1 25 oh 2 d in the kidney

... ¼ 53 .16 4 27 524 25 3 8 2. 38 5.5 1. 035 ˚ 4 .1 (10 0.0 2. 38 A) ˚ 25 .1 (2. 42 2. 38 A) ˚ 92. 7 (10 0.0 2. 38 A) ˚ 93.4 (2. 42 2. 38 A) 22 .6 ˚ 80.3 (10 0.0 2. 38 A) ˚ 46.3 (2. 42 2. 38 A) P 21 2 1 21 a ¼ 25 . 28 9, b ¼ ... ¼ 53.047 4 322 3 422 3 1. 85 4.3 1. 1 42 ˚ 4.9 (10 0.0 1. 85 A) ˚ 19 .5 (1. 92 1. 85 A) ˚ 93.0 (10 0.0 1. 85 A) ˚ 96.9 (1. 92 1. 85 A) 21 . 1 ˚ 80.3 (10 0.0 1. 85 A) ˚ 55.3 (1. 92 1. 85 A) 10 0.0 2. 38 20 .30/NA 445 ... 27 3, 17 02 17 05 26 Lah, J & Vesnaver, G (20 00) Binding of distamycin A and netropsin to the 12 mer DNA duplexes containing mixed AT.GC Ó FEBS 20 02 27 28 29 30 Two : binding modes for distamycin (Eur...

Ngày tải lên: 24/03/2014, 04:21

... Gln35 Ser 52 Asp74 Glu90 MAb-5C 11 Tyr107 Val1 21 Gly140 Arg156 10 11 D (Amino acids) 80 12 0 40 Glu174 MAb -10 A5 E Asn 51 1B7 C D C H B Asn 51 1B7 Asn78 G F E A 10 A5 10 A5 5C 11 N 5C 11 Fig Detection ... prostaglandin D synthase in kidney Monkey kidney L-PGDS A Glycopeptidase F (–) MAb kDa 1B7 Intact form 5C 11 10A5 27 kDa 28 L-PGDS Truncated form 22 19 .3 16 .2 B Glycopeptidase F(+) Fig Identification ... al Lipocalin-type prostaglandin D synthase in kidney 20 21 22 23 24 25 26 27 28 29 (20 02) Lipocalin-type prostaglandin D synthase in essential hypertension Hypertension 39, 449–454 Urade Y & Hayaishi...

Ngày tải lên: 30/03/2014, 01:20

... - 12 5.374 71. 119 -4 .19 2 -4 .19 2 - 12 4 .1 -10 4. 41 Pose - 12 2. 393 65 .18 4 -5. 026 -7. 415 - 12 3.899 -97.385 Pose - 12 2. 31 75.7 52 -6.849 -7 .29 4 - 12 1 . 12 4 - 92. 7 51 Pose - 12 0.076 71. 516 -2. 5 -2. 5 -11 9 .20 9 -95.735 ... -4 .19 2 - 12 4 .1 -10 4. 41 Pose - 12 2. 393 65 .18 4 -5. 026 -7. 415 - 12 3.899 -97.385 Pose - 12 2. 31 75.7 52 -6.849 -7 .29 4 - 12 1 . 12 4 - 92. 7 51 Pose - 12 0.076 71. 516 -2. 5 -2. 5 -11 9 .20 9 -95.735 Pose - 12 0.037 75 .25 7 ... and 13 .5 01 Å, with a mean of about 10 . 425 ± 0 .1 Å At about 22 5- 25 0 ps, the increase and then decease in the width of the cleft allows Compound A to be accommodated in the active site During the...

