design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti infective agent in vitro and ex vivo investigations

Design and development of novel bioadhesive niosomal formulation for thetranscorneal delivery of anti-infective agent: In-vitro and ex-vivo investigations Yahaya Zubairu, Lalit Mohan Neg

Design and development of novel bioadhesive niosomal formulation for the

transcorneal delivery of anti-infective agent: In-vitro and ex-vivo investigations

Yahaya Zubairu, Lalit Mohan Negi, Zeenat Iqbal, Sushama Talegaonkar

DOI: 10.1016/j.ajps.2015.02.001

Reference: AJPS 124

To appear in: Asian Journal of Pharmaceutical Sciences

Received Date: 23 July 2014

Revised Date: 8 February 2015

Accepted Date: 16 February 2015

Please cite this article as: Zubairu Y, Negi LM, Iqbal Z, Talegaonkar S, Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent: In-vitro and ex-vivo

investigations, Asian Journal of Pharmaceutical Sciences (2015), doi: 10.1016/j.ajps.2015.02.001.

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(mg)

Surfactant (mg)

Cholesterol (mg)

Chloroform (ml)

Water (ml)

Yield point (Pa)

% Permeated (24 h)

Mean zone of inhibition of B Subtilis (mm)*

Control Plecebo CN60-1 CN60-1 Marketed eye

Fig 3: Transcorneal permeation profile

Fig 4 In-house bioadhesion testing assembly

Fig 5: Fluorescent images showing permeation through the goat cornea (Dye solution) [(A1) 2 hours, (A2) 6 hours, and (A3) 12 hours], (uncoated niosomes, NS60-5) [(B1) 2 hours, (B2) 6 hours, and (B3) 12 hours], and (coated niosomes CNS60-1) [(C1) 2 hours, (C2) 6 hours, and (C3) 12 hours]

Fig 6: Histological study of goat cornea A KCl solution, B Normal saline, C Drug suspension, and D CNS60-1