supports for solid phase synthesis

... 1.1) Figure1.1 Illustration of a solid-phase synthesis This concept of solid-phase synthesis was first raised by R B Merrifield in 1963 for method for the synthesis of small molecules with ... results in solid-phase reactions For example sometime a specific co-solvent should be added to the solid-phase reaction to allow the resin to achieve better swelling property 1.2 Solid-phase synthesis ... diamine for other solid-phase synthesis including 1,7,8-trisubstituted purines, 8-unsubstituted purines, 8-azapurines and [i]-condensed purines In all these three projects, solid-phase-oriented synthesis

Ngày tải lên: 15/09/2015, 17:09

... title “Synthesis of silica-based reverse-phase material possessing octadecyl groups (C18) and polymer-based strong cation-exchange material containing sulfonate groups as stationary phases for solid-phase ... use for various applications where the retention requires one or more than one mode of interaction In addition, we made a lot of efforts in producing macro-porous polymer sheet (frit) used for ... property of the frit is good for this application, the cost is very cheap (~10 times lower than the commercial ones) but the fluid transfer characteristics requires more efforts to improve A modern

Ngày tải lên: 23/01/2021, 10:01

... liquid phase, to the headspace of the vial, or gas phase, depends on the volume of the liquid phase, the volume of the gas phase and the affinity of compounds for the liquid and gas phases [18] For ... identified per sample was determined for each volunteer For an overall com-parison across treatments, the number of compounds identified for a volunteer for all the different treatments tested ... Passos M, Câmara JS (2012) Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers—a powerful strategy for breast cancer diag-nosis

Ngày tải lên: 29/05/2020, 13:33

... These critical points for this research are as fol-lows: pH (A) = 3.02 for RB, 2.93 for MG, 6.04 for AR and 6.88 for MO, eluent volume (B) (µL) = 305 (for RB), 247 (for MG), 296 for AR and MO, the ... sampler 3950, was used for all analyzes Detection system was a diode array spectrophotometer, used at wavelengths of 448 nm for MO, 510 nm for AR, 555 nm for RB and 618 nm for MG Analytical column ... (0.15% v/v for MG and AR and 0.20% v/v for RB and MO) and 150  mg of KCl was added Then pH of solutions were adjusted to the desired value (pH = 3.0 for MG and RB, 6.0 for AR and 6.9 for MO) with

Ngày tải lên: 29/05/2020, 13:47

... catalyst supports is crucial for enhancing electrochemical activity in fuel cells Researchers aim to minimize Pt nanoparticle (NP) usage while maintaining electrocatalyst performance for commercialization ... determine the solid's surface area For analyzing the surface area and pore size of catalyst supports, nitrogen adsorption/desorption isotherms are conducted at 77K using a NOVA 1000e Before BET measurements, ... below 100 ºC for quick start-up These features, along with the ability to rapidly adjust power output, position the PEMFC as a leading choice for automotive applications Additionally, the solid electrolyte

Ngày tải lên: 11/07/2021, 16:05

... describes the solid-phase synthesis of brachystemin A (1) by using Kenner’s sulfonamide safety-catch linker The synthetic peptide was evaluated for its immunomodulatory activity by performing different ... complete solid-phase total synthesis of peptide 1 by using Kenner’s sulfonamide safety-catch linker strategy It was identified by QTOF/MS data and NMR studies Synthetic peptide 1 was tested for its ... Fang et al reported the combination of solid and solution-phase synthesis of brachystemin A in which triphosgene (BTC) was used as the coupling agent in the synthesis of the linear precursor of

Ngày tải lên: 12/01/2022, 23:45

... mesoporous solid catalysts to fine chemicalsynthesis, a field that is receiving increasing attention because of its high potentialfor the development of ‘green’ processes for the synthesis of ... network formed, thereby making thezeolite formation process reversible and steering it away from very unstablestructures for any given set of synthesis conditions This is important as less regularphases ... Dehydration of xylose 146 7.7 Synthesis of alkyl-D-glucosides 147 7.7.1 Synthesis of butyl-D-glucosides 147 7.7.2 Synthesis of long-chain alkyl-D-glucosides 150 7.8 Synthesis of alkyl-D-fructosides

