... HCR ⁄ C and HCR ⁄ D-SA, HCR ⁄ D did not show detectable cell binding, suggesting that HCR ⁄ D binding and affinity varied between HCR ⁄ C and HCR ⁄ D-SA Under similar conditions, HCR ⁄ A binding ... C, HCR ⁄ D and HCR ⁄ D-SA overlaid with HCR ⁄ A and HCR ⁄ B HCR ⁄ D-SA (blue, upper) includes the conserved Phe1280 and Trp1282 (black), and the GBL is enlarged, rotated (lower), and aligned with ... Ganglioside binding by BoNT ⁄ C and BoNT ⁄ D-SA A R Kroken et al gangliosides Directed mutagenesis experiments showed that HCR ⁄ C(W1258A) had reduced binding affinity for GD1b, and HCR ⁄ D-SA(W1252A)
Ngày tải lên: 22/03/2014, 15:21
... Performed the experiments: CCC, YCS, CYC, and YHL Analyzed and discussed the data: CCC, GD, and YHL Contributed reagents/materials/analysis tools: CCC, YCS, CYC, and YHL Wrote the paper: CCC, GD, and ... rate and blood lactate concentrations during the 4 TKD simulated matches The changes in heart rate and blood lactate concentrations significantly increased during TKD matches and rapidly declined ... Nursing and Health Sciences for providing us with necessary resources and administration support throughout the study Author Contributions Conceived and designed the experiments: CCC, and YHL Performed
Ngày tải lên: 15/01/2020, 07:34
Vitamin D for the management of asthma
... randomised, placebo of vitamin D in children and adults with Data collection and analysis Two review authors independently applied study inclusion criteria, extracted the data, and assessed risk ... micronutrient cholecalciferol (vitamin D3) and (vitamin D2) Background chronic inflammatory condition of by recurrent attacks of breathlessness, wheezing, cough, and chest 'exacerbations'. micronutrient: ... followed by daily dosing (Castro Trang 10 Asthma exacerbation treated with systemic corticosteroids Reduction in the rate of asthma exacerbations treated with systemic corticosteroids confidence
Ngày tải lên: 20/10/2017, 00:09
Reading 2 2 guidance for standards i(c) and i(d) answers
... #ÿ0(ÿ5 67ÿ* *ÿ*/ÿ8 ÿAC# 97* ÿÿ* *ÿ*/ÿ8 ÿACÿÿ (ÿ ÿÿ,ÿ& (ÿ/*!ÿÿ)%,ÿ*%#:7* ÿÿ* *ÿ*/ÿ8 ÿACÿÿ (ÿ ÿ* ÿ,ÿ& (ÿ/*!ÿÿ)%,ÿ*%# ... 01ÿ393ÿ3ÿ+99ÿH-2.ÿ/ÿ1787ÿ9ÿJ793967ÿ)9ÿ3ÿ3ÿ7D78ÿ7879ÿ ÿÿ99ÿ3ÿ 7 7ÿ9ÿ+99ÿ,-A.ÿ/ÿ 96ÿ3 ÿE97Bÿ7 7ÿ7D77ÿ07ÿÿ93ÿÿ393ÿ3ÿ+99ÿ,-A.ÿ/ÿ ... 5425ÿ ÿ273ÿ 2ÿ 2ÿ53944#ÿ5425ÿ ÿ980ÿ1ÿ2 ÿ5ÿ23ÿ273ÿ63523 =>?@,- +ÿ BCÿ Dÿ EF G77ÿ ÿ273ÿ 447ÿ5223325ÿ52ÿ #ÿ5535535ÿ43:5ÿ32ÿ2ÿ #ÿ 75ÿ ÿ727ÿ273ÿ873ÿ535232ÿ
Ngày tải lên: 27/10/2021, 15:18
Reading 2 2 guidance for standards i(c) and i(d)
... 121ÿ0ÿ901ÿ23ÿ718!73ÿ43718 812ÿ123ÿ'4 B@C0ÿ 123ÿ'4ÿ87703ÿ10ÿ0 34ÿ8 34391ÿ73370ÿ 63ÿ10ÿ8678 709ÿ 123 8 34391ÿ733743ÿ8 9ÿ87"73ÿ10ÿ77678 D@C0ÿ 123ÿ'4ÿ77ÿ8 877061809ÿ!0786ÿ10ÿ77678 ... 63ÿ29ÿAÿ 9ÿ789ÿ '1977ÿ9ÿAÿÿ 86389263ÿ989ÿ ÿ#=?ÿ2329287ÿ72ÿ 3ÿ 9ÿCÿDEEÿ&ÿ89ÿ789ÿFDGÿ23ÿ8ÿÿ9ÿ789ÿ 23ÿ9ÿ 3> *+,-./ 01ÿ 3Hÿ 05ÿ 67 (2ÿÿ9ÿ677623ÿ98939ÿ69ÿ ... 2ÿ2ÿ112ÿ ÿÿ2>1 ÿ 2ÿ4ÿ"?@ÿÿ ÿ1ÿ7 2ÿ %12919ÿ!BC( )*D8ÿ31ÿ 12ÿ279ÿÿÿ"E$ +*D8ÿ31ÿÿ>3ÿ1974ÿ2ÿ 9Fÿ 217ÿ 2 -*08ÿÿ 1ÿ
Ngày tải lên: 27/10/2021, 15:18
Reading 2 5 guidance for standards III(C), III(D), and III(E) answers
... 9210ÿ82ÿ0126(ÿ#$ÿ16ÿÿ25ÿ6 10ÿ>?,>@A BC57ÿ1057ÿ16ÿ25ÿ21ÿ0ÿ5ÿ ÿ 18502 DC57ÿ90ÿ617ÿ290ÿ25ÿ05E2ÿ,-$ÿ5E98 FC90(ÿ 20ÿ17ÿ5ÿ576178ÿ617ÿ2 9725 GHIJK6K3456 ... ÿ$ÿ2$ÿ=7 2>% F ÿ!ÿ Cÿ$ÿ"Gÿÿÿ68ÿÿCH2ÿ ÿ5ÿ#$ ÿ$ÿ ÿ5ÿÿ6%ÿ ÿ ÿÿCH2ÿ ÿ ÿ ÿI$ÿÿ ÿ7 2ÿÿ#ÿ#8ÿ ... =<!!!ÿÿ)ÿ+ÿ!'ÿÿ)ÿ)!# ><ÿ'ÿÿ)ÿ $$ÿÿ,$ÿ$# ?@ABC7C4567 Dÿ)ÿÿÿÿ$ÿ)ÿ!1ÿÿÿÿ'*'ÿ)ÿ)ÿÿÿ!'
