Diazepam D 623 [Alternatively to the Japp-Klingemann reaction phenylpyruvic acid or ethyl phenylpyruvatc can be condensed with 4-chlorophenylhydrazine.] Referencefs: a,bUS 3 109 843 Ho
Trang 1Diacerein D 621
synthesis of 1-methyl-7-methoxy-2-tetralone:
Howele, EH.; Taylor, D.A.H.: J Chem Soc (JCSOA9) 1958, 1248
pharmaceutical formulations:
US 4 605 671 (American Home; 12.8.1986; appl 23.7.1985; prior 28.9.1984)
WO 9 000 390 (American Home; appl 19.6.1989; S-prior 8.7.1988)
EP 180 303 (American Home; appl 27.8.1985; USA-prior 28.9.1984, 23.7.1985)
Formulation(s): vial and Tubex syringe 5 mg/2 ml, 10 mg/2 ml, 15 mg/2 ml
Trade Name(s):
USA: Dalgan (Wyeth-Ayerst;
1990)
Use: anti-inflammatory RN: 13739-02-1 MF: CI,H,208 MW: 368.30 EINECS: 237-310-2
LD,o: 7500 mglkg (R, route unreported)
CN: 4,5-bis(acetyloxy)-9,10-d~hydro-9,1O-dioxo-2-anthracenecarboxylic acid
1,8-dihydroxy-3- 1 ,a-dihydroxy-3-
hydmxyrnethyl- onthroquinone-
anthroquinone carboxylic acid
(e.g from
borboloin)
Diacerein
DOS 2 71 1 493 (C A Friedmann; appl 16.3.1977; SA-prior 16.3.1976)
Oesterle, O.A.: ~ r i h Pharm (Weinheim, Ger.) (ARPMAS) 241, 604 (1903)
Robinson, R.; Simonsen, J.L.: J Chem Soc (JCSOA9) 1909, 1085
Cahn, R.S.; Simonsen, J.L.: J Chem Soc (JCSOA9) 1932, 2573
Formulation(sJ: cps 50 mg
Trade Name(&
1: Artrodar (Proter) Fisiodar (Gentili)
Use: tranquilizer, hypnotic RN: 439-14-5 MF: C,,H,,ClN,O MW: 284.75 EINECS: 207-122-5
CN: 7-chloro-1,3-dihydro-l-methyl-5-phenyl-2H-l,4-benzodiazepin-2-one
Trang 2622 D Diazepam
2-amino-5- glycine ethyl ester 7-chlaro-2-0x0-
chlorobenzo- hydrochloride (11) 5-phenyl-2,3-di-
benzodiazepine
NaOCH, dimethyl sulfate (111)
p-toluenesulfonyl
chloride
(Tos-CI)
benzophenone (N)
H 3 C
C I hexomethylenetetrarnine + cl<cl
\
chloroocetyl
chloride
NaN02, HCI
ocetoacetate 4-chlorobenzene-
diazonium chloride
In
+ C I \
Trang 3Diazepam D 623
[Alternatively to the Japp-Klingemann reaction phenylpyruvic acid or ethyl phenylpyruvatc can be condensed with 4-chlorophenylhydrazine.]
