numerous combination preparations F: Alodont Warner-Lambert- comb.. CCtylyre Oberlin GB: Calgel Warner-Lambert Fluprim Roche Gola Sella Golagamma Avantgarde J: Neocepacol Lepetit Neocor
Trang 1Cetylpyridinium chloride C 421
k
2
1 Trade Name(s):
1 D: Cetrotide (ASTA Medica GB: Cetrotide (ASTA Medlca)
k
I AWD; 1999)
!
f Cetylpyridinium chloride
i
ATC: BO5CAO1; D08AJ03; D09AA07; R02AA06
Use: dls~nfectant, antisept~c
! RN: 123-03-5 MF: C,,H,,ClN MW: 340.00 EINECS: 204-593-9
i LD,,: 10 mglkg (M, i.v.); 108 rnglkg (M, p.o.),
E 200 mgkg (R, p.o.1
CN 1-hexadecylpyridinium chloride
pyridine cetyl chloride Cetylpyridinium chloride
Reference(s):
Budesinsky-Protiva, 53 1-532
Formulation(s): eff tabl 1.5 mg, 3 mg; lozenge 1.4 mg; sol 5 mg/lO rnl (0.01 %, 0.05 %); tabl 2 mg
Trade Name(s):
D: Dobendan (Cassella-med) Merocame (Seton)-comb Pcnaten (Johnson &
W~ilfing) I: Borocaina (Schiapparelli Ragaden (Ganassini)
Roland)-comb
numerous combination
preparations
F: Alodont (Warner-Lambert)-
comb
Broncorinol (Roche
Nicholas)-comb
CCtylyre (Oberlin)
GB: Calgel (Warner-Lambert)
Fluprim (Roche) Gola (Sella) Golagamma (Avantgarde) J:
Neocepacol (Lepetit) Neocoricidin (Schering-
Neoformitrol (Sandoz) Neogola (Sella) Noalcool (Sella)
numerous combination preparations
Colgen 123 (Kowa)-comb Pabron Troche (Taisho) Suprol (Iwaki) Cepacol (Lakeside)-comb.; wfm
Cobrex (Reid-Rowell)- comb.; wfrn
Chenodeoxycholic acid
(Chenodiol; Acide chenodtoxycholique;
Chenodesoxycholsaure)
ATC: AOSAAOI Use: choleretic, anticholethithogenic dissolution of cholesterol gallstones
RN: 474-25-9 MF: C24H4004 MW: 392.58 EINECS: 207-481-8
LD,: 100 mgkg (M, i.v.); 3 glkg (M, p.0.);
106 mdkg (R, i.v.); 4 glkg (R, p.0.);
> I d k g (dog, PO.)
CN: (3a,5P,7a)-3,7-dihydroxycholan-24-oic acid
Trang 2422 C Chenodeoxycholic acid
0 0
0/CH3 H~cAo"XH,
+ HO-CH, -+ E Me ,,\+ - 1
Me H
'"OH H O."' H H
"'OH
methyl 3a,7a-diacetoxy- methyl 3 a 7 ~ - d i o c e t o x y
12a-hydroxycholonote (I) 12-oxocholonote (11)
1 H2N-NH2 H20 H O ~ O H , 200 O C
2 HCI
1 hydrozine hydrote
I Chenodeoxycholic ocid
~ i e s e r , L.F.; Rajagopalan, S.: J Am Chem Soc (JACSAT) 72,5530 (1950)
Hauser, E et a].: Helv Chim Acta (HCACAV) 43, 1595 (1960)
Hofmann, A.F.: Acta Chem Scand (ACHSE7) 17, 173 (1963)
Sato, Y.; Ikekawa, N.: J Org Chem (JOCEAH) 24, 1367 (1959)
purification:
DOS 2 302 744 (Union International; appl 20.1.1973; GB-prior 20.1.1972)
DE 2 404 102 (Schering AG; appl 25.1.1974)
DOS 2 613 346 (Diamalt; appl 29.3.1976)
US 4 163 017 (Diamalt; 31.7.1979; D-prior 29.3.1976)
JP-appl 52 153 955 (Tokyo Tanabe; appl 18.6.1976)
isolation from animal bile:
US 3 919 266 (Intellectual Property Dev Corp.; 11.1 1.1975; prior 21.9.1972, 19 - 1973)
US 4 014 908 (Intellectual property Dev ~ o r p ; 29.3.1977; prior 21.9.1972, 19.1 1.1973,7.5.1974, 30.5.1974, 20.2.1976)
US 4 072 695 (Intellectual Property Dev Corp.; 7.2.1978; prior 21.9.1972, 19.1 1.1973, 7.5.1974, 30.5.1974, 20.2.1976, 17.9.1976)
combination with hymecromone:
DOS 2 700 085 (Lipha; appl 4.1.1977; F-prior 13.7.1976)
Trade Nante(s):
D: Chenofalk (Falk) Hekbilin (Strathmann)- GB: Chendol (CP Pharrn.)
