What is achalasia? potx

The term achalasia means "failure to relax" and refers to the inability of the lower esophageal sphincter a ring of muscle situated between the lower esophagus and the stomach to open an

What is achalasia?

Achalasia is a rare disease of the muscle of the esophagus (swallowing tube) The term achalasia means "failure to relax" and refers to the inability of the lower esophageal sphincter (a ring of muscle situated between the lower esophagus and the stomach) to open and let food pass into the stomach As a result, patients with achalasia have difficulty in swallowing food

ACHALASIA CAUSE

The specific cause of achalasia is unknown However, patients with achalasia have two problems in the esophagus (the tube that carries food from the mouth to the stomach)

* The lower two-thirds of the esophagus does not propel food toward the stomach properly

* The lower esophageal sphincter (LES), a circular band of muscle that lies at the junction of the esophagus and the stomach, does not function correctly Normally, the LES helps prevent food from flowing backwards, from the stomach into the esophagus The LES should relax in response to swallowing to allow food to enter the stomach

In people with achalasia, the LES fails to relax, creating a barrier that prevents food and liquids from passing into the stomach One theory is that the nerve cells responsible for relaxation are destroyed by an unknown cause

Damage to the LES and esophagus causes large volumes of food and saliva to accumulate in the esophagus Most people can initially compensate for this Eventually, the barrier progresses to the point where food and saliva cannot reliably enter the stomach As a result, food and saliva build up in the esophagus

ACHALASIA SYMPTOMS

The most common symptom of achalasia is difficulty swallowing (liquids or solids) This problem begins slowly and progress gradually; many people do not seek help until symptoms are advanced Some people compensate by eating more slowly and using specific maneuvers, such as lifting the neck or throwing the shoulders back, to improve emptying of the esophagus

Other symptoms can include chest pain, regurgitation of swallowed food and liquid, heartburn, difficulty burping, a sensation of fullness or a lump in the throat, hiccups, and weight loss

ACHALASIA DIAGNOSIS

Achalasia is usually suspected based upon symptoms, although tests are needed to confirm the diagnosis

Chest x-rays — A simple chest x-ray may reveal abnormal changes in the

esophagus and absence of air in the stomach, two abnormalities that suggest achalasia

Barium swallow test — The barium swallow test is the primary screening test for

achalasia The test involves swallowing a chalky-tasting, thick mixture of barium while x-rays are taken The barium shows the outline of the esophagus and LES (figure 2)

Barium swallows are usually performed under fluoroscopy, a continuous low-grade x-ray, which is helpful for studying the motion in the esophagus In achalasia, barium swallows usually reveals an absence of contractions in the esophagus after swallowing Sometimes this test shows esophagus contracting spastically in response to swallowing; this variation of achalasia is known as vigorous achalasia

After the barium swallow, you should drink extra fluid Stools may be light in color for a few days after testing as a result of the barium

Manometry — Manometry refers to the measurement of pressure within the

esophagus and the LES Pressures are measured by advancing a thin tube through

the mouth or nose into the esophagus The test is done after having nothing to eat

or drink for eight hours, while you are awake You will be asked to swallow while the tube is in place

Manometry is always used to confirm achalasia The test typically reveals three abnormalities in people with achalasia: high pressure in the LES at rest, failure of the LES to relax after swallowing, and an absence of useful (peristaltic) contractions in the lower esophagus The last two features are the most important and are required to make the diagnosis

Endoscopy — Endoscopy allows the physician to see the inside of the esophagus,

LES, and stomach using a thin, lighted, flexible tube Endoscopy is done while you are sedated This test is usually recommended for people with suspected achalasia and is especially useful for detecting other conditions that mimic achalasia

In people with achalasia, endoscopy often reveals abnormal changes in the esophagus and food that has become stuck; it may also reveal inflammation, small ulcers caused by residual food or pills, and candida (yeast) infection

The endoscope can be advanced through the LES and into the stomach to check for stomach cancer Cancer in the upper part of the stomach can produce symptoms almost identical to those of achalasia, and is called pseudoachalasia (meaning "false" achalasia) Thus, biopsies (small samples of tissue) are often

obtained in the lower portion of the esophagus Having a biopsy while sedated is not painful and is safe