dhea and cancer risk or prevention

... increased risks of all cancer, gastrointestinal cancer and colorectal cancer in male T2DM patients and with elevated risks of all cancer, gestational cancer and postmenopausal breast cancer in ... increased risk of overall cancer in both sexes, as well as increased risks of colon, rectum, prostate, and bladder cancers in men and increased colon, breast, and corpus uteri cancer risks in ... observed between BMI and the risk of both overall and breast cancer Obesity [1–4] and diabetes mellitus [5,6] are two inde-pendent risk factors for overall and certain types of cancer in general

Ngày tải lên: 03/07/2020, 01:21

... that the polymorphism was associated with a statistically significant decreased risk for nasopharyngeal cancer and bladder cancer, but an increased risk for esophageal cancer and skin cancer. Interestingly, ... using the following terms: “cyclooxygenase-2 or COX-2 or PTGS2” and “polymorphism or variant or geno-type” and “cancer or carcinoma or neoplasm” To expand our investigation, we also searched China ... between COX-2 8473 T > C polymorphism and cancer risk was detected. Keywords: COX-2 gene, 8473 T > C polymorphism, Cancer, Risk, Meta-analysis Background Currently, cancer is still considered

Ngày tải lên: 03/07/2020, 01:50

... ARA and risk of colorectal cancerAssessment Colorectal cancerassessment(diagnosis) Adjustment for potentialconfounders Assessment of reportingquality * Main findingsIntergroup comparison P or ... STROBE tool Trang 10and case-control studies were adjusted for well-knownpotential confounders, such as family history, body weight and smoking, and specific factors for colorectal cancer, such as ... cross-sectional studies, and target types of cancer were colorectal, skin, breast, prostate, lung, or stomach cancer Also included were studies investigating tissue ARA levels and target cancer risk The study

Ngày tải lên: 05/11/2020, 08:08

... Toll-like receptors (TLRs) and the transcription factor nuclear factor-κB (NFκB) are important in inflammation and cancer Methods: We examined the association between breast cancer risk and 233 tagging ... relationship between polymorphisms inTLR9 and breast cancer risk In exploratory pathway analyses we did not observe an association between TLR-NFκB related genes and breast cancer risk Although the results ... (GRASS) algorithm was used to conduct exploratory pathway analyses for genes in TLR or NFκB pathways [35] We examined the association between breast can-cer risk and two pathways for genes in

Ngày tải lên: 05/11/2020, 06:22

... prognosis and choosing the right candidates for adjuvant local irradiation or systemic treatments include tumor volume and pathological grade and status of surgical margins, seminal vesicles and pelvic ... tumor epithelial cells or by stromal cells, or by both, overexpression of POSTN in cancer stroma and/or in the epithelium is usually associated with the most ma-lignant phenotypes and with poor ... stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death Pier Vitale Nuzzo1,3, Alessandra

Ngày tải lên: 05/11/2020, 08:13

... b) risks in relation to hormone receptors, which are found on the tumor cell surface and bind estrogen or other endocrine-active agents, and c) interactions between prior agricultural work and ... reproductive risk factors such as: parity, dur-ation of lactdur-ation, menstrual and menopausal history, use of hormone replacement therapy and oral contra-ceptives, and family history Demographic and ... risk Table 1 Major and minor sectors, and counts of controls and cases by minor sector of longest duration 3 Petroleum/Petrochemical Petroleum, petrochemical, chemical manufacturing 8 6 Sector

Ngày tải lên: 06/03/2014, 02:21

... ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors [29] This study included 13,241 epithelial ovarian cancer cases and 3,605 borderline ovarian tumors ... biomarkers for predicting survival in ovarian tumor patients This chapter will discuss the new therapies, major risk factors in early and advanced ovarian cancer stage, and most prognostic factors as ... cervical cancer increases with the use of contraceptives in women with human papillomavirus infection They proved the increased risk for breast cancer and decreased risk for colorectal and endometrial

