Study Reason for Exclusion
Ansari, D., Rosendahl, A., Elebro, J., Andersson, R., Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic
No relevant articles
Study Reason for Exclusion cancer, British Journal of SurgeryBr J Surg, 98, 1041-55,
2011
Breitkopf, C. R., Sinicrope, P. S., Rabe, K. G., Brockman, T.
A., Patten, C. A., McWilliams, R. R., ... & Petersen, G. M., Factors influencing receptivity to future screening options for pancreatic cancer in those with and without pancreatic cancer family history. Hereditary cancer in clinical practice, 10(1), 8, 2012.
Participants not enrolled in screening/surveillance program.
Bruenderman, E. H., Martin, R. C., 2nd, High-risk population in sporadic pancreatic adenocarcinoma:
guidelines for screening, Journal of Surgical ResearchJ Surg Res, 194, 212-9, 2015
Checked, no additional relevant articles.
Calvez-Kelm, F. L., Foll, M., Wozniak, M. B., Durand, G., Chopard, P., Pertesi, M., Delhomme, T., Holcatova, I., Foretova, L., Janout, V., Fabianova, E., Vallee, M. P., Brennan, P., McKay, J. D., Byrnes, G., Scelo, G., NGS- based detection of KRAS hotspot mutations in plasma cell- free DNA of pancreatic cancer cases, Cancer Research.
Conference: 107th Annual Meeting of the American Association for Cancer Research, AACR, 76, 2016
Conference abstract
Chang, J. C., Kundranda, M., Novel Diagnostic and Predictive Biomarkers in Pancreatic Adenocarcinoma, International Journal of Molecular SciencesInt, 18, 20, 2017
Not systematic review
Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., Batra, S. K., Brentnall, T.
A., Canto, M., Cleeter, D. F., Firpo, M. A., Gambhir, S. S., Go, V. L., Hines, O. J., Kenner, B. J., Klimstra, D. S., Lerch, M. M., Levy, M. J., Maitra, A., Mulvihill, S. J., Petersen, G.
M., Rhim, A. D., Simeone, D. M., Srivastava, S., Tanaka, M., Vinik, A. I., Wong, D., Early detection of sporadic pancreatic cancer: summative review, Pancreas, 44, 693- 712, 2015
Not systematic review
Collins, J., Dixson, H., Baird, P., Meredith, C., Tumour markers using SurePath liquid-based cytology preparations from endoscopic ultrasound guided fine needle aspiration of solid pancreatic lesions, Journal of Gastroenterology and Hepatology (Australia), 31, 53, 2016
Conference abstract
Furuhata, A., Minamiguchi, S., Shirahase, H., Kodama, Y., Adachi, S., Sakurai, T., Haga, H., Immunohistochemical Antibody Panel for the Differential Diagnosis of Pancreatic Ductal Carcinoma From Gastrointestinal Contamination and Benign Pancreatic Duct Epithelium in Endoscopic
Ultrasound-Guided Fine-Needle Aspiration, PancreasPancreas, 18, 18, 2017
Conference abstract
Grover, S., Jajoo, K., Screening for Pancreatic Cancer in High-risk Populations, Gastroenterology Clinics of North America, 45, 117-127, 2016
Not systematic review
Hall, M., Olopade, O., Pancreatic cancer and BRCA mutation in familial breast cancer families, Journal of Clinical OncologyJ Clin Oncol, 23, 9550, 2005
Conference abstract
Harinck, F., Nagtegaal, T., Kluijt, I., Aalfs, C., Smets, E., Poley, J. W., Wagner, A., van Hooft, J., Fockens, P., Bruno, M., Bleiker, E. M., Feasibility of a pancreatic cancer
surveillance program from a psychological point of view, Genetics in Medicine, 13, 1015-24, 2011
More recent results updated and included in Konings et al. 2016
Hosmer, A., Merajver, S., Stoffel, E., Milliron, K., Kwon, R.,
Elta, G., Scheiman, J., Anderson, M., Menees, S. B., EUS Conference abstract
Study Reason for Exclusion and MRI/MRCP findings in pancreatic cancer screening for
individuals who harbor a BRCA2 deleterious germline mutation, American Journal of Gastroenterology, 111, S13, 2016
Hussein, N. A., Kholy, Z. A., Anwar, M. M., Ahmad, M. A., Ahmad, S. M., Plasma miR-22-3p, miR-642b-3p and miR- 885-5p as diagnostic biomarkers for pancreatic cancer, Journal of Cancer Research & Clinical OncologyJ Cancer Res Clin Oncol, 143, 83-93, 2017
Participants not adults with inherited high risk of PC
Ibrahim, I. S., Bonsing, B. A., Swijnenburg, R. J., Welling, L., Veenendaal, R. A., Wasser, M. N., Morreau, H.,
Inderson, A., Vasen, H. F., Dilemmas in the management of screen-detected lesions in patients at high risk for
pancreatic cancer, Familial CancerFam Cancer, 16, 111- 115, 2017
Case study of 2 patients
Kanda, M., Knight, S., Topazian, M., Syngal, S., Farrell, J., Lee, J., ... & Fujiwara, S., Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.