Referencefs):
a,bUS 3 109 843 (Hoffmann-La Roche; 5.1 1.1963; appl 21.6.1962; prior 28.7.1961 )
US 3 136 815 (Hoffmann-La Roche, 9.6.1964; USA-prior 10.12.1959)
DE 1 136 709 (Hoffmann-La Roche; appl 7.12.1960; USA-prior 10.12.1959)
DE 1 145 626 (Hoffmann-La Roche; appl 7.12.1960; USA Prior 10.12.1959)
DE 1 290 143 (Hoifmann-La Roche; prior 7.12.1960)
US 3 371 085 (Roche; 27.2.1968; CH-prior 2.10.1960)
c DAS 2 016 084 (Hoffmann-La Roche; appl 3.4.1970; CH-prior 16.10.1969)
DOS 2 233 482 (Hoffmann-La Roche; appl 7.7.1972; GB-prior 8.7.1971)
d Yamamoto, H et al.: Chem Ber (CHBEAM) 101,4245 (1968)
US 3 632573 (Sumitomo; 4.1.1972; J-prior 9.10.1967)
variant with a-benzylcyanoacetic acid ester:
US 4 069 230 (Surnitomo; 17.1.1978; J-prior 4.6.1975, 9.6.1975)
alternative syntheses:
DAS 1 545 724 (Delmar Chemicals; appl 14.1.1965; GB-prior 14.1.1964)
DAS 1 695 789 (Sumitomo; appl 2.1 1.1967; J-prior 2.1 1.1966, 16.1 1.1966, 6.9.1967)
DAS 1 944 404 (Takeda; appl 2.9.1969; J-prior 3.9.1968)
DOS 2 252 378 (Roche; appl 25.10.1972; CH-prior 18.1 1.1971 )
Sugasawa, T et al.: J Heterocycl Chem (JHTCAD) 16,445 (1979)
purificalion:
US 3 102 116 (Hoffmann-La Rochc; 27.8.1963; prior 12.3.1962)
DAS 1 906 262 (Sumitomo; appl 7.2.1969; J-prior 21.2.1968)
Fomulofion(s): amp (i.v or i.m.) 10 mg/2 ml; tabl 2 mg, 5 mg, 10 mg
Dade Namefs):
D: Faustan (ASTA Medica
AWD)
Lamra (Merckle)
Stesolid (Dumex)
Tranquase (Azuchemie)
Valiquid (Roche; 1985)
Valium (Roche; 1963)
F: Novazam (Gtntvrier)
Valium (Roche)
GB: Diazemuls (Dumex)
Stesolid (Dumex)
Valclair (Sinclalr)
Valium (Roche; 1963)
Ansiolin (Roussel) Eridan (SIT) Noan (Ravizza) Spasmeridan (UCB)-comb
Spasmomen (Menarini)-
Tranquirit (RhGne-Poulenc Rorer)
Valium (Roche; 1965) Valpinax (Crinos)-comb
Valtrax (Valeas)-comb
Vatran (Valeas)
Cercine (Takeda) Horizon (Yamanouchi) Sedaril (Kodama) Scrcnamin (Toyo Jozo) Serenzin (Sumitomo; 1968) Sonacon (Chugai)
Diastat (Athena) Dizac (Ohmeda) Valium (Roche Products; 1963)
Valrelease (Roche)
Trang 4624 D Diazoxide
Use: antihypertensive, hyperglycemic RN: 364-98-7 MF: C,H7ClN,0,S MW: 230.68 EINECS: 206-668- 1
LDsn: 228 mg/kg (M, i.v.); 444 mglkg (M, p.0.);
980 mglkg (R, p.0.)
CN: 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,l-dioxide
0
"a \A + H,C-40 , 0, CH3 _+
NH2
' 3 3
5-chloro-2- triethyl Diazoxide
arninobenzene- orthoacetote
sulfarnide
Reference(s1:
US 2 986 573 (Schering Corp.; 30.5.1961; prior 18.1.1961)
US 3 345 365 (Schering Corp.; 3.10.1967; prior 19.9.1960, 18.1.196.1, 31.3.1964)
Farmulation(s): amp 300 mgl20 ml (i.v inj.); cps 25 mg, 100 mg
Trade Name(s):
D: Hypertonalum (Essex Proglicem (Schering- Proglicem (Schering-
Proglicem (Essex Pharma) GB: Eudemine (Fink) USA: Hyperstat (Schering)
F: Hyperstat (Schering- I Hyperstat (Schering- Proglycem (Baker Norton)
Use: aminoglycoside antibiotic RN: 34493-98-6 MF: C18H3,N508 MW: 451.52 EINECS: 252-064-6
LD,,: 373-380 mgkg (M, i.p.); 61-68 mdkg (M, i.v.)
