tumour necrosis factor aand lipopolysaccharide

... glucose-6-phosphatase; Hnf-3, hepatocyte nuclear factor 3; PEPCK, phosphoenolpyruvate carboxykinase; TBP, TATA box-binding protein; TNFa, tumour necrosis factor-a. Trang 2and a parallel increase in ... K, Hauner H & Eckel J (1998) Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor Diabetes 47, 515–522 7 ... diabetes Keywords diabetes; Foxa2; insulin; phosphoenolpyruvate carboxykinase (PEPCK); tumour necrosis factor-a (TNFa) Correspondence M Datta, Institute of Genomics and Integrative Biology, Mall

Ngày tải lên: 16/03/2014, 02:20

... Technology of China, Hefei, Anhui, China Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted much attention because of its ability to kill tumour cells In this study, we demonstrated ... drug-resistant tumour cells, new meth-ods, which could bypass the resistance to chemotherapeutic drugs through activation of the death receptor-mediated pathway, need to be developed Tumour necrosis factor-related ... protein, is a member of the tumour necrosis factor death-ligand family [1,2] and it selectively induces apoptosis in a number of transformed cells in vitro [1–3] and tumours in vivo, while leaving

Ngày tải lên: 23/03/2014, 17:22

... dTNFR = dimeric TNFR2; TNF = tumour necrosis factor; TNFR = tumour necrosis factor receptor. Research article Inhibition of established collagen-induced arthritis with a tumour doxycycline regulated ... abundance of macrophage and fibroblast cytokines such as tumour necrosis factor (TNF)-α, IL-1, granulocyte–macrophage colony-stimulating factor and IL-6, along with smaller amounts of T-cell products ... clinical application Keywords: arthritis, doxycycline, gene therapy, regulated expression, tumour necrosis factor-α Open Access R103 Trang 2We previously constructed dTNFR, which is a smaller inhibitor

Ngày tải lên: 09/08/2014, 01:23

... AccessR1271 Vol 7 No 6 Research article Tumour necrosis factor- α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor- κB and activator protein-1 ... receptor interacting protein; TNF, tumour necrosis factor; TNFR, TNF- α receptor; TRADD, TNF receptor associated death domain; TRAF, TNF receptor associated factor. Trang 9inhibitor PD98059 and ... for 2 hours Thereafter, the cells were incubated with (solid bars) or without (open bars) tumour necrosis factor (TNF)- α for another 24 hours with 1.5 × 10 -8 mol/l 3 H-dehydroepiandrosterone

Ngày tải lên: 09/08/2014, 07:20

... responses to the same antigens Figure 4 Effect of tumour necrosis factor (TNF) antagonist treatment on anti-mycobacterial responses Effect of tumour necrosis factor (TNF) antagonist treatment on anti-mycobacterial ... delaying Figure 6 In vitro effect of tumour necrosis factor (TNF) antagonists on anti-mycobacterial proliferative response In vitro effect of tumour necrosis factor (TNF) antagonists on anti-mycobacterial ... hypothesis that Figure 7 In vitro effect of tumour necrosis factor antagonists on proliferative responses to recall antigens In vitro effect of tumour necrosis factor antagonists on proliferative

Ngày tải lên: 09/08/2014, 08:22

... rheumatoid factor; ST = synovial tissue; TLR = Toll-like receptor; TNF-α = tumour necrosis factor-α; TNFR1/2 = type 1 and 2 tumour necrosis factor receptor; TRAF = tumour necrosis factor receptor-associated ... delta/MIP-5 TNFRSF1B Tumour necrosis factor receptor superfamily, member 1B TNFR2/p75 2.64 0.91 TNFRSF11A Tumour necrosis factor receptor superfamily, member 11a, activator of nuclear factor-κB ... Figure 6 Tumour necrosis factor-α (TNF-α)-mediated interleukin (IL)-1β and IL-6 production by normal monocytes pretreated with IL-10 and/or macrophage colony-stimulating factor (M-CSF) Tumour necrosis