Ngày tải lên: 13/08/2014, 16:20

... a LPS +1, 25 vit -D 20 8 ± 21 4 a 12 ,0 ± 0 ,2 12 ,2 ± 0,7 11 ,4 ± 0,4 a 12 ,0 ± 0,4 53 ± 53 ± 12 4 ± 16 7 94 ± 24 a 0,68 ± 0 ,29 0, 62 ± 0 ,27 1, 77 ± 1, 10 2 , 12 ± 0,53 a 41 ± 46 ± 19 44 ± 57 ± 11 8 ,2 ± 0,5 ... 6 31 ± 48 Shamoperation + 1, 25 vit -D 5 51 ± 53 CLP +vehicle CLP + 1, 25 vit -D 647 ± 95 Control + 1, 25 vit -D 606 ± 13 9 418 ± 49 b 515 ± 53 c 12 ,0 ± 0 ,2 12 ,2 ± 0,7 11 ,4 ± 0,6 11 ,0 ± 0,8 12 ,5 ± 1, 2 12 ,7 ... 10 56 ± 19 6 Control + 1, 25 vit -D 980 ± 26 0 LPS + vehicle 10 480 ± 80 a LPS + 1, 25 vit -D 10 415 ± 63 a 21 , 4 ± 3,5 17 ,9 ± 2, 0 29 ,8 ± 6 ,1 26 ,6 ± 3,6 a 53 ± 18 78 ± 30 66 ± 93 ± 33 Int J Med Sci 20 07,...

Ngày tải lên: 26/10/2012, 09:57

Ngày tải lên: 21/12/2013, 01:20

... Japan Japan Ref Age sex 10 10 10 – 15 15 15 15 11 11 11 11 12 12 13 14 14 15 15 15 15 16 Mean (SD) 29 .1 31. 1 9.8 46–59 40–49 40–49 50–59 50–59 41 50 51 60 41 50 51 60 40–59 40–59 39 (Mean) 40–49 ... Mean (SD) 23 29 30 31 32 33 34 35 36 32 37 18 .18 9.7 11 .1 12 9.9 10 .1 17.34 14 .5 21 . 2G 32 .1 30.0 (8 .1) (4 .2) (2. 33)G (1. 70)G (3 .1) (1. 93)G (2. 09)G Analytical method Wet ash, Flameless AAS Dry ash, ... Male 23 .3 19 .5 19 .3 25 . 8 15 .6 21 . 2 23.2G 17 .5 16 .8 12 .7 87 99 58.8 85 .1 125 . 3 43 .2 82. 7 65.0 63 .2 11 4 .1 Analytical method Freeze-dry,emission S Dry, emission S Dry ash, emission S (0.33)G (1. 80)G...

Ngày tải lên: 15/03/2014, 23:11

... with the canonical GT–AG rule and the corresponding encoded amino acid sequences comprise 22 6 and 22 5 residues, respectively, and share 32% identity Orthologues of these genes are observed in other ... 5030–5040 ª 20 09 The Authors Journal compilation ª 20 09 FEBS 50 31 Glutathione transferase kappa in C elegans A 69 gstk -1 (zk1 320 .1) B AA position rGSTK1 GSTK -1 GSTK -2 4 62 51 150 18 2 15 1 gstk -2 (d2 024 .7) ... GenBank: BM883 827 .1) *Residues involved in glutathione binding site #Residues involved in dimer interface GSTK -1 and GSTK -2 are localized in peroxisomes and mitochondria, respectively The analysis...

Ngày tải lên: 16/03/2014, 03:20

... retinoic acid binding proteins I and 3570 R.-Z Liu et al 15 16 17 18 19 20 21 22 23 24 25 26 27 28 II with new antibodies J Histochem Cytochem 46, 11 03 11 11 Zetterstrom RH, Lindqvist E, de Urquiza ... aa 16 aa 12 22 bp 38 aa 22 77 bp 60 aa 511 bp 16 aa 7470 bp 3453 bp 554 bp 23 aa 16 aa 38 aa 6 815 bp 19 59 bp 23 aa Exon 326 2 bp 7 629 bp 23 aa Intron 38 aa 16 aa 4 313 bp 38 aa 2 925 bp 16 aa 4 328 ... retinoid-binding proteins In The Retinoids: Biology, Chemistry and Medicine, 2nd edn (Sporn MB, Roberts 3569 Duplicated crabp1 genes in zebrafish 10 11 12 13 14 AB & Goodman DS, eds), pp 28 3– 317 Reven Press,...

Ngày tải lên: 16/03/2014, 22:20

... 11 1 11 2 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 1 12 2 12 3 12 4 12 5 12 6 12 7 Hydroxyvitamin D levels and cognitive performance and decline in elderly men Neurology 2 010 , 74:33- 41 Llewellyn DJ, Lang IA, ... adjustments; 25 ( OH) D: 25 - hydroxyvitamin D; UV: Ultraviolet; 1, 25 ( OH) D: 1, 25 - dihydroxyvitamin D; mRNA: Messenger ribonucleic acid; CaBP: Calcium Binding Protein; OR: Odds ratio; VDR: Vitamin D receptor; ... http://www.jneuroengrehab.com/content/7 /1/ 50 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Investigators: Calcium plus vitamin D supplementation and risk of fractures N Engl J Med 20 06, 354:669-683 Law M, Withers...

