... of license 30 Distribution in the Body Binding to Plasma Proteins Having entered the blood, drugs may bind to the protein molecules that are present in abundance, resulting in the formation of ... drug-protein complexes Protein binding involves primarily albumin and, to a lesser extent, !-globulins and acidic glycoproteins Other plasma proteins (e.g., transcortin, transferrin, thyroxin-binding ... conditions of license 24 Distribution in the Body Blood-Tissue Barriers Drugs are transported in the blood to different tissues of the body In order to reach their sites of action, they must leave the...
Ngày tải lên: 22/01/2014, 00:20
... term, the profitability of producing ethanol from sugarcane and sugar beets depends on the prices of these two crops, the costs of conversion, and the price of gasoline A moderation in the price of ... reducing the supply of sugar for food use in the domestic market The purpose of this report is to investigate the feasibility of producing ethanol from sugar feedstocks in the United States In the ... factors affecting the price of gasoline in the U.S are the price of crude oil and gasoline refining capacity The world price of crude oil is projected to rise through 2006 and remain steady in 2007...
Ngày tải lên: 22/02/2014, 05:20
POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
... conflict of interest in mind 21 Relevant information for assessing potential conflict of interest includes the identification of the sponsor, determination of whether an independent team reviewed the ... remaining two areas – conflict of interest leading to biased selection of evidence, and bias in the interpretation of evidence – fall within the domain of the compendia publishers and under the ... Two of these areas – conflict of interest in evidence sources, and conflict of interest in the process of making study data available – lie beyond the control of the compendia publishers The...
Ngày tải lên: 09/03/2014, 00:20
Báo cáo khoa học: Cooperation of two carotene desaturases in the production of lycopene in Myxococcus xanthus pot
... insertion in crtE or in crtB of the carB operon prevents the accumulation of 4308 Fig The absence of CrtIa blocks the cis-to-trans isomerization of phytoene (A) Absorption spectra in hexane of ... resulting from the heterologous expression of crtIa in E coli (strain FD6 in Table 1), indicates that CrtIb is acting at one or two of the last dehydrogenation steps in lycopene production, after the ... as CrtIa Interestingly, CrtIa is unable to catalyze the four desaturations necessary for lycopene production in the absence of CrtIb, and instead it leads to the accumulation of the intermediates...
Ngày tải lên: 16/03/2014, 05:20
Báo cáo khoa học: The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies ppt
... nucleus in the brain, and to the intermediolateral grey column in the thoracic spinal cord, respectively From these sites of initial CNS invasion at the level of the thoracic spinal cord and the ... spread of infection and intestinal neuroinvasion following ingestion of TSE agents Neuroinvasion, sympathetic and parasympathetic spread to the CNS, and propagation from the brain and spinal cord ... (MF) In the GALT-draining lymph nodes, PrPTSE was then found to be associated with free ranging cells in the cortical and paracortical sinuses Following infection of the GALT and GALTdraining...
Ngày tải lên: 30/03/2014, 09:20
Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf
... partition method In the first stage, the hydrophylic upper phase contained the total original activity of the peroxidase inhibitor In the second stage of the purification, 70% of the inhibitory activity ... responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin In addition, our data suggest that insulin stimulates cell division, in bovine thyroid ... same order and with the same volumes of the four mixtures of solvents then used for the elution After seeding the sample, the elution was made in the following order of increasing polarity: (a)...
Ngày tải lên: 30/03/2014, 14:20
Báo cáo nghiên cứu nông nghiệp " Increasing the capacity of the Food Crops Research Institute to enhance the Production and Management of Potatoes in the Red River Delta " pot
... tubers to the i) The increased yield of crops planted in the first field generation RRD will be demonstrated This will involve the importation of high quality seed in the RRD and the final bulking ... This in part reflected the higher priority placed on the project by the Vietnamese counterparts as the results of the trials and training became evident 3.5 Monitoring of project In the initial ... and ware marketing A comprehensive survey was conducted providing an insight into the margins made in the sale of ware potatoes to Ho Chi Minh and the reasoning behind choice of seed It had been...
Ngày tải lên: 22/06/2014, 13:20
báo cáo khoa học: " The production of consumption: addressing the impact of mineral mining on tuberculosis in southern Africa" pdf
... tuberculosis in the general population to the number of mines in the population among southern African The relationship of tuberculosis in the general population to the number of mines in the population ... delineation of responsibilities between different institutions Several government ministries are involved in the management of TB in mining, including the Department of Minerals and Energy, the Department ... not causation, the finding indicates that the implications of mining for community-wide tuberculosis control requires further investigation What is currently being done? The mining industry has...
