development of novel antitumor agents

... of new drug substances and in under-standing the basis of drug-target protein interactions [21–23] In the light of the literature survey, the purpose of this study is to synthesise a number of ... aece@biruni.edu.tr 1 Department of Chemistry, Faculty of Science, Karabuk University, 78050 Karabuk, Turkey 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, ... 34010 Istanbul, Turkey Full list of author information is available at the end of the article Trang 2Due to widespread of infectious diseases killing mil-lions of people, the need for new active,

Ngày tải lên: 29/05/2020, 13:24

... (0) =0.1 Fig 4.11 The predicted outlet size of distorted region vs θ0 with smaller inlet size of distorted region of 0.1 Chapter 4 A Development of Novel Integral Method 92 Trang 7α (0)0.0 0.1 ... radius of curvature of outlet size of distorted region tends to be in-creased whatever the inlet size of distorted region is In Fig 4.6, smaller inlet incident angle induces a larger propagation of ... size of distorted region vs α( 0 ) with higher inlet size of distorted region of 0.5 When inlet flow angle is very small, the outlet size of distorted region will de-crease with the decreasing of

Ngày tải lên: 21/06/2014, 21:20

... Trang 1DEVELOPMENT OF NOVEL CHIRAL STATIONARY PHASES FOR HPLC BASED ON COVALENTLY BONDED POLYSACCHARIDE DERIVATIVES ZHANG SHENG NATIONAL UNIVERSITY OF SINGAPORE 2009 Trang 2DEVELOPMENT OF NOVEL ... addition of chloroform or dichloromethane generally improves the resolution of tested racemic analytes On the other hand, addition of tetrahydrofuran is only able to improve the resolution of a few ... major concern for the development of an efficient asymmetric synthetic route.1 The development of an economically efficient asymmetric synthesis of a specific enantiomer is often resource-intensive

Ngày tải lên: 14/09/2015, 08:40

... amounts of data and have a potentially unlimited lifespan [2] The combination of RFID tags with sensing capability is a recent development in the field of RFID [3] The automatic control of quality ... read-range of each tag is acceptable (37 cm and 26 cm) and for the detection of two states of food (fresh and contaminated) In the maximum direction of radiation, the maximum read-range and minimum of ... pattern of each tag changes little, which means the direction of maximum radiation for each tag is also the same as a function of time While the gain of the antenna is changed the directions of maximum

Ngày tải lên: 16/12/2017, 03:58

... that approximately 86% of the soft gel remained after 3 h of admin-istration and 73% gel remained after 6 h of adminadmin-istration (Fig.5) Maintenance of the integrity of the gel over this time ... in 16 h (Q16 h) (marker of drug release characteristics) (21) Table 1 of supplementary data summarizes the nu-ances of key elements of QTPP, while apt justifications of the CQAs selected for ... function by Btrading off^ of various CQAs, as per the selected acceptance criteria, i.e., maximization of T60%, Q16 h, Gs, and minimization of Foand η, respectively Validation of the QbD methodology

Ngày tải lên: 11/05/2020, 12:08

... Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Højbakkegård Allé 9-13, DK-2630 Taastrup, Denmark Full list of author information is available at the end of ... exceeded the diameter of the pollen grain Genetic distance ♀ ♂ No of flowers pollinated Mean no of seeds per capsule (SE)a Germination percentageb Total no of seedlings Total no of plants Seedling ... pollination Page of 15 Kuligowska et al BMC Plant Biology (2015) 15:15 Page 10 of 15 Figure Pollen tube growth and fertilization of Kalanchoë species (A) Pollen grains of K pubescens on stigma of K blossfeldiana

Ngày tải lên: 26/05/2020, 23:31

... weight (number of bases of the PCR product multiplied by the average molecular weight of a pair of nucleic acids, which is 660), as described elsewhere [35] Then, serial dilutions of the above-quantified ... measurement of correlcorrel-ation for continuous non-normally distributed variables Probit statistical analysis was used for estimation of the limit of detection in our novel assays The association of ... different variant in the design of the novel COL11A1 assays: variants A and C employ a common set of probes, variants B and E employ a second different common set of probes and a common reverse