CN: 0-3-amino-3-deoxy-a-~-g~ucopyranosy~-(l+6)-0-[2,6-diamino-~,3,4,6-tetradeoxy-a-~-erythro-
hexopyranosyl-(I +4)]-2-deoxy-D-slreptamine
sulfate
RN: 58580-55-5 MF: C1RH37NSOll xH2S04 MW: unspecified EINECS: 261-341-0
LD,,: 62.6 m g k g (M, i.v.); >6950 m g k g (M, p.0.);
140 mglkg (R, i.v.); 6950 mg/kg (R, p.0.)
Trang 5Dibekacin D 625
0
1 cI-R H,cKcH, K2c03
0 0 (1) H,C
3 dr: -idin
1 ethyl chloroFormate
2 2,2-dimethoxypropane
3 benzoyl chloride
bekanamycin
(4 4
0
II -+
3 methanesulfonyl chloride
H3C-
1 Dibekacin
1 Nal, Zn DMF
2 H, Pt
3 CH,COOH, H 2 0
4 BO(OH)
2
DE 2 135 191 (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai; appl 14.7.1971; J-prior 29.7.1970, 1 1 S.1971) Umezawa, S et al.: Bull Chem Soc Jpn (BCSJA8) 45, 3624 (1972)
Umezawa, H et al.: J Antibiot (JANTAJ) 24,485 (1971)
alternative syntheses:
DOS 2414 416 (Hoechst; appl 26.3.1974)
DOS 2 654 764 (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai; appl 3.12.1976; J-prior 10.12.1975,9.12.1975) DOS 2 655 731 (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai; appl 9.12.1976; J-prior 11.12.1975)
DOS 2 756 057 (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai; appl 15.12.1977; J-prior 16.12.1976)
US 4 169 939 (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai; 2.10.1979, J-prior 16.12.1976)
Migake, T et al.: Carbohydr Res (CRBRAT) 49, 141 (1 976)
Fomulrrtion(s)r amp 50 rng/rnl, 75 mg/ 1.5 ml
Trang 6626 D Dibenzepine
Trade Name(s):
D: Orbicin (Mack); wfrn I: Icacine (Bristol); wfrn J: Panirnycin (Meiji Seika
F: Dtbtkacyl (Bellon; as Kappabi (Carlo Erba); wfrn Kaisha)
sulfate)
Use: antidepressant RN: 4498-32-2 MF: C,,H,,N,O MW: 295.39
LD,,,: 22 mgkg (M, i.v.); 194 rngkg (M, p.0.);
22 mgkg (R, i.v.); 220 m a g (R, p.0.)
CN: 10-[2-(dimethylarnino)ethyl]-5,l0-dihydro-5-methyl-1lH-dibenzo[b,e][l,4]diazepin-ll-one monohydrochloride
RN: 315-80-0 MF: C18H2,N30 HC1 MW: 331.85 EINECS: 206-255-6
LD,,,: 22 mglkg (M, i.v.); 174 mglkg (M, p.0.);
22 mgkg (R, i.v.); 220 mgkg (R, p.0.)
