1. Trang chủ
  2. » Giáo Dục - Đào Tạo

Discovery of dengue virus host factors

199 214 0

Đang tải... (xem toàn văn)

Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống

THÔNG TIN TÀI LIỆU

Thông tin cơ bản

Định dạng
Số trang 199
Dung lượng 17,55 MB

Các công cụ chuyển đổi và chỉnh sửa cho tài liệu này

Nội dung

Trang 3

"#$1#5#A#1! #A)! #! &#78%! A243%7! 65! -6&&%#82%1! 5764! $0%! 92K%P=>,! -6442A($<!

;76B()%)! -7($(-#&! 7%#8%A$1D! 2A;23&(10%)!)#$#! #A)! %N;%7$(1%!$0#$! #&&6J%)!21! $6! 32(&)! 16&()!3#1(1!567!627!J67K!#A)!46B%!$0%!;76O%-$!$6!0(80%7!8762A)1L!E67!$0(1D!@!6J%!$0%4!

#! B%7<! (4;67$#A$! )%3$L! @! ;#7$(-2&#7&<! #&J#<1! 7%-%(B%)! $0%! 12;;67$D! %A-627#8%4%A$!

#A)!(A1(80$52&!-644%A$1!5764!4%43%71!65!4<!$0%1(1!#)B(167<!-644($$%%!971!9#B()! U(7102;D!+#7-!E(B#W!#A)!,0%%!+%(!S6KL!

E(A#&&<D! @! J62&)! &(K%! $6! #-KA6J&%)8%! (AB#&2#3&%! 12;;67$! 65! 4<! 5#4(&<L! E(71$D!

$0#$! 65! 4<! ;#7%A$1! J06! #&J#<1! %A-627#8%)! 4%!$6! 56&&6J! 4<! )7%#41D! %B%A! $06280!

$0%<! 0#;;%A%)! $6! 3%! (A! 5#7#J#<! -62A$7(%1L! /&16D! $0#$! 65! 4<! 87#A);#7%A$1! J06!

;76B()%)!4%!566)D!10%&$%7!#A)!2A-6A)($(6A#&!&6B%!#$!$0%!321<!$(4%1!65!J7($(A8!65!$0(1!

$0%1(1L! ! S#1$&<D! @! #4! 87#$%52&! $6! 4<! -64;#A(6AD! $0%! &6B%! 65! 4<! &(5%D! @#A! V2#A8! 567! 3%(A8!4<!3%1$!12;;67$%7L!@!-#AX$!J#($!$6!10#7%!$0%!7%1$!65!4<!&(5%!J($0!<62!567!4#A<! 467%!#)B%A$27%1L!

Trang 4

!

!".*"/($%)*&+"#,(

H '#776J1D! =LD! '7#)7(-KD! ,LD! '()%$D! "LD! /AJ#7D! /LD! R#7)D! /L+LD! E#4(16AD! ,LPLD!T%B($$D!'LD!T%,644%7D!bL!#A)!?#7(-#Q'&#A-6D!+L/LD!b0#;$%7!FHd!M0%!(A$%75#-%!3%$J%%A!)%A82%!B(721!#A)!$0%!024#A!061$D!9%A82%!FA)!%)($(6AD!;;IGfQIF`!

!

F '()%$D!"L!#A)!?#7-(#Q'&#A-6D!+L/LD!/!7%B(%J!65!061$!U=/Q3(A)(A8!;76$%(A1!(A!5&#B(B(7#&!(A5%-$(6A1L!'(6-0%4(-#&!E627A#&!*(A!;7%11.!

Trang 5

! e!

! e!

! ]! ]!

! HF!

! H^!

! HI!

!

! He!

! He!

!

Trang 6

! H]!

! H`!

! Ha! Ha!

! Hg!

! FG!

! FH! FH!

! FF!

! F^!

!

! Fe!

!

! F`!

! F`!

! F`!

! Fa!

!

! Fa!

! Fg!

Trang 7

! IH! IH!

! IF!

!

! I^! II!

! Ie!

! Ia!

! Ia! eG!

! eH! eH! eH! eF! eF! e^! e^! eI! eI! ee! e]! e]! e`!

!

Trang 8

! ]G!

! ]H! ]I!

!

! ]I!

! ]e!

! ]`!

! ]`! ]g!

! aF! aF!

Trang 9

! a^!

! aI! ae! a]!

! a]! a`!

! aa!

! aa!

! aa!

! ag!

!

! gH!

!

! gH!

! g^!

! g^!

! gI!

! ga!

! gg!

! HGG!

! HGF!

! HGF!

! HGI!

Trang 10

! HGa!

! HGa!

! HGg!

! HHG! HHH! HH^! HH^!

! HHI! HH]!

! HH`! HH`! HH`! HH`! HHa! HHg! HHg! HFG! HFH! HFF! HF^! HF^!

! HFI! HFI!

! HFI!

! HFe!

! HF]!

!

! HF`! HF`!

! HFa!

! H^G!

Trang 11

! H^e!

! H^`!

! H^`!

! H^g!

! H^g!

! HIF!

! HIF!

! HII!

! HI]! HI`!

!

! HIg!

! HIg!

! HeH!

! HeF!

! HeF!

! He^!

! Hee! Hee!

! He]! He`!

!

! Heg!

Trang 12

;#$068%A1! (A-&2)(A8! )%A82%! B(721%1! *9C=U.L! ! Q%! %N#4(A%)! $07%%! -6A1%7B%)! 061$! T=/P3(A)(A8! ;76$%(A1! *T':1.! ?^':HD! ?^':F! #A)! b/:T@=H! (A!)%A82%! B(721! *9C=UPF.! (A5%-$(6A! #A)! 562A)! #&&! $6! 3%! A6B%&! 7%82&#$671! 65! $0%! (A$%75%76A! *@E=.! 7%1;6A1%!

#8#(A1$! 9C=UPFL! M0%! $07%%! T':1! J%7%! 7%c2(7%)! 567! $7#A1&#$(6A! 65! (A$%75%76A! 1$(42&#$%)! 8%A%! *@,?.! 4T=/1D! J0(-0! ()%A$(5(%1! $0%4! #1! A6B%&! 7%82&#$671! 65! $0%!

#A$(B(7#&!1$#$%L!M0(1!#A$(B(7#&!#-$(B($<!J#1!#A$#86A(W%)!3<!$0%!#32A)#A$!9C=UPF!A6AP -6)(A8! 1238%A64(-! 5&#B(B(7#&! T=/! *15T=/.D! J0(-0! 362A)! $6! ?^':HD! ?^':F! #A)! b/:T@=HD! (A0(3($%)! $0%(7! #-$(B($<! #A)! &%#)! $6! ;76562A)! (A0(3($(6A! 65! @,?! 4T=/!

$7#A1&#$(6AL! M0(1! J67K! )%1-7(3%1! #! A%J! #A)! 2A%N;%-$%)! &%B%&! 65! 7%82&#$(6A! 567! (A$%75%76A!1$(42&#$%)!8%A%!%N;7%11(6A!#A)!;7%1%A$1!$0%!5(71$!4%-0#A(14!65!#-$(6A!567!

#A!15T=/!#1!#!46&%-2&#7!1;6A8%!65!#A$(PB(7#&!%55%-$671L!!

Trang 13

! I! a! g!

! FI!

! ]H! ]F!

! ]^! ]e!

! ]`!

! ]a!

! ]a! ]g!

!

Trang 14

! gG!

! gH!

! gF!

! ge!

! ge!

! g`!

! g`!

! gg!

! HGH!

! HGF!

! HGI!

!

!

!

! HGg!

! HFe!

! HF]!

! HF`! HFg!

! H^H!

Trang 15

! H^^!

! H^I!

! H^]!

! H^a!

! HIG!

! HIH! HI^!

! HIe!

! HIe!

! HI]!

!

!

! HeG!

!

!

Trang 19

!

