AN ATLAS OF DEPRESSION - PART 7 pptx

Figure 4.5 Flow chart illustrating the use of the DSM-IV criteria for the diagnosis of affective disorders with a seasonal pattern specifierDSM-IV diagnostic criteria met for diagnosis o

Figure 4.5 Flow chart illustrating the use of the DSM-IV criteria for the diagnosis of affective disorders with a seasonal pattern specifier

DSM-IV diagnostic criteria met for diagnosis of affective disorders

with a seasonal pattern specifier

DSM-IV diagnostic

criteria not met for

diagnosis of affective disorders with a seasonal pattern specifier

Yes

Yes

Yes

Yes

No

No

No

No

Has the patient had a regular temporal relationship between the onset of

their major depressive episode(s) in bipolar I and bipolar II disorder or major depressive disorder, recurrent and a particular time of the episode

(e.g regular appearance of the major depressive episode in the fall or winter*)?

A

Does the patient undergo full remission (or a change from depression to mania

or hypomania) at a characteristic time of year (e.g depression disappears in spring)?

B

In the last 2 years, has the patient had two major depressive episodes that

demonstrate the temporal seasonal relationships defined in A and B, and no

non-seasonal major depressive episodes have occurred during the same period?

C

Have the seasonal major depressive episodes (as described above) outnumbered

the non-seasonal major depressive episodes that may have occurred over the

patient's lifetime?

D

* Cases in which there is an obvious effect of season-related psychosocial stressors (e.g regularly being unemployed each winter)

should not be included

Figure 4.7 The causes of mania-like episodes

Figure 4.6 Graph showing the ten leading causes of worldwide disability Data from Murray CJL, Lopez AD, eds The Global Burden of Disease: a Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020 Boston:

Harvard University Press, 1996

Millions of people living with disability

Unipolar major depression Iron deficiency anemia

Falls Alcohol use Chronic obstructive pulmonary disease

Bipolar disorder Congenital anomalies Osteoarthritis Schizophrenia Obsessive–compulsive disorders

0

Antidepressant treatment (anti-depressant drugs, electroconvulsive therapy and light therapy)

Acute schizoprenic episodes

Manic

episodes

Non-prescribed

psychoactive

substances,

e.g amphetamines,

cocaine and

unassociated medical conditions, e.g hyper-parathyroidism

Prescribed medication

Possible causes of mania-like episodes

Figure 4.8 Flow chart illustrating the use of DSM-IV criteria for the diagnosis of mania

DSM-IV criteria met for diagnosis of mania

DSM-IV criteria not

met for diagnosis of mania – alternative diagnosis needed

No

No

No Yes

Yes Yes

No

Yes

No

Do the symptoms meet the criteria for a 'mixed' episode?

1 Inflated self-esteem or grandiosity (which may be delusional)

2 Decreased need for sleep (e.g feels rested after only 3 hours’ sleep)

3 Increased talkativeness or pressure of speech

4 Flight of ideas or racing thoughts

5 Distractibility (attention easily drawn to unimportant or irrelevant external stimuli)

6 Increase in goal-directed activity (socially, at work or school, or sexually) or

psychomotor agitation

7 Excessive involvement in pleasurable activities that have a high potential for painful

consequences

Has the patient had three or more of the following symptoms persisting (four if the

mood is only irritable) and have these symptoms been present to a significant degree?

Has the patient had a distinct period of abnormally and persistently elevated, expansive

or irritable mood lasting at least 1 week (or any duration if hospitalization is necessary)?

A

B

C

Is the patient's mood disturbance sufficiently severe to cause a marked impairment

in occupational or social function, relationships with others or to necessitate hospitalization to prevent harm to others, or are there psychotic features?

D

Yes

Are the patient's symptoms due to the direct physiologic effects of a substance

(e.g drug of abuse, medication or other treatment) or a general medical condition

(e.g hyperthyroidism)?

E

Figure 4.10 The psychologic responses to loss

Figure 4.9 The physical symptoms of normal grief

Aches and pains (e.g headaches, musculoskeletal pain, tightness in chest and throat)

Fatigue Changes in sleep pattern

Appetite changes

(usually anorexia with

weight loss) Gastrointestinal changes

(nausea, vomiting,

indigestion, constipation

and diarrhea)

Reduced immunologic

response and increased

incidence of infections,

such as colds and sore

throats

Depression Anxiety Hypervigilance Anger Guilt Loneliness

Lack of concentration and attention (memory loss for specific events) Preoccupation (repetitive thoughts about the deceased) Helplessness/hopelessness Feeling of detachment/

distance Sense of unreality

Psychologic responses to loss

Irritability (anger and hostility, suspiciousness, distrust)

Restlessness Searching Crying Social withdrawl

Figure 5.2 The physiologic response to ‘flight or fight’ stimuli

General unspecific

Metabolism: glucose mobilized Immune system suppressed

Brain

Mental activity increases Eyes

Pupils dilate Ciliary muscle relaxed (for far sightedness)

