structural noncorrespondence in translation

... spontaneous insertion mechan-ism involve binding of the intermediate-size protein to the membrane, after which both hydrophobic domains (one in the signal peptide, the other in the mature protein) insert ...
signal peptides, containing three distinct domains: an N-terminal charged region (N-domain), hydrophobic core region (H-domain) and more polar carboxyterminal region (C-domain) ending with an Ala-Xaa-Ala ... membrane involves targeting determinants located in the mature protein, and this has been experi-mentally confirmed for one thylakoid protein, the major light-harvesting chlorophyll-binding protein,

Ngày tải lên: 18/03/2014, 01:20

... three distinct catalytic site structures in the Trang 3sulfate-bound form, including one containing a novelmetal binding site Furthermore, they show structural heterogeneity in their inhibitor-bound ... site involving a His residue at position ‘0’ (i.e immediately preceding the natural initiator Met within the tail downstream of the thrombin cleavage site in the N-terminal extension containing ... contains an eightfold b⁄ a barrel domain preceded by an N-terminal a + b domain [6] The catalytic site is contained completely within a single subunit and lies at the interface of the two domains:

Ngày tải lên: 23/03/2014, 07:20

... the use of SFs in the current period The main areas of direct and indirect health investment indicated in the NSRFs and OPs for 2007– 13 include health infrastructure, e-health, inpatient care, ... employment regions Looking in more detail at the findings shown in Figure 1, the health services category includes inpatient, outpatient, emergency and primary care services Investments in these areas ... be supported by adapting the workforce and by investing in human resources In the EU-27, a total of 168 regions will be eligible, representing 314 million inhabitants Within these, 13 regions

Ngày tải lên: 23/03/2014, 08:21

... economics infused into other subjects Teacher knowledge of economics and teacher training in economics enhance student learning Instructional materials that reflect accurate economics content and incorporate ... schools in California (approximately 1000) were invited to participate in the assessment project, conducted in fall 2006 In order to introduce strong controls into the data, the only teachers included ... economics training is surprising but is broadly consistent with the finding of Harris and Sass (2007) described earlier, regarding the negative effects of teachers’ undergraduate math training on their

Ngày tải lên: 23/03/2014, 20:20

... the initiation process To function in cap-dependent translation initiation, eIF4E must form initiation complexes involving the scaffold protein eIF4G and its other binding partners, which include ... MAP kinase pathway (which leads to eIF4E phosphorylation) is known to regulate mRNA binding proteins involved in modulating the stability or translation of, e.g cytokine mRNAs [72] This kind of ... N-terminus of eIF4G, and the Mnks, which bind to the C-terminus of eIF4G A central domain in eIF4G binds eIF3, which will bring in the 40S small ribosomal subunit and consequently eIF2 withthe initiator

Ngày tải lên: 23/03/2014, 21:20

... 1.4 INTERLINGUAL TRANSLATION Just as it is possible to have intralingual gist and exegetic translation, so it is possible to have interlingual translation (i.e translation proper) which involves ... Explain the main textual changes you made (Do this by inserting into your TI a superscript note-number after each point you intend to discuss, and then discussing these points in order, starting ... sorts of translation problem is accompanied with plenty of practice in developing a rationale for solving them It is a course not in translation theory, but in translation method, encouraging thoughtful

Ngày tải lên: 03/04/2014, 12:45

... Lecturer and Head of Translation and Interpreting Studies Thinking Chinese Translation Trang 3Thinking Arabic TranslationA course in translation method: Arabic to English James Dickins, Sándor Hervey ... Ian Higgins Thinking German Translation A course in translation method: German to English Sándor Hervey, Ian Higgins and Michael Loughridge Thinking Italian Translation A course in translation ... hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. British Library Cataloguing in Publication

Ngày tải lên: 03/04/2014, 13:38

... j=1Aj− In and Γj =−Pp i=j+1Ai This representation can be used to define cointegration in a VAR system DEFINITION 1.1 (Cointegration) A VAR[p] system as defined in Assumption 1.1 is called cointegrated ... transformation Davidson (1998) provides coin-a progrcoin-am thcoin-at coin-allows to determine the irreducible cointegrcoin-ation vectors from coin-anestimated cointegration matrix Whenever the long ... 4 Inference in nonlinear models 129 4.1 Inconsistency of linear cointegration tests 132 4.2 Rank tests for unit roots 136 4.3 A rank test for neglected nonlinearity 144 4.4 Nonlinear

Ngày tải lên: 08/04/2014, 12:06

... sites that have related functions in the translated protein begin end begin end calmodulin binding plasma membrane binding calmodulin binding plasma membrane binding NC-GagTF cleavage Gag-Pol Table ... strings (mIMRs) Using symmetry criteria of ≥ 50% and discounting strings completely contained within other strings, the longest mIMRs in TnsA were found to coincide with key structural domains ... in Table 6 The mIMRs included in the test are all ≥58 nt and often span more than a single protein structural element The rdIMRs included in the test are all ≥15 nt Both mIMRs and rdIMRs begin

Ngày tải lên: 18/06/2014, 18:20

... approaches are broader and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or other catabolic factors Interleukin-1β For specific inhibition of the production/activity ... mitogen-activated protein kinase superfamily is composed of at least three main and distinct signalling pathways: the extracellular signal-regulated protein kinases, the c-Jun amino-terminal kinases or stress-activated ... glucosamine sulphate The long-term combined structure-modifying and symptom-modifying effects of glucosamine sulphate suggest that it could be used as a disease-modifying agent in OA These findings

