without compromising safety and efficacy

... The efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores were determined, at screening, and ... weeks of randomization and during the study, were not allowed Treatment compliance Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety Variables ... rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions were not affected by UC-II treatment, suggesting that UC-II is well toler- 320 ated and does...

Ngày tải lên: 26/10/2012, 09:48

... selfexpandable stents was simple and without complications In contrast to self-expanding stainless steel biliary wall stents and other nitinol stents [4,9-11], none of the nitinol expandable ... CT-TT CT-TT CT-TT CT-TT Results (clinical signs) No coughing and dyspnea No coughing and dyspnea No coughing and dyspnea No coughing and dyspnea *Grade I tracheal collapse is a 25% reduction in ... Pfizer, USA) and amoxicillin-clavulanic acid (12.5 mg/kg BW; Pfizer, USA) orally twice daily, body weight reduction, and occasional oxygen using a nebulizer, beginning days before and continuing...

Ngày tải lên: 07/08/2014, 20:23

... structures [7,17] Materials and methods Objective To evaluate the safety and efficacy of gamma knife surgery (GKS) for controlling the glomus jugulare tumors Method Between 2004 and 2008, 13 cases with ... achieved using MRI performed with T1 axial and coronal-weighted sequence at mm slice thickness with and without contrast, T1- fat saturation sequence and also T2 axial sequence was used to eliminate ... was 100% at and years, and 75% at 10 years Six patients (15%) experienced new deficits (hearing loss alone in three, facial numbness and hearing loss in one, vocal cord paralysis and hearing...

Ngày tải lên: 09/08/2014, 03:22

... (DRESS) and meningoencephalitis associated with nevirapine therapy Scand J Infect Dis 2001, 33(6):475-476 Anekthananon T, Ratanasuwan W, Techasathit W, Sonjai A, Suwanagool S: Safety and efficacy ... had a median CD4 cell count of 85, 125, 158 and 198 cells/mm3 and group B patients had a median CD4 of 240, 280, 305 and 331 cells/mm3 at 12, 24, 36 and 48 weeks, respectively (Figure 2) The increment ... HIV-infected patients with baseline CD4 cell count of

Ngày tải lên: 10/08/2014, 05:20

... Diagnosis and classification of AF were established by standard ECG and holter ECG in all patients prior to admission AF was defined paroxysmal in 29%, persistent in 31% and long standing persistent ... creates transmural lesions without the need of large thermal gradients and without jeopardizing adjacent structures (Figure 1) [6] The purpose of this study was to evaluate the efficacy of left atrial ... discontinued and replaced by β-blockage A physical examination, standard 12-lead ECG, 24hour Holter monitoring, and transthoracic echocardiography were conducted systematically at and 12 month...

Ngày tải lên: 10/08/2014, 09:22

... Vaccine Formulation: Assessment of Safety and Efficacy in the Induction and Protective Immune Responses to Lethal Bacterial infections in Mice J Immune Based Therapies and Vaccines 2006, 4:5 Bendavid ... investigated relative efficacy of phytols and known adjuvants in their ability to augment antigen-specific CTL activity in C57BL/ and BALB/c mice using two different tumor models, E.G7-OVA and 2C3 respectively ... target cells Evaluation of toxicity and safety of phytol adjuvants Adjuvants in general enhance interactions between innate and acquired immunity by mobilizing and activating the former, possibly...

Ngày tải lên: 11/08/2014, 10:23

Ngày tải lên: 11/08/2014, 10:23

... between changes in certain efficacy and safety variables and different study drug doses, no type I error adjustments for multiplicity were performed Results Safety and Tolerability Analyses As ... changes make interpreting our findings regarding safety and efficacy more difficult Conclusions Analyses of several clinically important safety and efficacy measures revealed significant dose-associated ... changes in prolactin, weight, and fasting glucose and lipids (using American Diabetes Association and National Cholesterol Education Program criteria) [11,16], and relapse and discontinuation rates...

Ngày tải lên: 11/08/2014, 16:23

... and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and bolus doses and ... (days and 5) to be started simultaneously and then titrated to provide optimal sedation and analgesia, according to standard clinical practice Methods This randomised, open-label, observational, ... analgesia and sedation, which were administered simultaneously and then titrated to response For all three treatment groups, on days 1–3 the hypnotic agent was propofol, and on days and propofol...