Mouth

Saliva production stops

Heart

Heart output increases Blood pressure rises

Under arms

Sweat glands: increase secretion Apocrine glands: increase seretion

Gastrointestinal

Digestion shuts down

Bladder

Bladder sphincters

contract

Skin

Blood flow to skin increases Blood coagulation increases

Kidneys

Kidneys decrease output

Muscles

Blood vessels mostly constrict, except to some muscles Muscle: increased strength

Lungs

Breathing increases Airways dilate

Figure 5.1 Comorbidity of ICD-10 anxiety and depressive disorders Reproduced with permission from Sartorius N, Üstün TB, Lecrubier Y,Wittchen HU Depression comorbid with anxiety: results from the WHO study on psychological disorders in primary health

care Br J Psychiatry 1996;suppl 30:38-43

Figure 5.3 Flow chart describing the use of DSM-IV criteria for the diagnosis of generalized anxiety disorder

DSM-IV criteria met for diagnosis of generalized anxiety disorder

DSM-IV criteria not

met for diagnosis of generalized anxiety disorder

Yes

No

No No

No No

Yes

Yes

No Yes

Is the disturbance due to the direct physiologic effects of a substance (e.g a drug of abuse or a prescribed medication or a general medical condition (e.g hyperthyroidism) and does not occur exclusively during a mood disorder,

psychotic disorder or pervasive developmental disorder?

1 Restlessness or feeling keyed up or on edge

2 Being easily fatigued

3 Difficulty concentrating or mind going blank

4 Irritability

5 Muscle tension

6 Sleep disturbance

Is the focus of the anxiety and worry not confined to features of an Axis I disorder –

e.g the anxiety or worry is not about having a panic attack (as in panic disorder),

being embarrassed in public (as in social phobia), being contaminated (as in obsessive–

compulsive disorder), being away from home or close relatives (as in separation anxiety

disorder), gaining weight (as in anorexia nervosa), having multiple physical complaints

(as in somatization disorder) or having a serious illness (as in hypochondriasis) and the

anxiety and worry do not occur exclusively during post-traumatic stress disorder?

Has the patient experienced excessive anxiety and worry (apprehensive expectation),

occurring more days than not for at least 6 months, about a number of events

or activities (such as work or school performance)?

A

D

H

Do the patient's anxiety, worry or physical symptoms cause clinically significant

distress or impairment in social, occupational or other important areas of functioning?

E

Yes

Are the patients's anxiety and worry associated with at least three of the following

six symptoms (with at least some of the symptoms present for more days than not

in the last 6 months)? NB Only one item is required in diagnoses of overanxious

disorder of childhood

C

B Does the patient find it difficult to control their worry ?

Yes

Figure 5.5 The symptoms of panic Compare with Figure 5.2

Figure 5.4 Lifetime rates of panic disorder Data from Weissman MM, Bland RC, Canino

GJ, et al The cross-national epidemiology of panic disorder Arch Gen Psychiatry

1997;54:305–9

3.0 2.5 2.0 1.5 10 0.5 0.0

USA (EC

A) Canada Puer

to Rico France

German

y Italy LebanonTa

iwan Kore

a

New Zealand

Fear of dying Fear of losing control Fear of collapse Fear of going mad

Depersonalization/ derealization

Choking Shortness of breath Palpitations

Chills/hot flushes Sweating Pins and needles

Dizziness Pallor

Chest pain Butterflies/nausea

Urge to defecate Trembling

Figure 5.6 Flow chart describing the use of the DSM-IV criteria for the diagnosis of panic disorder with agoraphobia

Criteria met for diagnosis of panic disorder with agoraphobia

Criteria not met

for diagnosis of panic disorder with agoraphobia

Yes

No

No

Yes Yes

Yes

No

Yes

No

Are the patient's panic attacks due to the direct physiologic effects of a substance (e.g a drug of abuse or a prescribed medication) or a general medical

condition (e.g hyperthyroidism)?

1 Persistent concern about having additional panic attacks

2 Worry about the implications of the attack or its consequences (e.g losing control,

having a heart attack, 'going crazy')

3 A significant change in behavior related to their attacks

Does the patient have the presence of at least one the following?

Does the patient have recurrent unexpected panic attacks?

Does the patient have agoraphobia?

A

B

D

C

No

Are the panic attacks better accounted for by another mental disorder – such as

social phobia (e.g occurring on exposure to feared social situations), specific phobia

(e.g on exposure to a specific phobic situation), obsessive–compulsive disorder (e.g on

exposure to dirt in someone with an obsession about comtamination), post-traumatic stress

disorder (e.g in response to a stimulus associated with a severe stressor) or separation

anxiety disorder (e.g in response to being away from home or close relatives)?

