identification of conduct in differentiated markets

... protein-3 (MCP3), cellular retinoic acid binding protein (CRABP-II), and selectin P (SELP) were found to be elevated in ApoE-/- mice [17] The proteins VCAM, ICAM, and P-selectin play a role in ... protein levels of TNFα were increased in the ApoE-/- mice, whereas protein levels of IFNγ and IL-5 were increased but not their corresponding transcripts in the microarray data The discrepancy in ... cathepsin B, and cyclooxygenase-2 (COX-2), in addition to VCAM and ICAM, are also increased in the aorta of ApoE-/- mice [18] Furthermore, the elevated levels of VCAM, ICAM, cathepsin B proteins in

Ngày tải lên: 14/01/2020, 22:48

... genes spanning 100–400 nt and further processed by the RNA-induced silencing complex containing Argo-naute (AGO) proteins At the end of processing, de-pending on the presence of the type of AGO effector ... purification Finally, the library products were ready for sequencing by using Illu-mina HiSeq 2000 sRNAs from deep sequencing covered almost every kind of RNA, including miRNAs, siRNAs, piwi-interacting ... Trang 5peel (fading of dark red) and arils inside the fruit (accu-mulation of dark red) is the reverse So, the anthocyanin is increasingly accumulating in arils during the later stages of fruit development

Ngày tải lên: 22/05/2020, 04:29

... incu-bated in pretreatment solution at 80 °C for 35 min, rinsed for 3 min in deionised water, incubated 10– 20 min in 0.15% pepsin in 0.1 N HCl solution at 37 °C, and rinsed again for 3 min in ... established in a combinatorial analysis based on percentage of cells containing a genomic abnormality Each cut-off was de-termined by simulating all possible cut-off combinations (for each parameter in ... combina-tions presented in Table 1 require 3–6 FISH probes Inter-estingly, increasing the number of parameters from 4 to 5 did not appear to increase the AUC Performance of FISH with clinical

Ngày tải lên: 23/07/2020, 23:51

... explain SF and/or PF The intersection of ST, PT, and NT are those propositions in the indicative mood which use existing ends in describing and explaining SF and/or PF Understand that only the intersection ... all society gains in the long run Interest in the tion of incidence implies interest in how to shift the gains and losses ing from technological change Thus questions arise concerning how to control ... view, let us gain some facility in applying the device by examining the view set forth in Northrop Northrop separates theory into three kinds: (1) theory of natural ence, (2) theory of social science

Ngày tải lên: 23/10/2022, 15:26

... including oil composition Results Cloning and identification of miRNAs in jatropha In order to identify miRNAs in jatropha, we generated two small RNA libraries ranging in size from 18-26 nt using ... we conducted marker-traits analy-sis by using interspecies crossing populations be-tween Jatropha curcas and Jatropha integerrima [11] Herein we are searching for epigenetic factors in-cluding ... repressive effect of miRNAs on their target protein-coding genes In some cases, upregulation of gene expression is desirable Anti-miRNA oligonucleotides were proved to be useful in inhibiting individual

Ngày tải lên: 04/12/2022, 15:13

... determinants of the decreased HRQOL Supportive psychological care should be integrated into the management of long-term survivors of DTC Background The incidence of thyroid cancer is rapidly increasing ... Fatigue Inventory (BFI) The BFI was developed for the rapid assessment of fati-gue in cancer patients The BFI consists of nine ques-tions on a single page Fatigue and its interference in daily living ... E, Augeri C, Rasore E, Minuto F: A case-controlled study on the quality of life in a cohort of patients with history of differentiated thyroid carcinoma J Endocrinol Invest 2005, 28(7):599-608.