F: ChCnodex (Hoechst HoudC) Chenossil (Midy)
Trang 3Chloral hvdrate C 423
Fluibil (Zambon Italia) Cholasa ('Tokyo Tanabe) USA: Chcnix (Reid-Rowell);
Use: hypnotic, scdative RN: 302-17-0 MF: C,H,CI,O, MW: 165.40 EINECS: 206-1 17-5
LD56 530 mglkg (M, i.v.); 1100 mglkg (M, p.o.1;
479 m a g (R, p.0.)
CN: 2,2,2-trichloro-1 ,l -ethanediol
ethanol trichloro- 1 Chlarol hydrate
acetaldehyde (1)
Reference(s1:
UUmanns Encykl Tech Chem., 4 Aufl., Vol 9, 377
Formulation(s): cps 250 mg, 500 mg
Trade Nume(s):
D: Chloraldurat (Pohl) GB: Welldorm elixir (S & N) USA: Noctec (Squibb); wrm F: numerous combination I: Cloral (Tariff Nazionale) generica
Chloralodol
(Chlorhexadol)
ATC: N05CC02 Use: hypnotic
RN: 3563-58-4 MF: C,HI,C1303 MW: 265.56 EINECS: 222-634-9
CN: 2-methyl-4-(2,2,2-trichloro-1-hydroxyethoxy)-2-pentanol
2-methylpentane- chloral hydrate
2,4-diol
Reference(s):
U S 2 931 838 (Det Danske Med.-& Kern.-Komp.; 5.4.1960; DK-prior 8.12.1956)
Fonnulation(s): tabl 400 mg, 800 mg
Trang 4424 C Chlorambucil
Trade Narne(s):
GB: Medodorm (Medo); wfm
Use: antineoplastic RN: 305-03-3 MF: C,,H,,C12N02 MW: 304.22 EINECS: 206-162-0
LD,,,: 80 m g k g (M, p.0.);
76 m g k g (R, p.0.)
CN: 4-[bis(2-chloroethyl)amino]benzenebutanoic acid
ocetanilide succinic 4-(4-ocetamidophenyl)-
anhydride 4-oxobutanoic ocid
oxide 4-(4-ominopheny1)-
Reference(s):
US 3 046 301 (Borroughs Wellcome; 24.7.1962; prior 29.10.1959)
1 POCI,
2 H 2 0
1 phosphorus ~ld
Formulation(s): drg 2 mg; tabl 2 mg, 5 mg
oxychlaride
Trade Narne(s):
D: Leukeran (Glaxo GB: Leukeran (Glaxo Linfolysin (Nuovo ISM)
F: Chloraminophtne (Techni- I: Leukeran (Glaxo Wellcome)
Chlorambucil
JOlBAOl; SOlAAOl; S02AAO1; S03AA08
Use: antibiotic RN: 56-75-7 MF: C, ,H12C12N20, MW: 323.13 EINECS: 200-287-4
LD,,,: 110 m g k g (M, i.v.); 1500 mglkg (M, p.0.);
171 mg/kg (R, i.v.); 2500 mg/kg (R, p.0.)