Ngày tải lên: 09/08/2014, 07:20

... the outer ring The blue line indicates changes in copy number as determined by read coverage density Intra-(green) and inter-chromosomal (purple) rearrangements are shown by lines within the circle ... code for any known protein domains, and all exons of Rnf217, which contains an abrogated zinc finger domain (IBR-ZNF) with a car-boxy-terminal transmembrane domain, are joined together The largest ... confirming the fusion at the RNA level A schematic representation of the putative fusion gene product IBR-ZNF, in between ring fingers-zinc finger domain PF01485; TM, transmembrane domain - predicted

Ngày tải lên: 09/08/2014, 22:23

... the termination signals that promotes NMD recognition of a stop codon in yeast is inefficient translation termina-tion [34] A key feature in determining efficiency of translation termination ... determining the 5′ boundary of the RSE, we inserted stop codons into the RSE and forced read-through of the gag termination codon by inserting a sin-gle nucleotide to shift the ribosome into the ... spacing of sub-elements within and flanking the RSE are important for maintaining function This sug-gests that truncation of the RSE, as was done in Figure 1, may be limited in its utility in

Ngày tải lên: 13/08/2014, 01:20

... Trang 7Single residue and mini-region mapping of the eighteen amino acid differences in the critical N-terminal region of HuPAR2 for binding and infection Figure 4 Single residue and mini-region ... 14/ 220* infection Thus, the N-terminal 135 amino acids are critical for PERV-A infection Six structural regions in HuPAR2 impact PERV-A infection but only one alters PERV-A binding Within the ... envelope binding These results demon-strate that the increased viral entry function of HuPAR2 for PERV-A 14/220* infection is not due to an increase in virus binding Trang 5N-terminal 135 amino acids

Ngày tải lên: 13/08/2014, 05:21

... report in England to illustrate: Lord Denning spoke against the artificial insemination of women in the House of Lord  In the speech presented in the House of Lord, Lord Denning spoke against ... sentence in syntax lead to structural ambiguity In the viewpoint of Cann, R (1993:9), if a single grammatical string of words can be interpreted into at least two syntactic structures, structural ... identical in pronunciation air and heir c) Homographs are one identical in spelling wind /wind/ (n): a current of air and wind /wind/ (v): to empower a clock Sources of homonymy In the viewpoint

Ngày tải lên: 02/03/2015, 14:32

... specializing in listing these kinds of headlines from various online newspapers For example, the web http://www.fun-with-words.com/ambiguous_headlines.html, http://www.squidoo.com/funniest-headlines, ... The distinctive features of electronic newspapers headlines will also be described briefly so as to give guidelines for analyzing lexical and structural ambiguity in humorous headlines During the ... newspapers headlines? 3 How is lexical ambiguity exploited in humorous headlines in English electronic newspapers? 4 How is structural ambiguity exploited in humorous headlines in English electronic

Ngày tải lên: 10/08/2015, 19:51

... mechano-transduction, a collection of “hub” proteins, such as, α-synuclein, p53, 14-3-3, AXIN, are indispensible proteins which bind to a number of other proteins via protein-protein interactions [204-207] When they ... POODLE [117-120], machine learning algorithms including neural networks (NN) and support vector machines (SVMs) are used as the basic methods The input features used in training these algorithms ... applied to the problem of identifying the specific regions that exhibit intrinsic disorder, which are becoming more helpful in working with intrinsic disordered proteins Trang 18Nuclear Magnetic Resonance

Ngày tải lên: 09/09/2015, 10:14

... 17Chapter 2 – BACKGROUND In this chapter, I will introduce some concepts in CNV/ROH analysis, including definitions and introduction to existing technology, software and algorithms in detection of ... that fall in each pre-specified window of a certain size (Abyzov et al., 2011; Yoon et al., 2009) The underlying concept of identifying CNVs using DOC is similar is that of using intensity ... Next-generation sequencing arrays that produce billions of reads in a single run The technologies to study genetics have certainly evolved very rapidly, bringing with it new challenges in terms of statistical

Ngày tải lên: 09/09/2015, 10:14

... repair to the originally intend-ed well-formintend-ed string In the absence of a grammar, there is inherent guity in what the creator intended For example, consider the string <name> ambi-E ... theoriginal intent was Furthermore, such ambiguities compound in larger strings,resulting in an explosive number of reasonable possibilities Since the user mayhave a (often ill-defined) grammar in ... validation,assuming the input is already well-formed Our work fits into the context of data cleaning to satisfy database integrityconstraints, including consistency under functional dependencies [16],inclusion

Ngày tải lên: 09/09/2015, 11:24

... Trang 1Exploiting Structural Constraintsin Image Pairs by Lin Wen Yan, Daniel A thesis submitted in partial fulfillment for a PhD dgree in Engineering in the Faculty of Engineering Department ... data compression, in which the information in a large collection of images is summarized within a single compact model, thussummarizing the information contained in multiple images into a form that ... correspond in a point to point fashion and are usuallynot incorporated into traditional camera pose recovery modules This work waspublished in [58] 1.2 Mosaicing Mosaicing is the process of integrating

Ngày tải lên: 11/09/2015, 09:08

... lưỡi gà) 4.1.6 Translating by using a paraphrase Translation by paraphrasing is another of the possible ways in coping with problematic items in translation. When using it the translator has ... Vietnamese is individualism. In some cultures, individualism is seen as a blessing and a source of well-being; in others, it is seen as alienating. In his publication, Hofstede exhibits 'Individualism ... difficulties in translation. The main disadvantage of this strategy is that it usually involves replacing one item with an explanation consisting of several items. Thus a striking disproportion in length...

Ngày tải lên: 10/04/2013, 10:37