Accelerated Partial Breast Irradiation Techniques and Clinical Implementation - part 5 pot

Brachytherapy Techniques: the University of Wisconsin/Arizona Approach 9.5.1 Open Freehand Interstitial Catheter Insertion Open freehand technique depends upon the skill of the brachy

9 Brachytherapy Techniques: the University of Wisconsin/Arizona Approach 

9.5.1 Open Freehand Interstitial Catheter Insertion

Open freehand technique depends upon the skill of the brachytherapist to insert eters or needles in an array that both covers the target volume, and provides a spacing that will insure a homogeneous dose distribution It was the original method of breast brachytherapy, used by Geoffrey Keynes in England in the 1920s as the original breast conservation therapy (Keynes 1937), Samuel Hellman from the Joint Center for Radio-therapy in the late 1970s and early 1980s as a boost, and myself in the early 1990s as the first modern day APBI technique

cath-At the time of a lumpectomy or reexcision, the radiation oncologist goes to the erating room with the surgeon With the skin incision open, the extent of the surgical excision can be determined by probing the cavity with an index finger A sterile magic marker delineates the edges of the cavity onto the skin surface A single, double, or rarely triple plane implant is then designed by marking the planned needle entry and exit sites

op-on the skin (Figs 9.3 and 9.4)

Fig 9.3 Two-plane interstitial implant as

per-formed on the RTOG 95-17 phase II trial With

the wound open, the edges of the lumpectomy

cav-ity are marked on the skin Deep and superficial

planes are placed posterior and anterior to the

cav-ity, extending 2 cm beyond the cavity in all

dimen-sions In the study, the end dwell positions of the

radioactive source(s) were planned 1 cm from the

skin surface on both sides, in contrast to modern

3D planning where the positions span the target

volume only

A single-plane implant is indicated if the thickness of the tissue to be covered is 1.5 cm

or less This typically is the case for very medial lesions near the parasternal breast sue or in very small breasts or in augmented breasts (Fig 9.5) It is appropriate to design

tis-a single-pltis-ane impltis-ant for one side of the ttis-arget volume, tis-and brotis-aden it out in tis-a “Y” pattern where the breast becomes thicker, such as under the nipple A double plane is

Robert R Kuske

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necessary if the tissue thickness is greater than 1.5 cm but less than 3 cm A third plane

is added when the target tissue exceeds or equals 3 cm

The spacing between needles within a plane varies with the size of the implant Smaller volumes require closer spacing and larger volumes can be cover with wider spacing For example, when using a single-plane implant, the needle spacing typically is 1.0–1.2 cm.For double-plane implants, the spacing is 1.5 cm In high-risk areas such as directly un-der the lumpectomy scar, smoother dose distributions under the skin can be obtained

by adding extra catheters in between the original marks at a superficial depth By adding these extra catheters, called the “gauntlet under the skin,” the dose under the skin can be feathered by varying the dwell times without overdosing the skin surface and running the late risk of telangiectasia

General principles of freehand technique include:

1 When in doubt about coverage, add an extra catheter in the OR, because you can always pull it or not use it if the dose distribution is acceptable without it, but it is harder (but not impossible!) to add it later after the patient has awoken

2 Catheter entry and exit locations should be selected at least 1 cm away from the target volume, or a source dwell will need to be in the skin, guaranteeing a telangiectatic spot

3 Ideally, the needles are perfectly straight and parallel to each other

4 At the ends of the implant, placing an extra catheter in between the two planes will prevent bowing in of the isodose curves

5 Crossing needles in a perpendicular orientation near the catheter entry and exit sites can be helpful in contouring the dose at these ends of the target volume, so that you

do not have to past-load dwell positions in each catheter to prevent a scalloping in of the dose at the ends of a line source (Fig 9.6)

Fig 9.4 Sagital cross-sectional view of a two-plane

implant with the cavity in purple and the catheters

represented by black dots

Fig 9.5 Prebrachytherapy photograph of a sternal medial tumor excision site in an augmented breast Ultrasound-guided catheter insertion is preferred, and the thin breast tissue can usually be covered by either a single plane or Y-shaped single plane branching out to a second plane laterally to- wards the nipple

