... energy of the protein-ligand complex and Gprotein and Gligand are total free energies of the isolated protein and ligand in solvent, respectively (Figure 2.1) Trang 23However, the solvent-solvent interactions ... biased ligands might result from differences in binding conformations of ligands and receptor Therefore, it is important to understand the binding conformations of µOR with both biased and unbiased ... binding free energy of ligands and protein, revealed the interaction of µOR with biased and unbiased ligands These results would be beneficial for future research, the design of painkillers targeting
Ngày tải lên: 22/09/2020, 00:49
... ligands might result fromdifferences in binding conformations of ligands and receptor Therefore, it isimportant to understand the binding conformations of µOR with both biased andunbiased ligands ... energy of the protein-ligand complex and Gprotein and Gligand are total free energies of the isolated protein and ligand in solvent,respectively (Figure 2.1) Figure 2.1: Illustration for ligand-protein ... binding free energy of ligands and protein, revealed theinteraction of µOR with biased and unbiased ligands These results would bebeneficial for future research, the design of painkillers targeting
Ngày tải lên: 27/10/2020, 19:58
LUẬN văn THẠC sĩ molecular study of interactions of mu opioid receptor with biased and unbiased ligands by molecular dynamic simulation
... energy of the protein-ligand complex and G protein and G ligand are total free energies of the isolated protein and ligand in solvent, respectively (Figure 2.1) However, the solvent-solvent interactions ... biased ligands might result from differences in binding conformations of ligands and receptor Therefore, it is important to understand the binding conformations of àOR with both biased and unbiased ... TRV130 and mOR is 0 to 2 bonds each frame (Figure 3.20) This is resulted from the differences in the number of acceptors and donors of 2 ligands, M6G has 5 pairs of donors and 10 acceptors, those of
Ngày tải lên: 05/12/2022, 10:23
Interactions of human mesangial cells with IgA and IgA-containing immune complexes
... Trang 1Interactions of human mesangial cells with IgA andDepartments of Microbiology, Pathology, and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA Interactions of human ... pathogenesis of IgAN [6, 10, 0.5% FCS) 24 hours before the experiment. 17–19], it is important to examine interactions of MC Isolation of IgA1 proteins, their Fab and with not only free IgA1 and de-galactosylated ... ASOR incubated with HepG2 and Trang 7Fig 6 Internalization of 125 I-labeled ASOR and 125 I-labeled asialo-(AS) IgA1 (Mce) by HepG2 and MC About 1 g of each radiolabeled Fig 7 HepG2 and MC cell-associated
Ngày tải lên: 10/01/2023, 10:56
Compton scattering of photons from electrons in thermal (maxwellian) motion electron heating
... incoming photon and electron energies be v’ and s’, and theoutgoing be v and c, with correspondingelectron momenta ~’ and ~, and photonmomenta ~’ and ~, respectively The angle between $’ and ~ shall ... between ~’ and ~’ shall be a’ and that between ~ and $’ shall be a.The azimuthal angle between the spherical triangle sides ~’ and <’$’ shall be 4 Thus on the surface of a sphere with origin of the ... scattering of aphoton of energy v’ from a Maxwell gas of electrons at a temperatureT is given by Eqs (l), (34), (33), (32), and (25) (or (23) and (24)) The scattering is to photon energy, v, and is
Ngày tải lên: 28/06/2018, 10:59
— Notes on some Species of Draivida and Pheretima with Descriptions of Three New Species of Pheretima
... relationships,locationofthemaleporesandcharacteristics ofthemalegenital terminalia, position ofthe spermathecal pores, number and location of the genital markings,length ofthe vas deferens, shapeof the central ... shortness of the clitellum, the completeness ofthesetalcircleofxvi,the pairedfemalepores,thenumerousgenital markings and their location, theabsenceof the heartsofxiii,and the inclusion ofthe anterior ... ventralportionofthe penisissoftandwithacollapsed, flattenedappearance Thetip of the penis is rather deeply cleft into two majorlobes, onelateral andone median,the ventralmarginofthelaterallobemarkedoffinto
Ngày tải lên: 20/07/2019, 10:11
Victimisation in a French population of children and youths with autism spectrum disorder: A case control study
... sample of 39 children and youths with ASD and 53 typically developing (TD) children and youths and tested the association of the victimisation with socio-demographic factors and clinical factors of ... social skills and the severity of post-traumatic symptoms Symptoms of anxiety were reported by parents of children and youths with ASD in 80% of cases Conclusions: Children and youths with ASD are ... of a population of 180 parents of children with autism This study showed that the risk of severe maltreatment increases with age and the severity of ASD [26] Children and youths with ASD have difficulties
