the phase 1 study of dmxba in schizophrenia

... JJ, Desjardins A, Reardon DA, Friedman HS: Experience with irinotecan for the treatment of malignant glioma Neuro Oncol 2009, 11(1):80–91 Page 10 of 10 10 11 12 13 14 15 16 17 18 19 United States ... scatterplot of TP3076 AUC C: The scatterplot of TP3011 Cmax D: The scatterplot of TP3011 AUC E: The scatterplot of the sum of TP3076 and TP3011 Cmax F: The scatterplot of the sum of TP3076 and TP3011 AUC ... of TP3011 AUC by AOX1(c3404 A>G) C:The boxplot of TP3076 AUC by UGT1A1 *28 D:The boxplot of TP3011 AUC by UGT1A1 *28 E:The boxplot of TP3076 AUC by CYP genotype F:The boxplot of TP3011 AUC by

Ngày tải lên: 05/11/2020, 07:48

... 2014;32:19–26 Battaglin et al BMC Cancer (2018) 18:98 Page 11 of 11 21 Extermann M, Boler I, Reich RR, et al Predicting the risk of chemotherapy toxicity in older patients: the chemotherapy ... Battaglin et al BMC Cancer (2018) 18:98 DOI 10.1186/s12885-018-4001-x STUDY PROTOCOL Open Access The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab ... compensation for Battaglin et al BMC Cancer (2018) 18:98 any injury associated with administration of the study drugs and other aspects of the conduct of the trial In case of important protocol

Ngày tải lên: 24/07/2020, 00:24

... Postoperative interstitial brachytherapy for resectable squamous cell carcinoma of the tongue Brachytherapy 2015;14:71 –6 https://doi.org/10. 1016/j.brachy.2014.09.011 15 Lapeyre M, Hoffstetter ... Cancer Institute and the French Health Ministry. The funding parties were not involved in the design and conduct of the study, nor in the collection, management, analysis, and interpretation of the ... planning organ at risk volume (PRV) The delineation includes different OAR according to Brouwer et al [31]: the spinal cord, the spinal canal, the brainstem, the parotid glands, the mandible, the

Ngày tải lên: 19/09/2020, 22:06

... 10 (5.5–17.5) 10 (5–19) 9.5 (6–14) 6480 (2187–12 480) 6750 (3580–14 634) 6397 (4302–11 198) 216 (189–247) 223 (189–233) 237 (179–261) 52 28 24 992 (600–1812) 987 (505–2021) 1008 (661–1597) 31.4 ... (months) 13.4 (12.1–17.5) 13.1 (11.4–18.3) 13.4 (10.1–17.9) Median OS (months) 38.1 (30.3–45.8) 38.1 (33.5–42.6) 47.0 (32.1–61.9) Data are given as the number of patients in each group or as ... first-line therapy for mCRC On the basis of results from the COIN trial, in which the dose of capecitabine was reduced in the triweekly XELOX and cetuximab group, the dose of capecitabine used in the

Ngày tải lên: 22/09/2020, 23:39

... Teaching Methodology Code: 60.14.10 Supervisor: Nguyễn Thị Vượng, MA HANOI – 2011 Trang 44 Methods of the Study 5 Scope of the study 6 Design of the study Trang 5 1.3.3.4 Vocabulary 1.3.3.5 ... background 1.1 Definition of Terminology 1.1.1 What is reading? In our daily life, we spend time reading books, newspapers, novels or stories because we find them interesting and useful When reading, ... understand the relation between the writing and the meaning In the other words, after reading students can find the way to bettering their grammar, words, pronunciation and understanding the content of

Ngày tải lên: 23/09/2020, 21:05

... of administration Day of administration Drug dose Arm A H0 1, 8, 15 nab-paclitaxel 125 mg/m 2 , 30 min IV infusion (maximum infusion time not exceeding 40 min) H + 0.5 1, 8, 15 gemcitabine 1000 ... approach The TUDD will be defined as the time from inclusion in the study to the first deterioration of a least 5-point MCID of the HRQoL score as com-pared to the baseline score, with no further ... proteins Bi-directional hENTs play a key role in this processs and thus in the efficacy of gem-citabine [16] Among these, hENT1 mediates the majority of gemcitabine transport [17] Preclinical

Ngày tải lên: 28/09/2020, 01:41

... rapidly during infusion and declined rapidly upon termination The concentra-tion of ganetespib declined to approximately 10% of Cmaxwithin 1 h of infusion termination and 1% of Cmax within 8 to 10 h ... B, et al: A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors Clin Cancer Res 2011, 17(6):1561 –1570. 28 Zhou ... cancer J Clin Oncol 2005, 23(6):1078 –1087. doi:10.1186/1471-2407-13-152 Cite this article as: Goldman et al.: A first in human, safety, pharmacokinetics, and clinical activity phase I study of once

