution related directly or indirectly

to the subject of this article: Dr Higginbotham and Dr Kuhn.

Reprint requests: Dr Kuhn, Vanderbilt Sports Medicine and Shoulder Surgery, 2601 Jess Neely Drive, Nashville, TN 37212.

Copyright 2005 by the American Academy of Orthopaedic Surgeons.

The sternoclavicular joint is the diarthrodial articulation between the axial and

ap-pendicular skeletons It is subject to the same disease processes that occur in joints,

including degenerative arthritis, rheumatoid arthritis, infection, and subluxation.

Most of these conditions present with swelling of the joint, which may be associated

with pain and/or tenderness Plain radiographs can demonstrate changes on both

sides of the joint Because of variations in anatomy, computed tomography scans

and magnetic resonance images are often necessary to clarify the pathology With

the exception of acute infection, most conditions can be managed nonsurgically, with

joint resection reserved for patients with persistent symptoms.

J Am Acad Orthop Surg 2005;13:138-145

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with symptoms of pain Laboratory

studies may help elucidate the

diag-nosis when infectious or

inflamma-tory conditions are suspected

Several atraumatic pathologic

con-ditions affect the sternoclavicular joint

(Table 1) There may be subtle

differ-ences in their presentation, findings

on physical examination and

radio-logic studies, and laboratory profiles

Osteoarthritis

The most common condition

affect-ing the sternoclavicular joint is

osteoar-thritis (OA), which can manifest as

part of a systemic process or as

arthri-tis affecting the sternoclavicular joint

only Degenerative changes in the

ster-noclavicular joint become

increasing-ly common with advanced age Kier

et al2radiographically examined 55

cadaveric sternoclavicular joint

spec-imens Moderate to severe

degener-ative changes were uncommon in

pa-tients younger than age 40 years but

were present in 53% of specimens

old-er than age 60 years Postmenopausal

women are more susceptible than

ei-ther men or premenopausal women

to OA of the sternoclavicular joint, but the etiology is unknown A history of manual labor or a radical neck dis-section are also risk factors for the de-velopment of OA of the sternocla-vicular joint

Patients with OA may report pain and swelling at the sternoclavicular joint, which may be aggravated by pal-pation, ipsilateral shoulder abduction,

or forward elevation of the shoulder beyond horizontal Some patients, however, may lack pain, have normal motion, and have no discomfort with stress testing Other physical findings include prominence at the medial end

of the clavicle (caused by osteophytes),

a fixed subluxation, or crepitus on range of motion The increase in size

or appearance of a mass may raise pa-tient concern about neoplasia or met-astatic disease, but these processes are exceedingly rare in the sternoclavicu-lar joint and can be ruled out with ap-propriate imaging Patients present-ing with an increase in the size of the medial clavicle should be imaged with plain radiographs CT is often required

to fully visualize the joint Osteophytes

indicative of OA may be seen on plain radiographs, but sclerosis and joint space narrowing may be difficult to see through variations in anatomy and overlap of bony shadows3(Fig 2) CT scans are helpful in diagnosing sub-tle degenerative changes in the infe-rior medial aspect of the clavicle and are more effective than either plain ra-diographs or bone scans

Most patients with symptomatic

OA of the sternoclavicular joint re-spond to nonsurgical treatment, such

as rest, anti-inflammatory medica-tion, and local corticosteroid injection Resection of the medial head of the clavicle is reserved for patients with severe symptoms who have been un-responsive to nonsurgical treatment for at least 6 months With resection, the costoclavicular ligament must

be preserved and the anterior capsule repaired to prevent residual joint instability In their review of resection arthroplasty for the treatment of degenerative sternoclavicular arth-ritis, Pingsmann et al4 reported good to excellent results in seven of eight patients (mean follow-up, 31 months)

Figure 1 A,Bony and ligamentous anatomy of the sternoclavicular joint The major supporting structures include the anterior capsule, the

posterior capsule, the interclavicular ligament, the costoclavicular (rhomboid) ligament, and the intra-articular disk and ligament B,

Ret-rosternal anatomy Note the proximity of the sternoclavicular joint to the trachea, aortic arch, and brachiocephalic vein.

