... people now take context-aware systems as systems that can manage context data and enable context-aware applications that automatically adapt their behaviors with situational information of users, ... the context data management so that application developers can be liberated from the laborious task of programming the process of data retrieval as well as data handling which is data source dependent ... mobile space that it represents, as well as functions for managing context data and services of the mobile space Secondly, to enable Trang 12systematic data access and lower level context data manipulations,
Ngày tải lên: 11/09/2015, 21:37
... data In addition to cleaning thedata, it may be necessary to transform the data into a form more amenable Trang 28for data analysis Mapping the data onto new ranges, transforming gorical data ... looking at the data in many ways using a combi-nation of data visualization, data analysis, and data mining methods Forexample, a retail company may want to understand customer profiles and other facts ... programs.Many free and commercial software programs exist to sift through data,such as spreadsheet applications, data visualization software, statisticalpackages and scripting languages, and data
Ngày tải lên: 05/11/2019, 14:29
Tài liệu Module 1: Introduction to Advanced Administration of a Windows 2000 Network docx
... resources as objects in a centralized database, Active Directory enables a single administrator to centrally manage and administer these resources ?? Active Directory contains attributes and information ... information available to users and applications Active Directory provides administrators with the capability to centrally manage resources because: ?? Active Directory is a central repository ... of access tokens Emphasize that access tokens are permanently attached to each resource Explain how access token and DACLs are used to gain access to Windows 2000 resources Emphasize that the process
Ngày tải lên: 17/01/2014, 08:20
Tài liệu Module 2: Choosing a Migration Path to Windows 2000 Active Directory doc
... its business and operations It specifies where and how information is stored (such as in databases) and how data is moved and shared throughout the organization It identifies data-management policies, ... Identify any domains and trust relationships that you do not want to move into your Windows 2000 forest Domains that are upgraded to Windows 2000 domains and designated as part of the same forest ... information, such as accounting data Document any guidelines that exist regarding appropriate network usage; for example, whether staff members can access the Web and for what purposes, and what
Ngày tải lên: 18/01/2014, 05:20
Tài liệu Module 1: Introduction to Managing a Windows 2000 Network doc
... capability to centrally manage your Windows 2000 network This capability means that you can centrally store information about the enterprise, and administrators can manage the network from a ... Is dynamically available to user applications, which enables user applications to read the schema to discover which objects and properties are available for use ! Is dynamically updateable, ... used in many object classes but is defined only once in the schema to ensure consistency The Active Directory database stores the schema Storing the schema in a database means that the schema: !
Ngày tải lên: 24/01/2014, 10:20
Tài liệu Báo cáo khoa học: Four divergent Arabidopsis ethylene-responsive element-binding factor domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference pptx
... Arabidopsis thaliana cor15a has cis-acting elements that confer cold-, drought- and ABA-regulated gene expression Plant Mol Biol 24, 701–713 15 Prabakaran P, An J, Gromiha M, Selvaraj S, Uedaira H, Kono ... sequences was calculated, leading to the establish-ment of the selected binding site Phylogenetic analysis The amino acid sequences of all AtERFs were downloaded from the Database of Arabidopsis Transcription ... KD (1997) The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis Proc Natl Acad Sci USA 94, 7076–7081 ERE-BP family of plant transcription factors Biol Chem
Ngày tải lên: 18/02/2014, 13:20
Báo cáo khoa học: Identification of the epitope of a monoclonal antibody that disrupts binding of human transferrin to the human transferrin receptor pptx
... used to amplify regions of the N- and C-lobes of hTF and clone into the pGEX 4T3 plasmid. AAAGCGGCCGCTTAGCATGTGCCTTCCCGTAG AAAGAATTCATTAAGGTCTACGGAAAGTGCAGG AAAGAATTCTTACAGGTGAGGTCAGAAGCTGATT AAAGAATTCTTAACCTGAAAGCGCCTGTGTAG ... AAAGAATTCTTAACCTGAAAGCGCCTGTGTAG AAAGAATTCTTAGGTGCTGCTGTTGACGTAATAT AAAGAATTCTTAGGCAGCCCTACCTCTGAGATTTT GGCGATGCAGTCTTCGGTGTTCTCTGCTGATACAC GGTGGTCTCTGCTGATTCACACTCTATTTTCCC a Restriction sites are ... peroxidase sub-strate system was from Kirkegaard and Perry Laboratories (Gaithersburg, MD) All other chemicals and reagents were of analytical grade Milli-Q water was used to prepare all solutions