Ngày tải lên: 10/01/2020, 14:20
The study of partial and excess molar volumes for binary mixtures of nitrobenzene and benzaldehyde with xylene isomers from T = (298.15 to 318.15) K and P = 0.087 MPa
... measurements, partial and excess molar volumes for binary mixtures of nitrobenzene and benzaldehyde with three isomers of xylene have been measured The whole range of composition and temperatures ... focused on volumetric properties of six binary mixtures of nitrobenzene and benzaldehyde with three isomers of xylene for whole range of composition at ambient pressure and temperatures from T = 298.15 ... qi in which q is density of mixture and qi, xiand Miare density, mole fraction and molar mass of pure component i, respec-Table 1 Provenance and mass fraction purity of the compounds studied
Ngày tải lên: 13/01/2020, 04:51
First experience with Tolvaptan for the treatment of neonates and infants with capillary leak syndrome after cardiac surgery
... presentation of third space volume overload with consecutive generalized edema and substan-tial gain of weight, intravascular hypovolemia, hypoalbuminemia and hemoconcentration in the absence of severe ... receptor antagonist and prohibits the movement of aquaporin 2 into the luminal wall of the collecting duct and thereby reduces the reabsorption of water [11, 12] TLV has been FDA (Food and Drug Administration) ... the treatment of hyponatremia associated with CHF in adults and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in adults and children The approval for treatment of hyponatremia
Ngày tải lên: 01/02/2020, 05:50
The association of dairy intake of children and adolescents with different food and nutrient intakes in the Netherlands
... associa-tions with higher consumption of vegetables and fruits (Table 2) and with lower consumption of soft drinks (−159 g ±28.2), fruit juice (−40.5 g ±14.8) and less tea or coffee (−15.5 g ... associated with incidence of dental caries, and hypertension; and positively associated with linear growth and bone health during childhood [2] Nonetheless, in recent decades, the consumption of milk and ... association of dairy intake of children and adolescents with different food and nutrient intakes in the Netherlands Marjo J E Campmans-Kuijpers1, Cecile Singh-Povel2, Jan Steijns2and Joline W
Ngày tải lên: 27/02/2020, 12:17
The interest rate sensitivity of output and prices with different levels of financial inclusion
... indicators of bank access for three types of services including deposits, loans and payments through two 115 IR sensitivity of output and prices Trang 3dimensions of access and use of financial ... (2016) and Sarma (2016), we consider two basic services of the banking system to be credit and deposit Accordingly, outstanding loans from commercial banks (% of GDP) and outstanding deposits with ... Deposits Outstanding deposits with commercial banks (% of GDP) FAS – IMF Loans Outstanding loans with commercial banks (% of GDP) Source: The authors Table I Summary of variables and data sources
Ngày tải lên: 22/05/2020, 01:53
The study on treatment of nitrogen and spacing with variety snowball
... Effect of various levels of N and on the number of leaves per cauliflower plant 0 5 10 15 20 25 30 35 40 45 50 N0 N1 N2 Fig.4 Effect of various levels of N and on the fresh weight of head of cauliflower ... the stages of the cauliflower plant Highest dose of nitrogen per hectare had significant effect on the height of the plant, fresh and dry weight of leaves and fresh and dry weight of curd at ... 10Fig.5 Effect of various levels of N on Dry weight of leaves of cauliflower plant 0 100 200 300 400 500 600 700 N0 N1 N2 Fig.6 Effect of various levels of N on dry weight of head of cauliflower
Ngày tải lên: 29/05/2020, 18:16
Microbiological quality of fish and shellfish, with special reference to Vibrio parahaemolyticus in domestic markets of West Bengal, India
... during 2007-2010 West Bengal is one of the major inland fish producing states, producing approximately 21-23% of inland fish production of India Export of marine and aquaculture product from West ... awareness and to ensure that the fish and shrimps are cooked properly and maintain sanitary hygiene The epidemiology of V parahaemolyticus infection has changed in India with emergence of pandemic ... hygienic and microbiological quality of fin fishes and shellfishes of domestic markets of West Bengal Although, overall microbial load was within permissible limits, fishes were contaminated with
Ngày tải lên: 17/06/2020, 14:42
Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN
... a loss of nuclear USP7 but increase of nuclear and cytosolic SUMO2/3 was found Loss of nuclear and cytosolic PTEN, loss of nuclear USP7 and increase of cytosolic SUMO2/3 thus correlated with poor ... 0 and cyto 0 C LCNEC with nucl 0 and cyto 3x100 Necrotic cells on the left side were not counted D TC with nucl 3x100 and cyto 1x100 E SCLC with nucl 0 and cyto 3x100 F TC with nucl 3x100 and ... 6Correlation of PTEN immunoreactivity with other markersand with clinico-pathologic data for carcinoids Irrespective of histology, loss of nuclear and cytosolic PTEN correlated with concomitant loss of
Ngày tải lên: 30/09/2020, 13:55
Báo cáo khoa học: Differential interactions of decorin and decorin mutants with type I and type VI collagens pptx
... dimerization of decorin and binding of both collagens to the inner surface of decorin (B) Interaction of type I collagen with the inner surface of the decorin core protein and type VI collagen binding with ... interaction of wild-type decorin and decorin mutants with type I and type VI collagen and, for the first time, we analysed the formation of triple complexes consisting of type VI collagen, decorin and ... experiments without the addition of complexes were performed For the analysis of interactions between proteoglycans and collagens, the sensograms were corrected by a modification of the method of Roden and...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors ppt
... interaction and the perturbation of flexibility of CA may be the most effective against HIV-1 The molecular details of LysRS, CyPA and TRIM5a interactions with CA remain incomplete and additional ... Proteomics of HIV-1 capsid A Fig Role of TRIM5a and homology model of its PRYSPRY domain (A) The hypothesized role of TRIM5a in the HIV-1 viral life cycle (B) A homology model of the PRYSPRY domain of ... other CA and CyPA atoms that stabilize binding though hydrophobic interactions [38] A hydrogen bond formed between R55 of CyPA and P90 of CA anchors the proline, whereas the oxygen atom of G89...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... Analyses of novel Thermus competence proteins J Rumszauer et al N-terminal domain of PilQ, and the colocalization of PilQ with PilW in inner and outer membranes and the results from the pilW and pilQ ... to the C-termini of other members of the secretion family, such as PilQ of Myxococcus xanthus [28], ExeD of Aeromonas salmonicida [29], PilQ of P aeruginosa [25,30], and PilQ of N gonorrhoeae ... formation of the corresponding PulD of Klebsiella and PilQ of N gonorrhoeae [31,32] Taken together, the conserved C-terminus of PilQ and its outer membrane localization are in agreement with our...
Ngày tải lên: 07/03/2014, 12:20
STUDYING THE EFFECTIVENESS OF ANIMATION AND GRAPHICS WITH TEXT ON FOURTH, FIFTH AND SIXTH GRADERS potx
... Life Cycle of a Monarch Butterfly The content of the animation -with- text group was delivered in electronic media in form of animations embedded with text, and the content of the graphics -with- text ... significant difference with the mean values of 5.5 and 7.1 respectively In the graphic -with- text group pre and post scores show a statistically significant difference with means of 5.1 and 7.1 respectively ... FIGURES AND TABLES viii I INTRODUCTION Context of Study Effects of combining visuals with text Cognitive processes involved in learning Purpose of the Study Significance of the Study Statement of...
Ngày tải lên: 17/03/2014, 12:20
Báo cáo toán học: " Enumeration of Tilings of Diamonds and Hexagons with Defects" potx
... Aztec diamond of order We are interested in tilings of hexagons with lozenges, which are rhombi with unit sides and angles of 120 and 60 degrees, and tilings of Aztec diamonds with dominoes, ... number of tilings of half of a hexagon or half of a diamond, with dents at given places This is not new: see [7] and [8] Express the number of tilings of the figure as a whole as a sum of squares of ... matrix and M t is its transpose, then the determinant of M M t is equal to the sum of the squares of the k by k minors of M The number of tilings of a (k, q, k) hexagon in which the indices of the...
Ngày tải lên: 07/08/2014, 06:20
Báo cáo khoa học: " Intensity-modulated radiotherapy of nasopharyngeal carcinoma: a comparative treatment planning study of photons and protons" pps
... temporomandibular (TM) joints, and parotid glands whose normal functioning is essential for maintenance of the patients' overall well-being A quality of life (QoL) study of patients with head and neck cancer ... protection of several OARs and optimization of dose homogeneity and conformity to the concave and often irregularly-shaped target volumes in NPC have been beyond the operational scope of 3D-CRT ... 3D-CRT and IMRT [8] Recently, much interest is devoted to application of protons in the treatment of head and neck cancers [9-11] The dosimetric characteristics of protons, with sharp distal fall-off...
Ngày tải lên: 09/08/2014, 09:22