Ngày tải lên: 20/06/2014, 16:20

... strains harbor the Bin A, Bin B and Mtx1 genes encoding Bin A 42-, Bin B 51- and Mtx1 100-kDa proteins Sequencing of the binary toxin gene operons from local strains The preliminary bioinformatics ... presence of binary toxin (Bin A, Bin B) and/or mosquitocidal (Mtx) toxin genes Binary toxin is comprised of two polypeptides of 42- and 51-kDa and produced during sporulation The other group of toxins ... the presence of genes encoding Bin A, Bin B and Mtx1 in all analyzed strains; they are consistent with protein profiles The preliminary bioinformatics analysis of the binary toxin genes sequence

Ngày tải lên: 20/06/2014, 20:20

... and in drafting of the manuscript YNL is the co-supervisor who participated in the data analysis and drafting of the manuscript XDS contributed in the planning of the experimental program and in ... furanic species The continued growth in size of the cross-linked furanic species eventually results in the precipitation of the molecular clusters out of the solution into the primary carbonaceous ... formation of carbonaceous spheres from saccharides has been proposed The mechanism involves three steps, including dehydration of fructose into HMF, polycondensation of HMF monomers into primary

Ngày tải lên: 20/06/2014, 23:20

... re-sults Use of this test should help when determining the origin of maritime pine stands in the Aquitaine region of France. cpSSR / microsatellites / terpene / origin identification / Pinus pinaster ... 1M.M Ribeiro, G LeProvost et al.Origin identification of P pinaster stands using cpSSR Original article Origin identification of maritime pine stands in France using chloroplast simple-sequence repeats ... programs that have been undertaken in most parts of the range of P pinaster since the beginning of the twentieth century [5] The use of seeds of different origins, together with gene flow, has

Ngày tải lên: 08/08/2014, 14:20

... [14] Furthermore, peptidylarginine deiminase (PAD) generates citrulline residues by deimination of arginine residues of proteins Isoforms 2 and 4 of PAD were expressed in mononuclear cells isolated ... reports in which citrullinated fibrinogen was one of the major citrullinated autoantigens in RA [25,26] Besides fibrinogen, we found asporin, cathepsin D, β-actin, CapZα-1, albumin, histamine receptor, ... vimentin A single screening is not ideal for iden-tifying all the citrullinated proteins Repeated screening would elucidate greater numbers of citrullinated proteins Table 3 Comparison of clinical

Ngày tải lên: 09/08/2014, 08:23

... compo-nents of the pannus [2-8] and participate in maintaining joint inflammation, degradation of extracellular matrix (ECM) com-ponents, and invasion of cartilage and bone [2,4] as well as fibrosis of ... (cytokine–cytokine receptor interac-tions) The mean gene expression (blue line) and the intra-group inter-individual variances in RA and NC synovial membrane (red bar) are indicated, resulting in ... a loss of inter-individual gene expression variances) or desynchronization (that is, increased inter-individual gene expression variances) of gene expression within a group of different individuals/patients

Ngày tải lên: 09/08/2014, 10:23

... recombinant inbred (RI) mice Thirty-nine RI lines are aligned to show the points in C57BL/6.NOD-Aec1Aec2R(n) recombinant inbred (RI) mice points of their individual crossovers in the Aec2 region of ... of offspring produced in the first few pregnancies following inbreeding Results indicate that the loss of secretory flow rates was clearly evident for several of the RI lines, thereby retaining ... crossovers in Aec2 of chromosome 1, consisting of 33 lines with a single crossover in Aec2 and 16 lines with a crossover in both Aec1 and Aec2 In addition, lines were established using mice with

Ngày tải lên: 09/08/2014, 13:22

... bisphosphonates, such as tubulin cofactor B and ASK/DBF4 (Activator of S-phase kinase) The up-regulation of tubulin cofactor B may explain some previously unknown effects of nitrogen-containing bisphosphonates ... nitrogen-containing bisphosphonates induce extensive DNA damage, we also document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects ... discovery rate of q < 0.001 for the haploinsufficient strains, and of q < 0.01 for the haploproficient ones since only a smaller number of strains displayed an increase in growth rate (see