Ngày tải lên: 05/11/2020, 07:32

... 57.0 (11.2) 58.1 (12.3) 57.5 (13.8) Table 2: Descriptive statistics of the classes of 1970, 1980 and 1990 Class of 1970 Class of 1980 Class of 1990 Number of physicians in their fifth year of experience ... surgery na 17.1 (16.6 – 17.6)* Cardiovascular surgery 11.6 (11.2 – 12.0)* 5.6 (5.4 – 5.8)* Paediatric surgery 11.3 (10.7 – 11.9)* 8.3 (7.7 – 8.9)* Orthopaedics 1.8 (1.7 – 1.9)* 1.4 (1.3 – 1.5)* ns ... work in hospitals between 1975 and 1984; F2, the number between 1985 and 1994; F3, the number between 1995 and 2004. n1, the number of physicians working in clinics in 1974; n2, the number in 1984;

Ngày tải lên: 18/06/2014, 17:20

... to 1.13) 1.08 (0.95 to 1.23) 1.12 (0.99 to 1.27) 1.00 (0.86 to 1.17) Men only 1.15 (1.00 to 1.33) 1.16*(1.01 to 1.33) 1.19* (1.04 to 1.29) 1.14 (0.96 to 1.36) Women only 0.87 (0.69 to 1.10) 1.06 ... 145 (116 to 174) 162 (133 to 191) 175 (144 to 205) 166 (131 to 200) MESA CAC score d 112 (100 to 125) 118 (105 to 130) 122 (109 to 134) 122 (109 to 135) a Associations in subjects with prevalent ... (0.13 to 1.25) 1.38 (1.00 to 1.88) <0.001 Total Sharp–van der Heijde Score 44 (16 to 116) 18 (5 to 36) 38 (20 to 68) 142 (83 to 221) <0.001 C-reactive protein (mg/l) 2.46 (1.09 to 7.17) 1.7

Ngày tải lên: 09/08/2014, 13:22

... 245 11.1 Functions of the turbocharger 248 11.2.1 Turbine and compressor designs 24911.2.2 Investment casting 252 A International standards conversion table for alloys 265 Trang 11D Types of cast ... peening 158 8.4.4 Cold and semi-hot forging 1758.4.5 Combination forging 1788.5 Surface-hardening methods 178 9.3 The needle roller bearing 212 9.3.2 Factors affecting the life of bearings 2159.3.3 ... mechanismsusing a piston and cylinder can be seen in a 1509 drawing by Leonardo daVinci, the famous painter and scientist of the Renaissance period There aretwo main types of reciprocating engine, the

Ngày tải lên: 10/08/2014, 12:21

... Non-respondents Foot pain in the last 12 months No foot pain in the last 12 months Phase 2: Clinical Assessment Study of the Foot (CASF) “Clinic” population Non-respondents/declined to make an appointment ... and pattern of co-occur-rence of radiographic features of symptomatic OA in the following foot joints: the 1stMTPJ, the 1st and 2nd CMJs, the NCJ and the TNJ (ii) Relate the occurrence of radiographic ... and the validity of their conclusions [69] This is especially true of observer-dependent methods of data-gathering In the clinical assessment phase of the study, the clinical interview and physical

Ngày tải lên: 10/08/2014, 21:24

... non-platinum containing salvage agents, including docetaxel in 12 (30.8%), gemcitabine in 11 (28.2%) and topotecan in (23 .1% ) All prior Page of 11 platinum-containing regimens were counted as regimen ... population in a phase randomized study [7,20] In our phase study, the response rate of 25.6% and DSR of 76.9% supports that the combination regimen is more active in the treatment of platinum resistant ... Screening Program Mol Pharmacol 19 96, 50 (1) :14 9-59 Page 10 of 11 14 Meng F, Brown GL, Keck JG, et al: TLK286-induced activation of JNKdependent apoptotic signaling pathway Proceedings of the AACR-NCIEORTC...

