regulation of extracellular k concentration

... marketed to investors who are professional clients or who can be treated as professional clients under Directive 2004/39/EC of the European Parliament and of the Council of 21 April 2004 on markets ... legally stable marketing environment for the marketing of European venture capital funds The determination of the essential characteristics of a European venture capital fund, in terms of its portfolio ... contained in the Regulation Article 19 – Sanctions Article 19 contains provisions on sanctions to ensure proper enforcement of the requirements of this Regulation Article 20 – Breach of key provisions

Ngày tải lên: 19/02/2014, 14:20

... activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site Rita Krumscheid1, Ru¨diger Ettrich2, Zofie Sovova´2, Kla´ra Susˇa´nkova´3, Zdeneˇk La´nsky´3, Katerˇina Hofbauerova´3,4, ... extrusion and uptake of Na+and K+ions across plasma membranes of mammalian cells The enzyme is a heterodimer of a 100 kDa catalytic subunit and a heavily glycosylated b subunit of about 55 kDa [1–3] ... the activity of a K+activated phosphatase, which represents a partial function of the ATP site [9–12], was almost unaffected by the blockade of the ATP site due to modification of K501 with fluorescein

Ngày tải lên: 19/02/2014, 16:20

... CA-MKK3CA-MKK4CA-MKK6 CA-MKK3 CA-RhoA CA-Cdc42 CA-MKK4 CA-MKK6 Fig 8 Effects of p38 on CTGF/CCN2 expression (A) Cells were transfected with expression vectors encoding the active forms CA-MKK3, ... kinases (MKK) depending on the cell system studied, although SAP/ERK kinase (SEK/MKK4) acti-vates mostly JNK whereas MKK3 and MKK6 directly activate p38 [31] We further examined the contribution of ... response of the cells The MAP kinase pathway was subdivided into the extracellular-regulated kinase (Erk1/2), the c-Jun N-terminal kinase (JNK) and the 38-kDa MAP kinase (p38) The Erk1/2 pathway

Ngày tải lên: 19/02/2014, 16:20

... 4, 679–689. 2 Keller,T.C.S., III, Higginbotham, M., Kazmierski, S., Kim, K.T. & Velichkova, M (2000) Role of titin in non muscle and smooth muscle cells In Elastic Filaments of the Cell (Granzier, ... Linke, W.A., Ivemeyer, M., Mundel, P., Stockmeier, M.R & Kolmerer, B (1998) Nature of PEVK-titin elasticity in skeletal muscle Proc Natl Acad Sci USA 95, 8052–8057. 18 Linke, W.A., Stockmeier, ... properties of an additional natural component of the thin filament framework, nebulin Nebulin spans the entire length of thin filaments and is capable of modulating the rate of formation of the actin–

Ngày tải lên: 19/02/2014, 16:20

... procedures Lane 88 kDa, RNA from 88 kDa full-length expression; lane 74 kDa, RNA from 74 kDa expression; lane 63 kDa, RNA from 63 kDa expression The relative positions of RNA size markers in kb are indicated ... Lane 88 kDa, RNA from 88 kDa full-length expression; lane 74 kDa, RNA from 74 kDa expression; lane 63 kDa, RNA from 63 kDa expression The relative positions of RNA size markers are shown in kb on ... Translational regulation of iPLA2cin myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcrip-tional and translatranscrip-tional regulation,

Ngày tải lên: 19/02/2014, 16:20

... whole cell extracts of an hst2 deletion yeast strain rather than purified ySir2 Therefore, Fig 3 (A) Known inhibitors of Sir2 deacetylases (B) Examples of known activators of Sir2 deacetylases. ... Phylogenetic classification of prokary-otic and eukaryprokary-otic Sir2-like proteins Biochem Biophys Res Commun 273, 793–798 4 Blander G & Guarente L (2004) The Sir2 family of pro-tein deacetylases ... S, King MT, Zhao P, Kashi-waya Y et al (2003) Sir2 regulates skeletal muscle dif-ferentiation as a potential sensor of the redox state Mol Cell 12, 51–62 17 Picard F, Kurtev M, Chung N, Topark-Ngarm

Ngày tải lên: 20/02/2014, 01:20

... but not PMA-induced up-regulation of TRAF4 was blocked These data suggest that activation of the NF-jB pathway is involved in up-regulation of TRAF4 in T-cells Keywords: IKKc; NF-jB; T-cells; localization; ... kDa), apoferritin (443 kDa), alcohol dehydro-genase (150 kDa), bovine serum albumin (66 kDa), carbonic anhydrase (29 kDa) and cytochrome c (12.4 kDa), all purchased from Sigma (Deisenhofen, Germany) ... The position of protected TRAF4-specific mRNA bands are indicated with an arrow. Trang 10line deficient in expression of IKKc/NEMO [15], anessential component of the NF-jB-inducing IKK complex [22]