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Fig 9.6 An ultrasound-guided implant

illustrat-ing: (1) triangulation between the superficial and

deep planes, where the superficial needles are in

between pairs of deep needles, and (2) the use of

crossing needles at right angles and between the

two planes, at the periphery of the target volume,

benefiting dosimetry in the z-plane of the implant

and avoiding medial sources too close to the skin

Clearly, freehand techniques require skill and experience from the brachytherapist For this reason, this technique is less commonly used than the other image-guided tech-niques discussed in this chapter This technique is still frequently used with augmenta-tion mammoplasty where seeing the silicone surface as you guide each needle across the target volume is helpful in avoiding augmentation implant puncture and subsequent rupture For the target volume not visible within the cavity at the right and left sides, however, it is much safer to have intraoperative ultrasound in order to avoid puncture

9.5.2 Ultrasound-Guided Supine Catheter Insertion

Ultrasound can be very helpful in guiding needle insertion in a closed lumpectomy ity In the presence of a seroma, the surgical excision cavity is readily seen by ultrasound Using real-time ultrasound, it is feasible to guide each brachytherapy needle millimeter

cav-by millimeter across the breast at a chosen depth (Figs 9.7 and 9.8) The deep plane is inserted either along the surface of the pectoralis major muscle or 5 mm deep to the lumpectomy cavity The superficial plane is inserted at a depth of 0.75 to 1.0 cm from the skin surface (Fig 9.9) A middle plane is added when the separation between the two planes, easily measured by the ultrasound device, exceeds 3 cm, or at the ends of the implant to prevent bowing in of the isodose curves as described above

Fig 9.7 Ultrasound-guided needle insertion The

lumpectomy cavity is marked by the dotted oval,

and the target 2 cm beyond by the solid oval

Cath-eter deep and superficial entry sites are marked as

dots on the skin The needle is bent for the deep

plane to facilitate its exiting on the other side The

ultrasound transducer, inside a plastic sleeve

con-taining gel, guides each needle millimeter by

mil-limeter across the pectoralis fascia, avoiding

pneu-mothorax and aiding precise localization

Robert R Kuske

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Fig 9.8 Ultrasound-guided needle insertion, illustrating freehand technique and catheter separation

Fig 9.9 Typical catheter distribution with supine ultrasound guidance Note the medial location

9 Brachytherapy Techniques: the University of Wisconsin/Arizona Approach 

Needles should be chosen that are easily seen by the ultrasound transducer The lenge is to make each needle go straight and parallel to the others while looking at the ultrasound monitor for proper depth Some brachytherapists will have a diagnostic ra-diologist present to hold the transducer and monitor depth and target volume coverage, while others will use their dominant hand for needle insertion and the other hand to hold the transducer

chal-This technique is also skill-dependent, since it is still a freehand technique without

a template to ensure a geometrical array of catheters across the target volume It can be done under local anesthesia with analgesia, or under conscious sedation Unless you are performing the implant at the time of axillary surgery or a excision/reexcision, general anesthesia is not required

Ultrasound catheter insertion in the supine position usually requires fewer catheters than the template-guided insertions below, because the breast flattens out in the supine position and there is no compression to elongate the lumpectomy cavity and subsequent target volume This fact makes hook-up to the HDR iridium-192 remote afterloading machine simpler (Fig 9.10)

Fig 9.10 After CT-based 3D brachytherapy treatment planning, the patient is connected to HDR remote afterloader for treatment

Robert R Kuske

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9.5.3 Image-Guided Prone Catheter Insertion with a Special Breast Template

In 1996, the lead breast imager at the Ochsner Clinic, Dr Gunnar Cederbom, asked

me if I had ever considered brachytherapy in the prone position on a stereotactic core needle breast biopsy table He pointed out the major advantages of such an approach:

1 In the prone position the breast hangs by gravity, pulling the breast tissue away from the pectoralis major muscle, ribs, and pleura

2 The built-in mammography equipment under the table could be used to image the breast, facilitating image-guided breast brachytherapy