Ngày tải lên: 27/10/2021, 15:18
Reading 2 5 guidance for standards III(C), III(D), and III(E)
... ()085ÿ5ÿ16ÿ19 1ÿC18159ÿ $%D&C8158ÿC886561 26ÿ085ÿ5ÿ19 $&E8 886561 +)085ÿ5ÿ19 1ÿC18159ÿ $%D&C8158ÿC886561ÿ26 085ÿ5ÿ16ÿ19 ... $%D&C8158ÿC886561ÿ26 085ÿ5ÿ16ÿ19 $&E8 886561 -)085ÿ5ÿ19 216ÿ 1ÿC18159ÿ $%D&C8158ÿC886561 $&E8 886561 ./0123 45ÿ 7Fÿ 49ÿ :; GÿH88ÿ558ÿ5ÿ586ÿ1ÿ516ÿ56ÿ# ... ;7ÿÿ%*ÿ#ÿ*ÿ""ÿÿÿÿÿ%ÿÿ#ÿ D)4 012345 67ÿ 9Eÿ 6ÿ Dÿ "&ÿBF&ÿÿ"%ÿ#ÿBFÿ)*ÿ#ÿ+*ÿÿ"ÿG*%ÿÿÿ*" #ÿ#ÿÿ%*C 67"ÿ
Ngày tải lên: 27/10/2021, 15:18
iec 60298 a.c. metal-enclosed switchgear and controlgear for rated voltages above 1 kv and up to
... Components contained in metal-enclosed switchgear and controlgear are to be designed and tested in accordance with their various relevant standards This standard supplements the standards for the individual ... Cubicle switchgear and controlgear Metal-enclosed switchgear and controlgear, other than metal-clad and compartmented switchgear and controlgear COPYRIGHT 2002; International Electrotechnical Commission ... SERVICE CONDITIONS 2 Normal and special service conditions Unless otherwise specified in this standard, the metal-enclosed switchgear and controlgear Refer to Clause 2 of I E C 694 For outdoor
Ngày tải lên: 25/12/2013, 10:57
Interferon-c Release Assays for Active Pulmonary Tuberculosis Diagnosis in Adults in Low- and Middle-Income Countries: Systematic Review and Meta-analysis pdf
... results, we fo-cused our review on the diagnostic accuracy of IGRAs for active tuberculosis We observed standard guidelines and methods for Search Methods We previously published systematic and narrative ... reviewed bibliographies of reviews and guidelines, screened citations of all included studies, searched clinicaltrials.gov for ongoing studies, and contacted both ex-perts in the field and IGRA ... summary receiver operating characteristic (HSROC) curves, and bivariate random effects models evaluating 590 human immunodeficiency virus (HIV)–uninfected and 844 HIV-infected individuals met inclusion
Ngày tải lên: 22/03/2014, 18:20
Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx
... coli BL21-DE3 cells Plasmids for T brucei cytochrome c (pKK223–Tbcytc), its CXXCH variant (pKK223–TbcytcCXXCH), S cerevisiae cytochrome c heme lyase (pACcyc3) and iso-1-cytochrome c (pScyc1) were ... acid polypeptide chain The fold is typical for a class I c-type cytochrome (e.g mitochondrial cytochrome c and bacterial cyto-chromes c2) [20] The structure unequivocally confirms the earlier conclusion ... structure coordinates for Crithidia fasciculata cytochrome c have been deposited in the Protein Data Bank under the accession code 2w9k (Received 23 December 2008, revised 19 February 2009, accepted
Ngày tải lên: 23/03/2014, 04:21
Báo cáo khoa học: Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx
... variant and classic patients (A97V and R301Q) were efficiently purified from transfected COS-7 cells, and their enzymatic and bio-chemical properties examined The cardiac mutations typically present ... can disrupt native protein folding, thereby producing proteins with misfolded conformations These misfolded proteins are consequently retained and degraded by endoplasmic reticulum-associated ... Keywords active-site-specific chaperone; 1-deoxygalactonojirimycin; endoplasmic reticulum associated degradation; Fabry disease; a-galactosidase A; pharmacological chaperone; protein misfolding Correspondence