"

*+,-.-./0121",/2","32401"56"-2785/9:5/42;"<51.8.-2"1.43+2"18/,4=2=")>%"??@A11)>%A"-.9/0121"8B,8"/2<+.7,82".4"8B2"7C85<+,1D"56",/8B/5<5=1",4="D,DD,+.,4".462782="72++1"!E"F8"75D9

</.121"40D2/501".D<5/8,48"B0D,4"<,8B53241"107B",1"=24302"-./0121"?G(>H!9IA;"J218">.+2"-./01"?J>HA;"C2++5K"62-2/"-./01"?L*HA;"M,<,4212"2472<B,+.8.1"-./01"?M(HA;",4="8.7N9:5/42"249

72<B,+.8.1"?'O(HA"?!"#$%&'()(A""#$E"P42"/2D,/N,:+2",1<278"56"6+,-.-./,+":.5+53C".1"8B2./",:.+.8C"85"/2<+.7,82" ,4=" </5<,3,82" 4" 8K5" =.662/248" B5181E" F4" 8B.1" 7C7+2;" /2-5+-.43" 2Q7+01.-2+C" ,/504="

)>%".482/D2=.,821;" *B2"?@A11)>%"3245D2"12/-21"D0+8.<+2"60478.541E"F8".1"012=",1"82D<+,82"

65/",48.3245D2"1C48B21.1",4="60/8B2/"3245D2",D<+.6.7,8.54;"65/"-./,+"</582.4"1C48B21.1",4=".1"<,7N,32=".485"42K".46278.501"-./.541E""

*+,-.-./,+"3245D21"2475=2"65/"54+C"824"-./,+"</582.41",4=".8"B,1":224"+543",7N45K+92=32="8B,8"8B2C"/2+C"B2,-.+C"54"72++0+,/"B518"6,785/1"65/"8B2./"/2<+.7,8.54"%E"'/,41+,8.54;"458"10/</.1.43+C;"=2<24=1"248./2+C"54"8B2"72++0+,/"D,7B.42/C;":08"+211"2Q<2782="72++0+,/"</5721121"107B",1",085<B,3C"5/"0:.R0.8.49D2=.,82="=23/,=,8.54"<,8BK,C1",/2"7/.8.7,+"65/"-./,+"</5<,9

Trang 20

#$%&'("!"#)"*("$++&%&'(,"&%"&-".-%$/0&-1.+"%1$%"2&3$0"456-"$3."3.7'#(&8.+"$(+"%$3#.%.+"/9"$"(.%:

;'3<"'="7.00>0$3"&(($%."&??>(."3.-@'(-.-"%1$%"$3."&("%>3("$(%$#'(&8.+"/9"$"2$3&.%9"'="2&3$0"7'>(%.3?.$->3.-"$%,$$)""

*("%1&-"7'(%.A%,"1'-%"456:/&(+&(#" @3'%.&(-"B4CD-E" ʹ"=0$2&2&3$0" 456" &(%.3$7%&'(-" 1$2."/ ("@3'@'-.+"%'"73&%&7$009"&(=0>.(7."2&3$0"3.@0&7$%&'(,"/'%1"%'"%1."/.(.=&%"$(+"%'"%1."+.%3&:

?.(%"'="%1."2&3>-)"F';.2.3,"'(09"$"=.;"'="%1.-."&(%.3$7%&'(-"1$2."/ ("71$3$7%.3&8.+)"*("%1&-"

&(%3'+>7%&'("*"$&?"%'"->??$3&8."%1."7>33.(%"<(';0.+#."&("=0$2&2&3$0"456"/&'0'#9"ʹ";&%1"$"=':7>-" '(" 3.@0&7$%&'(" &(" %1." ?$??$0&$(" 1'-%" 7.00," ;1&71" 1$-" / (" ?'3." A%.(-&2.09" -%>+&.+)"G>3%1.3?'3.,"*"1&#10&#1%";1$%"-%&00" &?@$&3"'>3" >(+.3-%$(+&(#"'="/'%1"2&3$0"$(+" 7.00>0$3"456"

?.%$/'0&-?"+>3&(#"&(=.7%&'()"

Trang 21

%4/;8%8":+;6%*42"E"('3%*6"26*''"<42<//%22&<'"*4"8%)%';:*4="(4"%&&%/6*)%"(46*E&'()*)*+('"6$%+(:0"E"

Trang 22

#$%&'()"&*"+"'%%,"-./(+01*)1/"&0,.$*)+0,10'"%2".034-+)1/"+/)151)1.*"+0,"678".9.-.0)*"10:5%95.,"10"51$+9"678"*40)(.*1*;""

&0/%+).,"+0,")$+0*9+).,")%"D$%,&/."+"*10'9."D%94D$%).10C"I(1/("1*")(.0"/9.+5.,"#4"51$+9"+0,"/.99&9+$"D$%).+*.*"10)%").0"51$+9"D$%).10*J"*)$&/)&$+9"D$%).10*"/+D*1,"@KBC"D$.:-.-#$+0."@D$LB"+0,".05.9%D."@MB"+0,"0%0:*)$&/)&$+9"D$%).10*"7N>C"7NO8C"7NOPC"7NQC"7N!8C"7N!P"+0,"7NR;"S1$+9" +0," /%:%D).," (%*)" D$%).10*" 10,&/." 2%$-+)1%0" %2" $.D91/+)1%0" /%-D9.T.*" @6KB" 10" I(1/("

Trang 23

!

#$%"&'()*"+,-./%0%1/%1#"+,-"02*34%()5%"6+/+07"531#$%5'8%5")"9:**.*%1;#$"<240*%4%1#)(3"4'1:5"5#()1/"+,-"#%(4%/"#$%")1#';%124%"66.7";+,-7=">$'5"+,-?")<#'1;")5"(%0*'<)#'&%"'1#%(.4%/')#%?"'5"#$%1":5%/")5")"#%40*)#%"92("4:*#'0*%"(2:1/5"29"6@7";+,-"531#$%5'5=">()15*)#'21")1/"0)<A);'1;"29"0(2;%13"6@7";+,-5";%1%()#%5"1%B"&'('215"#$)#")(%"5%<(%#%/"2:#"29"#$%"<%**")1/"<)0)C*%"29"5:5#)'1'1;"1%B"(2:1/5"29"'19%<#'21="

#$%"<2((%<#"/'1:<*%2#'/%"#2"C%" :5%/"92(" ()#"'$'" '1'#')#'21"ʹ"-P"92("C2#$"6@7")1/"6.7"5#()1/"

Trang 24

?(207#("&'("2(44740+"20**)%/"102')%(+$"+(#).(#")%"&'("%724(7#8"540-)-)+7#(#"'0-("(-,4-(."044"(%@$10&)2" 02&)-)&)(#" +(A7)+(." &," *(+5,+1" 20**)%/" )%" &'(" 2$&,*40#18" 2,%27++(%&4$" B)&'" -)+04"

;<="#$%&'(#)#9"<CD"0%."<CE"20%" +(20*)&740&("-)+04";<="20**)%/9":'("+(02&),%"#&0+&#"6$"+(>ŵŽǀĂůŽĨƚŚĞŐĂŵŵĂƉŚŽƐƉŚĂƚĞŽĨƚŚĞŵŽƐƚϱ͛ĂĚĞŶŽƐŝŶĞďLJĂĐƚŝŽŶŽĨƚŚĞE^ϯŶƵĐůĞŽƚŝĚĞƚƌŝ

>ƉŚŽƐƉŚĂƚĂƐĞ ;EdWĂƐĞͿ͕ ĨŽůůŽǁĞĚ ďLJ ƚƌĂŶƐĨĞƌ ŽĨ Ă ϱ͛ϱ͛ ůŝŶŬĞĚ ŐƵĂŶŝŶĞ ƌĞƐŝĚƵĞ ĐĂƚĂůLJnjĞĚ ďLJ

<CE"/70%$4$4&+0%#5(+0#("$$9"F0*"10&7+0&),%")#"&'(%"02')(-(."6$"#722(##)-("<>ϳĂŶĚϮ͛>G"1(>

&'$40&),%"6$"&'("<CE"H:0#("$%9"F0**)%/"0**(0+#"&,"6("+0&'(+"#(4(2&)-("5,+"-)+04"/(%,1)2"#(>A7(%2(#"$$9"I%&(+(#&)%/4$8"B')4("&'("J>K"/;<="'0."04B0$#"6((%"0##71(."&,"6("7%20**(."#)%2(")&")#"%,&".(#&)%(."&,"6("&+0%#40&(.8"&')#"B0#"%(-(+"-(+)5)(.")%")%"-)&+,"0##0$#",+")%"&'("2,%&(3&",5")%5(2&),%9""

"

" %#%#&#'#$()*$+","-./"0$+","/12$314"-01/5#$

I%"0 )&),%"&,")&#",6-),7#4$"2+)&)204"+,4(")%"-)+04";<="#$%&'(#)#8"&'("<CE"(++,+>*+,%(";.;*"02&)-)&$")#"+(#*,%#)64("5,+"/(%(+0&)%/"/(%(&)2".)-(+#)&$8"B')2'")#"6(4)(-(."&,"*+,-).("&'("60#)#"5,+"+0*)."(-,47&),%"0%."&'("(1(+/(%2(",5"#722(##574"*0%.(1)2#"$9"!"#$%&'("L)%(&)2"#&7.)(#".(>

&(+1)%(."&'("MN<O>P";.;*"1)#)%2,+*,+0&),%"+0&("&,"0%"0-(+0/(",5"QRSE8TTT"ʹ"0"-047("#)1)>

Trang 25

!