E

Figure 5.7 Flow chart describing the DSM-IV criteria for the diagnosis of social phobia

A marked and persistent fear of one or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others The individual fears that he or she will act in a way (or show anxiety symptoms) that will be humiliating or embarrassing Note: in children, there must be evidence of the capacity for age-appropriate social relationships with familiar people and the anxiety must occur in peer settings,

not just in interactions with adults

A

The fear or avoidance is not due to the direct physiological effects of a substance (e.g a drug

of abuse, a medication) or a general medical condition and is not better accounted for by another mental disorder (e.g panic disorder with or without agoraphobia, separation anxiety disorder, body dysmorphic disorder, a pervasive developmental disorder, or schizoid

personality disorder)

G

Exposure to the feared social situations almost invariably provokes anxiety, which may take the form of a situationally bound or situationally predisposed panic attack Note: in children, the anxiety may be expressed by crying, tantrums, freezing, or shrinking from social situations

with unfamiliar people

B

The avoidance, anxious anticipation, or distress in the feared social or performance situation(s) interferes significantly with the person's normal routine, occupational (academic) functioning,

or social activities or relationships, or there is marked distress about having the phobia

E

If a general medical condition or another mental disorder is present, the fear in criterion A

is unrelated to it (e.g the fear is not of stuttering, trembling in Parkinson's disease, or exhibiting abnormal eating behavior in anorexia nervosa or bulimia nervosa)

H

The person recognizes that the fear is excessive or unreasonable Note: in children, this feature

may be absent

C

In individuals under age 18 years, the duration is at least 6 months

Social phobia

F

The feared social or performance situations are avoided or else are endured with intense

anxiety or distress

D

Specify if the social phobia is generalized: if the fears include most social situations (e.g initiating or maintaining conversations, participating in small groups, dating, speaking to authority figures, attending parties) Note: Also consider the additional diagnosis of avoidant personality disorder

Figure 5.9 [Above and right] Flow chart illustrating the use of the DSM-IV criteria for the diagnosis of post-traumatic stress disorder

Yes

No

No

Yes

No No

1 Recurrent and intrusive distressing recollections of the event, including images,

thoughts and perceptions Note: in young children repetitive play may occur in which themes or aspects of the trauma are expressed

2 Recurrent distressing dreams of the event Note: in children there may be

frightening dreams without recognizable content

3 Acting or feeling as if the traumatic event were recurring (includes a sense of

reliving the experience, illusions, hallucinations and dissociative flashback episodes, including those that occur on awakening or when intoxicated) Note: in young children trauma-specific re-enactment may occur

4 Intense psychologic distress at exposure to internal or external cues that

symbolize or resemble an aspect of the traumatic event

5 Physiologic reactivity on exposure to internal and external cues that symbolize

or resemble an aspect of the traumatic event

Has the patient been exposed to a traumatic event?

A

Yes

Did the patient experience, witness or be confronted by an event or events that

involved actual or threatened death or serious injury, or a threat to the physical

integrity of themselves or others?

B

Yes

Does the patient persistently re-experience the traumatic event in at least one

of the following ways?

D

C Did the patient's response involve fear, helplessness or horror?

Note: in children, this may instead be expressed by disorganized or agitated behavior

Figure 5.8 Age of onset of social phobia Most cases of social phobia start before the age of 20 years Reproduced and adapted with permission from Schneier FR, Johnson J, Hornig CD, Liebowitz MR,Weissman MM Social phobia Comorbidity and morbidity in an

epidemiologic sample Arch Gen Psychiatry 1992;49:282–8

20

10

Age at onset (years) 0

%

0–56–

11–1516–2021–2526–3031–3536–4041–4546–5051–5556–6061–6566–7071–75

Is the duration of the patient's disturbance (symptoms in D, E and F) more than

1 month?

G

Yes

1 Difficulty falling or staying asleep

2 Irritability or outbursts of anger

3 Difficulty concentrating

4 Hypervigilance

5 Exaggerated startle response

Does the patient have persistent symptoms of increased arousal that was not

present before the trauma, as indicated by at least two of the following?

F

Yes

Does the disturbance cause clinically significant distress or impairment in social,

occupational or other important areas of functioning?

H

Yes

Specify: ACUTE if duration of symptoms is less than 3 months, CHRONIC if

duration of symptoms is 3 months or more, DELAYED ONSET if onset of

symptoms occurs at least 6 months after the stressor

Diagnosis of post-traumatic stress disorder

Criteria not met for diagnosis of post-traumatic stress disorder

No

No

No

Yes

1 Efforts to avoid thoughts, feelings or conversations associated with the trauma

2 Efforts to avoid activities, places or people that arouse recollections of the trauma

3 Inability to recall an important aspect of the trauma

4 Markedly diminished interest or participation in significant activities

5 Feeling of detachment or estrangement from others

6 Restricted range of affect (i.e unable to have loving feelings)

7 Sense of foreshortened future (e.g does not expect to have a career, marriage,

children or a normal lifespan)

Does the patient persistently avoid the stimuli associated with the trauma and is

there a numbing of general responsiveness (which was not present before the

trauma), as indicated by at least three of the following:

E