Ngày tải lên: 30/03/2014, 11:20
Báo cáo hóa học: " A Proxy Architecture to Enhance the Performance of WAP 2.0 by Data Compression" ppt
... at the wireless transaction layer in a manner that is transparent to the wireless data bearer service In WAP 1.x, a content encoding approach is used at the WAP gateway to compress the data Although ... such as bank and financial transactions and e-business, be-cause it is analogous to allowing your ISP to process (and inspect) the data of secure transactions The only viable so-lution that strictly ... infrastructure and to maintain their own gateways, the WAP clients also have to be configured to switch gateways to access various secure WAP applications The latter, like having to switch ISPs when accessing
Ngày tải lên: 23/06/2014, 00:20
Báo cáo y học: "A human functional protein interaction network and its application to cancer data analysis" potx
... unambiguously associate a position on the genome with a component of a pathway A putable data model and highly reliable data sets makeReactome an ideal platform for a pathway-based dataanalysis system ... pairwise relationships in a pathway context is that the data models used by path-way databases are much richer than a simple binary rela-tionship A pathway database describes pathways in terms ... pathway-based analyses For this reason,groups that make pathway-based inferences on high-throughput functional data sets inevitably draw oncurated pathway projects to cleanse their data and totrain
Ngày tải lên: 09/08/2014, 20:22
Báo cáo sinh học: " Exact distribution of a pattern in a set of random sequences generated by a Markov source: applications to biological data" pdf
... approaches to the tempting approximation that consists in concatenating the sequences in the data set into a single sequence Conclusions: Our algorithms prove to be effective and able to handle real data ... UniProtKB/TrEMBL database [3] Sequence ana-lysis has become a major field of bioinformatics, and it is now natural to search for patterns (also called motifs) in biological sequences Sequence patterns ... possible to associate a reg-ular expression to this particreg-ular pattern In that sense, PSSM may be seen as a particular case of the class of patterns we considered in this paper However, this approach
Ngày tải lên: 12/08/2014, 17:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 2 pptx
... for dealing with these reactions In theBrønsted—Lowry classification, an acid is any substance that can donate a proton, and a base is any substance that can accept a proton by reacting with a Brønsted—Lowry ... 16Table 2.4 Van der Waals radii for atoms in proteinsTable 2.4 provides the van der Waals radii for the most abundant atomsfound in proteins Imagine drawing a sphere around each atom with a radiusdefined ... unfavorable(nonspontaneous) reaction by coupling it to a favorable (spontaneous) one Suppose, for example, that the product of an unfavorablereaction was also a reactant for a thermodynamically
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 3 pot
... ligand at the initiation of the experiment) The chambers are then sealed, and the apparatus is place on an orbital rocker, or a mechanical rotator, in a thermostated container (e.g., an incubator ... plots are referred to as Hanes— Wolff plots A word of caution is in order with regard to these linear transformations Any mathematical transformation of data can introduce errors due to the transformation ... known as Scatchard plots, are the most popular linear transformation used for ligand binding data We shall encounter this same plot in Chapter for use in analyzing steady state enzyme kinetic data;
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 4 ppsx
... studies are now commercially available from anumber of manufacturers(e.g., BioRad, AmiKa Corporation) The second variation of size exclusion chromatography that is applicable to ligand binding measurements ... pressure, as in conventional chromatography After thecolumn has been equilibrated with buffer, a sample of the equilibrated receptor—ligand mixture is applied to the column A separate sample of ... signal at anypoint within a ligand titration will be given by: Since [R] is equivalent to [R]9[RL], we can rearrange this equation to: Equation 4.41 can be rearranged further to give the fraction
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 5 docx