Ngày tải lên: 19/06/2014, 08:20

... measured on leaves from the same seedlings are indicated in the insert Interestingly, they were very close to the value computed from equation [4] (α The points obtained during ) c increasing ... Finally, the 2 CO availability decreased with increasing drought in the soil, stressing the importance of reduced influx of CO as an important factor for drought-induced declines of photosynthesis These ... provided by a slide projector (Kindermann 25 0 SL) and a 25 0 W halogen lamp Irradiance levels were adjusted using neutral density filters to the desired incident value, and controlled with a Li-Cor...

Ngày tải lên: 08/08/2014, 18:21

... system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain Brain Res 20 08, 11 90 :23 -38 33 Chadi G, Gomide VC: FGF -2 and S100beta immunoreactivities ... one hour In a third step, sections were washed in PBS and incubated with avidin-biotin peroxidase complex (both diluted 1: 100, Vectastain, Vector) during 45 The staining was performed using 0.03% ... a single striatal injection of 6hydroxydopamine Int J Neurosci 20 04, 11 4 :19 7- 21 6 25 Paxinos G, Watson C: The rat brain: in stereotaxic coordinates San Diego: Harcourt Brace Jovanovich; 19 86 26 ...

Ngày tải lên: 10/08/2014, 10:20

... 13 75 ± 80.5 12 82 ± 82. 5 13 32 ± 72. 5 0 .23 7d 13 -18 15 45 ± 10 0.0 13 09 ± 89.0 15 49 ± 95.5 0. 016 d 19 -24 15 92 ± 94.5 12 02 ± 10 2. 5 14 97 ± 70.5 0.00 7d 25 - 30 31- 36 15 21 ± 76.5 14 83 ± 76.5 10 59 ± 10 9.0 854 ... 74.0 13 21 ± 56.5 10 18 ± 68.5 0. 010 d 0. 023 d 37- 42 14 10 ± 46.0 655 ± 65.0 789 ± 10 9.5 43-48 13 14 ± 55.0 5 72 ± 72. 5 6 72 ± 82. 0 49-54 12 54 ± 74.0 614 ± 84.0 55-60 9 62 ± 57.5 3 62 ± 62. 5 61- 66 727 ± ... Table CDNA density obtained for Wild type, K65R +L74V and K65R+L74I RTs Group of cDNA Bandsa cDNA Density WT 65R+74V 65R+74I p-values 1- 6 11 53 ± 10 3.0 11 25 ± 79.0 11 52 ± 10 2. 0 0.38b, 0.49c 7 - 12 13 75...

Ngày tải lên: 11/08/2014, 21:21

... warrants further study http://respiratory-research.com/content/6 /1/ 126 10 11 12 13 14 15 16 17 18 19 20 21 22 Acknowledgements The Wellcome Trust supported the work in Leicester RJ was in receipt ... clearance [11 ,17 ] In addition, binding of SPD to lipoteichoic acid and peptidoglycan [22 ] may suggest a role for SP -D in the prevention of bacterial colonisation of the alveolar epithelium Elimination ... pneumococci in the lungs of SP -D- /- mice at this timepoint This could have resulted in decreased levels of phagocytosis due to the deficiency in the binding and opsonisation of the pneumococcus due to the...

Ngày tải lên: 12/08/2014, 18:20

... viral shedding and spread, which could inform the decision regarding whether to institute antiviral therapy and help in determining the pathogenicity of the virus, we measured the PLI in four ... Mallincrodt Diagnostica, Petten, The Netherlands), using a modified in vitro method Ten minutes after injection of the labelled RBCs, transferrin was labelled in vivo, following intravenous injection ... parameters PaO2/FiO2 (mmHg) 345 19 5 19 0 98 Plateau airway pressure (cmH2O) 33 22 22 20 Positive end-expiratory airway pressure (cmH2O) 12 7 Total respiratory compliance (ml/cmH2O) 21 31 31 – Radiographic...

