a computational model of reference

... Average particle HL attachment rate LDL day-1 0.026 N.S Average particle HL attachment rate VLDL2 day-1 0.034 N.S Average particle lipolysis rate LDL Size and age parameters Average particle age LDL ... ben.vanommen@tno.nl APF: a.freidig@amtbiopharma.com JvdG: jan.vandergreef@tno.nl AAdG: albert.degraaf@tno.nl -1- Abstract Background Dyslipidemia is an important risk factor for cardiovascular ... rate information of each particle, the model can calculate the average metabolic rate of particles in a certain size range of interest, for instance the VLDL size range (see [13]) The model also

Ngày tải lên: 10/08/2014, 09:22

... Trang 1A computational model of gene expression reveals early transcriptional events at the subtelomeric regions of the malaria parasite, Plasmodium falciparum Matthias Scholz and Martin J Fraunholz ... Circular PCA can model intra-erythrocytic malaria parasite development We analyzed the comprehensive malaria IDC transcriptome data from Bozdech et al [1] and Llinas et al [2] using circular PCA ... investigated malaria parasites lasts about 47 hours This value is a result of component analysis and has not been supplied in advance The expected gaps for missing observations at 23 and 29 hours are also

Ngày tải lên: 14/08/2014, 08:21

... frontal and parietal areas that bridges between the other levels in aprincipled way The model has been evaluated against behavioral data collected from normalyoung adults, behavioral data collected ... four binary-valued and oneternary-valued They define a space of 48 model variants that are evaluated against the data Theresult of interest is not best-fitting values for the model’s free parameters ... variation between participants, enabling precisecalculation of the computational demand of each problem and, when a constrained presentationparadigm is adopted, of each move The casualty of explicit

Ngày tải lên: 13/11/2014, 10:58

... properties of the model Model Mathematical Modeling of Circadian Rhythms In all organisms studied so far, circadian rhythms that allow adaptation to a periodically changing environment originate from ... negative autoregulation of gene expres-sion Scheper et al [10] illustrated and analyzed the gen-eration of a circadian rhythm as a process involving a reaction cascade containing a loop, as depicted ... population The fre-quencies of alleles A and a are q and 1 - q, respectively For a particular genotype j of this QTL (j = 0 for aa, 1 for Aa and 2 for AA), the parameters describing circadian rhythms

Ngày tải lên: 13/08/2014, 16:21

... initial state of the comparison layer and choice model, which always start at neutral (in the current applications) Unlike the comparison layer of the model, the initial state of the value search, ... associated candidate values Almost all of the work is done by the computational model,which appears more complex than standard models of decisionmaking In reality, the model does not require an abundance ... transition probabilities amongvalues in the search layer Figure 3. Representation of sequential value matching, showing (a) valuesearch layer as a discrete Markov chain and (b) both search and

Ngày tải lên: 09/09/2020, 15:06

... constitution In Ivan Sag and Anna Sa- bolcsi (eds.), Lexical Matters, Chicago Univer- sity Press, 1991 [Lascarides and Asher, 1991] Alex Lascarides and Nicholas Asher Discourse relations and com- monsense ... including time adverbials, progressive aspect and various aspectual classes In particular, the gram- mar generates the required readings, accor- ding to the theoretical analysis of (Glasbey, forthcoming), ... ana- lysed as stative in the literature (for example, by Vlach (1981)) Part of the motivation given for the progressive-as-stative analysis concerns facts about temporal overlap and updating We

Ngày tải lên: 18/03/2014, 02:20

... incremental language compre-hension, especially, there is a substantial amount of computational work suggesting that humans be-have rationally (e.g., Jurafsky, 1996; Narayanan & Jurafsky, 2001; ... behavior of these models looks like human behavior, it suggests that humans are making rational use of all the infor-mation available to them in language processing In the domain of incremental ... strings, AB and BA, and assume that the eyes can only get noisy in-formation about the identity of one character at a time After obtaining a little information about the identity of the first character,

Ngày tải lên: 23/03/2014, 16:20

... probabilistic Combinatory Categorial Grammar (CCG) framework, and assume only that the learner has access to a small set of general combinatory schemata and a functional mapping from semantic ... syn-tactic productions are allowed in the grammar: START→ A to generate A as the top syntactic node of a parse tree and A→ [A]lex to indicate that A is a leaf node in the syntactic derivation and ... (2010) Learning general properties of semantic roles from usage data: a computational model Language and Cognitive Processes, 25:1 Beal, M J (2003) Variational algorithms for ap-proximate Bayesian

Ngày tải lên: 31/03/2014, 20:20

... 105) at passage 6 were transplanted into the cisterna magna of 10 ischemic rats seven days after the Trang 5induction of focal cerebral ischemia Transplanted ani-mals did not behave abnormally ... Transplantation Seven days after the induction of focal cerebral ischemia, animals were anesthetized with an intra-peritoneal injec-tion of 400 mg/kg chloral hydrate (Pharmaceutical Plant of ... occlusion of a cerebral artery with thrombi and emboli, which leads to an infarction and the death of neural tissue Current treatments are pri-marily palliative and are useful to only a minority of patients