#$%"&'"&($&" ')"(*+$,"-++*,'./)-0-/,01"2-%*3"45678" %/2/%3/"&%$,30%-9&$3/"4:;8"'%"9'#-'2-%*3"4<78":.:9=">,'?,")'%"&(/-%"9''%")-./#-&1"!"@";(-3"-+9#-0$&/3"&($&"',/"'*&"')"3/2/,"A/,'+/3"31,&(/3-B/.".*%-,A"-,)/0&-',"0',&$-,3"$&"#/$3&"',/"+*&$&-',"$,."($3"&(/"9'&/,&-$#"&'"C/"9'3-D

&-2/#1"'%",/A$&-2/#1"3/#/0&/."./9/,.-,A"',"-&3"C/,/)-0-$#"'%"./&%-+/,&$#"/))/0&@"6,&/%/3&-,A#1="-,0%/$3/."A/,/&-0".-2/%3-&1"?$3"'C3/%2/."-,"0/##3"-,)/0&/."C1"&(/"2$00-,/"3&%$-,"')"EF7"EF7DG!H"0'+9$%/."&'"9$&('A/,-0"%/#$&-2/3="3*AA/3&-,A"&($&"&''"+*0("-,)-./#-&1""0'%%/#$&/3"?-&("

$&&/,*$&-',"')".-))/%/,&"2-%*3"3&%$-,3"!#@"

!

!"!"#"$"#$!#%&#'(!)*+,-*,+$.!/'01%1%+0'!2"3)!+$&,'0*$!*#$!1%+0'!'%/$!-(-'$4!

dŚĞĨůĂǀŝǀŝƌĂůŐĞŶŽŵĞŝƐĨůĂŶŬĞĚďLJƚǁŽŚŝŐŚůLJƐƚƌƵĐƚƵƌĞĚhdZƐ͕ĂΕϭϬϬďƉϱ͛hdZĂŶĚΕϰϬϬ ƚŽ ϳϬϬďƉ ϯ͛hdZ͘ /ŶŝƚŝĂů ďŝŽŝŶĨŽƌŵĂƚŝĐƐ ƉƌĞĚŝĐƚŝŽŶƐ!$%&'=" #$&/%" 0',)-%+/." C1" /,B1+$&-0"

$,." 0(/+-0$#" 9%'C-,A" /I9/%-+/,&3" &!%&(" %/2/$#/." &(/" /I-3&/,0/" ')" 0',3/%2/.=" 3&$C#/"3/0',.$%1"$,."&/%&-$%1"3&%*0&*%/3@"J"+'./#")'%"+'3K*-&'DC'%,/")#$2-2-%*3/3="C$3/."',"HLM7D

N"-3"9%/3/,&/."5%&,+$!647@";(/-%")*,0&-',"?$3"&('%'*A(#1"-,2/3&-A$&/."C1".-%/0&/."+*&$A/,/D

3-3"3&*.-/3"-,"%/9'%&/%"%/9#-0',3"$,."-,)/0&-'*3"0#',/3"')=!'=!$=!*%&'=&$=&+%#+@"O(-#/"&(/" -,&/%0',D,/0&-',"')"&(/".-))/%/,&"3&/93"')"2-%$#"%/9#-0$&-',"3'+/&-+/3"(-,./%/."&(/"$C-#-&1"&'"$&&%-C*&/"

&(/"/))/0&"')"+*&$&-',3"&'"$"3-,A#/"3&$A/"')"&(/"2-%$#"#-)/"010#/="&(/3/"3&*.-/3="?(-0("$%/"3*+D+$%-B/."C/#'?="($."$"3-A,-)-0$,&"-+9$0&"',"'*%"*,./%3&$,.-,A"')">/1"/2/,&3"-,"&(/")#$2-2-%$#"

#-)/"010#/@!

!"!"#"!"$%&'()()*+,-,$./0$,1234-,),$*-5+)*-,$6-278-$919&):'3)72"$

F#$2-2-%*3":MJ"31,&(/3-3"'00*%3"&(%'*A("$,"$31++/&%-0"%/9#-0$&-',"010#/"-,"?(-0("&(/"

2-%$#":.:9"31,&(/&-B/3"!"#$%&%"$"0'+9#/+/,&$%1"$,&-A/,'+/"'%"4D8"A:MJ="?(-0("-3"&(/,"*3/."

Trang 26

#$" #" %&'()#%&" *+" %,&" $#'&" &-.+'&" %/" (0/123&" 456" %7'&$" '/0&" 89:" ;<=>"!?" @#0)+" $%217&$"ĚĞŵŽŶƐƚƌĂƚĞĚƚŚĂƚĐŽŵƉůĞŵĞŶƚĂƌLJƐĞƋƵĞŶĐĞƐŝŶƚŚĞϱ͛ĂŶĚϯ͛hdZĂƌĞƌĞƋƵŝƌĞĚĨŽƌĞĨĨŝĐŝĞŶƚ

<=>"$+-%,&$7$A"$2;;&$%7-;"%,#%")/-;B0#-;&"<=>B<=>"7-%&0#3%7/-$"37032)#07.&"%,&";&-/'&"C/0"C2))B)&-;%,"<=>"$+-%,&$7$"!"?"D,&"&E7$%&-3&"/C"%,7$"37032)#0"$%023%20&A"%&0'&1"(#-,#-1)&A"3#-"

*&"F7$2#)7.&1"*+"#%/'73"C/03&"'730/$3/(+"#$A"%"#-1"7$"'&17#%&1"*+" 7-%&0#3%7/-"*&%G&&-"%,&"3/'()&'&-%#0+"$&H2&-3&$"3+3)7.#%7/-"$&H2&-3&"8IJ:"#-1"2($%0&#'"/C">KL"0&;7/-"8K><:"7-"ƚŚĞϱ͛ĂŶĚϯ͛hdZ&'A#'A"!A""?"<&3&-%"$%217&$"(0/(/$&1"%,#%"#117%7/-#)"$&%$"/C"$&H2&-3&$A"$23,"

#$"1/G-$%0&#'"/C"K><"8M><:"/0"1/G-$%0&#'"/C"IJ"81IJ:"#$$7$%"7-";&-/'&"3+3)7.#%7/-""#A""A"(?"N/G&F&0A"G,&%,&0"%,&$&"&)&'&-%$"()#+"170&3%"0/)&$"7-"<=>"$+-%,&$7$"/0"0#%,&0";)/*#))+"3/-B

%07*2%&"%/"<=>"$%023%20&"0&'#7-$"%/"*&"&$%#*)7$,&1"""?""

J&F&0#)" &E()#-#%7/-$" G&0&" (0/(/$&1" %/" &E()#7-" %,&" 37032)#07.#%7/-" 0&H270&'&-%?" !"#

$%&'(" *7-17-;" &E(&07'&-%$" #-1" <=>$&" (0/%&3%7/-" #$$#+$" 0&F&#)&1" %,#%" $(&37C73" *7-17-;" /C"

Trang 27

!

#$%"&'(")*$%+ϮE^ϱŽĐĐƵƌƐĞdžĐůƵƐŝǀĞůLJĂƚƚŚĞ;нͿϱ͛^>!",#!,#$,#",#%"-./01"2/'(/'3"45"4.1"678"ϯ͛hdZŝƐŶŽŶƐƉĞĐŝĨŝĐ!",#!,#$,#",#%9":./;"/'(/<&41ƐƚŚĂƚŽŶůLJƚŚĞ;нͿϱ͛hdZŝƐĂďůĞƚŽĂĐƚĂƐĂƉƌŽͲ

=541>"?5>"@/>&0"6+8"3A$B";C'4.1;/;9":.1>1?5>1,"31'5=1"<C<0/D&4/5'"<5E0("&005-"&<<1;;"5?"4.1"ǀŝƌĂůƉŽůLJŵĞƌĂƐĞƚŽƚŚĞϯ͛ĞŶĚŽĨƚŚĞŐĞŶŽŵĞ͘^ƵƉƉŽƌƚŝŶŐƚŚŝƐŚLJƉŽƚŚĞƐŝƐ͕ŝƚǁĂƐƐŚŽǁŶƚŚĂƚ4.1"F>1;1'<1"5?"4.1"F50CG";1HE1'<1"(5-';4>1&="5?"IJB"&<4;"&;"&";F&<1>,"&005-/'3"<5>>1<4"ƉŽƐŝƚŝŽŶŝŶŐŽĨƚŚĞǀŝƌĂůƉŽůLJŵĞƌĂƐĞĨŽƌŝƚƐŝŶƚĞƌĂĐƚŝŽŶǁŝƚŚƚŚĞ;нͿϯ͛^>#$9"