Gut, gutjnl-2012, 2012
No relevant data for detection of PC
Kim, E. R., Bae, S. Y., Lee, K. H., Lee, K. T., Son, H. J., Rhee, J. C., Lee, J. K., Is health screening beneficial for early detection and prognostic improvement in pancreatic cancer?, Gut Liver, 5, 194-9, 2011
General screening study, sample not HRIs.
Konings, I. C., Harinck, F., Poley, J. W., Aalfs, C. M., van Rens, A., Krak, N. C., Wagner, A., Nio, C. Y., Sijmons, R.
H., van Dullemen, H. M., Vleggaar, F. P., Ausems, M. G., Fockens, P., van Hooft, J. E., Bruno, M. J., Dutch Research Group on Pancreatic Cancer Surveillance in High-Risk, Individuals, Prevalence and Progression of Pancreatic Cystic Precursor Lesions Differ Between Groups at High Risk of Developing Pancreatic Cancer, PancreasPancreas, 46, 28-34, 2017
Diagnostic yield data reported in Harinck et al. 2016
Kuroczycki-Saniutycz, S., Grzeszczuk, A., Zwierz, Z. W., Kolodziejczyk, P., Szczesiul, J., Zalewska-Szajda, B., Oscilowicz, K., Waszkiewicz, N., Zwierz, K., Dariusz Szajda, S., Prevention of pancreatic cancer, Wspolczesna Onkologia, 21, 30-34, 2017
Not systematic review/commentary article
Lachter, J., Cooperman, J. J., Shiller, M., Suissa, A., Yassin, K., Cohen, H., Reshef, R., The impact of endoscopic ultrasonography on the management of
suspected pancreatic cancer--a comprehensive longitudinal continuous evaluation, Pancreas, 35, 130-4, 2007
<66% high risk individuals. No separate data for HRI group provided.
Langer, P., Kann, P. H., Fendrich, V., Habbe, N.,
Schneider, M., Sina, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, M., Bartsch, D. K., Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer, Gut, 58, 1410-1418, 2009
Updated MRI and EUS results published in Potjer 2013 and Schneider 2011, respectively.
Linghu, E., Wang, Y., Wang, Z., Wang, X., Tang, P., Yang, J., Sun, Y., A prospective study of eus features, cyst fluid CEA, and lipase for differentiation of small pancreatic cystic neoplasms, American Journal of Gastroenterology, 111, S28-S29, 2016
Conference abstract
Lu, C., Xu, C. F., Wan, X. Y., Zhu, H. T., Yu, C. H., Li, Y.
M., Screening for pancreatic cancer in familial high-risk individuals: A systematic review, World Journal of Gastroenterology, 21, 8678-86, 2015
Checked, no additional relevant articles
Study Reason for Exclusion Maheu, C., Vodermaier, A., Rothenmund, H., Gallinger, S.,
Ardiles, P., Semotiuk, K., Holter, S., Thayalan, S., Esplen, M. J., Pancreatic cancer risk counselling and screening:
impact on perceived risk and psychological functioning, Familial Cancer, 9, 617-24, 2010
No relevant outcomes
Mastoraki, A., Chatzimavridou-Grigoriadou, V.,
Chatzipetrou, V., Mastoraki, S., Papanikolaou, I. S., Danias, N., Smyrniotis, V., Arkadopoulos, N., Familial pancreatic cancer: challenging diagnostic approach and therapeutic management, Journal of Gastrointestinal CancerJ Gastrointest Cancer, 45, 256-61, 2014
Narrative review
Mocci, E., Guillen-Ponce, C., Earl, J., Marquez, M., Solera, J., Salazar-Lopez, M. T., Calcedo-Arnaiz, C., Vazquez- Sequeiros, E., Montans, J., Munoz-Beltran, M., Vicente- Bartulos, A., Gonzalez-Gordaliza, C., Sanjuanbenito, A., Guerrero, C., Mendia, E., Lisa, E., Lobo, E., Martinez, J. C., Real, F. X., Malats, N., Carrato, A., PanGen-Fam: Spanish registry of hereditary pancreatic cancer, European Journal of Cancer, 51, 1911-1917, 2015
More recent results reported in Bartsch et al. 2016.
Papafragkakis, C., Thaiudom, S., Lanke, G., Chakinala, R.