3 Prior to the procedure, under ultrasound guidance, a small amount (about 3–5 ml)

of nonionic contrast such as Omnipaque along with 2 ml air can be injected directly into the lumpectomy cavity, highlighting the seroma as well as all its crevices and outpouchings

4 Attaching a template to the breast and taking a mammographic image directly down the holes should allow reliable, reproducible coverage of the target volume

5 Any margin around the lumpectomy cavity can be chosen (e.g 1, 1.5, 2.0, 2.5 cm, etc.) and theoretically one could have broader coverage on one side of the cavity, where the margin is perhaps tighter, and a smaller margin on the other side where the surgical margin is generous

6 The procedure can be performed totally under local anesthesia with analgesia

7 The resultant catheter distribution is a volume implant, rather than one or two planes, allowing much more flexibility for dosimetry and coverage of odd cavity shapes

8 Assuming the template is attached in the same way, a radiation oncologist in a ent state, or even a resident in training, would perform exactly the same implant as a very experienced brachytherapist would do

differ-A typical procedure would go as follows The patient or a nurse applies topical lidocaine cream (EMLA) to the involved breast 1 to 2 hours before the start time One hour before start time, the patient takes 5/325 mg Percocet and 5 mg Valium The patient is taken to the ultrasound suite, where the seroma is identified An ultrasound-compatible needle

is inserted at least 2 cm away from the seroma, to avoid leakage of contrast agent later, after a small amount of local anesthetic has been injected to raise a skin wheal and along the planned path of the needle The needle is positioned in the middle of the seroma, and approximately 80% of the seroma fluid is aspirated into a syringe This decreases the target volume Then 3 ml nonionic contrast agent and 2 ml air are injected directly into the cavity The needle is withdrawn The patient is taken to the stereotactic core biopsy suite in the Radiology Department, the surgeon’s office, or your department, wherever the device is located The table and underlying mammography equipment are draped in sterile fashion The patient’s breast is prepped with povidone-iodine or a similar solu-tion The patient is asked to lower her breast through the hole in the table, so that the nipple is centered and the breast hangs by gravity underneath the table (Fig 9.11) The radiation oncologist or surgeon then palpates the seroma and faces the lumpectomy scar (Fig 9.12) The template is positioned on the breast so that the surgical scar is between the two plates and visible to the physician (Fig 9.13) The surgical scar should not be up against one of the plates because the catheters need to be parallel to the skin under the lumpectomy scar, not perpendicular, for dosimetry reasons For smaller breasts, tincture

of benzoin or an equivalent may be applied to the skin before the template is attached

to prevent slippage Usually, the upper edge of the template is placed tightly up against

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the chest wall so adequate deep coverage is provided A mammographic image is taken with the line of the X-rays aligned along the holes in the template (Fig 9.14) Since the mammography unit below the table is rotatable, the correct angle can be chosen so that front and back holes of coordinate C12, for example, are superimposed on the image (Fig 9.15) The breast/template image obtained is remarkable, because the seroma is clearly seen with air/contrast and the template coordinates covering the target volume are easily identified (Figs 9.16 and 9.17) Half-strength buffered local anesthetic is in-jected just under the skin surface to raise a skin wheal, and more dilute tumescent local anesthetic with epinephrine is injected directly down the planned holes of insertion for

a relatively painless and bloodless procedure (Fig 9.18) Since moderate compression is applied by the template, the cavity is somewhat spread out and elongated, causing the use of many more catheters than is usually seen with the old-style one- or two-plane implants An average of 20 catheters are inserted with this procedure After the needles

Fig 9.11 Patient lowering herself onto the

ster-ilely-draped stereotactic core biopsy table with her

prepped breast hanging by gravity

Fig 9.12 Underneath the table, the breast separates from the chest wall, lungs, and pleura The physician faces the lumpectomy scar in preparation for attach- ing the template

Fig 9.13 The template is attached with the scar

facing outward and the base of the template

usu-ally up against the ribs

Fig 9.14 Overview of prone patient positioning and the underlying rotatable mammography equip- ment with drapes removed for clarity