... phosphate cofactor Pyridoxal phosphate(see Chapter 3) is a required cofactor for the majority of enzymes catalyzing chemical reactions at the alpha, beta, and gammacarbons of the-amino acids (Chapter ... bound to substrates can also affect the substrateconformation to enhance catalysis; that is, they can change the geometry of asubstrate molecule in such a way as to facilitate reactivity In the ATP-dependent ... withdrawal; and it can act to bridge a substrate and cataly-nucleophilic group; they can alter the pK? and reactivity of nearby nucleophiles.Metal ions are also used in enzyme catalysis as binding
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 6 pot
... which can be accessed on the Internet.* This data bank provides ECnumbers, recommended names, alternative names, catalytic activities, informa-tion on cofactor utilization, and associated diseases ... loss and product formation are linear with time As the reaction progresses, one should see curvature and an eventual plateau as the substrate supply is exhausted In some situations a lag phase may ... device A laboratory timer or stopwatch can be used todetermine the time gap Many nonspectroscopic assays require measurement times that are long incomparison to the rate of the enzymatic reaction
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 7 pdf
... integrated area under a peak in the chromatograph and compares it to a calibration curve of the area under the peak as a function of mass for astandard sample of the analyte of interest Let us again ... strip-chart paper with scissors The excised piece of paper is weighted on an analytical balance, and its mass is taken as a reasonableestimate of the relative peak area Obviously, the two manual methods ... silica-based resins that are coated ontopaper sheets or plastic or glass plates A capillary tube is used to spot samplesonto the medium at a marked location near one end of the sheet, which isplaced
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 8 docx
... that significant inhibitor effects are realized while maintaining sufficientsignal from the assay readout to obtain accurate data STRUCTURE—ACTIVITY RELATIONSHIPS AND INHIBITOR DESIGN 273 Trang ... for example, one may wish to screen severalthousand compounds as potential inhibitors to find those that have somepotency against a particular target enzyme These compounds are likely tospan a wide ... effects of a competitive inhibitor on the velocity of an enzyme catalyzed reaction The lines drawn in (B) are obtainedby applying Equation 5.24 to the data in (A) and using the apparent values of
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 9 ppt
... CONCENTRATION In many experimental strategies one wishes to know the concentration ofenzyme in a sample for subsequent data analysis This approach applies notonly to kinetic data, but also to other ... fitting of fractional velocity versus inhibitorconcentration data to Equation 9.6 Such data would call for predetermination of the substrate concentration in the assays Then the data, such as the points ... examples include inhibitors ofdihydrofolate reductase (as anticancer drugs), inhibitors of the HIV aspartylprotease,(as anti-AIDS drugs), and inhibitors of metalloproteases (as potentialcartilage
Ngày tải lên: 13/08/2014, 07:20
A Practical Introduction to Structure, Mechanism, and Data Analysis - Part 10 doc
... repeated atincreasing concentrations of A and AX, to keep the ratio [A]/[AX] constant(i.e., to avoid a shift in the position of the equilibrium) As the amounts of Aand AX are changed, the rate ... to be released If this is the case, the rate of radiolabel incorporationinto BX will initially increase as the concentrations of A and AX are increased mechan-As the concentrations of A and AX ... V.(1979) Annu Rev Biochem 48, 293. Copeland, R A.(1994) Methods for Protein Analysis: A Practical Guide to L aboratory Protocols, Chapman & Hall, New York, pp 151— 160. Copeland, R A., Williams,
Ngày tải lên: 13/08/2014, 07:20
Báo cáo y học: "Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data" ppt
... vincu-lin, and zyxin The peptides that interact with alpha-actinin tend to be basic, alpha-helical, and appear to inter-act with the conserved acidic surface of the alpha-inter-actinin rod [28] Alpha-actinin ... (Figure 3, panel c) Talin Talin is an abundant cytoskeletal protein that binds to the cytoplasmic tails of integrin beta subunits, to actin fila-ments, to other actin-binding proteins, and to phospholi-pids ... head (Vh) and tail (Vt) domains Vinculin activation, associated with junctional signaling, generates an open conformation that binds in vitro to talin, alpha-actinin, paxillin, actin, the Arp2/3
Ngày tải lên: 13/08/2014, 23:20
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