Ngày tải lên: 22/09/2020, 23:49

... characterized by its high oxygen content One of the primary applications of graphene oxide is in the development of thin membranes that facilitate the passage of water while effectively blocking harmful ... preparation of GO from graphite powder using a modified version of the Hummer method, as established by Hummers and Offeman in 1958.To synthesize the desired compound, combine 225 ml of H2SO4, 25 ml of ... upon the addition of acids or alkalis, 2.13g of ethane sulfonic acid (MES) was dissolved in 950 mL of deionized (DI) water, resulting in an initial pH of 4.02 Subsequently, 5 mL of sodium hydroxide

Ngày tải lên: 16/05/2021, 11:44

... load R I Radius of influence domain of node I th R0 Matrix form of original approximate function based RBF R1 Matrix form of first order derivative function based RBF R2 Matrix form of second order ... state of the art The necessary of mesh-free methods Parallel with the development of information technology and computer, the merical methods become indispensable tools for simulation and design of ... Finite Element Method Trang 15List of Notationsa Unknown vector in the approximation a I Set of expanded/unknown parameter A Area of nodal representation d Thickness of reinforced concrete slab d

Ngày tải lên: 16/03/2022, 14:21

... Talegaonkar S, Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent: In-vitro and ex-vivo investigations, Asian Journal of Pharmaceutical ... Trang 1Design and development of novel bioadhesive niosomal formulation for thetranscorneal delivery of anti-infective agent: In-vitro and ex-vivo investigations ... Trang 21(mg) Surfactant (mg) Cholesterol (mg) Chloroform (ml) Water (ml) Trang 23Yield point (Pa) % Permeated (24 h) Mean zone of inhibition of B Subtilis (mm)* Control Plecebo CN60-1 CN60-1

Ngày tải lên: 02/11/2022, 09:18

... load R I Radius of influence domain of node I th R0 Matrix form of original approximate function based RBF R1 Matrix form of first order derivative function based RBF R2 Matrix form of second order ... state of the art The necessary of mesh-free methods Parallel with the development of information technology and computer, the merical methods become indispensable tools for simulation and design of ... frameworkof a doctorate at Faculty of Civil Engineering, Ho Chi Minh city University ofTechnology and Education, Vietnam This work would have never been possiblewithout the support and help of many

Ngày tải lên: 09/12/2022, 08:12

... evaluation of novel N, N′-disubstituted benzimidazolium bromidessalts as antitumor agents Hasan K ¨ UC ¸ ¨ UKBAY1, ∗, Akın MUMCU1, Suat TEK˙IN2, S¨ uleyman SANDAL2 1Department of Chemistry, Faculty of ... microanalysis In vitro antitumor activities of the novel benzimidazole compounds (1–7) were determined by using ovarian (A2780) and prostate (PC-3) cancer cell lines Antitumor properties of all compounds ... data Each data point is an average of 10 viability measurements Table 5 Evaluation of the cytotoxicity and LogIC50 values ( µ M) of benzimidazole compounds (1–7) of two cancer cell lines (A2780

Ngày tải lên: 13/01/2022, 00:01

... Biological Evaluation of Novel 1-Alkyl-tryptophan Analogs as Potential Antitumor Agents Ting Sun 1 , Zhao-Long Li 2 , Hua Tian 3 , Shih-Chen Wang 1, * and Jiong Cai 1 1 Department of Nuclear Medicine, ... anti-neoplastic agents Keywords: tryptophan analogs; cytotoxicity; MTT OPEN ACCESS Trang 21 Introduction Tumor cells have the property of unlimited malignant growth The development of tumors is ... the site of active hydrogen in the indole ring of tryptophan was considered feasible[13] Unlike the common biosynthesis of natural amino acids and the complicated asymmetric synthesis of unnatural