Robert R Kuske

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Fig 9.15 Mammographic image with the front

and back template holes approximately aligned

Note the air-contrast level in the lumpectomy

cav-ity The target volume is delineated, and some of

the proposed coordinates are marked by an X

Fig 9.16 The radiation oncologist or surgeon views the films, noting the relation between the contrast and the lumpectomy scar marked by a wire, and plans the implant

re-Fig 9.17 Illustration with the contrast-enhanced

lumpectomy cavity in magenta, and the target

volume in gray, facilitating image-guided

brachy-therapy

Fig 9.18 Tumescent local anesthesia is injected directly down the path of all planned needles be- fore any needles are placed, making sure that a skin wheal is raised on both sides

Fig 9.19 A breast CT is obtained the day after the procedure for 3D treatment planning Note how the deep plane can be positioned across the pectoralis fascia with this prone technique The even distribution of catheters around the cavity promotes excellent dosimetry with a high dose ho- mogeneity index

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are in place, the template is disassembled and removed from the breast Plastic Comfort catheters are then inserted inside each needle and pulled until the needle is out and a distal hemispherical button touches the skin at the entry position A button is placed at the other end of each catheter and attached to the catheter, securing it in place, and the catheter is trimmed to the button Bacitracin ointment is applied at each entry/exit site, and a Surgibra is used to hold ABD pads in place over the implant so no tape is neces-sary A treatment-planning CT scan is obtained of the involved breast on the next day, after any swelling has subsided (Fig 9.19) The contrast-enhanced lumpectomy cavity is contoured on each CT slice, and this volume is expanded the desired amount (usually 1.5–2 cm) on the computer as the planning target volume (PTV) Within each catheter, dwell times are selected at 0.5-cm intervals so that the PTV is covered by the prescrip-tion isodose line, with an acceptable (>0.75) dose homogeneity index Treatment sys-tems have dose optimization algorithms that facilitate PTV coverage, but it is important

to make sure that none of the 150% isodose curves connect between one catheter and

an adjacent one

Since the catheter insertion with this technique is done in the prone position, and the CT-planning and HDR treatments are done in the supine position, there will be some change in the geometry of the catheters as the patient changes position This is accept-able, because the treatment is done in the same position as the CT-planning A practical advantage of treating the patient in the supine position is that the deep row of catheters usually drapes across the pectoralis major muscle and chest wall, insuring excellent deep coverage (Fig 9.19) that is usually the most problematic issue with freehand techniques Also, pneumothorax occurs in a small percentage of freehand procedures, either from the thin local anesthetic needle or the brachytherapy needle itself, but in the prone po-sition with a parallel plate template system, pneumothorax should never be seen as a complication

Figure 9.20 demonstrates the typical cosmetic outcome 6 months after brachytherapy with this technique Note the absence of radiation skin changes, and pock marks that will continue to become fainter and more subtle over time This is a soft breast

Not every radiation oncologist or surgeon has easy access to a stereotactic core biopsy table in order to perform prone brachytherapy catheter insertion The procedure can

Fig 9.20 The appearance of the breast 6 months

after template interstitial breast brachytherapy

tem-Fig 9.21 Supine CT-guided breast brachytherapy

with the special template (feet to left, head inside

the CT aperture) After a prep and sterile draping,

the left breast has been pulled up and away from

the chest wall as the template is attached

Fig 9.22 CT-compatible wires are placed in cific template holes to orient the template One is directly over the lumpectomy scar

spe-Fig 9.23 The CT images with 3-mm slice

thick-ness are sent to the treatment planning system For

image-guided catheter insertion, external beam or

brachytherapy planning systems both work After

the cavity is contoured and grown to the PTV, the

3D rendering can be rotated in virtual space on the

computer monitor

Fig 9.24 Using the three skin wires, circled here in blue, and the entry/exit holes, it is simple to rotate the image until a “needle’s eye view” is visualized with the cavity and PTV evident

