significance of the study in research paper example

... signaling and adaptor proteins.ECM binding initiates clustering of integrins in the plane of the membrane andreorganization of the actin cytoskeleton, which further stimulates the organization ofintegrins ... regulated in patients with Kindler syndrome, an autosomal recessive skin disorder.They therefore defined a family of kindlin-related proteins namely Kindlin-1, Kindlin-2 (mig-2) and Kindlin-3 (Siegel ... against different drugs in 4 cell lines A) One-Step RT-PCR showing the expression status of mig-2 in the 4 cell lines B) The absolute value oflogGI50 of anticancer drugs against these 4 cell lines,

Ngày tải lên: 05/10/2015, 22:15

... a factor influencing extent of resection in IDH-mut astrocytomas To our knowledge, this is the first study investigating the clinical factors and extent of re-section in relation to the mismatch ... on MRI examinations Areas attributed to mainly edema without convincing signs of tumor invasion were excluded In the gliomas with T2-FLAIR mismatch sign we used the outer margin of the peripheral ... le-sions) The rationale for “blindly” including these pa-tients was to enable the evaluation of the mismatch sign in a group with rather similar MRI appearance, but also differential diagnoses of LGG,

Ngày tải lên: 30/05/2020, 21:50

... differences in the detection rate of LVI could be due to variations in the detection methods The use of H & E staining, an elastic fiber stain and immunostaining are currently ac-cepted methods in the ... have investigated the prognostic sig-nificance of LVI in relation to GC in small selected co-horts The results of these studies indicated that the presence of LVI, either in the blood or lymphatics, ... system of GC as stated in the NCCN Guidelines for Gastric Cancer of 2013 [21] In this large-scale retrospective study, through the use of H & E staining, LVI was determined to be present in resected

Ngày tải lên: 30/09/2020, 10:45

... BCLXL [15] The formation of heterodimers be-tween BAX and other members of the BCL2 family is in-volved in the regulation of apoptosis [16,17] The high importance of BAX for the control of apoptotic ... variety of tumors can arise in the nasopharynx, the most common being the nasopharyngeal carcinoma (NPC) NPC belongs to the family of lymphoepithelial carcinomas; these morphologically distinctive ... mixture containing 2 μg of total RNA, following the manufacturer’s instructions Quantitative real-time PCR Since the four coding splice variants of the BAX gene encode proapoptotic protein isoforms,

Ngày tải lên: 05/11/2020, 06:43

... rewarding for elu-cidating the ‘yin-yang’ role of these factors in breast cancer As DC-SCRIPT can inhibit ERa and PR activity, a sec-ond aim of the study was to address whether DC-SCRIPT affects the ... therapy The significant relationships ofDC-SCRIPT as a continuous variable in these univariate analyses justified the use of the previously identified cut point that dichotomized the cohort in ... 2000 The study was performed in accor-dance with the Code of Conduct of the Federation of Medical Scientific Societies in The Netherlands [10], and consent was not required Wherever possible, the

Ngày tải lên: 02/11/2022, 09:03

... but in line with others [33] This difference between our study and others could result from differences in the EMG recording technique or in the sharpness of the between-groups weight matching In ... that, in OSAS patients studied awake, the MEPgg latency was inversely correlated with the AHI In other words, the more severe was the OSAS and hence the instability of the upper airway, the more ... Cz-AL-TMS in the OSAS patients, but not in the nor-mal individuals In both groups the amplitudes of the MEPgg in response to AL-TMS and Cz-TMS increased dur-ing tongue protraction in comparison

Ngày tải lên: 12/08/2014, 14:20

... number of transduced cells Interestingly, the increase of the number of positively transduced cells was not proportional to the increase of the vector inoculum volume The increase in the number of ... "infec-tious unit" refers to the smallest amount of virus capable of producing an infection in a susceptible cell The titre of the original suspension is defined as the number of infec-tious ... while maintaining the correct relative composition prior to cytokinesis [27] Theoreti-cally, during the intermitotic period the target cells will double the number of target binding sites for the

Ngày tải lên: 14/08/2014, 19:22

... DUONG The thesis was defended at the Council of Military Medical Academy Trang 3Due to the above issues, we implemented the study "The study in applicationof laparoscopic abdominoperineal ... ACADEMY PHAM VAN BINH THE STUDY IN APPLICATION OF LAPAROSCOPIC ABDOMINOPERINEAL RESECTION FOR TREATMENT OF LOW RECTAL CANCER Speciality: Gastrointestinal surgery Code: 62 72 01 25 Ph.D THESIS ABSTRACT ... application in rectal cancer surgery 1.1.1 Anatomical landmarks: The rectum is the last segment of the gastrointestinal tract connecting with sigmoid colon at the third sacral vertebra and ending at the

Ngày tải lên: 10/10/2014, 23:25

... Identification of RhoGDIα binding regions in the intracellular domain of pleinx-B3 120 3.4.3 Identification of fascin-1 binding regions in the intracellular domain of plexin-B3 122 3.4.4 Identification of ... vinculin, and ERM (ezrin, radixin, moesin) actin-binding proteins, act as linker proteins to connect the cytoplasmic domains of integrins to the cytoskeleton, resulting in complex interactions In ... Further, antibody clusteringof the recombinant cytoplasmic domain of plexin-B1 also triggers the activation of plexin-B1 (Oinuma et al., 2004b) Interestingly, the extracellulardomains of plexin

Ngày tải lên: 11/09/2015, 09:11

... of secondary flow in the form of a pair of counter rotating Trang 6vortices in the stream wise direction in both the laminar and turbulent regime But the differences lie in the magnitude of the ... and inside walls of the curved duct resulting in the formation of secondary flow The description in the previous sections for swirling flow in a single bend also occurs in the first bend of an ... developed velocity profile is maintained at the inlet At the bend inlet, the velocity profile shows a velocity maximum that is closer to the outer wall of the bend The opposite occurs for the turbulent

