is multiple sclerosis a vascular disease

... exception to this is in primary progressive MS, in which there is an equal ratio E Most MS patients are Caucasian F MS is rare among Africans, Asians, and Native Americans G African Americans have levels ... practice—Knowledge and skills: Relapse management Disease modifying agents Symptoms and symptom management Psychosocial issues G Advocacy tasks Negotiate for the patient and family in the healthcare system Advocate ... expertise, and even by cultural practices Measures of disease frequency involve a numerator (cases), and a denominator (population at risk) Incidence and death rates refer to new cases and to deaths...

Ngày tải lên: 15/03/2014, 19:20

... respondents with and without MS were then compared using analysis of covariance (ANCOVA), with adjustment for age, sex, education, marital status, social assistance as a source of income, and number ... impairment that is associated with MS, even among community dwelling individuals with the disease Although secondary analysis makes use of valuable data, the limitations of these findings are ... The research and analysis are based on data from Statistics Canada The opinions expressed not represent the views of Statistics Canada We also express our gratitude to Dr D.H Feeny for his constructive...

Ngày tải lên: 18/06/2014, 22:20

... therapy game (e.g car racing or card playing) The mechanical-assisted training was given supplementary on customary care comprising physical and/or occupational therapy aimed at the maintenance ... International Classification of Functioning, Disability and Health: ICF Geneva: World Health Organization; 2001 37 Timmermans AA, Seelen HA, Willmann RD, Bakx W, de RB, Lanfermann G, Kingma H: Arm ... insights and potential clinical applications Neurologist 2007, 13:45-56 Dalgas U, Stenager E, Ingemann-Hansen T: Multiple sclerosis and physical exercise: recommendations for the application of resistance-,...

Ngày tải lên: 19/06/2014, 08:20

... there is a possible alteration of sHLA-I and/or sHLA-II levels as a reflection of disease activity in multiple sclerosis (MS) Clinical and brain magnetic resonance imaging (MRI) disease activity ... sHLA-I or L 2.03 Mab for sHLA-II were added to each bead and incubated for an additional hour at 45°C After additional washes, the color reaction was started by adding the appropriate substrate ... Racial-ethnic factors may also have an influence on sHLA levels [18,19] Thus, it appears advantageous to assess sHLA measurements in subjects with a similar racial-ethnic background Theoretically,...

Ngày tải lên: 19/06/2014, 22:20

... therapy, with a surrogate marker, may have additional value as particularly effective immunomodulatory activity, such as that observed with natalizumab, may have a potential downside [26] that is ... to avoid the assumption of normality implicit in the analysis of variance J Amer Statist Assoc 1937, 32:675-701 Stone LA, Frank JA, Albert PS, Bash CN, Calabresi PA, Maloni H, McFarland HF: Characterization ... occurred in association with elevated levels of saliva sHLA-II levels at month Discussion There are a number of important reasons to have a reliable surrogate marker for disease activity in RRMS As the...

Ngày tải lên: 19/06/2014, 22:20

... necrosis factor-related apoptosis-inducing ligand is associated with favourable ovarian cancer survival Clin Cancer Res 2003, 9:762-766 Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, ... TRAIL, cisplatin and paclitaxelinduced cell death, cisplatin and paclitaxel being two drugs that are usually part of the initial treatment for ovarian cancer Cisplatin IC50 was increased by ascites ... proteomic analysis of ovarian cancer ascites demonstrated that malignant cells from ascites have higher levels of activated Akt and discriminated malignant ascites and poor survival outcomes [26] This...

Ngày tải lên: 20/06/2014, 07:20

... biopsy-proven multiple sclerosis (MS) shortly after receiving treatment for HSV-1 encephalitis Case presentation A 49-year-old Caucasian woman with a history of migraines and herpes labialis presented ... basal meningitis, and encephalitis of the peri-ventricular and right basal ganglia white matter (see Figure 1) Treatment with intravenous dexamethasone, ceftriaxone, and aciclovir was initiated ... nasal or pulmonary symptoms She had developed peri-oral fever blisters, a low-grade fever, and a disabling left temporal headache four weeks earlier Her headache was unlike the typical migraines...

Ngày tải lên: 11/08/2014, 00:22

... experimental groups Statistical Analysis Data are expressed as the mean ± SEM unless specified Statistical analysis of cell treatments was carried out using one-way ANOVA followed by Newman-Keuls ... distal limp tail; 1.5, complete limp tail; 2, mild paraparesis of the hind limbs, unsteady gait and impairment of righting reflex; 3, moderate paraparesis, partial hind limb paralysis, voluntary ... reduction assay was used as an indicator of cell viability MTT (Sigma-Aldrich, St Louis, MO, USA) was added to a well at a final concentration of 0.5 mg/mL After MTT incubation at 37°C, DMSO was added...

Ngày tải lên: 19/06/2014, 22:20

... D  B   H  +"G + *++ID D J "3   "G-G G B   KLM @A? NOLPANA >  (" *+ ' *?@ @A  ), * $- *#!    " B#,-+ B+" *  D%!Q  *+  B++ + !+ ,RB#+" ... !"$# $(:!(  # /!( +0% # +%

Ngày tải lên: 21/09/2012, 11:02

... Suzuki E, Satonaka H, Nishimatsu H, Oba S, Takeda R, Omata M, Fujita T, Nagai R & Hirata Y (2004) Myocyte enhancer factor mediates vascular inflammation via the p38-dependent pathway Circ Res ... vascular smooth muscle cells Association with the activated phenotype Circ Res 78, 196–204 19 Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M, Matsubara ... PKCdelta in vascular hypertrophy Biochem J 390, 761–767 11 Kuwano Y, Kawahara T, Yamamoto H, TeshimaKondo S, Tominaga K, Masuda K, Kishi K, Morita K & Rokutan K (2006) Interferon-gamma activates transcription...