/ŶĂĚĚŝƚŝŽŶ͕ŝƚǁĂƐƐŚŽǁŶƚŚĂƚƚŚĞůŽŶŐƚĞƌŵŝŶĂůϯ͛ƐƚĞŵůŽŽƉ;ϯ͛^>ͿƐƚƌƵĐƚƵƌĞŝŶƚŚĞ0/'1&>"31'5=1"/'./2/4;"$IK"&<4/@/4C"#%"F5;;/20C"21<&E;1"4.1"A$B+2/'(/'3"(5=&/'"5?"4.1"@/>&0"ƉŽůLJŵĞƌĂƐĞ ĐĂŶ͛ƚ ĂĐĐŽŵŵŽĚĂƚĞ ĚƐZE͘ DŽůĞĐƵůĂƌ ƉƌŽďŝŶŐ ĞdžƉĞƌŝŵĞŶƚƐ ƌĞǀĞĂůĞĚ ƚŚĂƚ ŐĞͲ

Trang 28

$%&#'()*+,#-&./0&#$%1$#213/4&5#/.&#6$478$74&#/4#$%&#/$%&49#%/:&3&49#&;<0<.1$&#3<41;#4&=;<+81$</.9#<.5<81$<.-#$%1$#$%&#1><;<$?#$/#6:<$8%#>&$:&&.#6$478$74&6#<6#4&@7<4&5#2/4#$%&#8/0=;&$&#3<41;#;<2&#8?8;&#!!A#

B%&#6?.$%&6<6#/2#CDE#-F)G#24/0#1#C+E#-F)G#$&0=;1$&9#/.#$%&#/$%&4#%1.59#<6#=//4;?#7.+5&46$//59#>7$#1#0&8%1.<60#6<0<;14#$/#$%&# /.&#5&684<>&5#1>/3&#8/7;5# ;/-<81;;?#>&#<.3/H&5A#/ŶĚĞĞĚ͕ĂƚƚŚĞĞŶĚŽĨĂĨŝƌƐƚƌŽƵŶĚŽĨƐLJŶƚŚĞƐŝƐ͕ƚŚĞϯ͛ĞŶĚŽĨƚŚĞŶĞǁůLJŐĞŶĞƌĂƚĞĚĂŶƚŝŐĞͲ./0&#C$%&#C+ͿĐϱ͛hdZͿǁŝůůůŝŬĞůLJďĞŝŶĐůŽƐĞƉƌŽdžŝŵŝƚLJƚŽƚŚĞ;нͿϱ͛^>ĨƌŽŵŝƚƐŽƌŝŐŝŶĂůƚĞŵͲƉůĂƚĞ͘/ŶƚŚŝƐŚLJďƌŝĚƐƚƌƵĐƚƵƌĞ͕ƌĞƐĞŵďůŝŶŐƚŚĞƉĂŶŚĂŶĚůĞĚĞƐĐƌŝďĞĚƉƌĞǀŝŽƵƐůLJ͕ƚŚĞ;нͿϱ͛^>8/7;5#18$#1-1<.#16#=4/0/$&4#>?#1;;/:<.-#$41.62&4#/2#1#.&:#=/;?0&416&#/.#$%&#C+ͿĐϱ͛hdZƚŽ

<.<$<1$&#.&:#4/7.56#/2#CDE#-F)G#6?.$%&6<6A##

G;$&4.1$<3&;?9# $%&# 1.$<-&./0&# 8/7;5# 8/.$1<.# 1# =4/0/$&4# 6$478$74&# 5<4&8$;?# 1;;/:<.-#

<.<$<1$</.#/2#CDE#-F)G#6?.$%&6<6A#I.5&&59#></<.2/401$<8#=4&5<8$</.6#<.5<81$&#$%&#=4&6&.8&#/2#1#ƐƚƌƵĐƚƵƌĞ ŵŝƌƌŽƌŝŶŐ ϱ͛^> ŝŶ Ăƚ ƚŚĞ ϯ͛ ĞŶĚ ŽĨ ƚŚĞ ;+E# -F)G9# 1;>&<$# 2/40&5# >?# 5<22&4&.$# 6&+

@7&.8&6A#J:1==<.-#&K=&4<0&.$6#<.#8%<0&4<8#3<476&6#8/.$1<.<.-#$%&#LBF6#/2#M)*#1.5#'()*+

,#4&3&1;&5#$%1$#M)*#F5F=#<6#1>;&#$/#76&#$%&#'()*+Ϯϱ͛^>ƚŽŝŶŝƚŝĂƚĞZEƌĞƉůŝĐĂƚŝŽŶ!"#$!$%#

"#

A#^ŝŵŝůĂƌƌĞƐƵůƚƐǁĞƌĞŽďƚĂŝŶĞĚǁŚĞŶƐǁĂƉƉŝŶŐƚŚĞϱ͛^> ŽĨĚŝĨĨĞƌĞŶƚEsƐĞƌŽƚLJƉĞƐ"!9#67 &6$<.-# $%1$# 2;13<3<41;# F5F=# 14&# 3&461$<;&# <.# 6&@7&.8&# 761-&# 1.5# 67==/4$<.-# $%&#

%?=/$%&6<6# $%1$# $%&# C+Ϳ Ɛϱ͛^> ĐŽƵůĚ ĂƐ ǁĞůů ĂĐƚ ďĞ ƵƐĞĚ ďLJ ƚŚĞ ZĚZƉ ĨŽƌ ĐŽŵƉůĞŵĞŶƚĂƌLJ6$41.5# 6?.$%&6<6A# J7==/4$<.-# $%<6# %?=/$%&6<69# N(*# )JO# <6# 1>;&# $/# &22&8$<3&;?# 7$<;<P&# $%&# C+E#

Đϱ͛hdZĂƐĂƚĞŵƉůĂƚĞĨŽƌZEƐLJŶƚŚĞƐŝƐ!"#$!&'%9#<.#$%&#1>6&.8&#/2#/$%&4#3<41;#6&@7&.8&6#$%A##

I0=/4$1.$;?9# >/$%# 0/5&;6# :/7;5# <0=;?# $%1$# <.<$<1$</.# /2# CDE# -F)G# 6?.$%&6<69# >&<.-#

<.5&=&.5&.$#/2#;/.-+41.-&#F)G+F)G#<.$&418$</.69#6%/7;5#>&#0/4&#&22<8<&.$#$%1$#$%&#C+E#-F)G#

Trang 29

&ůĂǀŝǀŝƌĂůƚƌĂŶƐůĂƚŝŽŶŝƐŝŶŝƚŝĂƚĞĚďLJďŝŶĚŝŶŐƚŽƚŚĞϱ͛ĐĂƉƐƚƌƵĐƚƵƌĞŽĨƚŚĞĐĂƉ=-)%+)%."78/&()%" >?@A>B" 5')0'" 8(086)&#" ," &8,%#1,&)/%" )%)&),&)/%" 0/*71(:" ʹ" >?@A@" ,%+" >?@AC" ʹ" ,%+" 8)=-/#/*(#"#6-6%)&#"&/"&'("&8,%#1,&)/%")%)&),&)/%"#)&(3"4'(";1,9)9)8,1"DEF")#"&'(%"&8,%#1,&(+",#","7/1$78/&()%" 6%&)1" 8)-/#/*(#" 8(,0'" &'(" #&/7" 0/+/%" ,%+" &(8*)%,&(" &8,%#1,&)/%3" 4')#" */+(1B"(#&,-1)#'(+"-$"#)*)1,8)&$"&/"&',&"/;"0(1161,8"*DEFB")#"#677/8&(+"-$"&'(";,0&"&',&"&'("78(#(%0("/;","0,7".8(,&1$"(%',%0(#"&8,%#1,&)/%"/;"8(7/8&(8";1,9)9)8,1"DEF#"!"B!#3""

