selected examples in connection with obesity and related disorders

... associated with reduced glucose tolerance and insulin sensitivity To determine the role of ApoE in the development of obesity- associated insulin resistance and glucose intolerance, we performed the standard ... leptin levels Insulin and leptin levels in the plasma of mice were determined spectrophotometrically by ELISA (Linco/Millipore, ApoE and obesity Billerica, MA, USA; cat no EZRMI-13K for insulin, ... link between obesity and hypertension in individuals with the metabolic syndrome [39,40] To determine whether the obesity observed in ApoE3knock -in and C57BL/6 mice is associated with FEBS Journal...

Ngày tải lên: 17/03/2014, 17:20

... tolerance and insulin sensitivity of the ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and obesity- related metabolic disorders ... observed in nonobese men [60], whereas the association between ApoE4 phenotype and insulin and glucose levels became stronger with increasing body mass index [60,61] These findings again raise the interesting ... triglycerides and fatty acids in the infected cells This finding is in agreement with a study by Zechner et al [40] who showed that ApoE expression in differentiating 3T3-L1 cells increases linearly with...

Ngày tải lên: 29/03/2014, 22:21

... with an increase in measurement after intervention for each measurement method, the subject numbers with this increase and patients with difficulty in achieving the standardised position in the ... methods of defining and diagnosing lymphoedema within the various studies A recent study by Bulley et al (2013a) examined different methods of measuring and classifying lymphoedema in order to ... valid and reliable method of measuring hand size in patients with hand oedema associated with BCRL This was investigated by comparing the figure of eight tape method of measurement against the...

Ngày tải lên: 22/12/2014, 21:42

Ngày tải lên: 13/02/2014, 12:20

... ANGPTLs in obesity and related metabolic diseases T Kadomatsu et al characterized by a coiled-coil domain in the N-terminus and a fibrinogen-like domain in the C-terminus Angiopoietins have a ... in ammation of adipose tissue in obesity and related insulin resistance [15] Here, we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ... concentration in the circulation is also upregulated in obesity (particularly visceral obesity) and correlated with the levels of systemic insulin resistance and in ammation [15] Circulating ANGPTL2...

Ngày tải lên: 14/02/2014, 22:20

... [14–19] In this minireview, we discuss the link between obesity and ED by focusing on the potential pathophysiological links including obesity- related androgen deficiency and obesity- induced endothelial ... contribute directly to ED in obesity presented in the literature regarding obesity and ED, and as discussed in this minireview, strongly suggests a link between obesity and ED This link is supported by ... hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52, 355–361 Wannamethee SG, Shaper AG, Morris RW & Whincup PH (2005) Measures of adiposity in the identification...

Ngày tải lên: 18/02/2014, 06:20

... equilibrated with buffer A containing 10 mM imidazole and 300 mM KCl After washing the column with buffer A containing 10 mM imidazole and 300 mM KCl, the enzyme was eluted with buffer A containing 50–100 ... (green) and K+ (cyan) are shown in ball-andstick models Cobalamin, pink (B) Residues hydrogen-bonded to cobalamin The residues interacting with cobalamin from distances ˚ ˚ shorter by 0.1 A and longer ... dehydratase [9] In addition, aG and bG are longer by one amino acid than aD in the N-terminal and by three than bD in the C-terminal, respectively In the final structure, all residues of the a chain (Met1–Glu555),...

Ngày tải lên: 21/02/2014, 03:20

... psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders This demand is driven by the sheer ... Dementia and When to Perform PET Linda M Ercoli and Gary W Small Clinical Interpretation of Brain PET Scans: Performing Visual Assessments, Providing Quantifying Data, and Generating Integrated ... assist with analysis, and then illustrates a straightforward approach for integrating the qualitative and quantitative findings in meaningful interpretations An Atlas in the final section of this...

Ngày tải lên: 05/03/2014, 23:20

... unbound RepA and RepA bound to either 1IR (as a dimer with both DNA-binding domains involved in binding), or 1DR-short (as a dimer, but presumably with only one domain involved), or indeed when ... in a binding stoichiometry of : 1, i.e dimer binding The reactant concentrations were too high to obtain relevant information on the binding afnity For binding to 1DR, the best t yielded a binding ... binding stoichiometry of $ : 1, i.e monomer binding, with a Kd between 0.2 and 0.6 lm With 1DR-short, a reliable estimate for the stoichiometry of binding could not be made Assuming binding as...

Ngày tải lên: 07/03/2014, 04:20

... the brain, and to study brain diseases including relevant age related illness and search for new therapies The overall aim is to gain a global understanding of the brain by exploring brain functions, ... knowledge into clinical applications including disease control and treatment, and to ensure that clinical (including epidemiological) data guide further research 2.1 INTEGRATING BIOLOGICAL DATA AND ... ON THE BRAIN AND RELATED DISEASES, HUMAN DEVELOPMENT AND AGEING 2.2.1 Brain and brain -related diseases The objectives of this area are to better understand the integrated structure and dynamics...

Ngày tải lên: 07/03/2014, 04:20

... phenomenon in international business transactions, including trade and investment, raising serious moral and political concerns, undermining good governance and sustainable economic development, and ... and meaningful steps in conformity with its jurisdictional and other basic legal principles to examine or further examine the following areas: i) awareness-raising initiatives in the public and ... ethics and compliance are in line with the following principles and are fully used in order to prevent and detect bribery of foreign public officials in international business, according to their...