Ngày tải lên: 09/08/2014, 08:22

... units; tetR-KRAB = tetracycline repressor-Kruppel-associated box; TNF-α = tumour necrosis factor-alpha; TNFR = tumour necrosis factor receptor. Trang 2vivo, achieving long-term expression, and because ... of dimeric tumour necrosis factor receptor II (dTNFR) from pGTTMIK and gene therapy application in the collagen-induced arthritis (CIA) model Expression of dimeric tumour necrosis factor receptor ... delivery methods will be Figure 6 Levels of dimeric tumour necrosis factor receptor II (dTNFR) in the circulation Levels of dimeric tumour necrosis factor receptor II (dTNFR) in the cir-culation

Ngày tải lên: 09/08/2014, 10:20

... adjuvant arthritis (AA) by in vivo tumour necrosis factor (TNF)α treatment of Lewis (LEW) rats Downmodulation of adjuvant arthritis (AA) by in vivo tumour necrosis factor (TNF)α treatment of Lewis ... vivo tumour necrosis factor (TNF)α treatment resulted in decreased interferon (IFN)-γ secretion by B177-restimulated LNC without affecting their proliferative response In vivo tumour necrosis factor ... of tumour necrosis factor (TNF)α-treated Lewis (LEW) rats was comparable to that of phosphate-buffered saline (PBS)-treated rats The composition of peritoneal lavage cells of tumour necrosis factor

Ngày tải lên: 09/08/2014, 10:23

... nuclear factor-κB; PBS = phosphate-buffered saline; PCNA = proliferating cellular nuclear antigen; PMSF = phenylmethylsulphonyl fluoride; RA = rheumatoid arthritis; TNF = tumour necrosis factor. ... minutes)-treated human heat shock protein 70 (HSP70;1 μg/ml) or lipopolysaccharide (LPS; 100 ng/ml) for 1 hour, washed and then exposed to tumour necrosis factor (TNF)-α (20 ng/ml) The superna-tants were ... and degradation of IκBα Heat shock protein (HSP)70 inhibits tumour necrosis factor (TNF)-α induced nuclear translocation of nuclear factor-κB (NF-κB) and degradation of IκBα in fibroblast-like

Ngày tải lên: 09/08/2014, 10:23

... lupus erythematosus; SS: Sjögren's syndrome; TNF: tumour necrosis factor; VCAM: vascular cell adhesion molecule; VEGF: vascular endothelial growth factor. Trang 2esis develops with the formation ... not been fully delineated in rheumatoid arthritis (RA) Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in ... memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor 1 Centro de Neurociências e Biologia Celular, Department of Zoology, University of

Ngày tải lên: 09/08/2014, 14:21

... Spondyloarthropathy; ST: synovial tissue; TGF: transforming growth factor; TIMP-1: tissue inhib-itor of metalloproteinase 1; TNF: tumour necrosis factor. Trang 2proteinase 1 (TIMP-1) [5] Joint destruction ... arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis Ellen M Moran, Ronan Mullan, Jennifer McCormick, Mary Connolly, Owen Sullivan, Oliver ... causing degradation via proteolytic cleavage of aggrecan and collagen [3] Cytokines and growth factors are required to stimulate cell survival, proliferation and extracellular matrix (ECM) tion

Ngày tải lên: 09/08/2014, 14:22

... Research article Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis ... in the presence of increasing concentrations of apremilast for 48 hours and spontaneous tumour necrosis factor-alpha (TNFα) production was analysed in culture supernatants by ELISA In addition, ... blood mononuclear cells; PDE4: phosphodiesterase type 4; RA: rheumatoid arthritis; TNFα: tumour necrosis factor alpha. Competing interests Peter Schafer is an employee of Celgene Corporation and

Ngày tải lên: 12/08/2014, 14:22

... NF-jB, nuclear factor jB; PBMNC, mononuclear cells; PMA, phorbol 12-myristate 13-acetate; RPA, RNAse protection assay; TNF, tumor necrosis factor; TRAF, TNF receptor-associated factor. (Received ... Christian-Albrechts-University of Kiel, Germany To gain insight in the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF4) we analyzed GFP chimeras of full-length TRAF4 and various deletion ... TRAF4 in T-cells Keywords: IKKc; NF-jB; T-cells; localization; TRAF4 The tumor necrosis factor (TNF) receptor-associated factor (TRAF) familycomprises a group of adaptor proteins that are involved