Ngày tải lên: 21/02/2014, 15:20

... Trang 1Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins Shotaro Kishikawa1,2, Takehide Murata1, Hiromichi Kimura2, Kunio Shiota2and Kazunari K Yokoyama1 1 ... 1188–1198. 26 Song, J., Murakami, H., Tsutsui, H., Tang, X., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K & Yokoyama, K.K (1998) Genomic organization and expression of a human gene for Myc-associated ... Tsukuba Institute, RIKEN (The Institute of Physical & Chemical Research), 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. Fax: + 81 298 36 9120, Tel.: + 81 298 36 3612, E-mail: kazu@rtc.riken.go.jp

Ngày tải lên: 22/02/2014, 07:20

... promoter region of INO1 and other genes that are part of the INO1 regulon [45] As regulation of phospholipid biosynthesis and degradation are likely to be coordinated, it was of interest to examine ... an obvious key to progress in understanding the structure, mechanism of action, localization, regulation and function of this intriguing enzyme A C K N O W L E D G E M E N T S We thank J Gerst ... 272, 36–39. 17 Ogino, C., Negi, Y., Daiso, H., Kanemasu, M., Kondo, A., Kuroda, S., Tanizawa, K., Shimizu, N & Fukuda, H (2001) Identification of a novel membrane-bound phospholipase D from

Ngày tải lên: 22/02/2014, 07:20

... characterization of theK¨ ahler cone of a compact K¨ ahler manifold By Jean-Pierre Demailly and Mihai Paun Abstract The goal of this work is to give a precise numerical description of theK¨ahler cone of a ... dimension dimCX As is well known, a K¨ ahler metric on X is a smooth real form of type (1, 1): ω(z) = i  1≤j,k≤n ω jk (z)dz j ∧ dz k; that is, ω = ω or equivalently ω jk (z) = ω kj (z), such that (1.1 ... study in great detail the structure of the K¨ahler cone of a compact K¨ahler manifold Recall that by definitionthe K¨ahler cone is the set of cohomology classes of smooth positive definite closed

Ngày tải lên: 05/03/2014, 23:20

... pro-tein tyrosine kinases of the src family J Physiol 492, 445–452 8 Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K & Niki H (1997) Fyn-kinase as a determinant of ethanol sensitivity: ... D101N/Y535F (3) K303R/Y535F (3) D101N/R183K/Y535F(3) D101N/R183K/Y535F C Src Src Y535F (5) R183K/Y535F (6) D101N/Y535F (6) K303R/Y535F (4) D101N/R183K/Y535F (5) Fig 3 Effects of dysfunction of the ... M, Ali MK, Jackson MF, Li H, Lei G, Xue S, Kwan CL, Manolson MF, Yang K transmis-sion by C-terminal Src kinase J Biol Chem 283, 17503–17514 18 Polte TR & Hanks SK (1997) Complexes of focal

Ngày tải lên: 06/03/2014, 01:20

... assistant professor of marketing at Cornell University, 353 Sage Hall, Ithaca, NY 14850 (mkt27@cornell.edu) Kalpesh Kaushik Desai is associate professor of marketing at State University of New York, Binghamton ... Journal of Consumer Research, Inc All rights reserved ● Vol 38 ● June 2011 How Credit Card Payments Increase Unhealthy Food Purchases: Visceral Regulation of Vices MANOJ THOMAS KALPESH KAUSHIK DESAI ... Relationship Marketing, State University of New York at Buffalo, for making the scanner panel data available for the field study The authors thank Napatsorn Jiraporn and Bora Park for assisting

Ngày tải lên: 06/03/2014, 04:21

... Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K: Stomach is a major source of ... plasma ghrelin-like immunoreactivity levels in humans J Clin Endocrinol Metab 2001, 86:4753-4758 Krsek M, Rosicka M, Haluzik M, Svobodova J, Kotrlikova E, Justova V, Lacinova Z, Jarkovska Z: Plasma ... and pharmacological aspects of ghrelin Endocr Rev 2004, 25:426-457 10 Klok MD, Jakobsdottir S, Drent ML: The role of leptin and ghrelin in the regulation of food intake and body weight in humans:...

Ngày tải lên: 13/08/2014, 20:22

... 96:14783–14788 Kihara M, Nakai W, Asano S, Suzuki A, Kitada K, Kawasaki Y, Johnston LH, Sugino A (2000) Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells Its protein kinase ... of Xlinked mutants of Drosophila melanogaster which are sensitive to mutagens Genetics 84:485–506 Brown GW, Kelly TJ (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase ... replication in the hamster dihydrofolate reductase gene initiation zone Mol Cell Biol 18:3266–3277 Kondo T, Kobayashi M, Tanaka J, Yokoyama A, Suzuki S, Kato N, Onozawa M, Chiba K, Hashino S, Imamura M...

Ngày tải lên: 25/10/2013, 21:20

... Fridtjof Nansen Institute, 1994), pp 32–3 A Kolodkin, O Kulistikova and E Mokhova, ‘Matters of Responsibility for Mariner Pollution under the Legislation of the Russian Federation’, INSROP Working ... 11 of the NSR Regulations N Koroleva, V Markov and A Ushakov, Legal Regime of Navigation in the Russian Arctic (Moscow: Russian Association of International Maritime Law, 1995), p 75 Franckx, ... 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of...

Ngày tải lên: 01/11/2013, 09:20

... [65] MAPK pathways consist of three major kinases: the activation of p38 MAPK, the extracellular signalregulated kinases (ERK) and Jun NH2 terminal kinases (JNK) [66] JNK and p38 MAPK activation ... direct dephosphorylation of Ser112 and negative regulation of the ERK pathway via p38 MAPK, both of which lead to impaired phosphorylation of Ser112 [70] After dephosphorylation of Ser112, Ser136 becomes ... multiple protein kinases [88], including the major phosphorylation site Thr125 The direct phosphorylation of this site by ERK, but not JNK or p38 MAPK/MAKP, suppresses the processing of caspase-9...

Ngày tải lên: 14/02/2014, 22:20

... study of the prevalence of PKM2 in cancers and the effect of PKM2 on tumorigenesis is still required NADPH A key molecule produced as a result of the promotion of the oxidative PPP by PKM2 is ... p53 PI 3K PTEN Glycolysis AMPK AKT Lactate Pyruvate TIGAR p53 SCO2 LKB1 mTOR PDH PDK Acetyl-CoA TCA OCT1 MYC HIF b Proliferating tumour cell Lactate Glucose MCT GLUT Glucose PI 3K AKT PKM2 TIGAR ... splicing The inclusion of exon in the PK mrnA leads to translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (ReF 71) MyC upregulates the expression of heterogeneous nuclear...

Ngày tải lên: 15/02/2014, 04:20

... Ferris DK (1997) Cell cycle regulation of the human polo-like kinase (PLK) promoter J Biol Chem 272, 9166–9174 Rother K, Li YY, Tschop K, Kirschner R, Muller GA, ¨ ¨ Mossner J & Engeland K (2007) ... NJ & Hickson ID (1998) Physiological regulation of eukaryotic topoisomerase II Biochim Biophys Acta 1400, 121–137 73 Adachi N, Nomoto M, Kohno K & Koyama H (2000) Cell-cycle regulation of the ... CDK1 cell division cycle ⁄ cyclin-dependent kinase cell division cycle 25 homolog C CDC28 protein kinase regulatory subunit mitotic kinesin-like protein ⁄ kinesin family member 23 polo-like kinase...

Ngày tải lên: 16/02/2014, 09:20

... K Bjork and L Sistonen ¨ Regulation of HSFs the results imply that, in particular, the promoterbound pool of HSF2 proteins is subjected to degradation (J .K Ahlskog, J .K Bjork, A.N Elsing, M Kallio, ... compilation ª 2010 FEBS J K Bjork and L Sistonen ¨ Pirkkala L, Nykanen P & Sistonen L (2001) Roles of ¨ the heat shock transcription factors in regulation of the heat shock response and beyond FASEB ... Goodson ML, Park-Sarge OK & Sarge KD (2001) Regulation of heat shock transcription factor by stress-induced SUMO-1 modification J Biol Chem 276, 40263–40267 59 Hietakangas V, Ahlskog JK, Jakobsson AM,...

Ngày tải lên: 18/02/2014, 04:20

... 2009 FEBS H M Hardin et al ă Enzyme kinetics for low substrate concentrations k2 e s R1 sị ẳ tot ỵ k1 s k2 p k1 1s k1 k2 k2 pị 70 etot ỵ k ks k 2k1 s k1 ịpị2 k k 1 2 50 q! ỵ 4asịcsị=ẵbsị2 30 ... with the denitions: Vs ẳ k2 etot ; Vp ẳ k1 etot ; Ks ẳ k1 ỵ k2 ị =k1 Kp ẳ k1 ỵ k2 ị =k2 and 13ị yields the reversible MichaelisMenten form: _ sẳ Vs Ks V s Kp p p p s ỵ Ks ỵ Kp 14ị This is the QSSA-reduced ... (11) and obtain: _ sẳ Vp Vs Ks s Kp pỵR1 sị1ị h Vp p s K s ỵ K p ỵ Vs p s 1ỵ Ks ỵ Kp  p s 1ỵ Ks ỵ Kp  Vp Vs Ks s Kp p i 21ị with Vs, ,Kp expressed in terms of k1 , ,k) 2 via the parameter change...

Ngày tải lên: 18/02/2014, 06:20