Ngày tải lên: 30/03/2014, 03:20

... cell therapy Transplantation 2005, 79:1097-1103 Suganami T, Nishida J, Ogawa Y: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor ... Morel CR, Subramanian V, Mukundan L, Eagle AR, Vats D, Brombacher F, Ferrante AW, Chawla A: Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance Nature 2007, ... experimental allergic encephalomyelitis (EAE), disease progression is exacerbated by Treg depletion [86], and natural protection against disease in certain models of EAE is associated with antigen-specific...

Ngày tải lên: 18/06/2014, 15:20

... infrared markers Mean and standard deviations for each parameter and time interval were calculated for each patient and used for further analysis Significant changes in the mean and standard deviations ... information on patient function Clinically, motor fatigue can be defined as a reduction in maximal walking distance that cannot be explained by the degree of paresis, ataxia or spasticity Many patients ... variability and was defined as · indexmean + indexvariability Nsignificant mean changes Nsigificant SD changes + Ngait parameters Ngait parameters indexfatigue = = · where Nsignificant_mean_changes...

Ngày tải lên: 19/06/2014, 08:20

... 1994, a trial of interferon β-1b was discontinued because of increased spasticity, and she was not a candidate for glatiramer She had no history of diabetes, cardiovascular, liver or kidney disease ... final draft of the manuscript Acknowledgements We thank Monica Menendez for secretarial assistance Supported by grants from the National Multiple Sclerosis Society (DLF), Takeda Pharmaceuticals ... clinical course of multiple sclerosis: results of an international survey National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis Neurology...

Ngày tải lên: 19/06/2014, 22:20

... de Graaf, Temmink, van Dijl and Verbiest, Amphia Ziekenhuis, Breda; dr Anten, Maaslandziekenhuis, Sittard; dr Koeman, Ziekenhuis Walcheren, Vlissingen; dr Strikwerda, ‘t Lange Landziekenuis, Zoetermeer; ... FIS values in treatment-naïve, pre-treated and total patient groups at baseline, month and month 12, and changes from baseline At month mean total FIS score had decreased in the treatment-naïve, ... practice and thus difficult to generalize Observational data obtained in ‘real-life’ are more informative on a patient’s chance to reach a pre-defined therapeutic goal As our patients were treated...

Ngày tải lên: 20/06/2014, 15:20

... MSRMS Acknowledgements We thank R Holliday and S Jain for assistance with the postal survey, A Lawrence, C Hill and T Lane for assistance with data entry, and the multiple sclerosis nursing team: ... example Rasch analysis or item response theory [28,29] Additional items could also be generated that could discriminate amongst those who rate the care as excellent Rasch analysis in particular ... Text Analysis Berlin: Sage Publications; 1996 Page of 10 Hobart JC, Lamping D, Fitzpatrick R, Riazi A, Thompson A: The Multiple Sclerosis Impact Scale (MSIS-29): a new patient-based outcome measure...

Ngày tải lên: 20/06/2014, 15:20

... organ damage IL-15 was therefore identified as an independent risk factor for cardiovascular complication This is particu- lar of interest considering the accelerated atherosclerosis that has ... lung disease and increased skin thickness is the hallmark of SSc IL-15 may enhance perivascular inflammatory infiltrates by activation of endothelial cells to promote CD44-mediated extravasation ... A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM, Martin GR, Black CM, Abraham DJ: Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis...

Ngày tải lên: 09/08/2014, 10:20

... cardiac output, and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome Am J Physiol Heart Circ Physiol 2007, in press Loevinger BL, Muller D, Alonso ... medically unexplained symptoms: a lost link between cardiovascular and nociception modulation? J Musculoskeletal Pain, in press Stewart J, Taneja I, Medow MS: Reduced central blood volume and cardiac ... erythematosus Data from LUMINA, a multiethnic cohort J Clin Rheumatol 2007, 13:128-133 Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC: Accelerated brain gray matter...

Ngày tải lên: 09/08/2014, 10:21

... sclerosis [1] Multiple sclerosis comprises a variety of symptoms including central paresis, spasticity, paraesthesia, ataxia, dysarthria, visual impairment, cognitive dysfunction and urinary and ... were calculated for each patient and used for further analysis Significant changes in the mean and standard deviations of these parameters were used as probable indicators of fatigue It was assumed ... identifying pathological gait parameters and evaluated patient’s videos IB contributed to data processing and analysis CD participated in study design, data interpretation and prepared the manuscript...

Ngày tải lên: 11/08/2014, 07:21

... Kahlert S, Schonfeld P, Reiser G: The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal ... causes cellular death through calcium deregulation, free radical formation and apoptosis [5] Phytanic acid is not only elevated in RD, but also in other peroxisomal disorders However, these can ... symptoms and have constricted visual fields at presentation [6] Cataract is also a frequent finding in almost 50% of all RD patients [6] There is a symmetrical mixed motor and sensory polyneuropathy...

Ngày tải lên: 11/08/2014, 23:21