Ngày tải lên: 11/08/2014, 14:21
the role of gga adaptors and the c terminus of glut4 in the biogenesis of insulin responsive glut4 vesicles
Ngày tải lên: 13/11/2014, 09:59
Role of myokines in the maintenance of whole body metabolic homeostasis pdf
... APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif) potentiating adiponectin signaling and promoting adiponectininduced GLUT4 membrane ... signaling pathway and suppression of MAPK phosphatase-1 [53] Adiponectin inhibits (NF)-κB-inducing kinase (NIK), an upstream kinase of NF-κB pathway, reducing inflammation and promoting insulin ... a myokine regulated through Aktdependent mechanisms [31] Levels of FGF21 in skeletal muscle were increased in response to insulin stimulation and to hyperinsulinemia [32] Interestingly, the expression...
Ngày tải lên: 22/07/2016, 08:48
Cambridge.University.Press.The.Crisis.of.Literature.in.the.1790s.Print.Culture.and.the.Public.Sphere.Nov.1999.pdf
... these values, could be contained The emotional intensity of the backlash against the intrusions of these subaltern groups suggests the importance of reading these developments in ways which interfuse ... advances in the print industry.22 In Letters on Education (1790), Catherine Macaulay argued that the ‘advantages of printing, by rendering easy the communication of ideas, giving an universality to their ... less one of selecting an alternative definition of the political’ than of synthesizing these domains (national agency and distinction) into a single field of contestation within which the struggle...
Ngày tải lên: 21/09/2012, 11:00
Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... to 4.4% of men and 1.8% of women over the age of 65 [4] A two-fold increase in incidence of gout has been reported in the USA and New Zealand over the past 30 years, while the prevalence of gout ... attacks in the first metatarsophalangeal joint he was unaware that gout could occur in his wrist Typical presentation includes sudden onset of intense pain, redness and swelling of the joint Examination ... any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity In this case, although the patient had...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease [8] In this study, 391 of the 1045 patients enrolled into the initial ... transplant outcome, and the difficulties in treatment of the infection following LT [12], it is reasonable to emphasize the importance of pretransplant treatment of HCV The International Liver Transplantation ... erythropoietin, has allowed more aggressive dosing of interferon and ribavirin [13, 14] Finally, growing experience with antiviral therapy in this high-risk group has led to novel approaches and increasing...
Ngày tải lên: 31/10/2012, 17:11
Báo cáo y học: "Usefulness of vitrectomy in the treatment of ocular toxoplasmosis"
Ngày tải lên: 03/11/2012, 11:01
A study on teaching oral skills to the first year students at Hanoi University of Industry in the Communicative Approach
... also inconsistent with their understanding of language teaching In the case of the activity Reading and reporting from website, only 14% of the teachers said they 'use it regularly' when 50% of them ... think the researcher wants to read rather than their real feelings Moreover, the number of the subjects is small which may influence the implications of the thesis to some extent The results of ... discussed in the introduction In response to question 5, every single teacher reported that they use CLT in their teaching These two questions confirm that the CA is the dominant paradigm and that the...
Ngày tải lên: 07/11/2012, 15:01
The Art of Building in the Classical World
... reading of Aristophanes, I assess textual evidence for the invention of linear perspective as a background for approaching the reshaping of the Theater of Dionysos in Athens I also interpret the ... of vision as principle of protraction The resulting invention of linear perspective for the painting of theater backdrops is then assessed as a device according to which the same projection of ... came into being in the graphic planning of the architectural type of the theatron (the place for seeing) as early as the fifth century Among the many implications of this circumstance, one may include...
Ngày tải lên: 15/11/2012, 10:32
Seawater Purification Experiment and Consideration about Photoreactivation of Coliforms in the Inside of Seawater
... coliforms, the number of fecal coliforms clearly increased after the rain due to the influence of CSO The influence of CSO occurred predominantly after the rain rather than during the rain and depending ... (44% of total days) outside against the 67days (64% of the total days) inside the purification zone The ranked days were 20 point higher inside rather than outside On the other hand, the number of ... provided on the inflow side of the primary seawater tank After filtrated, the seawater was aerated in the filtrated seawater tank increasing the DO level before discharging Therefore, the oxygen...
Ngày tải lên: 05/09/2013, 09:08
A STUDY ON THE ENGLISH VIETNAMESE TRANSLATION OF TERMS IN THE MATERIALS FOR MECHANICAL ENGINEERING
... important role in the development of Mechanical Engineering The thesis studies the English – Vietnamese translation of terms in the materials for Mechanical Engineering First, the thesis collects ... The thesis aims to draw out common translation strategies which can be applied in the English-Vietnamese translation of terms in materials for mechanical engineering Hopefully, the result of the ... Engineering terms and Vietnamese ones Next, the thesis works out and compares the English terms with the Vietnamese ones to finds out appropriate Vietnamese equivalents for the English terms The...
Ngày tải lên: 07/09/2013, 13:04