Ngày tải lên: 10/08/2014, 22:20

... (p.p.m.) H3ax 1. 61 H3eq 2.62 H4 4.02 H5 3.53 H6 3.95 H7 3.89 H8 3.89 H9 1. 20 NAcCH3 2.08 1. 86 1. 89 2.48 2. 51 3.33 3.37 ND ND 4 .19 4 .13 3.68 3.75 4 .19 4 .13 1. 17 1. 16 2 .17 ND C1 17 4.47 C2 10 1.86 C3 39.40 ... dH 2. 51 Z) in COSY, and for H7 (dH 3.68 E, dH 3.75 Z) and CˆO of the 7-acetamido group (dC 17 5. 91 E, dC 17 5.74 Z) in the 1H ,13 C HMBC experiment In addition, signals for H9 (dH 1. 17 E, dH 1. 16 Z) ... derivative of L-fucose in the LPS of Bordetella pertussis strain 14 14 [48,49], in which the N-methyl group gave a single singlet in the 1H NMR spectra Similarly, the minor pair of signals at dH 2.97...

Ngày tải lên: 08/03/2014, 10:20

... United Kingdom and internationally (The Telegraph, 2 012 ; Wikipedia, 2 012 ) The Telegraph Online is the online version of the newspaper It includes the articles from the print editions of The Daily ... archive of three million stories In the 19 90s, in the midst of the price war amongst the other broadsheets, The Guardian remained at full price, “investing resources in journalism and distancing ... and the Public Agenda of the University of Maryland in terms of transparency The Guardian was awarded the National Newspaper of the Year in 19 99, 2006 and 2 011 by the British Press Awards in addition...

Ngày tải lên: 10/09/2015, 09:22

... Utilising the USAS semantic domains within WMatrix as the starting point of the analysis, an analysis of the semantic tagset was carried out, with the initial focus being the frequency counts of the ... examination of the lexical item ‘oil’ (Fig 3.8) clearly shows that virtually all the top-30 instances in the concordance refer to either the size and scale of the oil spill (Lines 1, 7, 10 , 11 , 15 , ... overcoming the pressure of the oil spewing out of the well/ the experimental procedure will help stem the flow of crude oil spewing into the Gulf of Mexico/ the picture of an uncontrolled gusher of...

Ngày tải lên: 10/09/2015, 09:22

... strengthen the moral legitimacy of the Obama administration while galvanizing the electorate against the “other”, concealing the multiple failings of the US government In contrast, the predominantly ... eight concordance lines references the 9 /11 attacks in terms of the scale and unprecedented nature of the oil spill, rather than on the incompetence of the parties involved or in the search for justice ... displays all eight instances of the 9 /11 references in the NYT-corpus A dominant unifying thread in these concordances is the constant allusion to the details associated with the “9 /11 victim’s compensation...

Ngày tải lên: 10/09/2015, 09:22

... % Incorrect % Athletics 28 18 .79 16 10 .74 Boxing 19 12 .75 23 15 .44 Swimming 17 11 . 41 13 8.72 Basketball Football 23 15 .44 10 6. 71 Handball Volleyball Total 87 (58.39%) 62 ( 41. 61% ) 14 9 (10 0%) The ... Athletics 24 14 .12 19 11 .18 Boxing 28 16 .47 22 12 .94 Swimming 19 11 .18 17 10 .00 Basketball Football 26 15 .29 15 8.82 Handball Volleyball Total 97(57.06%) 73(42.94%) 17 0 (10 0%) From the results of table ... line instead of side tended to add a "to" before the second verb or to change the form of line, *cross goal line instead of goal line, * two in zero instead of two the second verb into the V-ing...

Ngày tải lên: 26/11/2013, 13:19

... enhance the author to this thesis Then, the purpose of the study introduces the aims to the thesis And the scope of the study gives the details about the objects that the thesis studies and the main ... further research in the future In conclusion, the thesis will present all the results of the process of studying the theoretical background, then working out the real difficulties in learning the ... the current situations of teaching and learning the English listening skill in the Asemlink of International Language Center 3.2 .1. 1 The difficulties in teaching and learning English in the international...

Ngày tải lên: 14/12/2013, 00:41

... mechanical engineering terminology, it is time to give standards on the terminology In the process of carrying out the study, the author finds different English-Vietnamese mechanical engineering term ... twofold meaning: (1) it is the discipline concerned with the principles and methods governing the study of concepts and their designations (terms, names, symbols) in any subject field, and the ... the precise contextual meaning of the original within the constraints of the TL grammatical structures” and “it attempts to be completely faithful to the intentions and the text-realization of...

Ngày tải lên: 29/01/2014, 10:43

... neutrality of the Internet may be at risk.” 12 0 Therefore, there is “growing international interest as to whether, and to what extent, traffic management should 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 Note ... core of the examination of any interference in the exercise of freedom of opinion is therefore a balancing of interests in which the Court takes account of the significance of freedom of opinion ... schools.” The OSCE PC Decision 633 further asks the participating States to study the effectiveness of laws and other measures regulating Internet content” 13 10 11 12 13 Final Act of the Conference...

Ngày tải lên: 18/02/2014, 00:20