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Many individuals who develop

changes in the sternoclavicular joint,

such as enlargement, subchondral

sclerosis, and osteophytes, are

com-pletely asymptomatic These patients

may be referred for an evaluation of

the asymmetry of the

sternoclavicu-lar joint This condition would be

bet-ter called osteoarthrosis because there

does not seem to be an inflammatory

component to the condition In the

ab-sence of symptoms, no treatment

oth-er than counseling is required

Rheumatoid Arthritis

Involvement of the sternoclavicular joint in rheumatoid arthritis (RA) is variable One study indicated ster-noclavicular joint involvement in 30%

of 105 patients.5Changes were gen-erally present within 1 year of diag-nosis of RA, but plain radiographs were frequently unremarkable The pathologic process of RA involves synovial inflammation, pannus for-mation, bony erosions, and

degener-ation of the intra-articular disk Isolated involvement is rare, and ev-idence of polyarticular disease and bi-laterality are common Patients may report swelling, tenderness, crepitus, and painful limitation of movement The underlying process is treated, usually in conjunction with a rheu-matologist As with degenerative ar-thritis, patients with symptoms re-fractory to medical management may benefit from medial clavicle exci-sion

Table 1

Features and Test Results of Atraumatic Disorders of the Sternoclavicular Joint

Disorder

Age (yrs) Sex Pain Side

Associated Conditions and Risk Factors Erythema

Radiographic Findings

Laboratory Values Osteoarthritis >40 M = F + B Manual labor,

radical neck dissection, postmenopausal women

Rare Sclerosis,

osteophytes

Normal

Rheumatoid

arthritis

Any F > M + B Symmetric

polyarthritis

+ Minimal

change

May have +RF, +ANA Septic arthritis Any M = F +++ U HIV, intravenous

drug abuse, diabetes

+++ Sclerotic, lytic, or

mixed lesions ↑WBC,

↑ESR,

↑CRP Atraumatic

subluxation

10-30 F > M Infrequent U Generalized

ligamentous laxity

− Normal Normal

Seronegative

spondylo-arthropathies

<40 M > F Occasional B Urethritis, uveitis,

nail pitting − Marginal

erosions, cysts

+HLA-B27

Crystal

deposition

disease

>40 M > F +++

during flare

U Other joint involvement

++ Calcification of

soft tissue

+BRFC,

−BRFC

Sternocosto-clavicular

hyperostosis

30-60 M > F + B Synovitis, acne,

pustulosis, hyperostosis, osteitis

− Hyperostosis,

ossification

of intercostal ligaments

↑ESR, other rheumatologic markers normal Condensing

osteitis 25-40 F > M + U None − Medial clavicle

enlargement, preserved joint space, marrow obliteration

Normal

Friedrich’s

disease

(aseptic

osteonecrosis)

Any F > M + U None − Irregular end of

medial clavicle

Normal ESR, normal WBC

ANA = antinuclear antibodies, B = can present bilaterally, BRFC = birefringent crystals, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, HIV = human immunodeficiency virus, RF = rheumatoid factor, U = typically presents unilaterally, WBC = white blood cell count + = elevated levels or presence of, ++ = moderate elevation, +++ = marked elevation, − = not seen or

absence of.

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Isolated septic arthritis of the

sterno-clavicular joint is uncommon and

fre-quently is associated with an

under-lying disease or other risk factors

Conditions known to be associated

with infectious arthritis are RA,

sep-sis, infected subclavian central lines,

alcoholism, human

immunodefi-ciency virus (HIV) infection,

immu-nocompromised status, renal dialysis,

and intravenous drug abuse Prompt

diagnosis and treatment are crucial

because untreated infection may lead

to life-threatening consequences Pain,

swelling, and tenderness over the

sternoclavicular joint, in association

with fever, chills, or night sweats, are

usual Plain radiographs may disclose

sclerotic, lytic, or mixed lesions but

may be less sensitive than spiral CT,

which is useful in the diagnosis of

septic sternoclavicular joint arthritis6

(Fig 3) MRI may be particularly

use-ful in identifying soft-tissue

involve-ment and abscesses Definitive

diag-nosis is achieved with aspiration or

open biopsy and laboratory

evalua-tion of the joint fluid Although

com-mon organisms such as

Staphylococ-cus aureus and StreptococStaphylococ-cus species

have been reported,7 patients with

risk factors may have other causative

organisms Pseudomonas aeruginosa

has been associated with intravenous drug abuse.8Neisseria gonorrhoeae and

fungal infections with Candida albicans

have been reported in HIV-positive patients.9,10Infection with

Mycobacte-rium tuberculosis has been reported in

patients in third world countries as well as in immunocompromised pa-tients Diagnosis requires needle as-piration or biopsy, and infected pa-tients are treated with appropriate antitubercular therapy.11

