cancer molecular mechanisms of therapy

... AccessMolecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells Alex Y Chang1,2*and Miao Wang1 Abstract Background: Molecular ... evaluating the molecular mechanisms of dasatinib on human solid tumor cells such as prostate cancer, head and neck squamous cell carcinoma, non-small cell lung cancer, breast cancer, but the ... and invasion Inhibition of this pathway is one of the mechanisms of action of dasatinib In MDA-MB-231 human metastatic breast cells, dasatinib also showed the inhibition of cell proliferation,

Ngày tải lên: 05/11/2020, 06:36

... 1 Cellular and molecular mechanisms of atherosclerosis and role of EPA Mechanisms are depicted in the illustrations and described below; effects of EPA are listed to the right of each figure indicating ... biologic plausibility of its effects on multiple key atherosclerosis processes Herein, we re-view the integrated effects of EPA on the cellular and molecular mechanisms of atherosclerotic plaque ... prevention of CV events, as well as its cellular effects and molecular mechanisms of action REDUCE-IT is an ongoing, randomized, controlled study evaluating whether the high-purity ethyl ester of EPA

Ngày tải lên: 01/11/2022, 08:56

... subunit isoforms [23,24] Elucidation of the architecture of these eukaryotic NaV elements begins to flesh out key pieces of the NaV molecular framework but has left the larger question of understanding ... From the standpoint of ion channel biophysics, studies of NaVs have set a number of paradigms for understanding channel function including the importance of the S4 segment of the VSD in voltage ... light of the PD of the full-length structure of the prototypical potassium channel, KcsA [77] (Fig 3b and Table 1) This comparison reveals the striking conservation of the core tertiary fold of

Ngày tải lên: 02/11/2022, 08:55

... 2075-1729 www.mdpi.com/journal/life Review Molecular Mechanisms of Adaptation of the Moderately Inga Hänelt and Volker Müller * Department of Molecular Microbiology and Bioenergetics, Goethe ... and 2.0 M NaCl but can tolerate NaCl concentrations of up to 3.0 M NaCl with a growth rate of 38% of the optimum [3] Strategies of osmoadaption of H halophilus have been studied extensively in ... germination of endospores [8] and the motility of the vegetative cell [9] but also to control the expression of genes and the enzymatic activity of proteins needed for the halophilic life style of H

Ngày tải lên: 02/11/2022, 14:41

... ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Review Molecular Mechanisms of Taste Recognition: Considerations about the Role of Saliva Tibor Károly Fábián ... leading to the generation of action potentials by means of the voltage-gated sodium channels (VGSC) of cells [3,25,48] The generation of action potential leads to the release of adenosine 5'-trisphosphate ... and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/) Copyright of International Journal of Molecular Sciences is the property of MDPI Publishing

Ngày tải lên: 02/11/2022, 14:42

... and the analysis of transcription factors (TFs) Ultimately, this work will provide new insights into the molecular mechanisms of maize kernel and silk development Results Overview of RNA-seq data ... is the main component of mature maize kernels, and starch content is one of the main targets of maize breeding Starch biosynthesis requires the proper execution of a series of coordinated enzymes ... transcript profiles were determined in an elite maize inbred line (KA105) to investigate the molecular mechanisms functioning in self-pollinated and unpollinated maize kernels and silks A total of 5285

Ngày tải lên: 30/01/2023, 20:20

... IC50 of 10.0 àM [78] Notably, colossolactone IV has been shown to exert anticancer effects on various cancer cell lines, including breast cancer (MCF-7), cervical cancer (HeLa), colorectal cancer ... insights into the molecular mechanisms of action and aids in the chemical optimization of lead compounds to improve their biological activity.Molecular docking has limitations, as most software treats ... mutations are linked to various cancers, notably non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer (Figure 1.1). Figure 1.1 Schematic diagram of the EGFR signaling pathway

Ngày tải lên: 23/07/2025, 00:30

... AccessTraffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy Viera Dobrotkova1,2, Petr Chlapek1,2, ... of biological anticancer therapy, the discovery of bio-markers that indicate retinoid resistance or sensitivity in each individual patient seems to be important for the re-cent personalized therapy ... and a poor prognosis [42–45] One of the Fig 1 Possible mechanisms of retinoid resistance Cancer cell retinoid resistance may be caused by several independent mechanisms including (1) decreased

Ngày tải lên: 03/07/2020, 00:52

... most types of early-stage cancers, let alone precancerous lesions Once cancer has been detected, the next challenge is to classify that specific tumor into one of various subtypes, each of which ... concentration of a specific protein on a cell’s surface Identification of a cancer by its molecular expression profile, rather than by one specific biomarker, might be necessary to thoroughly classify cancer ... the emergence of gene and protein profiling and microarray technology, high-throughput screening of biomarkers has generated databases of genomic and expression data for certain cancer types,

Ngày tải lên: 15/02/2014, 05:20

... tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors Kenji Takeuchi and Fumiaki Ito Department of Biochemistry, Faculty of Pharmaceutical ... Regulation of Bcl-2 family members can occur by a number of mechanisms, including up-regulation of synthesis, enhancement of degrad-ation and phosphoryldegrad-ation In the event that cancer cells ... associated with stimulation of ERK1⁄ 2 and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi-tion of ERK1⁄ 2 and Pak1 The use of gefitinib in cells