Ngày tải lên: 21/02/2014, 15:20

... nuclear factor-jB (NF-jB) subunits p65⁄ RELA and p50⁄ NFjB1, and also through modulation by tumor necrosis factor a Transcriptional up-regulation of Rnf33 by NF-jB and tumor necrosis factor-a wfactor-as ... NF-jB and tumor necrosis factor-a wfactor-as directly demonstrfactor-ated in TM3 factor-and TM4 cells by refactor-al-time PCR qufactor-anti- quanti-fication of the Rnf33 mRNA levels Small interfering ... before placental implantation and Keywords nuclear factor-kappa B (NF-jB); p65 and p50 proteins; Rnf33; testis-specific gene expression; tumor necrosis factor-alfa (TNF-a) Correspondence Chiu-Jung

Ngày tải lên: 29/03/2014, 00:20

... to be activated by numerous factors, including transforming growth factor b (TGFb) and interleukin (IL)-1b [2], platelet-derived growth factor and b fibroblast growth factor [3], thrombin [4], Abbreviations ... produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation Crit Care Med 27, 2184–2187 19 Imaizumi T, Itaya H, Fujita K et al (2000) Expression of tumor necrosis factor-alpha ... PEG, poly(ethylene glycol); ROS, reactive oxygen species; TGFb, transforming growth factor b; TNFa, tumor necrosis factor a FEBS Journal 272 (2005) 5821–5831 ª 2005 The Authors Journal Compilation

Ngày tải lên: 30/03/2014, 11:20

... the discovery of a serum factor capable of inducing Trang 3hemor-rhagic necrosis of tumors in vivo and of killing tumor cells in vitro This factorwas termed tumor necrosis factor (TNF) and was shown ... Cachectin/tumor necrosis factorstimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts J Exp Med 162, 2163–2168. 5 Saklatvala, J (1986) Tumour necrosis factor ... (1987) The active form of tumor necrosis factor is a trimer J Biol Chem 262, 6951–6954. Trang 2310 Meager, A., Leung, H., and Woolley, J (1989) Assays for tumour necrosis factorand related cytokines

Ngày tải lên: 11/04/2014, 10:38

... responsive to and dependent on trophic factors such as nerve growth factor (NGF) We previously showed in NGF-responsive PC12 cells that tumor necrosis factor alpha (TNFα) and NGF synergistically ... survival on target derived neuro-trophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or glia-brain-derived neu-rotrophic factor (GDNF) The same neurodegenerative ... pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells Address: 1 Department of Neuroscience and Cell Biology,

Ngày tải lên: 19/06/2014, 22:20

... Trang 1Open AccessResearch Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal ... cells, activates macrophages TGF- β cytokine, inhibits cell growth IL-2 cytokine, T cell growth factor IL-6 cytokine, B and T cell growth and differentiation IL-8 cytokine, secreted by macrophage(predominately

Ngày tải lên: 19/06/2014, 22:20

... tumor necrosis factor-alpha in the intact and injured rat sciatic nerve J Neurosci 2002, 22:536-545 Schafers M, Geis C, Svensson CI, Luo ZD, Sommer C: Selective increase of tumour necrosis factor-alpha ... induced by tumor necrosis factor-alpha J Neurosci 2010, 30:12844-12855 Zhang H, Dougherty PM: Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor J Physiol ... Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons J Neurosci 1997, 17:975-982 Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM: Tumor necrosis factor

Ngày tải lên: 19/06/2014, 22:20

... interferon regulatory factor 7; ISG15: interferon-stimulated gene, 15 kDa; MAPK: mitogen-activated protein kinase; MHC: major histocompatibility complex; NFB: nuclear factor of kappa light ... reverse transcription; SLE: systemic lupus erythematosus; TLR: Toll-like receptor; TNF: tumor necrosis factor. Trang 2observed [5,6] Cytokines are pleiotropic in their biologicalactivity, and it ... Roux-Lombard P, Meyer O, Dayer JM, Vischer T, Yazici H, Guerne PA: Circulating levels of tumor necrosis factor soluble receptors in systemic lupus erythema-tosus are significantly higher than in

Ngày tải lên: 09/08/2014, 01:22