177 optimization of adenoviral agents for virotherapy

177 Optimization of Adenoviral Agents for Virotherapy Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene TherapyS60 ���"������������ ����"�� �"��������[.]

Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

S60

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175 Adenoviral Delivery of a Secreted Form of Human

Liver Carboxylesterase-2 Sensitizes Osteosarcoma to

CPT

CPT-1 -1 -11 1

M Adhiambo Witlox,1 Dinja Oosterhoff,2 Victor W van

Beusechem,2 Frank A Kruyt,2 Hidde J Haisma,3 Gerard R

Schaap,4 Hans Bras,5 David T Curiel,2,6 Paul I J M Wuisman,1

Herbert M Pinedo,2 Winald R Gerritsen.2

1 Orthopedics, VU University Medical Center, Amsterdam,

Netherlands; 2 Division of Gene Therapy Departmen of Medical

Oncology, VU University Medical Center, Amsterdam,

Netherlands; 3 Therapeutic Gene Modulation, University Center

for Pharmacy, Groningen, Netherlands; 4 Orthopedics, Academic

Medical Center, Amsterdam, Netherlands; 5 Pathology, Academic

Medical Center, Amsterdam, Netherlands; 6 Gene Therapy Center,

University of Alabama at Birmingham, Birmingham, AL, United

States

176 Bicistronic Conditionally Replication Competent

Adenoviral V

Adenoviral Vectors Which ectors Which ectors Which Are Selectively L Are Selectively L Are Selectively Lytic for ytic for

Breast and Ovarian Cancer Cells but Which Are

Non-T

Toxic for Normal Breast and Ovarian Epithelial Cells oxic for Normal Breast and Ovarian Epithelial Cells

Lixin Zhang,1 Hakan Abkulut,1 Albert Deisseroth.1

1 Sidney Kimmel Cancer Center, San Diego, CA, United States

177 Optimization of Adenoviral Agents for Virotherapy

Marianne G Rots,1 Gera K Kamps,1 Simone J van Eert,1 Masato Yamamoto,4 Pamela M J McLaughlin,2 Ate G van der Zee,3

Jerome Schaack,5 Erik Falck-Pedersen,6 David T Curiel,4 Hidde J Haisma.1

1 Therapeutic Gene Modulation, University Center for Pharmacy, Groningen, Netherlands; 2 Pathology and Laboratory Medicine, University of Groningen, Groningen, Netherlands; 3 Obstetrics and Gyneacology, University Hospital Groningen, Groningen, Netherlands; 4 Medicine, Pathology and Surgery and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, United States; 5 Microbiology, University of Colorado Health Sciences Center, Denver, CO, United States;

6 Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, United States

Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts

" " "" !

178 Adenylyl CyclaseVI Blocks ααααα-Adrenergic -Adrenergic

Stimulation-Induced Hypertrophy in Cultured Neonatal

Rat Cardiomyocytes

Hong Zhu, Suzy Fine, Meihua Gao, David A Roth, David M Roth,

John Warner, Kirk Hammond

1 Cell & Molecular Biology, Collateral Therapeutics, Inc., San

Diego, California, United States; 2 Medicine, UC San Diego, Lo

Jolla, California, United States

179 Development of Gene Therapy V

179 Development of Gene Therapy Vectors Based on ectors Based on

Chimpanzee Adenoviruses

Soumitra Roy,1 Roberto Calcedo del Hoyo,1 Julie Johnston,1

Guang-ping Gao,1 James M Wilson.1

1 Institute of Human Gene Therapy, University of Pennsylvania,

Philadelphia, PA, United States

!";

180 Development of Internally Labeled Adenovirus with EGFP for Imaging

Long P Le,1,2 David A Matthews,3 Julia Davydova,1,2 Masato Yamamoto,1,2 David T Curiel.1,2

1 Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery, University of Alabama at Birmingham, Birmingham, AL, United States; 2 Gene Therapy Center, University

of Alabama at Birmingham, Birmingham, AL, United States;

3 Molecular Medicine Unit, University of Leeds, Leeds, United Kingdom