CH3
I
CH3
methyl N-methyl-
anthranilate
CH3 2 2-(dimethylomino)-
ethyl chloride
1 1 -om-5-methyl-
10.1 1 -dihydro-5H- dibenza[b.e][l.4]- diozepine
Dibenzepine
Referencefs):
DE 1 263 774 (Wander; appl 13.9.1960; CH-prior 22.9.1959),
US 3 41 9 547 (Wander; 3 171 2.1968; ~ ~ - ~ r i o r 22.9.1959)
GB 961 106 (Wander; appl 22.9.1960; CH-prior 22.9.1959)
FR 1 295 37 1 (Wander; appl 20.9.1960; CH-prior 22.9.1959)
Hunziker, F et al.: Arzneirn.-Forsch (ARZNAD) 13, 324 (1963)
Formulation(s): amp 20 rnglrnl; drg 40 mg, 80 mg; s r tabl 240 mg; tabl 80 mg
Trade Name(s):
D: Noveril (Novartis Pharrna); Noveril (Sandoz); wfrn J: Noveril (Morishita)
F: Ecatril (Sandoz); wfm I: Noveril (Sandoz)
Trang 7Dibrompropamidine D 627
Use: chemotherapeutic
RN: 496-00-4 MF: Cl7HIRBr2N4o2 MW: 470.17
CN: 4,4'-[1,3-propanediylbis(oxy)]bis[3-bromobenzenecarbox1midamide]
dlisethionate (1:Z)
RN: 614-87-9 MF: C17H,,Br2N402 2C2H,04S MW: 722.43 EINECS: 210-399-5
1,3-dibrorno- (1)
propane
Dibrornpropomidine
GB 598 91 1 (May & Baker; appl 1945)
nulation(s): eye drops 0.1 %; eyc ointment 0.15 %
B: Brolene (May & Baker) Golden Eye Ointment Phenergan (May & Baker; Bmlidine (May & Baker) (Typharm) as isethionate)-comb
Otamidyl (May &Baker)
ATC: D07AA Use: topical glucocorticoid
RN: 7008-26-6 MF: C2,H2&l2o4 MW: 413.34 EINECS: 230-283-8
CN: (1 1 P)-9,ll-dichloro-17,21 -dihydroxypregna-l,4-d1ene-3,20-dionc
acetate
!i RN: 79-61-8 MF: C2,H2,Cl,05 MW: 455.38 EINECS: 201-213-3
f
0
H,C-SO2-CI, pyridine, DMF
Trang 8628 D Dichlorophen
Reference(s):
US 2 894 963 (Schering Corp.; 1959; prior 1958)
Robinson, C.H et a].: J Am Chem Soc (JACSAT) 81,2191 (1959)
Formulation(s): cream 0.25 %
Trade Name(s):
I: Astroderm (Lagap); wfrn J: Diloderm Cream
(Schering-Shionogi)
Neo-Diloderm Cream (Schering-Shionogi)-coml
Use: antifungal, antiseptic, anthelmintic RN: 97-23-4 MF: Cl3H,,,C1,0, MW: 269.13 EINECS: 202-567-1
LDso: 1 glkg (M, p.0.);
17 mglkg (R, i.v.); 1506 mglkg (R, p.0.);
2 glkg (dog, p.o.1
CN: 2,2'-methylenebis(4-chlorophenol)
4-chloro- form-
Dichlorophen
I
Reference(s):
DRP 530 219 (I G Farben; appl 1927)
GB 1 208 325 (BDH; appl 22.4.1968; valid from 15.4.1969)
US 2 334 408 (B.T Bush; 1943; appl 1941)
DAS 2 551 498 (Bayer; appl 17.1 1.1975)
Formulation(s): cream 10 mg; powder 50 mg; sol 10 mg; spray 10 mg
Trade Name(s):
D: Fissan Brustwarzensalbe Ovis FuRbad/Spray GB: Anthiphen (May & Baker);
Onychofissan (Fink)- Wespuril (Spitzner)-comb.;
Ovis Fliissigkeithalbe F: Plath-Lyse (GCntvrier);
Trang 9Diclofenac D 629
Use: anti-inflammatory, antirheumatic RN: 15307-86-5 MF: C,,HI1CI2NO2 MW: 296.15 EINECS: 239-348-5
LD,: 170 mglkg (M, p.0.);
62.5 mgkg (R, p.0.)
, CN: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
osodium salt
: 15307-79-6 MF: C,,HloC12NNa0, MW: 318.14 EINECS: 239-346-4
, 116 mgkg (M, i.v.); 390 mgkg (M, p.0.);
117 mgkg (R, i.v.); 150 mg/kg (R, p.0.)