Ngày tải lên: 18/06/2014, 16:20

... Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, PR China Full list of author information is available at the end of the article © 2011 Xu et al; ... 30672438) and the Hubei Provincial Natural Science Foundation of China (Nos 2006ABC009 and JX4A06). Author details 1 Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, ... toxicity, as shown by serum analysis for biochemical markers of liver and kidney and the histological examination of hematoxylin and eosin stained major organs (Figure 5) Taking all these data into

Ngày tải lên: 18/06/2014, 19:20

... interface of ablated and distant tumors, at the abla-tion injury front and within vascular lakes of ablated and distant tumors These increases persisted at high levels compared to shams at all ... mice had sham TA performed (LA probe was not activated) Panels a and b tumor sections from control (sham ablated) and LA treated animals at day 5 post treatment respectively, stained with rat anti ... post ablation from areas indicated in the diagram of panel a Control mice had sham LA performed (LA probe was not activated) Panels b-d are CD3+ stained tissues from control animals; b liver parenchyma,

Ngày tải lên: 18/06/2014, 19:20

... Rüttinger1†, Margareta Rusan1, Robert Kammerer2, Wolfgang Zimmermann3, Rudolf A Hatz1and Hauke Winter1 Abstract Background: Active-specific immunotherapy used as an adjuvant therapeutic strategy is rather ... Trang 1R E S E A R C H Open AccessCombination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Natasja K van den ... were analyzed in duplicate Extinction was analyzed at 405/490 nm on a TECAN microplate ELISA reader (TECAN, Crailsheim, Germany) with the EasyWin software (TECAN) The detection limit of the ELISA

Ngày tải lên: 18/06/2014, 22:20

... Microbrightfield software and cell density was calcu-lated for striatal and midbrain volumes The striatum was outlined according to anatomical landmarks following the Paxinos atlas[31] To avoid bias in the ... weeks after the striatal lesion All ani-mals showed a marked asymmetry (~90% of the contacts were made using the ipsilateral paw) Histological and stereological procedure Animals were terminally anesthetized ... Neuroregeneration Laboratories, McLean Hospital, Belmont, Massachusetts, USA and 3 Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA Email: Rosario Sánchez-Pernaute

Ngày tải lên: 19/06/2014, 22:20

... using Axiovision 3.1 software Digital images were analyzed using KS300 analysis program (Zeiss) Percentage of immunostained area (area of immunostaining/total image area × 100) was Table 1: Summary ... Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity among the animals groups A second method of quantification ... thioflavine and anti CD45 reactivity Figure 2 Immunization of animals at 12–16 months with MAPA β1–33 decreases thioflavine and anti CD45 reactivity A Representative photomicrographs of thioflavine

Ngày tải lên: 19/06/2014, 22:20

... ggaggaatgggagtt-gctgttgaa-3'; iNOS, forward primer, 5'-ggaagaggaacaactactgctggt-3', reverse primer, 5'-gaactgaggg-tacatgctggagc-3' Thermal cycling conditions were as fol-lows: activation of iTaq DNA polymerase at ... homeothermic blanket control unit (Harvard Apparatus, Holliston, MA) Cranial temperature was measured by HSE Plugsys TAM-D (Harvard Apparatus) Blood gases and blood pH were measured by pH/blood gas analyzer ... external carotid artery (ECA) was isolated and ligated A 4-0-monofilament nylon suture (Harvard Apparatus, MA) was inserted through the ECA into the internal carotid artery until a mild resistance

Ngày tải lên: 19/06/2014, 22:20

... prevent disease Histological analysis demonstrated that diazoxide elicited a significant reduction in myelin and axonal loss accompanied by a decrease in glial activation and neuronal damage Diazoxide ... para-paresis of the hind limbs, unsteady gait and impairment of righting reflex; 3, moderate paraparesis, partial hind limb paralysis, voluntary movements still possible and ataxia; 4, paraplegia and ... equally 1 Neurotec Pharma SL, Bioincubadora PCB-Santander, Parc Científic de Barcelona, c/Josep Samitier 1-5, 08028 Barcelona, Spain Full list of author information is available at the end of

Ngày tải lên: 19/06/2014, 22:20

... Program of Shanghai Municipality (S30202), Shanghai Key Project of Basic Science Research (10411954500), and Program for Outstanding Medical Academic Leader of Shanghai (LJ 06003) Author details ... striatum may spread into the SN, causing abnormal activation of Zhang et al Journal of Neuroinflammation 2011, 8:154 http://www.jneuroinflammation.com/content/8/1/154 microglia and damage to dopaminergic ... counts of contralateral rotation and a significant decrease in TH-immunoreactive (TH-ir) neurons in SN A marked decrease in monoamine levels was also detected in 6-OHDA/BAb-treated rats, in comparison

Ngày tải lên: 19/06/2014, 22:20

... presence of degeneration, necrosis, and disappearance of marrow cells as well as the nuclear disappearance and hypochromasia of trabecular osteocytes as early signs of ON Trang 8[15] Early signs of ... obtained from Charles River Laboratories (Pointe-Claire, QC, Canada) The rats were tagged and housed in plastic cages (2 animals per cage) under standard laboratory conditions with a 12-hour dark/12-hour ... MRI or radiograph from a mouse with the goal of differentiating a normal hip from a hip with ON changes A rat model would allow easier radiographic interpretation, allow facile surgical interventions,

Ngày tải lên: 20/06/2014, 07:20