Treatment of septic sternoclavicu-lar joint arthritis is determined by the

antibiotic sensitivity of the pathologic organism and the extent of the infec-tion (ie, abscess) In most cases, prompt irrigation and drainage are done in the operating room, along with ad-ministration of appropriate parenteral antibiotics Aggressive organisms may require resection of the sternoclavicu-lar joint and involved portions of the first and second ribs with appropri-ate soft-tissue coverage.12In some patients, aspiration and parenteral an-tibiotics alone have produced success-ful outcomes.13Untreated infections

of the sternoclavicular joint can de-velop into cutaneous, extrapleural, or intrathoracic abscess, which could be-come life threatening if the retroster-nal vascular structures are involved

Spontaneous Anterior Subluxation

Spontaneous atraumatic anterior sub-luxation of the sternoclavicular joint may occur during overhead elevation

of the arm Affected patients are gen-erally in their teens or twenties, and many demonstrate signs of general-ized ligamentous laxity on physical examination Patients report a sudden subluxation of the medial end of the clavicle, and many remember feeling

an associated pop The majority of

Figure 2 Axial computed tomography scan demonstrating osteoarthritis of the

sternocla-vicular joint Note sclerosis on both sides of the joint with subchondral cysts in the clavicle,

and anterior soft-tissue swelling.

Figure 3 Axial computed tomography scan demonstrating septic arthritis of the sternocla-vicular joint Fluid has collected in the joint (arrow), and bony destruction is evident.

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cases are not painful, and the

sublux-ation usually reduces with lowering

the arm Most patients seek medical

treatment because of initial pain and

concern regarding the potential harm

of the condition In a review of 37

pa-tients with spontaneous anterior

sub-luxation of the sternoclavicular joint,

subluxations were reproducible and

painless in 29 patients.14Eighty

per-cent of the patients demonstrated

ev-idence of generalized ligamentous

laxity Twenty-nine patients were

treated nonsurgically with

strength-ening exercises and advancement to

unrestricted activity as tolerated

Al-though many patients subsequently

reported intermittent episodes, few

reported discomfort, and most were

able to participate successfully in

ath-letics The most common reason for

surgery was the failure of a previous

attempt at reconstruction Surgery is

rarely indicated Nonsurgical

man-agement, including patient education

of the benign nature of the condition,

is recommended.14

Atraumatic anterior

pseudosub-luxation mimics atraumatic

sublux-ation in the older patient This

ante-rior fullness of the medial clavicle is

caused by a degenerative process The

subluxation generally is fixed rather

than dynamic

Seronegative

Spondyloarthropathies

The sternoclavicular joint is involved

in seronegative spondyloarthropathies,

including ankylosing spondylitis,

pso-riatic arthritis, Reiter’s syndrome, and

colitic arthritis These disorders are

characterized by onset usually before

age 40 years, inflammatory arthritis

affecting large peripheral joints,

ab-sence of serum autoantibodies, and

association with antigen HLA-B27

Em-ery et al15reported acute

inflamma-tory arthropathy of the

sternoclavicu-lar joint in 2 of 52 patients with

ankylosing spondylitis Involvement

was unilateral in both patients and

con-sisted of symptoms of swelling and tenderness of the sternoclavicular joint

as well as pain with full arm abduc-tion, which responded to nonsurgi-cal treatment with oral nonsteroidal anti-inflammatory drugs (NSAIDs)

Approximately 15% to 20% of pa-tients with psoriasis develop a sym-metric polyarthritis that resembles

RA.16Although psoriasis usually pre-cedes joint involvement, arthritis may precede the skin disease in up to 25%

of patients Affected joints include the sacroiliac joint, the spine, and the dis-tal interphalangeal joint of the hands (ie, nail pitting, onycholysis).16 Oligoar-ticular involvement is parOligoar-ticularly destructive Taccari et al17reported ra-diographic or scintigraphic abnormal-ity of the sternoclavicular joint in 9

of 10 patients admitted to the hospi-tal with psoriatic arthritis Radiographs and CT scans demonstrate marginal erosions of the sternum, clavicle, or both, as well as subchondral cysts and sclerosis (Fig 4) The sternoclavicu-lar joint was clinically involved in only

