Molecular and Cell Basis of Inheritance

NQH, DDL, HTMN @ HUS 7 th Week, 3 rd Semester Molecular and Cell Basis of Inheritance... How cells repair replication mistakes 3.. How to perform DNA synthesis in test tube a.k.a.. Mei

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NQH, DDL, HTMN @ HUS

7 th Week, 3 rd Semester

Molecular and Cell Basis of Inheritance

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Announcements

The 2 nd practical section on genetics starts

this week , in R 235, T1 (Dept Genetics)

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Overview of today’s topics:

Reading: Chapter 14.1 - 5; 19.2 - 3

1 The end replication problem and telomerase

2 How cells repair replication mistakes

3 Other types of DNA repair

4th theme DNA replication and repair

1 How to perform DNA synthesis in test tube (a.k.a PCR)

2 The process of meiosis

3 Nondisjunction – when good spindles go bad

6th theme Meiosis and Genetic Variability

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4 th theme

DNA replication and repair

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5 th theme

Application of DNA synthesis

in molecular biology

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If we mix all of these ingredients in the test tube, can we get

DNA synthesis outside of the cell?

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6 th theme

Meiosis and Genetic Variability

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Movies of meiosis I in the crane fly

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Movies of meiosis II in the crane fly

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- What happens when mistakes in meiosis

occur ( nondisjunction – when chromosomes

don’t segregate properly)

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MOLECULAR AND CELL BASIS OF INHERITANCE

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