Ngày tải lên: 23/05/2022, 11:48

... Mn3O4-TiO2 nanocomposite was applied as a new solid phase adsorbent for preconcentration of Molybdenum before determination by an UV-Vis spectrophotometer The solid-phase extraction conditions as pH, the ... been used for the determination of Mo in a variety of samples Therefore, it is usually necessary to carry out a separation and preconcentration step before the analysis Some methods for separation ... Wu, Yucheng, A Facile one-step synthesis of Mn 3 O 4 nanoparticles-decorated TiO 2 nanotube arrays as high performance electrode for supercapacitors, Journal of Solid State Chemistry, 246, 2017,

Ngày tải lên: 25/10/2022, 11:22

... (S/N)ofthreetoone.TheMDLsmeasuredforalkanesrangedfrom 0.036␮g L−1 to0.822␮gL−1,forestersfrom0.003␮gL−1 to 0.071␮gL−1,foraldehydesfrom0.050␮gL−1to2.89␮gL−1, forketonesfrom0.145␮gL−1to11.9␮gL−1,forlactonesfrom ... com-poundsforgroups2and3.Forreasonsofcostandefficiency,we usedatemperatureof10◦CforthePTV(Fig.7) 3.1.4 Sampletemperatureandextractiontime Theeffectofthesampletemperaturewasevaluatedfor tem-peraturesbetween30and80◦Cusingthedescribedexperimental ... accordingtothesupplier’srecommendations(270◦Cfor60min) ACMandyoghurtsampleswerenotconditionedforthis experi-ment.Thesampleheadspacewasextractedfor30minat55◦Cwith anagitationrateof250rpm.Theboundvolatilesweredesorbedfor 60sat240◦Cintheinjector,whichwasinthesplitlessmodefor60s

Ngày tải lên: 25/12/2022, 00:42

... this paper, a micro- solid-phase extraction system (μ-SPE) for clean-up was combined with a robotic autosampler to yield ready-to-analyze extracts The system was evaluated for its applicability ... liquid-liquid extraction (LLE) [5], gel permeation chromatography (GPC) [14], solid phase microextraction (SPME) [24], and matrix solid phase dispersion [12], have been explored, and some have been successfully ... recent years, much effort has been devoted to eliminate these drawbacks This has led to the development of robotic auto- mated techniques Currently, an automated micro-solid phase ex- traction

Ngày tải lên: 25/12/2022, 02:42

... varies with the derivative: C11H23 for dilauroyl (1,3lb1) C13H27 for dimyristoyl (1,3lb2) C15H31 for dipalmitoyl (1,3lb3) C17H35 for distearoyl (1,3lb4) C17H31 for dioleoyl (1,3lb5) Fig 1 Structure ... is equal to 1 for a univalent base (and -1 for a monoprotic acid) The pKa values listed in Table 1 for the bivalent lipids are the mean of two acid dissociation constants, one for each of the ... with a dp ⁄ dAcvalue of 1 mNÆm)1ÆA˚)2 Phase-transition temperature studies DPH (1,6-diphenyl-1,3,5-hexatriene) was used to probe for cationic lipid bilayer phase changes by monitoring the depolarization

Ngày tải lên: 23/03/2014, 07:20

... and assumes no responsibility for any errors or omissions No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein This ... and assumes no responsibility for any errors or omissions No liability is assumed for incidental or consequential damages in connection with or arising out of information contained in this book ... C ONGRESS C ATALOGING - IN -P UBLICATION D ATA Chemical reactions in gas, liquid, and solid phases : synthesis, properties, and application / editors, G.E Zaikov, R.M Kozlowski p cm Includes

Ngày tải lên: 28/03/2014, 10:20

... level in terms of their pore texture (for example mesopore carbon) and at the macroscopic level in terms of their form (for example microsphere) The examples are supports produced from ordered mesoporous ... level in terms of their pore texture (for examplemesopore carbon) and at the macroscopic level in terms of theirform (for example microsphere) The examples are supportsproduced from ordered mesoporous ... PC-II (unlike PC-I), no melting occursbefore precursor decomposition; as a result, the carbon networkforms through solid-state reactions, resulting in macroporeformation [72] Finally, the SEM of the