-chlom- 2.6-dichloro- 2-(2,6-dichloro-
bnzoic aniline anilino)benzoic
acid (I)
2,6-dichloro-
diphenylomine
690 (Geigy; 26.1.1971; CH-prior 8.4.1965, 25.2.1966, 30.3.1966,20.12.1967)
3 639 (Ciba-Geigy; appl 7.4.1966; CH-prior 8.4.1965)
DAS 1793 592 (Ciba-Geigy; appl 7.4.1966; CH-prior 8.4.1965)
3 652 762 (Ciba-Geigy; 28.3.1972; prior 9.12.1968, 29.9.1969, 14.4.1970)
3 778 470(Geigy; 11.12.1973; appl 2.10.1970; prior 4.4.1966)
492 679 (Geigy; appl 30.3.1966)
Trang 10630 D Diclofenamide
alternative syntltesis:
DOS 2 613 838 (Ikcda Mohando; appl 3 1.3.1976; J-prior 3 1.3.1 975)
Formulation(s): amp 75 mg; cps and drg 25 mg, 50 mg, 100 mg, 140 mg; eye drops 1 mg, 0.3 mg, 5 mgI5 ml;
gel 1 1.6 mg, 1 %; inj sol 7 5 mg/3 ml; suppos 12.5 mg, 25 mg, 5 0 mg, 100 rng; tabl 25 mg,
5 0 mg, 75 mg
Trade Name(s):
D: Allvoran (TAD)
arthrex (BASF Generics)
Benfofen (Sanofi
Winthrop)
Delphimix (Cy anamid)
Delphinac (Lederle)
Diclac (Hcxal)
d i d o (ct-Arzneimittel)
Diclofenbeta (betapharm)
Diclo KD (Kade)
Diclophlogont
(Azupharma)
Diclo-Phlogont
(Azuchemie)
Diclo-Puren (Isis Puren)
Diclo-rectal (Beiersdorf)
Diclo-saar (Chephasaar) F:
Diclo-Spondyril (Dorsch)
Diclo-Tablinen (Beiersdorf-
Dolgit-Diclo (Dolorgict) 1:
Dolobasan (Sagitta) Duravolten (durachemie) Effekton (Brenner-Efekd Law)
Jenafenac (Jenapharm) Lexobene (Merckle) Monoflam (Lichtenstein) J:
Myogit (Pfleger) Rehumavincin (Owege) Rcwodina (ASTA Medica
AW D) Sigafenac (Kytta-Siegfried) Toryxil (Baer)
Voltaren (Novartis Pharma;
1976) Flector (Gtntvrier) Voltartne (Novartis; 1976) USA:
Xenid (Biogaltnique) Tablinen) GB: Voltarol (Novartis; 1979)
Diclo-Wolff (Wolff) numerous generics
Dicloreum (Alfa Wassermann) Flogofenac (Ecobi)
~ o r g e n a c (Zoja) Novapirina (Zyma) Voltaren (Ciba-Geigy; 1975)
Adefuronic (Taiyo) Dichronic (San-a) Docell (Nippon Kayaku) Irinatolon (Tatumi) Neriodin (Teikoku) Nifleriel (Mohan) Sofarin (Nippon Chemiphar) Tsudohmin (Toho) Voltaren (Fujisawa; 1974) Voltaren (Novartis; as sodium salt)
Diclofenamide
(Dichlorphenamide)
ATC: SOIEC02 Use: carboanhydrase inh~bitor (against glaucon~a)
RN: 120-97-8 MF: C6H6C12N204S2 MW: 305.16 EINECS: 204-440-6
LDso: 643 mglkg (M, i.v.); 1710 m g k g (M, p.0.)
CN: 4,5-dichloro- l,3-benzenedisulfonamide
2-chloro-
phenol
Reference(s1:
US 2 835 702 (Merck & Co.; 20.5.1958; prior 2.5.1956)
Diclofenarnide
Formulation(s): tabl 50 mg
Trade Name(sJ: