protein gene and other molecule delivery systems

... 1.1.3 Angiogenesis of cancer 7 1.1.4 Relationship of angiogenesis with tumor growth and metastasis 9 1.2 Antiangiogenesis therapy 10 1.2.1 Antiangiogenesis inhibitors 10 1.3 Drug delivery system ... were utilized and the findings confirmed that this sequential drug delivery system was able to inhibit the angiogenesis progress, suppress primary tumor proliferation and angiogenesis, and also prevent ... adhesion molecule; FGF2: fibroblast growth factor 2; ADAM: a disintegrin-like and metalloproteinase NA: data not available Intervention with metalloproteinase: Another mechanism of angiogenesis

Ngày tải lên: 11/09/2015, 09:58

... Trang 1THE STUDY OF GENE AND PROTEIN VACCINES FOR ALLERGIC DISEASES IN MICE TAN LI KIANG NATIONAL UNIVERSITY OF SINGAPORE 2007 Trang 2THE STUDY OF GENE AND PROTEIN VACCINES FOR ALLERGIC ... receptor-like protein DEC-205 (Jiang W et al., 1995) as well as adhesion (CD11a and CD54) and accessory molecules (CD40, CD80 and CD86) (Steinman RM, 1997) DCs in culture exist in two functional and phenotypically ... house dust mites House dust mites are complex organisms that produce thousands of different proteins and other macromolecules These products as well as the extracts of mites are capable of inducing

Ngày tải lên: 14/09/2015, 14:20

... Switzerland 3 B Rai, S.H Teoh and K.H Ho An evaluation of PCL-TCP composites as delivery systems for platelet-rich plasma Regenerate Conference, 1-3June 2005, Georgia, USA 4 Y Lei, B Rai, K.H Ho and ... differentiation to mineral, (2) not toxic to the cells and (3) its 3D-architecture and porosity allowed for the infiltration of cells and loading of proteins The protein release profile is a function of the ... shorten wound healing time and stimulate mandibular bone regeneration simultaneously in mongrels PRP-treated defects had 98.3 and 58.3 % higher bone volume than controls at 6 and 9 months respectively

Ngày tải lên: 15/09/2015, 17:10

... 2HIGH-TEMPERATURE AND OTHER OXIDE SYSTEMS Nikita Aleksandrovich Toropov and Valentin Pavlovich Barzakovskii Leningrad Institute of Silicate Chemistry Academy of Sciences of the USSR C Nigel Turton and ... oxides and systems consisting of two and more oxides is expanding greatly re-Of particular importance are investigations of oxide systems at high temperatures when the evaporation of oxides and ... cristobalite in these systems changes regularly, as is shown in Fig 1 While in systems with cesium and rubidium this curve is almost linear, in systems with potas-sium, and sodium, and particularly

Ngày tải lên: 13/03/2017, 14:48

... including 10 protein bauds in Artocarpus melinoTtjla Gagii and 11 ones in Artocarpus chaplasha Roxb Among these bands, the protein ones with Rin=0.39; 0.44; 0,58; and 0.62 were inajor bands It was ... convenience, the Rin of protein bands was calculated and listed ill table 2 The d ata in photo 1 showed th a t the protein pattern of seed extract of AHocaryus melinoxyla Gagii and Artocarptis chaplasha ... chaplasha Roxb and Delavaya toxocarpa The shiiplost protein pattern with 5 protein bands ill which the major one with Riii = 0.Í6 was foiiiic] in Abelniocfms escĩdenÌMS L Although, ton protein bauds

Ngày tải lên: 11/12/2017, 11:35

... (see below) and a study using truncated MalK proteins and chimeras suggested that both N- and C-terminal parts of the protein are required for its struc-tural integrity (Schmees and Schneider, ... and maltodextrins intothe periplasm (Boos and Shuman, 1998; see also Box 9.2) In Gram-positive bacteria, which lack a periplasmic space, and in some archaea,maltose-binding proteins are lipoproteins ... of 11 genes (for review, see Boos and Shuman, 1998) Transcription of maltose-regulated genes is governed by the action of a positive regulator protein, MalT, that requires maltotriose and ATP

Ngày tải lên: 29/12/2017, 16:31

... several secondary motifs, and report evi-dence for significant excess of coevolution between helix and helix, helix andstrand, strand and strand, helix and loop, and strand and turn Such large-scaleanalyses ... , and S 2 Closed circles and open circles respectively mean proteins encoded by duplicated gene pair sharing no PPI and sharing PPIs F (light gray arrow) and S (gray arrow) mean faster rate and ... on the allelic states taken by some otherloci Epistasis plays a major role in population and quantitative genetics, and inour understanding of the importance and evolution of recombination [10].Finally,

Ngày tải lên: 14/05/2019, 14:36

... infotainment systems, intelligent electric devices, safe lighting, andadvanced driver assistance systems However, USB charging, heads up display systems, electricmirrors, seats HVAC systems, and LED ... control, and planting techniques can push yields to 350 times more than of a typical farm And allproduce will be free of pesticides, herbicides, and GMOs And because the farms are indoors and no ... asuperpower, and it’s also coming sooner than you think.Alphabet, Sony, and Samsung have all filed patents for contact lens systems that use tiny electronicantennas and optical sensors to record video and

Ngày tải lên: 03/01/2020, 09:52

... the other BBrMV isolates and found to be identical at both the nucleotide and amino acid sequence level of other isolates with 99 to 96 per cent and 95 to 83 per cent respectively The phylogenetic ... percent) and amino acid identity (95 to 83 percent) with other BBrMV nucleotide and protein sequence of BBrMV in the database The Phylogenetic analysis (Fig 7) by the alignment of CP gene sequences ... aligned sequence The CP gene sequences of BBrMV isolates generated in this study was aligned with 22 CP gene sequences of BBrMV isolates of banana and cardamom from India and Southeast Asia were

Ngày tải lên: 14/01/2020, 13:00

... drugs in conventional drug delivery systems (CDDSs) have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery Systems (SDDSs) SDDSs ... agents together with chemotherapeutics, liposomes are promising in the co-delivery of two chemotherapeutic drugs, gene agents [57] with chemotherapeutics as well as chemotherapeutics with anti-cancer ... chemotherapy have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery System (SDDSs) SDDSs promise to apply drugs to specific and

Ngày tải lên: 15/01/2020, 17:52

... attributes, and (b) to understand and control the impact of formulation components and process parameters on the critical quality attributes To get an insight into both the main and interaction ... with the capillary voltage and temperature set at−4500 V and 400 °C, respec-tively A Peak Scientific AB-3G gas generator (UK) was used to generate N2used as curtain gas and air used as source gas ... and Transcutol HP was used as the cosurfactant Surfactant and cosurfactant were mixed in different weight ratios (5:1, 4:1, 3:1, 2:1, 1:1 and 1:2) to ob-tain Smix For each phase diagram, oil and

Ngày tải lên: 20/01/2020, 07:31

... Encountered in Infrastructure Delivery Systems 56 3.4.3 Factors Causing Complexity in Infrastructure Delivery Systems 57 3.4.4 Infrastructure Delivery Systems as Complex Systems 58 3.5 Viability ... strategy and policy of the client, • The methods and procedures, • The personnel and organisation, and; • Source of project finance, • Leadership and authority, and; • Responsibility and performance ... effective and efficient delivery, transparencyand accountability issues, project governance and management, administration andpartnership-oriented issues The attention to infrastructure delivery

Ngày tải lên: 20/01/2020, 11:49

... Peptide /protein drug delivery 15 2.2.1 Structural aspect of protein 15 2.2.2 Challenges in peptide /protein drug delivery 17 2.2.3 Approaches for delivery of peptide /protein ... to initial and stimulate carcinogenesis (Feng and Chien, 2003) There are a few effective ways to treat cancer such as surgery, radiotherapy, chemotherapy, hormone therapy and immunotherapy Each ... PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer drug and...

Ngày tải lên: 26/11/2015, 22:41

... digestion of purified apoprotein with trypsin (T) and Asp-N endoproteinase (D), and of native protein with Glu-C endoproteinase (S) Amino acids identified by Edman degradation and MS tandem fragmentation ... automated Edman degradation and tandem MS of peptides generated by different digestions on apoprotein and native protein (Table 1) GHP contains 72 amino-acid residues, and the measured mass (Fig ... horse cytochrome c as internal calibrant Peptides from the tryptic and Glu-C endoproteinase digestion on apoprotein and native protein, respectively, were separated on a Pep-S II C2 ⁄ C18 column...

Ngày tải lên: 08/03/2014, 08:20

... b-strands A’ and G of the I27 protein showing the protein backbone only for simplicity C) Snapshot of the bstrands A’ and G of the I27 protein showing D2O molecules bridging the protein backbone ... experiments and in SMD simulations was attributed to an unfolding intermediate in the protein Disruption of the relevant hydrogen bonds in the A and B b-strands protein by site-directed mutagenesis ... of b-strands A’ and G for unfolding the I27 protein in D2O The pulling coordinate for the separating b-strands is defined as the distance between the first amino acid of strand A’ (Y9) and the...

Ngày tải lên: 22/03/2014, 18:20

... lipid-binding proteins and their genes Annu Rev Nutr 17, 277–303 25 Wu, Q., Andolfatto, P & Haunerland, N.H (2001) Cloning and sequence of the gene encoding the muscle fatty acid binding protein from ... between zebrafish and human, mouse and pufferfish B-FABP is 83%, 76% and 83%, respectively The percentage amino acid identity between zebrafish and human and mouse is higher in the exons and than it ... testes and between 50 and 160 times higher in brain than in muscle, intestine and heart No product was generated by qRT-PCR from liver, ovary, skin and kidney RNA Both conventional RT-PCR and qRT-PCR...

Ngày tải lên: 31/03/2014, 07:20

... zebrafish fabp3 gene Using 5¢ RLM-RACE, we determined the 5¢ end of the capped and complete zebrafish fabp3 gene transcripts A major band of approximately 200 bp, and two minor bands of 250 bp and 180 ... a-oxidation in muscle and lipogenesis in other tissues in fish and mammals FABP3 (H-FABP) may play a general and fundamental role in fatty acid transportation in tissues exhibiting anabolic and catabolic ... mouse fabp3 gene on mouse chromosome Four other genes syntenic to the fabp3 gene in zebrafish, however, reside on human chromosome at 6p21.3 and mouse chromosome In a Northern blot and hybridization...

Ngày tải lên: 31/03/2014, 07:20

... lanes Ki and rP/Ki/his) and U1snRNP-A (U1-A, lanes nRNP and Ku/nRNP), RPA70 co-migrates with Ku p70 (lanes Ku/nRNP and Ku), and RPA14 co-migrates with histone H4 (lanes rP/Ki/his, Histones, and BM6.5) ... structure consisting of several protein components in snRNPs [13] and DNA-dependent protein kinase (DNA-PK) [14] On the basis of these observations in other autoantibody systems, we suspected that ... rheumatic diseases to other components involved in DNA replication Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa (RPA70, RPA32, and RPA14, respectively),...

Ngày tải lên: 09/08/2014, 08:22

... Ad.BMP-2 and Ad.BMP-4 generated approximately 30 to 60 ng/mL of gene product per 24 hours at day post-infection (Figures 1a, b) The amount of each transgene Figure Transgene expression and biochemical ... chondrocytic and hypertrophic marker gene expression To examine further the effects of BMP-2 and BMP-4 gene delivery on hypertrophic differentiation, we analyzed the temporal expression profiles of genes ... X and OP at day 3, IHH and ALP at day and RUNX2 at day 14 compared with Ad.GFP controls (Figure 7) These results suggest that BMP-2 and BMP-4 gene transfer induced a significant chondrogenic and...

Ngày tải lên: 09/08/2014, 14:22

... gains and losses of genes gradually accumulate in each of them Thus, the presence of genes unique to one species relative to another indicates either gene gains in one or gene losses in the other ... genes and edit annotations based on homology to aligned mRNA, expressed sequence tag and protein evidence by adding transcripts, exon coordinates, CDSs, gene names and descriptions, remarks and ... orthologs of human unitary pseudogenes as their proxies To perform the analyses, we combine all human genes and the 76 mouse genes into one gene list and retrieve their GO and Pfam annotations from...

Ngày tải lên: 09/08/2014, 20:21