Ngày tải lên: 30/03/2014, 03:20
Báo cáo hóa học: " Development and preliminary evaluation of the participation in life activities scale for children and adolescents with asthma: an instrument development study" pptx
... changes in coming to accept asthma as a chronic condition In preparation for testing an acceptance model for older school-age children and early adolescents diagnosed with asthma, the Participation ... state, and socioeconomic status Soci-oeconomic status was computed using the Nam-Powers Socioeconomic Index Scores (SEIS) by averaging parents' occupation and education scores, and family income score ... indicator scores functioned as predicted Mean scores indicated that Table 4: Cross-group Comparisons in PLA Scores by Age, Race, Socioeconomic Status, and Area of Residence Age Race ‡ Socioeconomic
Ngày tải lên: 18/06/2014, 22:20
Báo cáo hóa học: " Reliability and construct validity of the Participation in Life Activities Scale for children and adolescents with asthma: an instrument evaluation study" docx
... scale for children and adolescents with asthma demonstrated internal consistency reliability and construct validity based on exploratory and confirmatory factor analysis techniques for the combined ... collect demographic and disease-related information [2-4]. Demographic informa- tion reported here relates to sex/gender, race, age, and socioeconomic status. Socioeconomic status was com- puted ... similarities and differences in scores based on race between Black and White Americans. Demographic considerations Asthma-related health statistics indicate that children, ages 9–14 years, experience increase
Ngày tải lên: 18/06/2014, 22:20
Báo cáo hóa học: " Analysis of in vitro replicated human hepatitis C virus (HCV) for the determination of genotypes and quasispecies" docx
... consistent sequence changes, while HCV grown in T-cells had inconsistent changes, therefore lacked sequence commonality cells contained a mixture of T-cell subtypes, including CD4+ and CD8+ T-cells Guglietta ... retransmission for over three years We noted minor sequence changes when HCV was cultured for extended periods of time HCV in T-cells and non-committed lymphoid cells showed a few differences when compared ... chelyapo@usc.edu; David Bayles - dave@inlandbuilderssupply.com; John G Prichard - johnprichard@mail.co.ventura.ca.us; S Zaki Salahuddin* - phoenix@cimm.net * Corresponding author Abstract Isolation and
Ngày tải lên: 20/06/2014, 02:20
báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx
... were respectively washed, deprotected and coupled as described above The resulting N-terminal Fmoc was deprotected in 20% piperidine in DMF for 15 min, and the resin was washed as described above ... peptides were separable The peptide fraction was collected, evaporated and counted in a Capintec radioisotope calibrator (Capintec, Inc., NJ, USA) to calculate the specific activity of the product ... electroplating and 64Cu-labeling BF participated in the conception and design of the study LeR participated in the coordination of the study and reviewed the manuscript GB conceived of the study, participated
Ngày tải lên: 21/06/2014, 17:20
FIRST- AND SECOND-ORDER DYNAMIC EQUATIONS WITH IMPULSE F. M. ATICI AND D. C. BILES Received 3 pdf