Ngày tải lên: 15/01/2018, 11:08

... polymorphism and susceptibility to colorectal cancer: a meta-analysis Tumor Biol 2013;34(1):555 –63. 26 Yang H, Li G, Li W Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer ... al. The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990 –2017: a systematic analysis for the global burden of ... 596) n (%) Tumor location Tumor differentiation Stage Status at last follow-up NOTE- Unknown data: Tumor location for 4 patients; Tumor differentiation for 7 patients; Tumor stage for 3 patients;

Ngày tải lên: 30/05/2020, 21:40

... racquet sports, swimming, aerobics, strenuous sports, or while at work)?” Physical activity was reported for three timepoints; young adulthood (20s and 30s), mid-adulthood (40s and 50s) and 2 years ... include both leisure and work activity together during each time period Moderate and vigorous physical activity are reported separately for each timepoint (20s and 30s, 40s and 50s, and 2 years ago) ... task (MET) score An average MET score of 7 was used for vigorous activity, and a score of 3 was used for moderate activity These average MET scores were Fig 1 Sampling flow diagram for cases from

Ngày tải lên: 17/06/2020, 03:13

... en-vironment and present in low concentrations in ambient air Silica is a metal oxide that exists in both crystalline and amorphous forms and is a major component of sand, rock, and mineral ores It ... almost 90% of all bladder cancers [13] Smoking is the most important risk factor for bladder cancer based on an attributable risk of 50% [14] Other established risk factors include older age, male ... our study, the results for workplace silica suggest that workers exposed at high frequencies and/or for long durations are at increased risk of bladder cancer The re-sults for asbestos do not suggest

Ngày tải lên: 17/06/2020, 03:18

... adjusted for beer and liquor, beer adjusted for wine and liquor, liquor adjusted for beer and wine) Trang 8Table 4 Potential effect modifiers of multivariable adjustedaHR and 95% CI for risk of ... analyses for a specific type of alcohol, our models additionally adjusted for other types of alcohol (wine adjusted for beer and liquor, beer adjusted for wine and liquor, liquor adjusted for beer and ... adjustedaHR and 95% CI for mortality risk associated with alcohol consumption before breast cancer diagnosis Person-years Breast cancer-specific mortality Mortality due to causes other than breast cancer

Ngày tải lên: 17/06/2020, 17:16

... his-tory, and genetic factors [3–5] Among these risk factors, family history is a recognized risk factor for the develop-ment of prostate cancer [6,7] Patients with a family his-tory of prostate cancer ... history of breast cancer and risk of prostate cancer Eighteen studies with 17,004,892 individuals in total evaluated the association between family history of breast cancer and risk of prostate cancer ... between history of breast cancer in daughters Fig 4 Forest plot of studies reporting association between family history of female breast cancer and lethal prostate cancer risk Trang 10only and increased

Ngày tải lên: 17/06/2020, 17:42

... endometrial cancer risk by approximately 42% Background According to GLOBOCAN worldwide cancer incidence and mortality report, there are annually 14.1 million new cases and 8.1 million deaths due to cancers ... risk of epithelial ovarian cancer [8,9] Bilateral salpingo-oophorectomy decreases the risk of ovarian cancer, but increases the risk of other cancers, cardiovascular disease, and all-cause mortality ... cancer risk In this random-effects analysis, Odds Ratios (OR) were summarized and a summary OR (SOR) was reported to examine the relationship More-over, a sensitivity analysis was performed when

Ngày tải lên: 17/06/2020, 18:26

... for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017 Fifteen and three studies were eligible for inclusion for body mass index and ... physical activity and colorectal cancer risk for those without and with a first-degree family history of colorectal cancer were 0.56 (95% confidence interval (CI) = 0.39–0.80) and 0.72 (95% CI ... activity as a cancer prevention strategy in population groups with strong risk factors for colorectal cancer Additional research among these subgroups is warranted Keywords: Exercise, Colorectal neoplasms,