5 of 10 patients in the series of Tac-cari et al.17Three patients reported spontaneous pain NSAIDs are the treatment of choice for psoriatic

ar-thritis; gold therapy and/or metho-trexate are used for resistant cases Suc-cessful treatment of skin lesions is commonly associated with improve-ment in joint symptoms

Crystal Deposition Disease

Gout, pseudogout, and tophaceous pseudogout have been described in the sternoclavicular joint.18 Examina-tion of joint fluid with a polarizing light microscope reveals characteristic pos-itive (pseudogout) or negative (gout) birefringent crystals NSAIDs and cor-ticosteroid injections typically are used

to manage acute exacerbations A va-riety of medical treatments exist to manage the underlying condition These include medications to reduce uric acid production (eg, allopurinol)

or to increase uric acid excretion (eg, probenecid, sulfinpyrazone)

Sternocostoclavicular Hyperostosis

Sternocostoclavicular hyperostosis, also known as

intersternocostocla-Figure 4 Anteroposterior radiographic view of the chest demonstrating psoriatic arthritis

of the sternoclavicular joint Joint space narrowing, osteopenia, erosions, and irregularity of the joint surface are evident.

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vicular ossification or pustulotic

arthro-osteitis, is a rare disorder that presents

with soft-tissue ossification and

hy-perostosis between the clavicles The

anterior portions of the upper ribs and

sternum, the distal femur and tibia,

and the vertebral bodies also may be

involved The etiology of this

disor-der is unknown, but it is often

encoun-tered in association with

palmoplan-tar pustolosis and severe acne Other

manifestations include synovitis,

hy-perostosis, and osteitis.19Patients are

generally males in their fourth to sixth

decade of life The disorder has been

reported with more frequency in

Ja-pan than in the United States or

Eu-rope Patients present with pain,

swell-ing, and localized warmth over the

sternoclavicular joint and upper chest

wall Symptoms are often bilateral In

advanced cases, range of motion of

the shoulders may be severely

limit-ed Radiographs demonstrate

hyper-ostosis of the sternum, clavicles, and

upper ribs as well as ossification of

the costoclavicular, costosternal, and

intercostal ligaments20(Fig 5)

Lab-oratory studies reveal an elevated

erythrocyte sedimentation rate;

how-ever, other rheumatologic markers are

generally negative Biopsy specimens

demonstrate chronic nonspecific

in-flammation with new bone formation

Although the causative factors in this

condition are still unknown, it is

thought that the clinical course of

sternocostoclavicular hyperostosis is

benign Thus, treatment is directed

at reducing pain and inflammation

NSAIDs have been used with some success, and immunosuppressive ther-apy with cyclosporin A also has been effective in some series

Condensing Osteitis

Condensing osteitis is a rare condi-tion characterized by sclerosis and en-largement of the medial end of the clavicle with preservation of the ster-noclavicular joint Although its etiol-ogy is unknown, chronic mechanical stress at the sternoclavicular joint may play a role.21Patients with this dis-order are usually women in their late childbearing years Involvement typ-ically is unilateral, and pain and swelling over the affected area, exac-erbated by shoulder abduction, is a typical presentation Radiographs demonstrate sclerosis and enlarge-ment of the medial clavicle; isolated increased uptake in this region is found on bone scan MRI and CT scans will demonstrate obliteration of the marrow space (Fig 6) The clin-ical course of condensing osteitis is thought to be benign Most patients respond to NSAIDs Partial resection

of the involved clavicle may offer symptomatic relief in patients who fail nonsurgical treatment.22

Friedrich’s Disease

Aseptic osteonecrosis of the medial clavicle, also called Friedrich’s disease,

is a rare condition characterized by discomfort, swelling, and crepitus of the sternoclavicular joint in the absence

of trauma, infection, or other symp-toms Patients may report loss of ip-silateral shoulder motion Laboratory values, such as erythrocyte sedimen-tation rate, white blood cell count, and rheumatologic factors, are normal Plain radiographs demonstrate irregularity

or curved deformation of the medial end of the clavicle; MRI demonstrates necrotic islands of bone in the meta-physis (Fig 7) Although the pathol-ogy of this disorder is unknown, bi-opsy specimens typically demonstrate cystic degeneration with necrotic bone fragments surrounded by intact bone consistent with osteonecrosis.23The clinical course of Friedrich’s disease

is not well understood; however, most authors report success with NSAIDs

or local corticosteroid injection.23 Sur-gical resection of the affected clavicle has been reported to have poor results; however, these are generally isolated case reports