Ngày tải lên: 12/08/2014, 20:20

... attributed binding to damaged DNA binding protein and Cullin 4a-associated factor1 (DCAF -1) [ 12 2 - 12 8] (originally identified as a binding partner called VprBP [ 12 9]), and is a result of subsequent induction ... negative Page 18 of 20 14 6 14 7 14 8 14 9 15 0 15 1 15 2 15 3 15 4 15 5 15 6 15 7 15 8 15 9 16 0 16 1 16 2 16 3 16 4 16 5 regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis ... transcription and infectivity in primary human macrophages J Exp Med 19 98, 18 7 :11 03 -11 11 122 Belzile JP, Duisit G, Rougeau N, Mercier J, Finzi A, Cohen EA: HIV -1 Vprmediated G2 arrest involves the DDB1-CUL4AVPRBP...

Ngày tải lên: 13/08/2014, 01:20

... U.FR.96 . 12 034 998 10 00 767 HIV2.C.LR .22 381G HIV2.A.DE.BEN HIV2.A.CI.88.UC2 HIV2.A.GH.GH1 HIV2.A.GM.ISY HIV2.A.SN.ST HIV2.A.SN.85.ROD 839 10 00 853 HIV2.B.CI.88.UC1 HIV2.B.GH.86 .D2 05 976 10 00 996 ... HIV surveillance in a West African research clinic reveals divergent epidemic trends of HIV -1 and HIV -2 Int J Epidemiol 20 06, 35 :13 22 -13 28 Drylewicz J, Matheron S, Lazaro E, Damond F, Bonnet F, ... Virol 19 97, 71: 3953-3960 Gottlieb GS, Hawes SE, Kiviat NB, Sow PS: Differences in proviral DNA load between HIV -1- infected and HIV -2- infected patients Aids 20 08, 22 :13 79 -13 80 Popper SJ, Sarr AD,...

Ngày tải lên: 13/08/2014, 05:21

... [11 0] 12 The C-terminus of dynamin is the PRD (proline-rich domain) which mediates the binding with multiple partners including cortactin Figure Dynamin structural domains Fig The structural domains ... possibly other kinases in vivo have been identified to be Tyr -2 31 in the GTPase domain and Tyr-597 in PH domain for both dynamin-I and dynamin-II [11 8, 12 0] Tyrosine phosphorylation of dynamin by ... were added into purified recombinant dynamin [11 3] Purified recombinant dynamin was also demonstrated to bind to anionic phospholipid bilayers in the absence of other proteins or guanine 13 nucleotide...

Ngày tải lên: 24/08/2014, 12:36

... between the dependency of Nrf2 inducers on cysteine 15 1 of Keap1 and their effect on the Keap1Cullin3 interaction 61 4 .2. 5 Proposed model through which Keap1 Cys1 51- independent Nrf2 inducer compounds ... hand, the quinol compounds function independently of cysteine 15 1 in Keap1 Interestingly, the quinol compounds markedly increased the binding between Keap1 and Cullin3 whereas andrographolide did ... is distinct from Cys1 51- dependent Nrf2 inducers The elucidation of the mechanism of action of Cys151independent Nrf2 inducers is expected to improve our understanding of the regulation of the...

Ngày tải lên: 09/09/2015, 08:16

... Line 24 2. 3 Vectors 24 2. 4 Plasmids 2. 4 .1 Expression plasmids 25 2. 4 .2 Reporter plasmids 25 2. 5 Immunohistochemistry 2. 5 .1 Patient biopsies 26 2. 5 .2 Mouse model 26 2. 5.3 Fixation and sectioning 26 ... mouse model 50 3 .2 .1 ACADVL staining is increased in type diabetic mouse model 50 3 .2. 2 ACADVL staining is increased in proximal tubules 52 3 .2. 3 ACADVL staining is increased in human diabetic ... co-localisation 61 Fig 21 GLUT2 upregulated and mislocalized in type diabetic mice 62 Fig 22 Increased nitrotyrosine staining in type diabetic mice mice 64 Fig 23 Increased nitrotyrosine staining in diabetic...

Ngày tải lên: 16/10/2015, 15:38

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Ngày tải lên: 08/11/2016, 16:02