Ngày tải lên: 09/08/2014, 20:20

... optimal for the inclusion of noncoding functional sig-nals within genes [8] Such findings suggest that a tremen-dous amount of noncoding functional information may be contained in coding sequences ... non-coding motifs in non-coding regions based on sequence conserva-tion Much remains to be discovered about splicing, RNA-protein binding, microRNA binding, and the diverse other possible noncoding ... capable of detecting coding motifs functional at the DNA level MicroRNA binding motifs Finally, we considered whether COMIT was able to detect microRNA binding sites in coding regions We first examined

Ngày tải lên: 09/08/2014, 20:21

... most of the fusions (23 of 27) were predicted to be in-frame (Table 1), assuming that the splicing pattern of the rest of the transcript is retained. Should the reading frame not be retained ... to interact with Bcl-xL, and Ras in T-cells, resulting in the inhibition of apoptosis [29,30]. IKZF3 is located at the most common telomeric breakpoint of the ERBB2- amplicon [31]. Interestingly, ... present multiple lines of evidence suggesting the potential functional importance of the fusion genes, including the involvement of known oncogenic partner genes, exclusive expression of the partner

Ngày tải lên: 09/08/2014, 22:23

... affected residue being a part of the winged-helix DNA-binding motif observed across all E2F family of transcription factors [17] The arginine residues of E2F4 and its DP binding partner Trang ... are listed below Protein visualization and homology modeling Protein modeling of the mutated and wild-type DNA binding domain of E2F1 was done using the automated mode of SWISS-MODEL [18], a ... containing 2ml Master mix containing 4 microlitre of Rnase A, 100 microlitre of QIAGEN protease and 2 microlitre of Buffer G2 and mixed thoroughly The mixture is incubated in 50 degrees celsius incubator

Ngày tải lên: 09/08/2014, 23:20

... [11,13,2,5,0] At FU 103 of the healthy individuals had remained at KL 0, and 25 individuals had progressed (defined as an increase in KL score by one or more grades) Additionally, 10 of those individuals ... of pattern recognition methods [35] Here, methods also exist for combining markers in non-linear or non-parametric fashion [35] We limited ourselves to combinations defined by linear discriminant ... analysis, however, since it allows direct interpretation of the aggregate biomarker as a weighted sum of individual markers Evaluation of aggregate markers When performing linear discriminant analysis,...

Ngày tải lên: 09/08/2014, 14:22

... Guangdong Province of South China, just a couple of years after the first arrival of Chinese immigrants in the early nineteenth century [12] After being successful, many of them shifted their business ... components in the urine samples (Figure 13) 32    The total amount of maltol excreted in urine was estimated by enzyme digestion of the urine samples The HPLC method for determination of maltol in dark ... amounts excreted in urine for such two cases are also shown in (B) 40 Figure 17 The average total maltol (standardized with creatinine) measured in the different time point urine samples of 24 young...

Ngày tải lên: 09/10/2015, 10:49

... domain located at the amino-terminal and AF-2 domain at the carboxy-terminal The DNA binding domain (DBD) is connected to the ligand binding domain (LBD) by a flexible hinge Upon ligand binding ... ligand binding domain as illustrated in Figure NHRs are able to induce or regulate drug metabolism by binding to small lipophilic ligands Following ligand binding and dimerization, they then bind ... endogenous and exogenous toxins by modulating the expression of the genes involved in drug metabolism and disposition The detoxifying and elimination of these toxins is mainly mediated by cytochrome...

Ngày tải lên: 09/10/2015, 11:06

... definition of predatory practices in the airline industry and concepts of relevance in identifying these practices In addition, they highlight the irrelevance of cost-based tests of predation in airline ... complexity of airline pricing, scheduling and revenue management processes, not to mention the intricacies of modeling demand, booking behaviors, forecasting, and competitive airline interactions ... simulator of a competitive airline network, is used.1 To illustrate the impacts of entry, a single market network is simulated, with a set of competing airlines offering service in this market Initially...

Ngày tải lên: 25/11/2016, 21:53