Other Conditions

Sternoclavicular joint hypertrophy may occur after radical neck dissection for head and neck cancer, especially when the spinal accessory nerve has been damaged Cantlon and Gluckman24

reported sternoclavicular joint hyper-trophy in 27 of 50 patients Because most patients are asymptomatic, an extensive work-up may be required only when there is a concern for met-astasic disease Metastases to this re-gion are very rare, but this diagnosis should be considered when other fea-tures in the patient’s history are sug-gestive.25The few cases of metastatic disease to the sternoclavicular joint that have been reported include squamous cell carcinoma, lymphoma, and ad-enocarcinoma

Tietze’s syndrome is a benign, self-limiting nonsuppurative swelling of the anterior chest wall of sudden or gradual onset Symptoms are

unilat-Figure 5 Axial computed tomography scan of sternoclavicular hyperostosis Note the

os-sification of the anterior capsule (arrow).

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eral in most patients, and

radio-graphs, laboratory studies, and

oth-er physical findings are normal

Physical examination reveals

non-fluctuant, firm, tender swelling

in-volving the articulations of the

cos-tosternal or sternoclavicular joints

Tietze’s syndrome seems to affect the

second, third, and fourth costosternal

articulations, with the

sternoclavicu-lar joint less commonly involved

Symptoms of discomfort are

gener-ally self-limited and usugener-ally resolve

within days to weeks Swelling may

persist for months or years

Hemophilic pseudotumor, a

com-plication of hemophilia, may affect

the proximal clavicle In this process, subperiosteal bleeding may cause a soft-tissue mass, leading to pressure necrosis and bone destruction In-traosseous hemorrhage may lead to cyst formation within bone, with sub-sequent hemorrhagic episodes caus-ing enlargement of the cyst and thin-ning of the bony cortex

Even less common sternoclavicu-lar joint conditions exist

Neuropath-ic arthropathy of the sternoclavNeuropath-icular joint occurs secondary to syringomy-elia with massive joint destruction.26

Erosion of the medial clavicle has been reported as a result of both pri-mary and secondary

hyperparathy-roidism.27Hemodialysis-related amy-loidosis involving the deposition of

β2-microglobulin has been reported

in the sternoclavicular joint It often mimics chronic infection in these im-munocompromised patients Sterno-clavicular joint involvement has been seen with leprosy Ganglion cysts28

and synovial osteochondromatosis of the sternoclavicular joint also have been described.29

Surgical Treatment

Indications for surgery are rare and include infection, for which an

ar-Figure 6 Axial computed tomography scan (A) and computer reconstructed coronal view (B) of condensing osteitis of the sternoclavicular

joint (arrow) Both views demonstrate ossification of the marrow space.

Figure 7 T1- (A) and T2-weighted (B) magnetic resonance images of Friedrich’s aseptic osteonecrosis of the sternoclavicular joint Note

the area of necrosis in the medial clavicle (arrows).

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throtomy may be required, and

se-vere pain refractory to nonsurgical

management.4,30The vital retrosternal

contents must be protected when

per-forming a resection of the medial

clavicle In addition, it is imperative

to maintain the integrity of the

liga-mentous supporting structures of the

sternoclavicular joint because pain

and instability are frequently

report-ed complications of mreport-edial clavicle

excision.30Rockwood et al30

recom-mend inserting the intra-articular

disk and ligament into the

intramed-ullary space of the resected clavicle

to improve the stability of the

resect-ed joint One clear contraindication for a medial clavicle excision is atrau-matic joint instability.30

Summary

The sternoclavicular joint is subject to the same disease processes that affect other synovial joints Degenerative, rheumatoid, and septic arthritis are relatively common and are likely to

be seen in clinical practice Patients also may present with spontaneous anterior subluxation, seronegative spondyloarthropathy, or crystal dep-osition disease Rarer conditions with similar presentations may be encoun-tered, such as sternocostoclavicular hyperostosis, condensing osteitis, and Friedrich’s disease Surgery is rarely indicated, except for patients with an infection who require arthrotomy or who present with severe pain unre-sponsive to nonsurgical manage-ment

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