Ngày tải lên: 14/09/2015, 08:37

... from the side and the top The coordinate system used in this experiment is shown in Fig 2.3 and its origin is at the center of the inlet plane of the S-duct, with the positive s-coordinate pointing ... wall of the first bend of the S-duct to show and observe the presence of flow separation Fig 2.8(a) shows the approximate location of the three smoke wires in the first bend of the S-duct The ... could be inserted into the wind tunnel A diffuser was installed downstream of the test section and it is 2000 mm in length, with a half angle of 3.5O and an area ratio of 5.585 The exit of the diffuser

Ngày tải lên: 14/09/2015, 08:37

... to a change in the sign of the radial pressure gradient Similar to the cases for the flow in a single 90O bend, the advantage of presenting data in such a manner is that the scatter in C P variation ... O ) instead of side wall C P with (s/S O ) since the scatter in the C P data as depicted in the latter figures is significantly reduced (and in the earlier part of the flow (s/S O<0.6), the ... between the side walls The magnitude of these two forces within the duct is dependent on the curvature of the duct For example, in a curved duct of a sharper bend (or smaller curvature ratio), the

Ngày tải lên: 14/09/2015, 08:37

... in the flow model that the flow develops a swirl (in Region A) after passing through the first bend of the S-duct, while in the second bend of the duct, the swirl of the opposite direction (in ... upstream of C (in the first bend of the S-duct), the flow carries the smoke in an upward trajectory away from the bottom wall However, upon entering the second bend and crossing the dividing line ... those in the core Furthermore, the normalized cross flow vector plots showed generally that in the central region of the duct, the main bulk of the cross flow is from the far-side wall to the near-side

Ngày tải lên: 14/09/2015, 08:37

... features of the swirl development are reflected accurately in the multiple plane measurements These features include the generation of the initial swirl in the first bend of the S-duct, the production ... gradients of ∂u/∂z produced in the vicinity of the inflection plane of the S-duct, close to the near-side wall The subsequent growth of stream-wise vortices of different configurations in the second ... increases the swirl magnitude as compared to that at a thinner boundary layer of 0.05D Hence one of the effects of increasing inlet boundary layer thickness is to increase the swirl magnitude in the

Ngày tải lên: 14/09/2015, 08:37

... indicated in Fig 6.1(b) Also shown in Fig 6.1(b) is the coordinate system used in this experiment Its origin is at the center of the inlet plane of the S-duct, with the positive s-coordinate pointing ... blowing of VG jet into the Trang 7first bend of the S-duct The increased momentum that enters the S-duct transversely interacts with (or disrupts) the main flow and decreases the kinetic energy in ... around the four surrounding walls as compared to the core region In addition, the corresponding normalized cross flow velocity plots showed that, in the central region of the duct, the main bulk of

Ngày tải lên: 14/09/2015, 08:37

... aătr ngă i h c Kinh t Tp HCM hay Ch ng trình Gi ng d y Kinh t Fulbright Tác gi lu n v n Nguy n Xuân Vinh Trang 3L I CÁMă N Tôi xin chân thành c m năCh ngătrìnhăGi ng d y Kinh t Fulbrightăđƣăcóănh ... ra theo ngành ngh 44 Ph l că10.ăPh ngăphápăti p c n thông tin v giá 45 Ph l că11.ăPh ngăphápăti p c n thông tin v v n h giaăđình 45 Ph l c 12 T l h giaăđìnhăphơnătheoăcácălo i t năth ngătheoăngh ... khung phân tích sinh k b n v ng c a C c phát tri n qu c t , V ngăqu c Anh (DFID) Theo DFID “Sinh k bao g m các kh n ng, tài s n và các ho t đ ng c n thi t nh m ph c v sinh s ng Sinh k b n v ng

Ngày tải lên: 09/10/2015, 14:27

... that females gain indirect genetic benefits as a result of their mate choice In conclusion, the findings in this thesis support the hypotheses that UV-reflecting ornamentations in C umbratica ... is important in intraspecific interactions in this species For instance, in male-male interactions, UV reflectance may have a role in indicating the resource holding potential (RHP) of C umbratica ... and each of the two individuals randomly assigned to one of the two male display chambers to eliminate the possibility of any side bias None of the spiders were used more than once in these mate

Ngày tải lên: 16/10/2015, 12:00

... Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy ... determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, ... and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government The National Academy of Engineering also sponsors engineering

Ngày tải lên: 04/04/2017, 08:51

... paper are integrated producers of the writing and printing paper. By calculating the average of the three Brazilian companies and comparing with the international Paper performance, the Brazilian ... empirical study on the innovation efforts are contradictory. On the other hand, we can explain it through the hypothesis that the TNCs locate in Brazil just the initial phases of their R&D ... sector FDI; the role of the TNC affiliate into the technological network of the TNC; the modality of the FDI; the technological gap between the TNC affiliates and the local firms; the domestic...

Ngày tải lên: 22/02/2014, 09:20

... analyzed to gain insight into the “complexity” of the plan, including the plan sponsor’s number of business locations, the number of payrolls and the method of submitting payrolls. This information ... by their primary line of business and their platforms of investment options may include investment products from other business lines within the company or from other companies. Recordkeeping ... observed in the 2009 Fee Study, which was 0.86% of assets (Exhibit 2). There are a number of factors that may contribute to the decline in the ‘all -in fee between the 2009 Fee Study and the study...

Ngày tải lên: 07/03/2014, 13:20