... IMPULSEF M ATICI AND D C BILES Received 3 December 2004 and in revised form 11 February 2005 We present existence results for discontinuous first- and continuous second-order dy-namic equations ... periodic boundary conditions The mono-tone iterative technique was employed in [14] for antiperiodic and nonlinear boundary conditions Lower and upper solutions and periodic boundary conditions ... existence result for second-order dynamic equations on a time scale subject to fixed-time impulses and nonlinear boundary conditions Nonlinear boundary conditions cover, among others, the periodic and
Ngày tải lên: 23/06/2014, 00:20
Báo cáo toán học: " Geometrically constructed bases for homology of partition lattices of types A, B and D" ppt
... when c was introduced), it follows that ϕ(c 0 ) precedes ϕ(c) in Ω, and hence that c 0 precedes c in Ω P rM. Hence the matrix (hρc , c 0 i)c,c 0 ∈F(P rM) is lower triangular with 1’s on the diagonal ... precedes c 0 in ΩP rM if and only if ϕ(c) precedes ϕ(c 0) [2, Th 4.1] Let F(P<m) and F(P r M) denote the sets of full restriction facets induced by Ω <m and ΩP rM Recall from [6, Section ... F(P<m c ) Let ρ c be the element of B(P <m c) corresponding to c So, ρ c is the (r − 1)-cycle in P<m c with coefficient +1 at c and coefficient 0 at all c 0 ∈ F(P<m c)r {c}. Suppose
Ngày tải lên: 07/08/2014, 08:22
Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
... recorded in CDCl 3 and COSY spectra lacked fine detail. HSQC and expanded COSY were not provided by Guryev et al. [2] and, without these, it is difficult to distinguish between hydroxylation at C2 2 ... of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by P450scc Incubation of 20-hydroxyvitamin D3 in cyclodextrin with P450scc resulted in the formation of 20,23-di- hydroxyvitamin D3 (RT = ... hydroxylation at C2 2 and C2 0, and subsequent oxidative cleavage of the bond between C2 0 and C2 2. It has now been established that cyto- chrome P450scc can also act on both vitamins D2 and D3 ,...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Gas6 and protein S Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily pptx
... S ND ND ND ND 3 [45] ND ND 3 [45] ND Rat protein S ND ND ND ND ND ND ND ND 3 [28] Bovine protein S X [28] ND ND 3 [55,60] 3 [89] ND ND ND 3 [28] The Gas6Axl system S. Hazi and B. Dahlba ă ck 5236 ... [62,66]. A mouse Axl ectodomain was detected in tumour cell and dendritic cell medium and in serum, and the disintegrin-like metalloproteinase ADAM 10 was suggested to be involved in its generation ... adhesion and pha- gocytosis. Consequently, altered activity ⁄ expression of its components has been detected in a variety of pathologies such as cancer and vascular, auto- immune and kidney disorders....
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
... growth factor domain indicates the disulfide bridges in PDGF -C to consist of Cys250 and 294, Cys280 and 335, and Cys287 and 337, and the inter- monomeric bonds to consist of Cys274 and 286 [57]. At ... secretion includes covalent binding to the extracel- lular secreted protein, acidic and rich in cysteine (SPARC), which only binds PDGF-AB and -BB, decreasing their reactive concentrations and ... residues in PDGF-A and -B responsible for receptor binding reside in loop 2, in addition to RKK161 in PDGF- AA and R27 and I30 in PDGF-BB. The residues involved in PDGF-CC and -DD receptor binding remain...
Ngày tải lên: 19/02/2014, 07:20