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CT-compatible catheters or needles can be placed within specific template holes on the skin surface or through breast tissue to also anchor the template and prevent slippage (Fig 9.22) These marker needles help orient the template and label coordinates on the subsequent images A CT of the breast is obtained The images are electronically trans-ferred to the treatment-planning computer The contrast-enhanced lumpectomy cavity

is contoured on each CT slice, and the PTV is grown to the desired margin A color wire frame illustrates the lumpectomy cavity when the treatment planning computer is put

in 3D mode (Figs 9.23 and 9.24) This visualization works with external beam planning systems such as Pinnacle or brachytherapy planning systems such as Plato The patient can be rotated in virtual space until the holes in the template are aligned with the marker

Fig 9.25 For smaller breasts, three pre-CT therapy needles can be inserted through the tem- plate and breast tissue after local anesthesia, provid- ing fiduciary markers as well as anchors preventing template slippage

brachy-Fig 9.26 This technique for catheter insertion

al-lows real-time image guidance to check coverage

of the PTV Changes to catheter distribution can

be planned and checked as you go along In this

case, the PTV extended deep to the “A” row of the

template, so an additional three catheters were

in-serted underneath the template while an assistant

lifted the template further off the chest wall Depth

for coverage and avoidance of the pleura can be

measured off the CT image, and all the previous

needles provide spatial orientation to help keep the

free-hand insertion parallel and straight

Fig 9.27 The procedure is done under local

anes-thesia with analgesia A skin wheal is raised at each

template hole, front and back, with half-strength

buffered lidocaine, and the breast parenchyma is

injected with tumescent 10% strength buffered

lidocaine By numbing all needle paths before

in-serting brachytherapy needles, the local anesthetic

is given time to diffuse and act

Robert R Kuske

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needles helping this process (Fig 9.25) The coordinates of holes to be implanted are then determined by where the PTV overlaps with the holes in the template in the aligned position (Fig 9.26) A rule of thumb for any template catheter insertion method is to add a catheter beyond the PTV if the closest hole is inside the PTV If the template hole

is at the edge of the PTV, no additional catheter is necessary

This technique provides real-time documentation of coverage of the target volume, and allows immediate adjustments or additional catheters Deep coverage is not as reli-able as with the prone technique, but by having an assistant grasp the template, pulling

it off the chest wall, an additional row of deep needles can be added using CT guidance (Fig 9.27) By staying parallel to the previous needles and checking the desired addi-tional depth on the CT scan, pneumothorax can be avoided If in doubt, a few CT images can be taken after the needles are part-way through the breast

All needles are inserted with the same analgesia and tumescent local anesthetic cedure described above At the end, it is advisable to add a few closely spaced superficial catheters flanking the lumpectomy scar, the “gauntlet,” ensuring good coverage under the skin without the prescription isodose line going beyond the surface (Fig 9.28) At the end of the procedure, the catheters do not protrude beyond the skin surface (Fig 9.29),and connection to the HDR remote afterloader is easily accomplished (Fig 9.30)

The MammoSite balloon can be inserted at the time of surgery or later as a separate procedure In the first couple of years after the catheter became available, most of our MammoSite catheters were inserted at the time of surgery for the patient convenience of having everything done at once Now, closed wound catheter insertion is preferred be-cause the pathology report is available confirming that the patient is indeed a candidate for APBI or the balloon We can also perform a preimplant ultrasound or CT to check the skin flap thickness and shape of the cavity, maximizing our success rate with bal-loon insertion There are fewer aborted procedures, down from approximately 20% with intraoperative insertion to 10% with a closed wound Finally, the sutured lumpectomy wound has fully healed and hemostasis has occurred, which further ensures the success

of the balloon and in our opinion provides a better cosmetic outcome

We insert the MammoSite either with the scar-entry technique (SET) or the lateral trocar tunneling technique In the SET a #11 blade is used to reopen the lumpectomy scar approximately 0.75 cm under local anesthesia The seroma is rarely more that 1–

2 cm deep to the lumpectomy scar, making entry into the seroma easy After the blade nick, a hemostat or Kelly clam is inserted under ultrasound guidance into the wound and gently opened, and this process repeated until a gush of seroma fluid emanates out

of the hole All the seroma is expressed with the hemostat in place Immediately upon removal of the hemostat, it is replaced with the deflated MammoSite catheter, check-ing its position using the ultrasound The balloon is inflated while the ultrasound im-age is observed After the balloon is inflated, Steristrips are placed across the rest of the lumpectomy scar so that the wound does not propagate causing a dehiscence