G(9(8,1"#&860&68(#")%"&'(";1,9)9)8,1".(%/*("',9("-((%"8(7/8&(+"&/"71,$"08)&)0,1"8/1(#")%"ƚƌĂŶƐůĂƚŝŽŶ͘ tŚŝůĞ ƚŚĞ ĐŽŵƉŽƐŝƚŝŽŶ ŽĨ ƚŚĞ ϱ͛ hdZ ĚŽĞƐ ŶŽƚ ŝŶĨůƵĞŶĐĞ ƚƌĂŶƐůĂƚŝŽŶ ŝŶŝƚŝĂƚŝŽŶ(;;)0)(%0$"$!B"&'("0HI"#&860&68(")**(+),&(1$"+/5%#&8(,*"/;"&'("#&,8&"0/+/%"+)8(0&#")%)&),&)/%"0/+/%"#(1(0&)/%"!%3"?%+((+B")&"5,#"78/7/#(+"&',&"78(#(%0("/;"&'("',)87)%"#&860&68("0,6#(#"&'("8)-/#/*("&/"#&,11",%+")%)&),&("78/&()%"#$%&'(#)#",&"&'("0/88(0&"7/#)&)/%"*/8(";8(J6(%&1$"&',%",&"%().'-/8)%."FKC"0/+/%#"!%3""

dŚĞ ϯ͛hdZ͕ ƐŝŵŝůĂƌůLJ ƚŽ ƚŚĂƚ ŽĨ ĐĞůůƵůĂƌ ƚƌĂŶƐĐƌŝƉƚƐ͕ ĚƌĂŵĂƚŝĐĂůůLJ ĞŶŚĂŶĐĞƐ ĨůĂǀŝǀŝƌĂůDEF"&8,%#1,&)/%"!&B!"B%'(%"͘/ŶƚĞƌĞƐƚŝŶŐůLJ͕ƚŚĞƉŽůLJĂĚĞŶLJůĂƚĞĚϯ͛K4D"/;"0(1161,8"*DEF#",0&#"-$"8(086)&)%."&'("7/1$"F"-)%+)%."78/&()%"LIFMIN"&/"(%',%0("&8,%#1,&)/%3"O')1(";1,9)9)8,1"DEF")#"+(9/)+" /;","7/1$F"&,)1B" )&",1#/"-)%+#"IFMI"&'8/6.'"F=ƌŝĐŚƐƚƌĞƚĐŚĞƐŝŶƚŚĞϯ͛ĚƵŵďďĞůů;Ϳ8(.)/%"%$3"P/%#)#&(%&"5)&'"&')#B"+(1(&)/%"/;"&'("QM"8(.)/%"+(08(,#(#"&8,%#1,&)/%"(;;)0)(%0$"!&3"

Trang 30

dŚĞƚĞƌŵŝŶĂůϯ͛^>ǁĂƐĂůƐŽƌĞƉŽƌƚĞĚƚŽŝŶĨůƵĞŶĐĞƚƌĂŶƐůĂƚŝŽŶĞĨĨŝĐŝĞŶĐLJŽĨĨůĂǀŝǀŝƌĂůZEƐ͕ĂůͲ

$%&'# (&')# *+,-.&*'&,/# 0%12.'13# 45678Ϯ ϯ͛^> ǁĂƐ ƌĞƋƵŝƌĞĚ ĨŽƌ ƚƌĂŶƐůĂƚŝŽŶ ŽĨ Es ƌĞƉŽƌƚĞƌƐ

!"9!#͕ ǁŚŝůĞ ƌĞƉŽƌƚĞƌƐ ĐŽŶƚĂŝŶŝŶŐ ƚŚĞ tEs ϯ͛:;# '0<,1.<'%=# %11# % &*&%,'.># ')<,# *+,'0+.1#$"9#ƐƵŐŐĞƐƚŝŶŐ ĞŝƚŚĞƌ ĚŝĨĨĞƌĞŶĐĞƐ ďĞƚǁĞĞŶ ǀŝƌƵƐĞƐ Žƌ ŵŽƌĞ ůŝŬĞůLJ ƚŚĂƚ ƚŚĞ ƌŽůĞ ŽĨ ƚŚĞ ϯ͛^> ĚĞͲ

?%,=1#+,#<,#&,'%0?.<>#(&')#+')%0#@6A#%.%B%,'13##

C,#<==&'&+,9#D&021%1#-0+B#')%#E57#12$/0+2?# 8#&,*.2=&,/#E579# F67#<,=#G200<>#D< %>#

%,*%?)<.&'&1#D&021#HG757I#ʹ#(%0%#?0%=&*'%=#'+#*+,'<&,#<#*+,1%0D%=#?1%2=+J,+'#?0%*%=%=#$>#

<#1.&??%0>#)%?'<,2*.%+'&=%#B+'&-#<'#')%#1'<0'#+-#')%#6:"A#*+=&,/#1%K2%,*%#$!3##L)&1#B+'&-#1&/8,<'20%9#*+BB+,#&,#?.<,'#D&021%19#*+0+,<D&021%1#<,=#0%'0+D&021%19#*<21%1#?<21&,/#+-#')%#0&$+81+B%# =20&,/# %.+,/<'&+,# <,=# 8!# 0&$+1+B<.# -0<B%1)&-'&,/# <,=# &1# &B?+0'<,'# '+# ?0+=2*%# ?0+8'%&,1#%,*+=%=#&,#<.'%0,<'&D%#0%<=&,/#-0<B%1#$$3#C,=%%=9#&'#(<1#=%B+,1'0<'%=#')<'#&,#')%#F67#ƐƵďƚLJƉĞ<ƵŶũŝŶǀŝƌƵƐ;<hEsͿƚŚŝƐŵŽƚŝĨƌĞƐƵůƚƐŝŶƉƌŽĚƵĐƚŝŽŶŽĨE^ϭ͛ĐŽŶƚĂŝŶŝŶŐĂůůƐĞƋƵĞŶĐĞƐ+-# 6:!# -21%=# '+# !M# <B&,+# <*&=1# -0+B# <,# <.'%0,<'&D%# -0<B%# +-# ')%# 6:"A# 1%K2%,*%#$!3#WƌŽĚƵĐƚŝŽŶŽĨE^ϭ͛ŝƐƌĞƋƵŝƌĞĚĨŽƌ<hEsƉĂƚŚŽŐĞŶŝĐŝƚLJĂŶĚƐƉĞĐŝĨŝĐĂůůLJŶĞƵƌŽƚƌŽƉŝƐŵ$!9#12/8/%1'&,/#')<'#')%#<$&.&'>#+-#0%.<'%=#D&021%1#'+#21%#'0<,1.<'&+,<.#0%?0+/0<BB&,/#B&/)'#%N?.<&,#

=& %0%,*%1#&,#?<')+/%,%1&1#+$1%0D%=#$%'(%%,#-.<D&D&021#12$/0+2?13#

!

!"!"#"#"$%&'(&)*+)$,-$-.&/*/*0&.$123$*4$5,,0.6$7+8904:,,8"$

O,.&J%# 0%'0+D&021%1# +0# <.?)<D&021%1# ()%0%# <11%B$.># 0%K2&0%B%,'1# )<D%# $%%,# (% #

=%-&,%=9#.&''.%#&1#J,+(,#<$+2'#-.<D&D&0<.#@6A# ?<*J</&,/#<,=#')%#0+.%#=& %0%,'#D&0<.# ?0+'%&,1#

?.<>#&,#')%#?0+*%113#L)%#*<?1&=#?0+'%&,#(<1#0%?+0'%=#'+#<11&1'#&,#@6A#-+.=&,/#<,=#1?+,'<,%8

Trang 31

!

$%&'(#)*+,-&./,0)&#1.2,'#345#!"#$!%&'#!"6#"6#$7#8$9)1)26#0:.&#-2$+)&&#.&#'.;)'(#*$*<&-)+.=.+#,*/#9:)0:)2#$2#*$0#&.>*,'#&)?%)*+)&#.*#0:)#1.2,'#345#,2)#2)+$>*.@)/#2)A,.*&#0$#B)#/)0)2A.*)/7##

345#2)-'.+,0.$*#,*/#)C-2)&&.$*# $=#4D"#.*#%&(")#,2)#09$#$0:)2#=,+0$2&#0:,0#9)2)#2)<

-$20)/#2)?%.2)/#=$2#1.2.$*#=$2A,0.$*#0$#$++%2##%6#&7#E*#,//.0.$*6#&0%/.)&#$*#=',1.1.2,'#1.2%&<'.;)#-,20.+')&#FGHIJ#2)1),')/#0:,0#+)''#'.*)&#)C-2)&&.*>#KL4G#&02%+0%2,'#-2$0).*&#M6#-2N#,*/#O#,2)#,B')#0$#-,+;,>)#KL4G#,*/#PO4G#2)-'.+$*&6#.*#9:.+:#2)>.$*&#+$/.*>#=$2#&02%+0%2,'#)')A)*0&#