Ngày tải lên: 24/07/2020, 00:13

... predictors Thus, 637 cases and 489 controls for risk analyses and 489 patients for survival analysis were included in the final study Trang 3Diet assessment and baseline information collectionInformation ... cases and 12,768 controls of European ancestry found no evidence for associations betweenGC rs2282679 and the risk of CRC overall or for colon or rectal tumor separately [26] In a Mendelian Randomization ... NFCCR: Newfoundland Familial Colorectal Cancer Registry; NFCCS: Newfoundland and Ontario Familial Colorectal Cancer Study; OR: Odds Ratio; OS: Overall Survival; PHQ: Personal History Questionnaire;

Ngày tải lên: 24/07/2020, 00:33

... most important risk factors for sev-eral major non-communicable diseases, including car-diovascular diseases, diabetes, and cancer, and the widespread prevalence of obesity is becoming a major threat ... Teppo L, Pukkala E Leanness and lung-cancer risk Int J Cancer 1991;49(2):208 –13. 7 Henley SJ, Flanders WD, Manatunga A, Thun MJ Leanness and lung cancer risk: fact or artifact? Epidemiology 2002;13(3):268 ... hazard ratios or odds ratios) and 95% confidence intervals (CIs) for never smokers were reported or could be calculated from the data 4) the outcome was the incidence or mortality of lung cancer; 5)

Ngày tải lên: 24/07/2020, 01:27

... EPIC cohort (Table1) In the SCS and SCHS cohort and for some of the EPIC participants (mainly for Oxford co-hort, Norwegian cohort and approximately two-thirds of the French cohort) height and weight ... between BMI and lung cancer risk was similar for overweight and obese men (OR 0.71, 95% CI: 0.62– 0.81 for overweight group; and OR 0.63, 95% CI: 0.52– 0.78 for obese group); the association for women ... adjusted ORs and 95% CIs for lung cancer according to baseline BMI categories Consider-ing all participants, and usConsider-ing normal weight as the reference group, a decreased risk of lung cancer

Ngày tải lên: 24/07/2020, 01:55

... Early Cancer and Cancer Risk Infrastructures were built to improve informatics and information flow across the Network A public web site and a secure web site contained general and specific information ... on Biomarkers of Early Cancer and Cancer Risk Biomarker Development Laboratories in 2008 These laboratories are responsible for development and characterization of new, or refinement of existing, ... colon cancer project; the Carotene and Retinol Efficacy Trial (CARET) for a lung cancer and mesothelioma project; and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) for...

Ngày tải lên: 14/02/2014, 21:20

... bioassays and are carcinogenic (Gold et al., 1997b) Dehydroepiandrosterone (DHEA) and DHEA sulfate are the major secretion products of adrenal glands in humans and are precursors of androgenic and ... divided by (Gaylor and Gold, 1998) Both linear extrapolation and the use of safety or uncertainty factors proportionately reduce 806 CHAPTER 38 Pesticide Residues in Food and Cancer Risk: A Critical ... cell killing and consequent cell replacement (a risk factor for cancer that can be limited to high doses) and that ignoring this effect in risk assessment can greatly exaggerate risks We estimate...

Ngày tải lên: 14/02/2014, 22:20

... Primary handler - Mixing/loading/applying wettable powders to fruit trees Residential Food Aggregate DWLOC cancer Cancer Cancer Food and ppb Risk Risk Residential 6.5x10 Secondary handler - Painting ... Acceptable daily intake for man: - 0.1 mg/kg Signs of Toxicity – Humans: Individuals working with captan or in fields where captan was applied reported eye and skin irritation Investigators conducted patch ... health effects Distribution and excretion Cancer risk Characterization Toxicity on animal Toxicity to human Cancer risk Notes Captan introduction 1,2,3,6-tetrahydro-N- (trichloromethylthio) phthalimide...

Ngày tải lên: 28/05/2016, 11:38