CN: [R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-l-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]aceta~de
Trang 5Chloramphenicol C 425
2 HCI
1 hexamethylene- "."-"a OH.[
4'-nitro-
acetophenone
2-bromo-4'-nitro- ocetophenone
2-amino-4'-nitroaceto- phenone hydrochloride (I)
acetic anhydride 2-acetamido-4'-nitro-
acetophenone
D-camphorsulfonic ocid
1 Chloramphenicol I
H C CH,
cinnarnyl
alcohol
2 - b r o m o - l - phenyl-12- proponediol
5-bromo-2.2- dimethyl-4- phenyl-l,3- dioxane (IV)
DL-threo-5-
omino-2.2-
dirnethyl-4-
phenyl-
1.3-dioxone
D(-)-threo-5- amino-2,2- dirnethyl-4- phenyl-1,3- dioxane
D(-)-threo-5-di- chloroacetarnido- 2.2-dimethyl-4- phenyl-1.3-dioxane (V)
Trang 6426 C Chloramphenicol
p h e n y l ) 1,3-propane-
dial dinitrate
Rqference(s):
Ehrhart-Ruschig IV, 398 ff
a Long, L.M.; Troutman, H.D.: J Am Chem Soc (JACSAT) 71,2469,2473 (1949)
US 2 483 871 (Parke Davis; 1949; appl 1948)
US 2 483 884 (Parke Davis; 1949; appl 1948)
US 2 483 885 (Parke Davis; 1949; appl 1949)
US 2 483 892 (Parke Davis; 1949; appl 1948)
US 2 687 434 (Parke Davis; 1954; appl 1953)
US 2 651 661 (Monsanto; 1953; appl 1950)
US 2 786 870 (Parke Davis; 1957; appl 1954)
Rebstock, M.C et al.: J Am Chem Soc (JACSAT) 71,2458-2468 (1949)
b BE 539 991 (Boehringer Mannh.; appl 1955; D-prior 1954)
DE 1 01 6 718 (Boehringer Mannh.; appl 1953)
BE 558 378 (Boehringer Mannh.; appl 14.6.1957; D-prior 27.6.1956,22.12.1956)
alternative synthesis (from benzaldehyde and nitromethane o r 0-nitroethanolvia 2-n~tro-1-phenyl- l,3- propanediol):
DE 862 302 (Parke D a m ; appl 1949; USA-prior 1948)
DE I 064 937 (Roehringer Mannh.; appl 1957)
DOS 2 708 301 (Egyt; appl 25.2.1977; H-pnor 25.2.1976)
0-3-monophosphate:
DAS 1 668 96 1 (Roussel-Uclaf; appl 20.2.1968; I-prior 20.2.1967, 18.5.1967)
Formulation(s): amp 1 g (as hydrogen succinate sodium salt); cps 250 mg, 500 mg; ear drops 5 g/100 ml,
50 mglg; eye drops 5 mg, 10 mg; ointment 1 % (10 mglg) Trade Name(s):
D: Aquamycetin (Winzer)
Chloramphenicol-PW
(Pharma Wernigerode)
Chloramsaar (Chephasaar)
Oleomycetin (Winzcr)
Paraxin (Boehringer
Mannh.)
Thilocanfol C (Alcon)
numerous combination
preparations
F: CCbtdexacol (Chauvin)-
comb
CCbCnicol (Chauvin)
numerous combination
preparations
GB: Chloromycetin (Goldshield) Kemicetine Succinate (Pharmacia & Upjohn) Minims Chloramphenicol (Chauvin)
SNO Phenicol (Chauvin) I: Chemicetina (Carlo Erba) Chloromycetin (Parke Davis)
Cloram (Formulario Naz.) Minims (Smith & Nephew) Mycetin (Farmigea) Sificetina (SIFI) Vitamfenicolo (Allergan)
numerous salts and combination preparations J: Antacin (Sumitorno) Chloromycetin (Sankyo) Kemicetine (Fujisawa) Myclocin (Takeda) Paraxin (Yamanouchi) Synthomycetine (Otsuka) numerous gcncrics and combination preparations USA: Elase-Chloromycetin (Fujisawa)
Trang 7Chlorazanil C 427
Use: diuretic RN: 500-42-5 MF: C9HRC1N5 MW: 221.65 EINECS: 207-904-6
LD,,: 300 mglkg (M, p.0.);
16 mglkg (R, i.v.)