9)2)#2)-',+)/#B(#2)-$20)2#>)*)&6#.*#%&(")#"'7#Q:.&#.*/.+,0)&#0:,0#-,+;,>.*>#2)?%.2)A)*0&#,2)#'.;)'(# &:,2)/# B)09))*# =',1.1.2%&)&# ,*/# /$# *$0# *1$'1)# +.&<,+0.*># )')A)*0&# *# M6# -2N# ,*/# O#+$/.*>#&)?%)*+)&7#8$9)1)26#0:)#345#)')A)*0&#,*/#-2)+.&)#A$')+%',2#A)+:,*.&A&#.*1$'1)/#.*#-,+;,>.*>#2)A,.*#,#B',+;#B$C#$=#=',1.1.2,'#&0%/.)&7#

#

!"!"#"$"%&'()%*+,-%+./01.2%*/03434+5).)%6/07%8,19%:,;).+3.2%0;2%)6.:4*4:%+,/.)%4;%34< +0/%+.6/4:014,;"%

R.1)*#0:).2#:.>:#&)?%)*+)#,*/#&02%+0%2)#+$*&)21,0.$*6#=',1.1.2,'#LQ3&#:,1)#B))*#:(<-$0:)&.@)/#0$#-',(#+$*&)21)/#2$')&#.*#1.2,'#2)-'.+,0.$*7#4$0,B'(6#&9, .*>#)C-)2.A)*0&#:,1)#ƐŚŽǁŶƚŚĂƚƚŚĞϱ͛^>ƉůĂLJƐĂŚŝŐŚůLJĐŽŶƐĞƌǀĞĚƉƌŽŵŽƚĞƌƌŽůĞŝŶZEƐLJŶƚŚĞƐŝƐ(!6()6(%6#9:.')#ĞdžĐŚĂŶŐŝŶŐĚŽŵĂŝŶƐŝŶƚŚĞϯ͛hdZŽĨƌĞůĂƚĞĚǀŝƌƵƐĞƐ<#ǁŝƚŚƚŚĞĞdžĐĞƉƚŝŽŶŽĨƚŚĞϯ͛^><#'),/&#0$#-2$/%+0.$*#$=#,00)*%,0)/#B%0#.*=)+0.$%&#1.2%&)&#('6"*6"!7#M$*&.&0)*0#9.0:#0:.&#:(-$0:)&.&6#/)')<0.$*# $=# +$*&)21)/# */.1./%,'# /$A,.*&# *# 0:)# LQ3&# $=# A$&?%.0$<B$2*)# =',1.1.2%&)&# '),/&# 0$#ƐŝŵŝůĂƌĨƵŶĐƚŝŽŶĂůĐŽŶƐĞƋƵĞŶĐĞƐ͘ďƐĞŶĐĞŽĨϱ͛^>͕ŵƵƚĂƚŝŽŶƐŝŶƚŚĞĐLJĐůŝnjĂƚŝŽŶƐĞƋƵĞŶĐĞƐŽƌ ŝŶ ƚŚĞ ϯ͛^> Ăůů ĂďŽůŝƐŚ ZE ƐLJŶƚŚĞƐŝƐ͕ ǁŚŝůĞ ĚĞůĞƚŝŽŶ ŽĨ ƚŚĞ  ĂĨĨĞĐƚƐ ZE ƚƌĂŶƐůĂƚŝŽŶ

!*6!#6!%6('6()6(%6))6)%

7##

Trang 32

/ŶƚĞƌĞƐƚŝŶŐůLJ͕ ƚŚĞ ƌŽůĞ ŽĨ ƚŚĞ ǀĂƌŝĂďůĞ ƌĞŐŝŽŶ ;sZͿ ŝŶ ƚŚĞ ϱ͛ ƌĞŐŝŽŶ ŽĨ ƚŚĞ ϯ͛hdZ͕ ŝƐ

$%&'#'()*+,'-#.+&*/0#/1'#230#4(5'+/#$4+6/4+6+67#8%6*'&,'9#*'8%694&:#*/&)8/)&'*#469#;*')9%<=ŶŽƚ;W<ͿĞůĞŵĞŶƚƐ͕ǀĂƌŝĞƐŝŶůĞŶŐƚŚĂŶĚƐĞƋƵĞŶĐĞƐŝŐŶŝĨŝĐĂŶƚůLJŵŽƌĞƚŚĂŶƚŚĞϱ͛hdZ͕ϯ͛Žƌϯ͛^ͬ^>ƌĞŐŝŽŶƐ!"0#$0#"0"!%"&-#>'('/+%6#%?#/1'#23#4(*%#14*#?4&#('**#9&4$4/+8#'??'8/# %6#?(4,+,+&4(#

&';(+84/+%6# /146# +/*# %/1'&# 9%$4+6# 8%)6/'&;4&/*# &';(+84/+%6##$0"#0""-# @/# 4(*%# 4;;'4&*# /%# 14,'#1%*/# *;'8+?+8# '??'8/*0# 4*# 9'('/+%6# %?# /1'# >AB2=C# 23# $%9'*/(:# +$;4+&'9# ,+&4(# &';(+84/+%6# +6#

$4$$4(+46# 5)/# 6%/# +6*'8/# 8'((*##$-# +64((:0# /1'# DB2# 469# E.2=!F># 23# G4*# +$;(+84/'9# +6#

?%&$4/+%6#%?#6%6=8%9+67#?(4,+,+&4(#3BH*#"#0""0#G1+81#4*#9'*8&+5'9#+6#*)5*'I)'6/#*'8/+%6*#4&'#'$'&7+67# 4*# $4J%&# &'7)(4/%&*# %?# 1%*/=;4/1%7'6*# +6/'&48/+%6*-# K%7'/1'&0# /1'*'# *)77'*/'9#/14/#/1&%)71#(%%*'&#*'I)'68'#8%6*'&,4/+%6#/1'#23#$+71/#?)68/+%6#4*#4#;(4/?%&$#?%&#4#$%&'#8%$;('L#1%*/=;4/1%7'6#+6/'&;(4:0#G1+81#*;'8+?+8#9'/'&$+646/*#&'$4+6#8%$;('/'(:#)6<6%G6-#

?&%$#1'&'#%6#&'?'&&'9#4*#1%*/#,+&4(#3BH#5+69+67#;&%/'+6*#%&#1%*/#,3MN*#=#14,'#5''6#&';%&/'9#/%# 8&+/+84((:# +6?()'68'# ;&%8'**'*# ?%&# G1+81# ?(4,+,+&)*'*# G'&'# +6+/+4((:# /1%)71/# /%# 5'# *'(?=

*)??+8+'6/0#*)81#4*#3BH#*:6/1'*+*#469#'684;*+94/+%6-#@6#/1+*#*'8/+%60#@#&',+'G#<6%G6#+6/'&48=/+%6*# 5'/G''6# 1%*/# ,3MN*# 469# ,+&4(# &';(+84/+%60# ?%8)*+67# %6# /1'# $4$$4(+46# 1%*/0# 469# 9'=

*8&+5'#1%G#/1'*'#?+69+67*#1'(;'9#9'';'6#%)&#)69'&*/469+67#%?#/1'#?(4,+,+&4(#(+?'#8:8('-#

Trang 33

=)&-,+# 14# 64)0# &# /4-1(-*4*+# -,1>4)?# 46# ),5%(/&1(4-# /405%,@,+# A;BC# 5)4'(.,+# &# 0(/)4,-'(<)4-0,-1# ),D*(),.# 64)# 5)4.*/1(',# 6%&'('()&%# ),5%(/&1(4-# !9!"9!#7# E2(+# &)/2(1,/1*),9# (1# >&+#5)454+,.9# &%%4>+# 2(32# %4/&%# /4-/,-1)&1(4-# 46# '()&%# 6&/14)+# &-.# /,%%*%&)# 6&/14)+# 14# 451(0(F,#),5%(/&1(4-9#>2(%,#+2,%1,)(-3#'()&%#5)4.*/1+#6)40#/G145%&+0(/#/,%%*%&)#.,6,-+,+7##

E2,# (054)1&-/,# 46# 24+1# 6&/14)+# (-# '()&%# 5)45&3&1(4-# >&+# &/?-4>%,.3,.# ,&)%G# (-#6%&'('()&%#),+,&)/27#E2(+#5)4051,.#+,',)&%#3)4*5+#14#5)4=,#12,#(-1,)&/140,#46#12,#3,-40,#