C., Wang, X., Bhutani, M. S., Lee, J., Pancreatic cancer screening (PCS) in high risk individuals (HRI) with genetic mutations, Gastroenterology, 150, S255, 2016
Conference abstract
Parker, L. A., Lumbreras, B., Lopez, T., Hernandez- Aguado, I., Porta, M., How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis, European Journal of Clinical Investigation, 41, 793-805, 2011
Checked, no relevant articles
Parker, L. A., Porta, M., Lumbreras, B., Lopez, T., Guarner, L., Hernandez-Aguado, I., Carrato, A., Corominas, J. M., Rifa, J., Fernandez, E., Alguacil, J., Malats, N., Real, F. X., Clinical validity of detecting K-ras mutations for the
diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients, European Journal of EpidemiologyEur J Epidemiol, 26, 229-36, 2011
Participants not adults with risk of PC
Pugliese, V., Pujic, N., Saccomanno, S., Gatteschi, B., Pera, C., Aste, H., Ferrara, G. B., Nicolo, G., Pancreatic intraductal sampling during ERCP in patients with chronic pancreatitis and pancreatic cancer: cytologic studies and k- ras-2 codon 12 molecular analysis in 47 cases,
Gastrointestinal endoscopy, 54, 595-9, 2001
Comment article
Queneau, P. E., Adessi, G. L., Thibault, P., Cleau, D., Heyd, B., Mantion, G., Carayon, P., Early detection of pancreatic cancer in patients with chronic pancreatitis:
diagnostic utility of a K-ras point mutation in the pancreatic juice, American journal of gastroenterology, 96, 700-4, 2001
Unclear whether participants have hereditary chronic pancreatitis
Robays, J., Stordeur, S., Hulstaert, F., Maerken, T., Claes, K., Janin, N., Matthijs, G., t Kint de Roodenbeke, D., Berlière, M., Wildiers, H., Poppe, B., Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, LiFraumeni syndrome and Cowden syndrome (Structured abstract), Health Technology Assessment Database, 2015
No relevant articles
Rulyak, S. J., Brentnall, T. A., Inherited pancreatic cancer:
surveillance and treatment strategies for affected families, Pancreatology, 1, 477-85, 2001
Updated results reported in Kimmey 2002
Study Reason for Exclusion Schneider, R., Slater, E. P., Sina, M., Habbe, N., Fendrich,
V., Matthai, E., Langer, P., Bartsch, D. K., German national case collection for familial pancreatic cancer (FaPaCa): ten years experience, Familial cancer, 10, 323-30, 2011
More recent results reported in Bartsch et al. 2016.
Shaojun, L., Sun, S., Gao, J., Sun, F., Methylated genes p16 and ppenk for diagnoses of pancreatic cancer:
Systematic review and meta-analysis, International Journal of Clinical and Experimental Medicine, 9, 15379-15386, 2016
Checked, no relevant articles
Shin, E. J., Topazian, M., Goggins, M. G., Syngal, S., Saltzman, J. R., Lee, J. H., Farrell, J. J., Canto, M. I., Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study, Gastrointestinal Endoscopy, 82, 812-8, 2015
No relevant data
Slotwinski, R., Slotwinska, S. M., Diagnostic value of selected markers and apoptotic pathways for pancreatic cancer, Central European Journal of Immunology, 41, 392- 403, 2016
Not systematic review
Stoffel, E., Carulli, A., McCarthy, S., Hosmer, A., Scheiman, J., Koeppe, E., Everett, J., Kwon, R., Prevalent and incident lesions identified with pancreatic cancer screening in high risk individuals, American Journal of Gastroenterology, 111, S35, 2016
Conference abstract
Vasen, H. F., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J., Morreau, H., Bonsing, B.
A., de Vos tot Nederveen Cappel, W. H., Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation, Gastroenterology, 140, 850-6, 2011
More recent MRI results published in Potjer 2013
Wada, K., Takaori, K., Traverso, L. W., Screening for Pancreatic Cancer, Surgical Clinics of North AmericaSurg Clin North Am, 95, 1041-52, 2015
Not systematic review
Xu, Y., Hu, D. M., Zhu, Q., Sun, Y. W., Performance of K- ras mutation analysis plus endoscopic ultrasoundguided fine-needle aspiration for differentiating diagnosis of pancreatic solid mass: A meta-analysis, Chinese Medical Journal, 127, 3296-3301, 2014
Not HRI or at risk sample.
Zhao, Y. P., Zhou, P. T., Ji, W. P., Wang, H., Fang, M., Wang, M. M., Yin, Y. P., Jin, G., Gao, C. F., Validation of N- glycan markers that improve the performance of CA19-9 in pancreatic cancer, Clinical & Experimental MedicineClin Exp Med, 17, 9-18, 2017
Sample not high risk individuals