Ngày tải lên: 23/03/2014, 02:20

... was no inhibition with 10 mm NaCl, the Tris and the calcium ions are the inhibiting species Comparison with ligand binding in Tr_Cel7A To date, five structures have been published for the related ... for binding in the product sites are conserved in C, E and F, but not in A and B isozymes Arg240 is replaced by Ser (in A) or Ala (in B), while Asp336 is replaced by Glu (in A) or Gly (in B) ... The glucosyl unit in the +1 site continues to make good stacking interactions with Trp373, although it now lies more directly against the six-membered ring of the indole O2 maintains the hydrogen...

Ngày tải lên: 23/03/2014, 13:20

... strengthened included tourism, trade and investment, information and communication technology and population and migration In line with the current inter-agency coordination mechanism mandated by ... Scientific and Cultural Organization prepared jointly a report entitled “Investing better in order to invest more: finance and management of education in Latin America and the Caribbean”, which examines ... inequality, which is increasing within and among countries in most regions, with Latin America being the most unequal region in the world, is also becoming a matter of major concern Sustainable development...

Ngày tải lên: 23/03/2014, 21:20

... reduced drinking and other nondrinking related activities Importantly, skills training also has been shown to be an effective intervention for improving functioning in SPMI clients, and behavioral ... scores This list included social skills training (2nd highest rating in the 1995 review and 3rd highest rating in the 1998 review); behavioral contracting (ranked 5th and 7th in 1995 and 1998 respectively); ... skills training; chapter considers education and coping skills training; chapter 10 discusses relapse prevention and problem solving; and chapter 11 covers graduation and termination Part III includes...

Ngày tải lên: 29/03/2014, 00:20

... expression of multiple proteins regulating insulin sensitivity, including the insulin-dependent glucose transporter GLUT4 and the insulin-sensitizing hormone, adiponectin [13] Indeed, two recent studies ... of the depot [5] In rodents, BAT is mainly concentrated within the interscapular regions throughout adult life, whereas, in humans, it exists within these regions during fetal and neonatal periods ... is mainly divided into two groups with distinct functions: subcutaneous (buttocks, thighs and abdomen) and intra-abdominal ⁄ visceral fat (omentum, intestines and perirenal areas) [5] Each of...

Ngày tải lên: 29/03/2014, 22:21

... those with effects unrelated to metabolism These include the adipocyte-specific proteins adiponectin and leptin, the in ammatory chemokines tumor necrosis factor-a (TNFa) and an array of interleukins, ... associated with adipose expansion and obesity Rich in vasculogenic and proinflammatory adipokines, adipose tissue serves as an intriguing model system for understanding the contributory molecules in angiogenesis ... of WAT results in hypoxia and increased levels of HIF-1a that, in turn, lead to an up-regulation of the in ammatory adipokines interleukin-6, TNFa and monocyte chemotactic protein-1, amongst others...

Ngày tải lên: 29/03/2014, 22:21

... due to the accepting handling of my disease, I have got a better understanding to deal with the troubles in life K16 know that I have to live with my disease and have to care each and every to prevent ... 0.598) With respect to the adaptive coping styles, we found a strong correlation between "Conscious Dealing with Illness" and "Conscious and Healthy Living" (r = 0.696) and with "Perspectives and ... Contentedness and Well-Being Conscious Dealing with Illness Rejection of an Irrational Dealing with Disease Disease Acceptance Conscious Dealing with Illness Rejection of an Irrational Dealing with Disease...

Ngày tải lên: 18/06/2014, 22:20

... diabetes) Using the methodology of Cavrini and associates and Sitoh and colleagues [18,19], an ordinal variable for the EQ-5D index was created by categorizing the continuous variable into levels, and ... well when compared with other generic HRQoL and utility-based instruments, including the Health Utilities Index Mark and and SF-6D [26,29] In the present study, no clear trend in the EQ-5D VAS ... Sapin C, Fantino B, Nowicki M, Kind P: Usefulness of EQ-5D in assessing health status in primary care patients with major depressive disorder Health and Quality of Life Outcomes 2004, 2:20 Kind...

Ngày tải lên: 18/06/2014, 22:20

... strain with opticospinal EAE [19, 20] Expressing T cell and B cell receptors specific for MOG, these mice showed inflammatory demyelinating lesions in the optic nerve and spinal cord, sparing ... Co-staining of AQP4-IgG and MOG-IgG antibodies (red) and TCC (green) was investigated in a blinded fashion (SM, KS and VG), and dead cells were visualized by DAPI staining Control experiments using ... cells expressing MOG without EmGFP fusion protein, we cloned MOG into the pCMV vector (Invitrogen) Briefly, after incubating the cells with heat-inactivated samples and active versus inactive complement...

Ngày tải lên: 19/06/2014, 22:20

... Mathematics in Science and Engineering, Academic Press, Boston, Mass, USA, 1992 D S Mitrinovi´ , J E Peˇ ari´ , and A M Fink, Classical and New Inequalities in Analysis, vol 61 of c c c Mathematics and ... following inequality holds Ms,t ≤ Mv,u 3.19 Journal of Inequalities and Applications 17 References D S Mitrinovi´ and J E Peˇ ari´ , “Generalizations of two inequalities of Godunova and Levin,” ... notation Ms,t instead of Ms,t and we replace vi x with ui x , ui x with D∗a ui x , and q x with QD x Remark 2.21 In the case of L∞ fractional derivative, we will use the notation Ms,t instead of...

Ngày tải lên: 21/06/2014, 07:20