&-.# &-1(3,-40,# *)(-3# (-6,/1(4-# (-# 4).,)# 14# (.,-1(6G# 24+1# 5)41,(-+# &++(+1(-3# 4)# ),+1)(/1(-3#'()&%#),5%(/&1(4-#12)4*32#=(-.(-3#14#'()&%#;HI+7#E2,+,#4)(3(-&%#1&)3,1,.#+1*.(,+#'&)(,.#%(11%,#(-#12,#+1)&1,3G#,05%4G,.J#%&=,%,.#;HI#4%(34-*/%,41(.,+#/4)),+54-.(-3#14#54)1(4-+#46#'()&%#;HI#

>,),#*+,.#14#5*)(6G#(-1,)&/1(-3#5)41,(-+#6)40#/,%%#%G+&1,+7#K)40(-,-1#/4<5*)(6(,.#24+1#6&/14)+#

>,),#(.,-1(6(,.#=G#0&++#+5,/1)40,1)G#4)#(00*-4.,1,/1(4-#&-.#3,-,1(/#&-&%G+,+#>,),#5,)<64)0,.#(-#4).,)#14#(.,-1(6G#12,()#6*-/1(4-#(-#6%&'('()&%#(-6,/1(4-#!$%"!7#L4>,',)9#=,/&*+,#46#12,#

%&/?#46#,+1&=%(+2,.#0,124.+#14#.(++,/1#12,#.(66,),-1#+1,5+#46#6%&'('()&%#),5%(/&1(4-#(-#12,#/4-<1,@1#46#(-6,/1(4-9#4-%G#&#2&-.6*%#46#24+1#;MK+#>(12#5)4<#4)#&-1('()&%#6*-/1(4-#(-#'()&%#),5%(/&<

1(4-#/4*%.#=,#'&%(.&1,.7#E2,#.&1&#&'&(%&=%,#64)#,&/2#46#12,0#(+#+*00&)(F,.#(-#?'@&:$!"!7##

Trang 34

$%&#'()*)+'+,-./#-+01,#&21#34'%.(&1#51*1,51,6/# %7#0+)('1'#%,#2%'&#&)3,'.3&+%,8#'1091)3.#2%'&#0:;<'#=1)1#)1*%)&15#&%#)1-(.3&1#0+)3.#:$>#&)3,'.3&+%,#&2)%(-2#+,&1)36&+%,#=+&2#&21#

;нͿϯ͛hdZ͘WWďŝŶĚƐƚŽEs9Ϯ;нͿϯ͛!"8#$?@;AB<!CC#&%#&21#DE$F9Ϯ;нͿϯ͛^>ĂŶĚďŽƚŚ1,23,61#&)3,'.3&+%,##$G#H;I!#3,5#?;<!8#%,#&21#6%,&)3)/8#4+,5#&%#&21#DE$F9ϮĂŶĚ:s;нͿϯ͛JK8#)1'*16&+01./8#3,5#+,2+4+&#&)3,'.3&+%,#%7#)1*%)&1)#:$>'#%&8%'G##

?()&21)L%)18# 3# 03)+1&/# %7# 2%'&# 0:;<'# =3'# )1*%)&15# &%# +,7.(1,61# :$># '/,&21'+'8#

&2)%(-2#L1623,+'L'#&23&#3)1#'&+ #*%%)./#(,51)'&%%5G#M1L41)'#%7#&21#$?>:#73L+./#N$?OC8#

Trang 35

%/)(>>?@# 05211# 5D<0# H+BV<# 4121# 21GD201*# 0D# /)012(30# 4/05# C9.# 3JK+<# DN# 051# N>(H/H/2(>#+$-:#VKBW)VKB@#K;-+#()*#5)+$V-S#(21#1<<1)0/(>#ND2#67$89S@#O$8#()*#M78#21G>/3(0/D)@#219

<G130/H1>?#!&@!'@()@(":#K5/<#<P(>>#)FPL12#DN#*/<3DH121*#N(30D2<#/)012(30/)=#4/05#051#()0/=1)DP1#3DPG(21*# 0D# 051# =1)DP1# 3DF>*# L1# *F1# 0D# 051# N(30# 05(0# 051# ()0/=1)DP1# P(?# L1# NDF)*#P(/)>?#(<#G(20#DN#(#*DFL>1#<02()*1*#21G>/3(0/H1#/)012P1*/(01@#D2#/0#3DF>*#P121>?#L1#1UG>(/)1*#L?#051#N(30#05(0#N14#<0F*/1<#1U(P/)1*#051#/)012(30DP1#DN#051#C9.#3JK+<#/)#051#N/2<0#G>(31:#

#

!"#"!"$"%&'()*(+,(-%.+,/0/,/(1%23%04561%1788(1,%39.0/0/:.9;1*(+/3/+%<2-(1%23%.+,/2'"%

X1)12(>>?@#051#/*1)0/N/1*#5D<0#H+BV<#<5(21*#(#N14#35(2(3012/<0/3<:#->>#(21#3D)<12H1*@#(LF)*()0#5D<0#G2D01/)<@#<F==1<0/)=#1/0512#05(0#N>(H/H/2F<#5(H1#1HD>H1*#0D#G21N121)0/(>>?# 5/9Y(3Z#21(*/>?#(H(/>(L>1#5D<0#N(30D2<#D2#05(0#051#>(3Z#DN#<1)</0/H/0?#DN#051#*10130/D)#P105D*<#*/*#)D0#(>>D4#*/<3DH12?#DN#2(212#N(30D2<:##

Trang 36

$%&'()#*%%#)+,(,#+'()#-./0(#+*1#2,,3#45,-6'7(%8#%639,1#)'#-65*%#63:,;)6'3(<#='>,-,5?#)+,65#*;)6-6)8#63#:%*-6-65*%# 63:,;)6'3# 6(#':),3#(6@36:6;*3)%8#16::,5,3)#)'#>+*)#>*(#1,(;562,1#28#')+,5(<#0A/#*31#BB/?#:'5#63()*3;,?#5,@7%*),#C.DBE&,16*),1#)5*3(%*)6'3#':#=FG?#4'%6'-657(#H0GI#'5#&,*(%,(#-657(#HJ,GI#.K$(#!"#!$#27)#>,5,#3')#:'731#)'#*::,;)#:%*-6-65*%#)5*3(%*)6'3#!%<#L/0!#

*31# M/N!# +*-,# 45'-65*%# ,::,;)(# '3# ,3),5'-657(# HDGI# )5*3(%*)6'3# *31# =FG# 4*5)6;%,# *((,&2%8?#5,(4,;)6-,%8#!&?!!?# >+6%,# )+,65# :73;)6'3# 63# :%*-6-657(# 63:,;)6'3# 6(# *3)6-65*%#&%?&'<# A'@,)+,5?# )+6(#(7@@,()(#)+*)#)+,#*;)6-6)8#':#+'()#-./0(#+6O*;9,1#28#:%*-6-657(,(#;'7%1#1,4,31#'3#(4,;6:6;#63E)563(6;# ;+*5*;),56()6;(# ':# :%*-6-65*%# K$# '5# '3# )+,# (4,;6:6;# &6;5',3-65'3&,3)# ;5,*),1# 63#:%*-6-657(E63:,;),1#;,%%(#)+*)#5,&*63#)'#2,#1,),5&63,1#:'5#,*;+#4'),3)6*%#)*5@,)#45'),63<#

Trang 37

!

$%&'# ()*&# +,# -./0# 12./# 3,4# 56/# +,789'+%,#!"#:# 583&'# ';%# $<=>+4# ?5@AB# &9>88,&# ;8>8# C8>D7%>E84# '%# C>%=8# F+>3G# C>%'8+,# +,'8>39'%E8&#$#"#%:# H%E=+,840# '$8&8# 43'3# +48,'+7+84# &8F8>3G#C3'$;3<&#+EC%>'3,'#7%>#7G3F+F+>3G#>8CG+93'+%,:##

#

! !"#"#"#"$%&'$()*(+,-*$()-.$/012(2(310$-31)*01-(.)$4&5,1)(*4*"$

I,98# 3J3+,0# '$8# G83&'# &K>C>+&+,J# 93'8J%><# %7# $%&'# 739'%>&# '$3'# 8E8>J84# 7>%E# '$8&8#

&9>88,&#;3&#'$3'#%7#()*&#+,F%GF84#+,#'>3,&G3'+%,:#L>3,&G3'+%,#+,+'+3'+%,#739'%>&#2M6NO0#2M6PQ#3,4#2M6RS#;8>8#+48,'+7+84#3&#+,'8>39'%>&#%7#12./D@#.TR##&0#%#3,4#56/#.TP#$#:#L>3,&G3'+%,#8G%,DJ3'+%,# 739'%># 226!Q# 3,4# 226@# &9%>84# 3&# $%&'# 739'%>&# 7%># -./# 3,4# 56/D!U10# >8&C89'+F8G<0#9%,7+>E+,J#'$8#+EC%>'3,98#%7#'$8&8#93'8J%>+8&#%7#C>%'8+,&#+,#7G3F+F+>3G#+,789'+%,&##0!':##

