new approaches to software packaging

... Trang 1NEW APPROACHES TO THE STUDY OF MARINE MAMMALS Edited by Aldemaro Romero and Edward O Keith Trang 2New Approaches to the Study of Marine Mammals Publishing ... asclepiads usually taught their children reading, writing, and anatomy (Moseley 2010, p 10) In 367 BCE Aristotle moved to Athens to study at Plato’s Academy, and later travelled throughout Asia Minor and ... related more closely to “viviparous quadrupeds” than to fish 4 These citations for Historia Animalium follow the Bekker’ pagination Trang 18Aristotle followed his teacher Plato in classifying

Ngày tải lên: 07/11/2018, 20:54

... experiences related to novel approaches to software engineering Theconference acknowledges an evolution in systems and software thinking due to con-temporary shifts of the computing paradigm to e-services, ... CLI-based tools such as VCF Tools and VTC Incontrast, data operations to retrieve data (e.g., querying andfiltering) are more common on web-based tools Although there are several tools aimed to support ... increase too The tool musthandle this increase of data and concurrent users satisfactorily, it must have the elas-ticity to allow dynamic growing of stored knowledge base and compute capacity tomanage

Ngày tải lên: 02/03/2019, 10:35

... Designing peptides to map discontinuous epitopes de-signed to propose an alternative to the existing time-and ressource-consuming methods used to map discon-tinuous epitopes The idea is to use a mixture ... pre-diction tool The first version of PEPOP proposed three different methods to design peptides and we showed that they can be used to generate anti-protein Abs [34] or to map epitopes [35] In our new ... epitopes (immunogen, epitopes generated from peptides, truncated protein, cross-reacting molecules) [59] Theoretically, a tool can-not predict an epitope because an epitope only exists thanks to

Ngày tải lên: 25/11/2020, 12:24

... preparation.5The Director’s New Innovator Awards support exceptional new investigatorswho have not yet received an NIH R01 grant, but who take particularly innova-tive approaches to biomedical or ... using a multi-disciplinary approach to understand the principlesgoverning T cell-mediated autoimmunity The research could lead to new ways topredict or preempt autoimmune diseases such as multiple ... the tools needed to translate ideas into actions Intoday’s biomedical research labs, tools and technologies are being imported from Trang 31an impressive spectrum of sciences, and finding new

Ngày tải lên: 28/01/2021, 20:32

... preparation.5The Director’s New Innovator Awards support exceptional new investigatorswho have not yet received an NIH R01 grant, but who take particularly innova-tive approaches to biomedical or ... using a multi-disciplinary approach to understand the principlesgoverning T cell-mediated autoimmunity The research could lead to new ways topredict or preempt autoimmune diseases such as multiple ... the tools needed to translate ideas into actions Intoday’s biomedical research labs, tools and technologies are being imported from Trang 31an impressive spectrum of sciences, and finding new

Ngày tải lên: 17/03/2021, 20:17

... -Viết VTV Toán LUYỆN TẬP CHUNG I MỤC ĐÍCH YÊU CẦU Biết lập đề toán theo hình vẽ, tóm tắt đề toán ; biết cách giải và trình bày bài giải bài toán. II.ĐỒ DÙNG DẠY – HỌC GV: ĐD dạy toán, sách toán ... các em nhìn vào bài toán để nêu tóm tắt rồi giải bài toán Hôm nay , chúng ta sẽ luyện tập về dạng nhìn vào tranh vẽ viết tthêm vào phần còn thiếu để có bài toán rồi giải bài toán đó 2.Hướng dẫn ... HDluyện tập Chính tả : Mời vào Luyện đọc Luyện đọc bài Chuyện ở lớp Buổi chiều Luyện toán Toán : Luyện tập Toán 113 Luyện tập chung Mĩ thuật 29 Vẽ tranh đàn gà Chính tả 13 Chuyện ở lớp Thứ ba

Ngày tải lên: 30/03/2021, 05:22

... general users would read from top to bottom and left to right, but this is not always the case For example users tended to read the sticky note thatwas the closest to where their cursor was (i.e ... notes – for eager 1st time users to try out features  (* most closely related to IIG)  Introductory tutorial – explain commonly used features  Thorough tutorial - covers typical and advanced ... likely to be incomplete (opposed to the more traditional reference manuals or tutorials which are supposed to cover all aspects of the system, exceptions, etc) The designer’s role is to choose