There are advantages and disadvantages of SET SET is an easier technique that avoids the large sharp threatening trocar Since the ends of a line source are relatively colder, the anisotropy of the isodose curves helps pull the dose away from the skin, which is usually

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the biggest problem with MammoSite, and the chest wall An additional cosmetically detrimental scar on the breast is avoided On the other hand, some surgeons sometimes object on basic surgical principles to reopening and entering through the same wound The catheter enters normal to the skin, which can produce bandaging and patient com-fort issues In a worst case scenario, usually happening if the insertion is performed too early for wound healing, the lumpectomy scar can propagate after the MammoSite is put

in, causing a wound dehiscence

Fig 9.28 After the template is removed, the

phy-sician and physicist survey the needle distribution,

looking for potential gaps that could create cold

spots Usually, additional superficial needles are

inserted freehand so that there is a smooth isodose

curve under the skin near the lumpectomy scar

Fig 9.29 With a catheter-within-a-catheter

sys-tem, there is no catheter protruding past the

but-tons, making bandaging easier and enhancing

pa-tient comfort between treatments

Fig 9.30 Treatment delivery with a HDR

iridium-192 source using a remote afterloading machine

Treatment times are typically 5–10 minutes for a

source strength of 4–10 Ci

Robert R Kuske

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The lateral trocar tunneling method is simpler if done at the time of lumpectomy or reexcision, but intraoperative insertions are plagued with the issues noted above This procedure can be performed with a closed wound using ultrasound guidance Since breast tissue tends to collapse after a lateral dissection, the large trocar is necessary to provide a path for the catheter into the lumpectomy cavity This trocar results in a larger scar on the breast, typically 2 cm or larger

With either technique, good tissue conformance to the balloon surface must be checked Separations of the breast tissue requiring treatment from the prescription iso-dose curve by air gaps or seroma/hematoma fluid collections are to be avoided

9.6 Judgment: Selecting the Optimal Technique for a Particular Patient

The major decision trees are:

1 When to offer external beam PBI techniques or breast brachytherapy

2 If you have decided that breast brachytherapy is preferable, do you select balloon tracavitary or interstitial breast brachytherapy techniques?

in-For issues and concerns highlighted in the summary section of this chapter, most of the author’s patients will receive brachytherapy over external beam PBI Note that these are theoretical concerns, and more data will be required before one can apply these selection criteria uniformly The phase III trial does not ask participants to choose patients in the same way that the author selects patients in his clinic; otherwise selection bias would preclude meaningful data analysis to see if these issues withstand the test of randomized scrutiny

In the author’s clinic, those patients who are offered external beam PBI are usually women with large breasts or subareolar primaries, and favorable tumor factors such as older age, generous surgical margins >0.5 cm, and smaller tumors lacking EIC or lym-phovascular invasion (LVI)

Similarly, patients who are offered balloon intracavitary brachytherapy have more favorable tumors in breasts that have a thick skin–cavity separation as determined by pretreatment ultrasound The prescription point for the balloon catheter is only 1 cmbeyond the balloon surface, in contrast to the prescription point for interstitial brachy-therapy at 2 cm or whatever distance the radiation oncologist and physics team choose Despite one paper in the literature (Edmundson et al 2002) implying that breast tissue

is compressible, and the balloon can treat as much as 1.6 cm of breast tissue beyond the surgical margin, there are data from the University of Wisconsin indicating that inter-stitial consistently treats more breast tissue than the balloon catheter (Patel et al 2005) Furthermore, the compressibility of breast tissue varies between premenopausal dense breasts and postmenopausal fatty breasts

Because of the physics of balloon intracavitary brachytherapy, prescribing beyond

1 cm results in extraordinary high doses in the breast tissue touching the balloon, so this

is strictly forbidden Interstitial brachytherapy is only limited by the number of catheters inserted, and is determined by geographic coverage By its nature, interstitial brachy-therapy can cover any size or shape cavity, so it is much more dose-controllable than the balloon catheter As a result, most patients who cannot be treated by the balloon, be-