L$8#>%G8#%7#+,4+F+4K3G# >+=%&%E3G#C>%'8+,&0#3#E3V%>#$+'# +,#3#(.Q+#&9>88,# 7%>#56/D!U1#

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ʹ#3G&%#3#56/D!U1# $%&'#739'%>##ʹ)3,4#(*S@@#;8>8# >8[K+>84# 7%>#/T/#+,789'+%,#7%>#'$8+>#3=+G+'<#'%#+,$+=+'#M6.#8WC>8&&+%,#3,4#E%4KG3'8#LS(R#&+J,3G+,J##*:#

# M,#344+'+%,0#%,8#&'K4<#>8F83G84#'$3'#12./D@#(.Q#;3&#3=G8#'%#'>3,&G3'8#3&#877+9+8,'G<#K,48># G+E+'+,J# 2M6N2# #+0# +ECG+93'+,J# '$3'# 7G3F+F+>K&8&# 3>8# 3=G8# '%# K&8# 3G'8>,3'+F80# 93CD+,48C8,48,'#E%48&#%7#'>3,&G3'+%,:#L$+&#9$3>39'8>+&'+9#+&#9%EE%,#7%>#(.Q#F+>K&8&#3,4#3GG%;&#F+>3G#'>3,&G3'+%,#'%#>8&+&'#9%,4+'+%,&#%7#98GGKG3>#&'>8&&#K&K3GG<#+,4K984# =<#F+>3G#+,789'+%,# ?7%>#

Trang 38

$%&'%()#*%%#!"+,#-.'/%#01#2%3.40'*2#(4*#5$151*%6)#7.%*%#8'06'09#'06'347%*#7.47#7.%#'07%$43:7'10#;%7(%%0#8/4&'&'$<*%*#406#4#8'0%:7<0%6#3%//</4$#7$40*/47'104/#243.'0%$=#31</6#;%#18#54$:7'3</4$#'251$7403%#'0#6%7%$2'0'09#7.%#1<7312%#18#'08%37'10#'0#5.=*'1/19'34/#3106'7'10*,#

MV10<3/%4*%*# 4&%# 4/*1# ;%%0# =517.%*'B%6# 71# 5/4=# '251$7407)# =%7# 6'&%$*%)# $1/%*# '0#ĨůĂǀŝǀŝƌĂůŝŶĨĞĐƚŝŽŶƐ͘dŚĞϱ͛:ϯ͛ĐLJƚŽƉůĂƐŵŝĐĞdžŽŶƵĐůĞĂƐĞyZEϭ͕ĂŵĂũŽƌĐŽŵƉŽŶĞŶƚŽĨƚŚĞĐĞůͲ/</4$#2?@>#6%34=#243.'0%$=)#(4*#'25/'347%6#'0#6%9$4647'10#18#7.%#-@G#406#WXG:QYC#9?@>#406#433<2</47'10#18#4#010:316'09#?@>#8$492%07#'0#'08%37%6#3%//*)#(.'3.#'251$7403%#('//#;%#6%74'/%6# /47%$##')##͘ ϯ͛:ϱ͛ %V10<3/%4*%*# 4&%# 4/*1# ;%%0# '6%07'8'%6# '0# 4//# *3$%%0*# 81$# 8/4&'&'$4/#.1*7#84371$*,#-@G#$%S<'$%*#MDNTZ[)#CM@G:!#MDC\!#406#M?HI)#406#WXG:QYC#-?@#81$#$%5/'34:

Trang 39

!

$%&'#!"#(#)*++,)$%'+#$-.$#-,/,#.+.%'#0-%1,#2.$-0.3)#4.3#5,#6&'),/7,8(#8%99,/,'$#7%/*),)#-%:

;.6<#/,1.$,8#5*$#8%)$%'6$#9.6$&/)=#>'#.#2./.11,1#0%$-#,?&'*61,.),)#,'6&8,8#53#6&/&'.7%/*),)###(#ƚŚĞƐĞŚŽƐƚĞŶnjLJŵĞƐǁĞƌĞƉƌŽƉŽƐĞĚƚŽďĞŝŶǀŽůǀĞĚŝŶĨůĂǀŝǀŝƌĂůZEƉƌŽŽĨƌĞĂĚŝŶŐĂŶĚϯ͛ĞŶĚ/,2.%/=#@&',$-,1,))(#$-,#9*'6$%&'#&9#$-,#-&)$#,?&'*61,.),)(#%'61*8%'+#$-,#2&$,'$%.1#9&/#%'8%:/,6$#/,A*%/,4,'$)(#6.''&$#5,#,?61*8,8#.'8#/,4.%'#$&#5,#%'7,)$%+.$,8=#

H-,# 4,45/.',:5&*'8# $&11:1%<,# /,6,2$&/)# EHIJF# %'61*8,# 8)J@B# EHIJKF# '8# ))J@B#EHIJL# '8# HIJMF# ),')&/)=# HIJK# 2./$%6%2.$,)# %'# 6$%7.$%&'# &9# $-,# >D@# /,)2&'),# $&# N@O# '8#PQ@O:!(#2&))%513#53#8,$,6$%'+#%'6&4%'+#7%/.1#J@B)#/,1,.),8#.9$,/#,'8&)&4.1#.6%8%9%6.$%&'#$%%:"R!

=# HIJL(# &'# $-,# &$-,/# -.'8(# 0.)# /,2&/$,8# $&# 2/&$,6$# $-,# 6,'$/.1# ',/7&*)# )3)$,4# ES@TF#

Trang 40

#$#%&'(")*+"%&,-.(%/&"#&0"(/"1-"%23/4(#&(",/4"-'(#15%'62-&("/,"#"'7'(-2%.".-5585#4"%228&-"4-'3/&'-"!"#9!"$:""

;6-" -5585#4" 7(/35#'2%." '-&'/4'" <=>?=" @AABCDE" #&0" FAGC" @=H=IJE" #4-" '(4/&$57"834-$85#(-0"#,(-4",5#K%K%4#5"%&,-.(%/&'"/,"K#4%/8'".-55"(73-'"#&0"3#(%-&('"!!":"H8&.(%/&#5579"<=>?

%&"2/085#(%&$"(6-"%&&#(-"4-'3/&'-"(/"%&,-.(%/&:"H/4"%&'(#&.-"AABSB"/4"AABS"ʹ"T6%.6"#4-"4-?.48%(-0"(/"'%(-'"/,"AL*+?!"#&0")*+"4-35%.#(%/&")!9)("ʹ"T-4-"'6/T&"(/"3#4(%.%3#(-"%&"=H*"34/?2/(-4"#.(%K#(%/&:"G&"/33/'%(-9"%&6%1%(/47"4/5-"/&"=H*"34/08.(%/&"T#'"0-'.4%1-0",/4"AIBCDUV>R!9"T6%.6"#.('"#'"#"0/2%&#&("&-$#(%K-"4-$85#(/4"/,"<=>?="#.(%K#(%/&"!!!*!!#:""

"

!"#"$"#"%&'()'*+,-./-/%.+0%./%-11-+0)2/%)1%03-%.'04542.,%2-/6)'/-""

W-5585#4"<XR'"#4-"#5'/",/8&0"#'"-,,-.(/4'"/,"(6-"#&(%K%4#5"4-'3/&'-:";6-"1-'("Y&/T&"%'"(6-"=H*?%&08.%15-"-&0/&8.5-#'-"<*G'-"V"@<*GZLVE:"<*G'-"V"%'"#15-"(/".5-#K-")*+"<*G"%&"K%(4/" #&0" (6%'" #.(%K%(7" 3#4(%.%3#(-'" %&" /&(4/5" /," )*+" 4-35%.#(%/&"!"(9!!$:" I/T-K-49" <*G'-" V"/K-4-O34-''%/&" 6#'" &/" -,,-.(" /&" AL*+?!" #&0" PH+?JQA" 4-35%.#(%/&"!"'9!"(9" '8$$-'(%&$" (6#("'/2-",5#K%K%48'-'".#&"#K/%0"%('"#&(%K%4#5"-,,-.(':"=&(-4-'(%&$579"(6-"&/&?=H*"%&08.%15-"-&0/&8?

Ngày đăng: 09/09/2015, 11:16

TỪ KHÓA LIÊN QUAN