CN: N-(4-chloropheny1)- 1,3,5-triazine-2,4-diamine
monohydrochloride
RN: 2019-25-2 MF: C,HRC1N5 HC1 MW: 258.1 1 EINECS: 21 7-962-4
1-(4-chlaropheny1)- formic I C ~ o r a z a n i l
biguonide hydrochloride acid
Reference(s):
DE 1 008 303 (Heumann & Co.; appl 1955)
Formulation(s): tabl 150 mg
Trade Name(s):
D: Orpidan-150 (Heumann);
wfm
Use: anticholinergic RN: 522-18-9 MF: C,,H,,ClN,O MW: 435.01 EINECS: 208-323-0
CN: I-[2-[(2-chlorophenyI)phenylmethoxy]ethyl]-4-[(2-methylphenyl)methyl]piperazine
dihydrochloride
RN: 5576-62-5 MF: C,,H,,ClN,O 2HCl MW: 507.93 EINECS: 226-951-3
LD,,: 1400 mglkg (M, p.0.);
66 mgkg (R, i.v.); 3350 mglkg (R, p.0.)
Reference(s):
BE 549 420 (H Morren; appl 10.7.1956),
2-chlarobenz- 1 -(2-hydroxyethyl)-
Formulation(s): tabl 30 mg (as dihydrochloride)
Chlorbenzoxamine hydlyl chloride 4-(2-methylbenzy1)-
piperazine
Trang 84 2 8 C Chlorcyclizine
n a d e Name(s):
D: Libratar (UCB); wfm Gastomax (Brocchieri); Libratar (UCB-Smith)
Chlorcy clizine
(Histachlorazine)
ATC: R06AE04 Use: antihistaminic RN: 82-93-9 MF: ClxH2,CIN2 MW: 300.83 EINECS: 201-446-0
CN: 1-[(4-chlorphenyl)phenylmethyl]-4-methylpiperazine
monohydrochloride
RN: 14362-3 1-3 MF: C,,H2,CIN2 HCI MW: 337.29
dihydrochloride
RN: 129-71-5 MF: ClxH2~C1N2 2HCI MW: 373.76
4-chlorobenz- 1 -methyl- / Chlorcyclizine 1
hydryl chlaride piperazine
Reference(s):
US 2 630 435 (Burroughs Wellcome; 1953; prior 1948)
Formulation(s): tabl 50 mg (as hydrochloride)
Trade Name(s):
F: Di-ParalCne (Abbott); wfm I: Clorciclizina (Tariff USA: Mantadil (Burroughs
Di-Paralene (Abbott); wfm hydrocortisone; wfm
Use: tranquilizer RN: 58-25-3 MF: C,,H,,ClN,O MW: 299.76 EINECS: 200-371-0
LD,,,: 95 m g k g (M, i.v.); 200 m g k g (M, p.0.);
165 mg/kg (R, i.v.); 392 mglkg (R, p.0.)
CN: 7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
2-arnino-5-
chlorobenzo-
phenone
6-chloro-2-chloromethyl 4-phenylquinazoline 3-oxide (I)
Trang 9Chlorhexidine C 429
g
Chlordiazepoxide
f
:: Referencefs):
US 2 893 992 (Hoffmann-La Roche; 7.7.1959; prior 15.5.1958)
1 ,DE 1096 363 (Hoffmann-La Roche; appl 24.4.1959; USA-prior 15.5.1958)
P Stembach, L.H et al.: J Org Chem (JOCEAH) 26, 11 11 (196 1)
1
? Formulation(s): drg 10 mg; f c tabl 5 mg; tabl 5 mg, 10 mg, 25 mg
D: Limbatril (Roche)-comb
Multum (Rosen Pharma)
Radepur (ASTA Medica
AWD)
F: Librax (Roche)-comb
GB: Librium (Roche)
1: Diapatol (Teofarma)-comb
Librium (Roche)
Limbitryl (Roche)-comb
Psicofar (Terapeutico) USA: Librax (Roche Products; as Reliberan (Geymonat) hydrochloride)
Sedans (Ganassini)-comb Librium (Roche Products; Seren Vita (Synthelabo) as hydrochloride) J: Balance (Yamanouchi) Limbitrol (Roche Products)
Sophiamin (Kyowa Yakuhin)
Trakipearl (Hishiyama)
D09AA12; R02AA05; SO1 AX09; S02AA09; S03AA04
Use: antiseptic RN: 55-56-1 MF: C22H,oC12Nlo MW: 505.46 EINECS: 200-238-7
LD,: 24 mgkg (M, i.v.); 25 15 nig/kg (M, p.0.);
21 mgkg (R, i.v.); 9200 pL/kg (R, p.0.)