Ngày tải lên: 20/10/2022, 01:59

... similar to Topologi-cal sorting; from the Data Flow Graph, we have to choose an order that satisfies the constraints of the graph Our schedul-ing problem is to find a topological order so that the total ... optimization problems in the embedded software development as in Fig 1 According to this over-all model, the optimization problem of embedded software is divided into two main approaches such as optimization ... code to source code, converting the source code to models and optimizing embedded software under different levels such as source code and model Then, the optimal source code is recompiled To develop

Ngày tải lên: 24/10/2016, 11:09

... 1Synthetic approaches to the 2009 new drugs a Pfizer Inc., La Jolla, CA 92037, USA b Pfizer Inc., Groton, CT 06340, USA c Shenogen Pharma Group, Beijing, China a r t i c l e i n f o Article history: ... online 24 December 2010 Keywords: Synthesis New drug molecules New chemical entities Medicine Therapeutic agents a b s t r a c t New drugs are introduced to the market every year and each individual ... N O CF3 O N Cl CO2H CO2H • • • • Trang 321 new drugs marketed in 2009 (Fig 1) and excludes new indica-tions for known drugs, new combinaindica-tions, new formulaindica-tions and drugs synthesized

Ngày tải lên: 29/08/2021, 10:59

... NMO acetone, H 2 O 0 °C to 5 °C, 52% Ac2O, AcOH ZnCl 2 , 35 °C to 40 °C 84% MeO 2 C TMS BF 3 •OEt, CH 3 CN 0 °C to 5 °C Triton B(OH) THF, MeOAc 38% for 2 steps NaIO4, EtOAc, H2O 0 °C to 10 °C ... 1Synthetic approaches to the 2010 new drugs Kevin K.-C Liua, , Subas M Sakyab,à, Christopher J O’Donnellb,⇑, Andrew C Flickb,§, Hong X Dingc,– a Pfizer Inc., La Jolla, CA 92037, USA b Pfizer Inc., Groton, ... moving bed (SMB) chromatography to give enantiopure 52 in 45% yield over the two steps The secondary alcohol of 52 was reacted with p-toluenesulfonyl chloride and DMAP to give tosylate 53 in 78%

Ngày tải lên: 29/08/2021, 10:59

... edoxaban tosilate involves the integration of three essential structural components. Cl F ketoreductase, Na-NADP GDH, glucose, N(EtOH) 3 1 PdCl 2 (dppf )ãCH 2 Cl 2 ,120, Cs 2 CO 3 Bu 4 NBr, toluene/H ... yield The final step included treatment with TsOH, leading to the isolation of edoxaban tosilate (XI).Eldecalcitol (Edirol Ò )Eldecalcitol, a vitamin D3 analog developed by Chugai in collaboration ... reduction in new vertebral fractures compared to alfacalcidol Research on the discovery and structure-activity relationship (SAR) of vitamin D3 analogs has led to the identification of eldecalcitol,

Ngày tải lên: 29/08/2021, 10:59

... inhib-itor51,52which provides an alternative treatment to patients exhib-iting immunity to imatinib and other kinase inhibitors utilized forthis treatment.53,54 In contrast to competitor tyrosine ... subjected to lithium hal-ogen exchange conditions and subsequent exposure to lactone 64,provided a mixture of lactols which were then immediately sub-jected to methanesulfonic acid, leading to glucol ... type 2 (SGLT-2) inhibitor, was developed by Bristol–Myers Squibb (BMS) and AstraZeneca for the once-daily treatment of type 2 diabetes As opposed to competitor SGLT-2 inhibitors, dapagliflozin was