Ngày tải lên: 16/02/2014, 09:20

... understanding of the molecular features of Ngb in dictating its biological function is of great interest, especially considering the possible implications of this protein in the pathophysi-ology of conditions ... [22,26] Clearly, it is of interest to take advantage of the wealth of structural information available for Mb and apoMb for the comparative study of the molecular features of the homologous Ngb ... H64Q mutant of Ngb was followed by measuring the decrease in intensity of the Soret band (Ngb, kmax of 412 nm; H64Q, kmax of 406 nm; Mb, kmax of 409 nm) in the absorption spectra of the proteins,

Ngày tải lên: 07/03/2014, 02:20

... cells, of caspase 8, followed by later activation of caspase 9 In IMR90 cells only moderate activation of caspase 3 was found as a consequence of the modest activation of caspase 9 and the lack of ... University of Florence, Italy 4 Interuniversity Centre for the Study of the Molecular Basis of Neurodegenerative Diseases, University of Florence, Italy Keywords amyloid toxicity; apoptosis; mitochondrial ... followed by a sudden repair of membrane integrity with rapid and efficient inhibition of cytochrome c and AIF release, and upregulation of Bcl-2 The greater resistance of IMR90 fibroblasts may also

Ngày tải lên: 16/03/2014, 13:20

... marked by aster-isks) Estimation of the performance of classification of breast can-cer samples Figure 1 Estimation of the performance of classification of breast cancer samples A – The total error ... differences of serum proteome patterns between sub-groups of breast cancers patients Figure 3 Estimation of differences of serum proteome pat-terns between sub-groups of breast cancers patients ... work is properly cited. Trang 2level of osteopontin in blood of the group of cancer patients studied (however, the plasma level ofosteopontin classified cancer samples with 88% sensitivity but

Ngày tải lên: 18/06/2014, 15:20

... “anti-viral state” is a characteristic molecular phenotype of a subset of pancreatic cancers that may be the result of a specific mutational profile of cancer cells which is difficult to be understood ... human cancers and can predict responsiveness of breast cancer to chemotherapy and radiation therapy based on the expression pattern of ISGs In this study, we identified by transcriptional profiling ... gene therapy We believe that this finding can be of crucial interest for the field of cancer vaccines and gene therapy by giving important pre-screening tools that could aid in the selection of

Ngày tải lên: 18/06/2014, 16:20

... classification of breast cancer Here we aimed to identify changes in serum proteome patterns related to therapy of breast cancer patients Methods: Blood samples were collected before the start of therapy, ... Time-of-Flight (ToF) analyzer Numerous works have been published aiming to verify the applicability of MALDI- and SELDI-based analyses of the low-molecular-weight fraction of blood proteome for cancer ... start of therapy and one year after the end of therapy (A vs C), as well as samples collected after the surgery and one year after the end of therapy (B vs C) Figure 1B shows location of such

Ngày tải lên: 18/06/2014, 16:20

... which were restored by GH1 therapy GH therapy also decreased the severity of fatty liver in alcohol-fed mice Conclusions: GH therapy had positive effects on AFLD and may offer a promising approach ... models of alcoholic fatty liver disease (AFLD) and explored the underlying molecular mechanisms Methods: Male C57BL/6J mice were fed either an alcohol or a control liquid diet with or without GH therapy ... receptor (GHR) on the surface of target cells and induces the association of GHR with Janus kinase (JAK)-2 to initiate tyrosine phosphorylation of GHR and JAK2 Phosphorylation of GHR and JAK2 consequently

Ngày tải lên: 18/06/2014, 16:20

... and biological therapy of cancer: a summary of the 2010 program James M Balwit1, Patrick Hwu2, Walter J Urba3, Francesco M Marincola1,4* Abstract The Society for Immunotherapy of Cancer, SITC (formerly ... Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy The society ... Cancer Immunotherapy Kim A Margolin, MD (University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance) presented on the immunobiology of cyto-kines A model of

Ngày tải lên: 18/06/2014, 19:20

... Open Access In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers Karen J Wong1, Kwamena E Baidoo2, Tapan K Nayak2, ... 59.5% of the radioactivity was bound The addition of 10 μg of unlabeled fragment, which reduced the percentage of bound radioactivity to an average of 3.5%, demonstrated the specificity of the ... et al.: In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers EJNMMI Research 2011 1:1 Submit your manuscript

Ngày tải lên: 21/06/2014, 02:20

... expression profiles of these selected genes, particularly of pairs or triplets of genes detected 3 days after the start of treatment, were identified as being closely associated with the outcome of therapy ... the cutoff point to define genes as differentially regulated. Second, an algorithm for learning of classifiers used for predic- tion of the therapy outcome on evaluation of the fold change of pairs ... by a good therapy response, as indicated by a signif- icant reduction of the DAS28 >1.2 without progression of bone erosions as shown by X-ray scans of hands and feet. Three out of seven nonresponders

Ngày tải lên: 09/08/2014, 10:23

... molecular mechanisms of the enzyme action Most importantly, we want to critically review the evidence that Pin1 would or would not act as a prolyl cis ⁄ trans isomerase Molecular mechanisms of ... et al Molecular mechanisms of Pin1 tPro213 Fig NOESY spectrum of the triply phosphorylated SRSRpT212PpS214LPpT217PPTR peptide of Tau The cis conformation for the Pro219 is below the limit of detection ... 2007 FEBS 5215 Molecular mechanisms of Pin1 G Lippens et al populations, as one of the forms would continuously disappear from the pool of free peptides Structural characterization of the MPM-2...

Ngày tải lên: 07/03/2014, 05:20