CN: N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
diacetate
RN: 56-95-1 MF: C22H30C12Nlo 2C2H,02 MW: 625.56 EINECS: 200-302-4
dihydrochloride
RN: 3697-42-5 MF: C22H~oC12N~o~2HCI MW: 578.38 EINECS: 223-026-6
LD,,: >5 g/kg (M, s.c.)
di-~.glW~nate
RN: 18472-51-0 MF: C22H30C12NLo 2C6H1207 MW: 897.77 EINECS: 242-354-0
24.2 mglkg (R, i.v.); 2 @kg (R, p.0.)
Trang 10430 C Chlorhexidine
hexornethylenebis- 4-chlorooniline
(dicyonodiornide) hydrochloride
I Chlorhexidine I
hexornethylenediornine (4-chlorophenyl)-
dihydrochloride dicyonodiomide
Reference(s):
GB 705 838 (ICI; appl 1951; valid from 1952)
1
$
I Formlclation(s): gel 1 g1100 g; powder 1 g1100 g; sol 0.1 g/100 g, 0.2 g1100 g, 1 g/50 ml (as digluconate)
D: Chlorhexamed (Blend-a- Hibidil (Zeneca; as Hibidil (Zeneca)
C hlorhexidindigluconat Hibiscrub (Zeneca; as Hibitane (Zeneca) (Engelhard)
Corsodyl (SmithKline Beecham OTC Medicines) Frubilurgyl (Boehringer Mannh.)
Hansamed (Beiersdorf) numerous combination preparations
F: Antalyre (Boehringer Ing.;
as g1uconate)-comb
Collunovar (Dexo; as gluconate)
Collupressine (SynthClabo;
as g1uconate)-comb
Collustan (Oberlin; as dig1uconate)-comb
Corsadyl (SmithKline Beecham; as digluconate) CytCal (Sinbio; as g1uconate)-comb
Dacryne (Johnson &
Johnson) Diseptine (Nicholas; as g1uconate)-comb
Eludril (Inava; as
digluconate) Hibitane (Zeneca; as gluconate)
Merfene (Novartis; as
- gluconate) Plurexid (Evans; as gluconate) Prexidine (Pred; as gluconate) SepCal (Sinbio; as digluconate) Thiovalone (Eurorga; as diacetate)-comb
GB: Bactigras (Smith &
Nephew) Chlorhexitulle (Hoechst) Corsodyl (SmithKline Beecham)
numerous preparations I: Clorex (Formulario Naz.) Contact (Vaas; as
Lenixil (Eurospital) Neomercurocromo (SIT) Neoxene (Ecobi) Odontoxina (Ipfi) Oramil (Ganassini) Plak Out (Byk Gulden) Sanoral (Kemiprogress) Savlodil (Zeneca)-comb Savlol (Zeneca)-comb Vaxidina (Vaas) Vidermina (Ganassini) J: Hexad01 (Green Cross) Hibiscrub (ICI) Hibitane Digluconate (Sumitorno) Maskin (Maruishi) Pabron (Taisho Seiyaku) White Go1 (Tamagawa Eizai)
White Rive (Eisai) USA: Betasept (Purdue hydrochloride) Frederick; as gluconate) Corsodyl (SmithKline Hibiclens (Zeneca; as
Effetre (Farma3 Medicalex) Hibistat (Zeneca; as