Chapter 086. Breast Cancer (Part 13) ppsx

Breast Cancer Part 13 Follow-Up of Breast Cancer Patients Despite the availability of sophisticated and expensive imaging techniques and a wide range of serum tumor marker tests, survi

Chapter 086 Breast Cancer

(Part 13)

Follow-Up of Breast Cancer Patients

Despite the availability of sophisticated and expensive imaging techniques and a wide range of serum tumor marker tests, survival is not influenced by early diagnosis of relapse Surveillance guidelines are given in Table 86-5

Table 86-5 Breast Cancer Surveillance Guidelines

Recommended

History; eliciting symptoms;

physical examination

q3–6 months x 3 years; q6–12 months x 2 years; then annually

Breast self-examination Monthly

Patient education about

symptoms of recurrence

Ongoing

Coordination of care Ongoing

Not Recommended

Complete blood count

Serum chemistry studies

Chest radiographs

Bone scans

Ultrasound examination of the liver

Computed tomography of chest, abdomen, or pelvis

Tumor marker CA 15-3, CA 27-29

Tumor marker CEA

Source: Recommended Breast Cancer Surveillance Guidelines, ASCO

Education Book, Fall, 1997

Further Readings

Breast International Group (BIG) 1-98 Collaborative Group: A comparison

of letrozole and tamoxifen in postmenopausal women with early breast cancer N Engl J Med 353:2747, 2005

Citron ML et al: Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of intergroup trial C9741/cancer and leukemia group B trial 9741 J Clin Oncol 21:1431, 2003 [PMID: 12668651]

Cleator S et al: Triple-negative breast cancer: Therapeutic options Lancet Oncol 8:235, 2007 [PMID: 17329194]

Early Breast Cancer Trialists' Collaborative Group: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials Lancet 365:1687, 2005

———: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials Lancet 366:2087, 2005

Giordano S et al: Breast cancer in men Ann Intern Med 137:678, 2002 [PMID: 12379069]

Ingle JN et al: Fulvestrant in women with advanced breast cancer after

progression on prior aromatase inhibitor therapy: North central cancer treatment group trial N0032 J Clin Oncol 24:1052, 2006 [PMID: 16505423]

Jakesz R et al: Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: Combined results of ABCSG trial 8 and ARNO 95 trial Lancet 366:455, 2005 [PMID: 16084253]

Partridge A, Schapira L: Pregnancy and breast cancer Oncology 19:693,

2005 [PMID: 15971447]

Romond EH et al: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer N Engl J Med 353:1673, 2005 [PMID: 16236738]

Santen RJ, Mansel R: Benign breast disorders N Engl J Med 353:275,

2005 [PMID: 16034013]

Shapiro CL, Winer EL (eds): Late effects of treatment and survivorship issues in early-stage breast cancer Sem Oncol 30:729, 2003

Bibliography

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Braun S et al: A pooled analysis of bone marrow micrometastasis in breast cancer N Engl J Med 353:793, 2005 [PMID: 16120859]

Fyles AW et al: Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer N Engl J Med 351:963, 2004 [PMID: 15342804]

Harris J et al (eds): Diseases of the Breast 3d ed Philadelphia,

Lippincott-Raven, 2004

Jones SE et al: Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer J Clin Oncol 23:5542, 2005 [PMID: 16110015]

Kendall A et al: Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors Annals Oncol 17:584,

2006 [PMID: 16443612]

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Oh DS et al: Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers J Clin Oncol 24:1656, 2006 [PMID: 16505416]

Piccart-Gebhart M et al: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer N Engl J Med 353:1659, 2005 [PMID: 16236737]

Ragaz J et al: Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia Randomized Trial J Natl Cancer Inst 97:116, 2005 [PMID: 15657341]

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