Ngày tải lên: 29/08/2021, 10:59

... magnesium malonate 65 to give ketoester 66 after workup Next, condensation with DMF–DMA converted ketoester 66 to the vinylogous amide 67, and this material was immediately subjected to an addition–elimination ... advancement of gemigliptin to O OEt HO F F NfSO2Cl, Et3N, CH2Cl2 O OEt NfO F F O OEt EtO F F O NaBH4, EtOH Br EtO F F O O OEt O NH 2 F F OH OH O OH O O NH F F 87 3 tartaric acid EtOH, H 2 O Boc Boc Boc ... drug effec-tively promoted apoptosis, inhibited proliferation, and also CN O Cl O O O N OH O N N O AlCl3, NHEt2toluene, rt 1 SOCl2, toluene rt to 50 °C 1 ethanolamine toluene, 83 °C XIII Levomilnacipran

Ngày tải lên: 29/08/2021, 10:59

... epoxidation and ethanolamine treatment lead to trans aminoalcohol, which is tosylated and cyclized to yield a bis-toluenesulfonamide, resolved to >99% ee to obtain the desired (S,S)-enantiomer.116using ... replication complex inhibitor, ombitasvir, an NS4A replication complex inhibitor, and ritonavir, a cytochrome P450 inhibitor, alongside dasabuvir, an NS5B polymerase inhibitor. Scheme 29 Synthesis ... reaction, referred to as 185, offers an enhanced method for synthesizing NK 1 receptor antagonists This innovative approach was utilized to directly add the C4-o-tolyl substituent to 6-chloronicotinic

Ngày tải lên: 29/08/2021, 10:59

... refluxing toluene to provide divinyl imine 95, which underwent immediate reduction using NaBH(OAc)3in AcOH/toluene to furnish the free amine The free amine was converted to the corresponding tosylate ... 10% NaOCl aqueous solution in EtOAc to giveenone 122, and this material was then hydrogenated over 10%Pd/C in EtOAc to afford the saturated ketone 123 Next, theketone within 123 was selectively ... Commercially available acid 132 was treated with CDI prior to subjection to Meldrum’s acid to afford ketodiester 133.Subjection of 133 to warm EtOH triggered a decarboxylationevent, and this was followed

Ngày tải lên: 29/08/2021, 10:59

... knowledge of new chemical entities and approaches to their construction will enhance the ability to discover new drugs more efficiently This review describes the most likely process-scale synthetic approaches ... 1Synthetic Approaches to New Drugs Approved During 2016Andrew C Flick,†Hong X Ding,‡Carolyn A Leverett,†Sarah J Fink,§and Christopher J O’Donnell *, † †Pfizer Worldwide Research and Development, Groton ... corresponding acyl halide of 13 en route to ester 15 (Scheme 2) Next, a Fries rearrangement was employed to effect ester-to-ketone trans-position Exposure of 15 to a mixture of methanesulfonic acid

Ngày tải lên: 29/08/2021, 10:59

... believed to total about $600 million, this leaves a substantial funding gap More funding has to be directed towards research and development of new TB drugs and vaccines if the pandemic is to be ... Drugs near the top of the list are more effective and less toxic while drugs placed near the bottom of the list are less effective or more toxic, or more difficult to obtain Resistance to one drug ... regimen This new approach has the potential to shorten the time needed to develop new TB treatment regimens by decades, as well as significantly reduce development costs However, to be able to test...

Ngày tải lên: 23/03/2014, 17:20

... Domestication, 2nd ed D Appleton, New York, ny, usa Davidson, A 1992 Europeans’ wary encounter with tomatoes, potatoes, and other New World foods In N Foster and L S Cordell (eds.), Chilies to Chocolate: Food ... sequence data to eliminate certain species of Artocarpus from consideration as putative ancestors of cultivated breadfruit and were able to narrow down the candidate ancestors to two other species ... both tomatoes and potatoes are of New World origin (figure 1.1) At the time of their introduction into the Old World, Europeans did not immediately accept these crops because they were similar to...

Ngày tải lên: 03/04/2014, 12:10

... semi-automatic and fully automatic face recognizer The goal of an automatic face detector is to search for human faces in a still image and, if found, to accurately return their locations In order to ... order, from top to bottom, and this sequence is 10 New Approaches to Characterization and Recognition of Faces immutable, even if the face is moderately rotated The first attempts to use HMMs ... Segmental K-means: according to the new segmentation performed at step 4, another K-means is applied to the current set of observation vectors corresponding to each new state, and new observation probability...

Ngày tải lên: 27/06/2014, 05:20