Ngày tải lên: 23/04/2014, 22:32

... catalysts for oxidation and reduction will befeatured and, of equal importance, the use of preferred catalysts for carbon±carbon bond formation will be described In the first phase, therefore, thisseries ... 0-471-98123-0 Trang 3Catalysts for Fine Chemical Synthesis Volume 3Edited by Eric Derouane University of Liverpool, UK ISBN 0 471 49054 7 Trang 4Catalysts for FineChemical Synthesis Volume 1 Hydrolysis, ... Trang 2Catalysts for FineChemical Synthesis Volume 1 Catalysts for Fine Chemical Synthesis: Hydrolysis, Oxidation and Reduction Volume 1 Edited by

Ngày tải lên: 09/05/2014, 17:00

... going through the substrate layer Different profiles for the air-inlet tem-perature and flow rate can be elaborated and generate useful information for the scaling-up studies Trang 3Fig 2 Photography ... line, (6) rollers, (7) rotating drum, (8) solid medium, (9) rim. Trang 4Fig 4 Perforated drum bioreactor.Another concept, based on continuous agitation of the solid medium, was developed by several ... and the solid medium and also to provide oxygen to the micro-organism For rotating drum bioreactors, as an horizontal cylinder, the mixing is pro-vided by the tumbling motion of the solid medium

Ngày tải lên: 12/06/2014, 11:37

... the phase of the transmitted symbols conveys (part of) the information of a coherent transmission, the carrier phase must be known to the receiver before the recovery of the transmitted information ... iteration) 10−4 10−3 10−2 10−1 10 0 Eb /N0 Phase-based A Phase-based B Symbol-based Soft decision Hard decision Pilot only Perfect phase Figure 2: BER performance for uncoded setup ( σ2=2◦, QPSK, 5% ... Trang 910−4 10−3 10−2 10−1 10 0 Eb /N0 Phase-based A Phase-based B Symbol-based Soft decision Hard decision Pilot only Perfect phase Figure 3: BER performance for coded setup ( σ2=2◦, QPSK, 5% pilots)

Ngày tải lên: 21/06/2014, 23:20

... University, August 2010, Solid- Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids Major Professor: Martin J 9^/NMMEKl, Ph.D A novel route has been developed for the solid- phase synthesis of Ncarboxyalkyl ... %-Halocarbonyl CNLONSMDQZZZZZZZZZZZZZZZZZZZZ'''13 1.3 Examples of Solid- Phase Synthesis of Substituted AminesZZZZZZ'ZZZ.18 1.3.1 Solid- Phase Synthesis of ACE Inhibitors with %-Ketocarbonyl Compounds ... solution -phase chemistry The utilization of solidphase methods and combinatorial chemistry for the synthesis of amino acid derivatives has become an important methodology since the beginnings of solid- phase...

Ngày tải lên: 24/08/2014, 13:46

... Ph Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis ... Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin 1.2 ... the solid support, and should provide a means for their chemical attachment and cleavage • Stability of the linker affects the scope of the chemistry that can be employed in the library synthesis...

Ngày tải lên: 17/04/2015, 09:11

... Wiley-Interscience: New York, 1998 Lednicer et al The Organic Chemistry of Drug Synthesis; Wiley-Interscience: New York, 1977 Ellman’s solid- phase synthesis of 1,4-benzodiazepines Ưu điểm Tổng hợp Pha rắn? Không ... hóa trình tổng hợp TỔNG HỢP PHA RẮN TỔNG HỢP PHA RẮN SOLID PHASE SYNTHESIS • The scale SPS is limited and restricted by the amount of the solid support and its loading capacity • The preparation ... PEG-polystyrene graft supports X= OH or NH2 Polystyrene-Polyethyleneglycol graft (TentaGel) Drawbacks that limit the use of TentaGel resin as a universal support for solid- phase chemistry: The...

Ngày tải lên: 12/10/2016, 14:11

... separated, so this technique can be used for solution as well as solid phase synthesis diversification reaction divide diversification reaction Split-pool Synthesis • Optimization of reactions leads ... β-elimination of resin-bound leaving groups has been used as a cleavage strategy for the release of alkenes from supports Preparation of Alkenes by β-Elimination Preparation of Alkenes by β-Elimination ... of Alkenes by C-Vinylation The Heck, Stille, and Suzuki couplings Synthesis of tetrahydroisoquinolines Parallel Library Synthesis • Optimization of 12 reactions provides compounds • The library...

Ngày tải lên: 17/04/2015, 08:58