Ngày tải lên: 19/03/2023, 15:26

... modifications of the enzyme. Application of the fibrinolytic enzymes has also been of great interest in Vietnam, focusing especially on the use of local enzyme sources. The preliminary experiments of this ... tienta2512@dhtcct.edu.vn 2 Faculty of Food Processing Technology, Can Tho University of Technology, Can Tho, Vietnam Full list of author information is available at the end of the article Phan et al. ... sets of three different chains: Aa,Bb and g (Mosesson 2005). The conversion of fibri- nogen into fibrin requires the presence of thrombin, a serine protease that cleaves the N-terminus of Aa

Ngày tải lên: 20/06/2014, 23:20

... also corrected the English of this manuscript SK conceived the Snapshots of representative outputs of RiCES Figure 3 Snapshots of representative outputs of RiCES A: List of cis-element candidate ... of the promoters of a given set of genes This evaluation is achieved by an association rule analysis Here, we present technical details of the tool and demon-strate the practical assessment of ... expression profiles The strategy depends on the idea that motifs overrepresented in the promoter region of the genes of interest could play specific roles in regulation of the expression of those

Ngày tải lên: 12/08/2014, 05:20

... composition of the mammary adipose compartment from brown fat to white fat during early development [4] By 3 weeks of age, the onset of puberty heralds the beginning of the process of ductal morphogenesis, ... sensitivity of differential gene expression The number of probe sets shown to increase from 2 to 5 weeks of murine mammary gland development was tabulated as a function of the number of probe sets ... characterization of early mammary gland development The goal of these methodological developments has been the elucidation of biological mechanisms underlying mammary gland development and carcinogenesis

Ngày tải lên: 14/08/2014, 14:21

... goal of this study is to develop novel microfabrication methods and microfluidic devices for BioMEMS applications The emphasis is on the development of new hot embossing techniques, the design of ... implementation of necessary microfluidic functions; integration of these functions with complete automation; and development of cost-effective manufacturing technology [Madou 2001] Microfluidics is ... contaminating the microfluidic channels 1.3 Outline Chapter contains a comprehensive literature review of microfabrication and and microfluidics Chapter contains experimental and simulation of the laser...

Ngày tải lên: 14/11/2014, 13:26

... FANGRUI Table of Contents Acknowledgements i Thesis Declaration iii Table of Contents iv Summary x xiii List of Tables List of Schemes xv List of Figures xx List of Abbreviations xxii List of Publications ... DEVELOPMENT OF NOVEL AMINO ACID-DERIVED MULTIFUNCTIONAL PHOSPHINES FOR ENANTIOSELECTIVE REACTIONS ZHONG FANGRUI (B.Sc., Zhejiang Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... Meanwhile, significant progress has also been made in the development of chiral phosphines This thesis describes the development of novel amino acid-derived multifunctional phosphines for several...

Ngày tải lên: 09/09/2015, 10:06

... support and encouragement I TABLE OF CONTENTS ACKNOWLEDGEMENT I TABLE OF CONTENTS II SUMMARY V LIST OF FIGURES VIII LIST OF TABLES XII LIST OF SYMBOLS LIST OF NOMENCLATURE XIII XV CHAPTER INTRODUCTION ... resistance of permeation exists through out the cross-section of a symmetric membrane The development of asymmetric membranes has brought the application of membranes into a new era The advantages of ... solution free of microsolute, microsolute solution free of macrosolute Liquid Solution free of microions, concentrated solution of microions, fractionation of microions Liquid Solvent free of all solutes,...

Ngày tải lên: 14/09/2015, 08:49

... DEVELOPMENT OF NOVEL MICROEXTRACTION METHODS WITH APPLICATION TO ENVIRONMENTAL ANALYSIS BY XIANMIN JIANG A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY ... investigate the application of these techniques to trace environmental analysis These novel microextraction techniques include the use of a new type of fiber for SPME; a novel mode of LPME/HF, solvent ... (a) conditioning of solid phase; (b) eluting of the unwanted components; (c) clean-up; (d) eluting the analytes of intent; (e) evaporation of the organic solvent and concentration of the analytes...

Ngày tải lên: 15/09/2015, 17:09