Ngày tải lên: 12/08/2014, 20:20

... fluoxetine and CBT in adolescents with major depression, behavior problems, and substance use disorders, greater efficacy in combined fluoxetine and CBT treatment in comparison to placebo and CBT ... Rating Scale-Revised (CDRS-R) [27] and the Clinical Global Impressions Scale- Severity and Improvement (CGI) [29] were obtained at baseline and the week 1, 2, 3, 4, 6, and study visits The Beck Depression ... conditions, concomitant psychotherapy, pre-randomization positive drug toxicology, and dose increases http://www.capmh.com/content/3/1/11 Efficacy and other psychometric measure analyses As in...

Ngày tải lên: 13/08/2014, 18:21

... that RGD modification increases the specificity and safety of oncolytic adenovirus without compromising the efficacy in an experimental model and gives rationale for testing the RGD modification ... mouse model was designed and developed by SLA MRI methods were validated by UAR and SLA, interpretation of MR images was done by JH and SLA and quantification of tumor volumes and subsequent analysis ... cells (e.g 24 bp deletion in E1A; “D24”) would make the virus more tumor specific and increase efficacy and safety Conclusions Here, the antitumor potency of RGD modified viruses was proved to...

Ngày tải lên: 18/06/2014, 16:20

... patients who received at least dose of study medication and had at least postbaseline safety assessment Efficacy and Safety Measures The primary efficacy variable was the proportion of patients with ... treatment regimen, we evaluated the efficacy and safety of saquinavir-soft-gelatin capsule (SGC)/ritonavir 1600 mg/ 100 mg vs efavirenz 600 mg in a prospective, randomized, multicenter clinical trial ... observational value for all efficacy variables and laboratory measurements, at that particular timepoint in the study The safety- evaluable population included all randomized patients who received...

Ngày tải lên: 20/06/2014, 08:20

... with and without chronic hepatitis and/ or cirrhosis, only (0.6%) and 13 cases (5.4%), respectively, developed grade 3-4 transaminase increases Moreover, none of these cases was symptomatic, and ... Tansuphasawadikul S, LeBraz M, Jupimai T, Ubolyam S, Schutz M, Hirschel B, Staccato Thailand Study Group: Long-term efficacy and safety of first-line therapy with once-daily saquinavir/ritonavir Antivir Ther ... by on-treatment analysis (figure 1) In both cases, the efficacy was higher in the simplification group (p = 0.000, and 0.01, respectively) and with no significant differences between the other...

Ngày tải lên: 10/08/2014, 05:21

... tolerable dose Efficacy, safety and tolerability were assessed at 12 clinic visits over the 34-week study: a baseline visit at day 1, visits at weeks 1, 2, 4, 6, and every weeks until 32 weeks and a follow-up ... MADRS scores from baseline and changes in Clinical Global Impressions - Improvement of Illness (CGI-I) scale [11] Outcome measures: Safety and tolerability Safety and tolerability outcomes were ... Neurim and Pharmaneuroboost CPS Research of which GC and AGW are directors has received financial and research support from H Lundbeck A/S, Pharmaneuroboost, Neurim, Wyeth, Pfizer and Servier GC and...

Ngày tải lên: 11/08/2014, 16:23

... compared to placebo Materials and methods This multicenter, randomized, double-blind, parallel, placebo-controlled clinical study was designed to assess the efficacy, safety, and pharmacokinetics of ... acquisition of data and the interpretation of data PM and PW drafted the manuscript and PM, JP, KG, PW and MA revised it critically for important intellectual content PM, JP, KG, PW and MA have given ... population (ITT) Continuous data were summarized by mean and standard deviation or standard error Categorical data were summarized by frequency and the percentage of subjects in each treatment group...

Ngày tải lên: 13/08/2014, 21:20

... IMPLANON ™ and NORPLANT® on carbohydrate metabolism, parameters of adrenal and thyroid function, lipid metabolism and liver function Furthermore, contraceptive efficacy, safety, acceptability and vaginal ... diminish infant, child and maternal morbidity and mortality and significantly reduce illegal abortions and health hazards (c) Limiting population growth - the economic and environmental aspect ... living and health condition improves and death rates fall, but birth rates remain high and the population grows rapidly In the third stage economic and social gains combine to 20 reduce poverty and...

Ngày tải lên: 15/09/2015, 21:09

... about safety matters or your legal responsibilities, contact your local inspector of health and safety The telephone number of your local HSE office will be in the phone book under Health and Safety ... Printed and published by the Health and Safety Executive INDG231 6/01 C300 ORDER FORM Please send me: ISBN Title Unit price Quantity Total price 7176 0716 X Essentials of health and safety at ... ELECTRICAL SAFETY The following publications contain advice on the safe use of electricity for particular industries or in high risk circumstances Risk assessment and general health and safety steps...

Ngày tải lên: 12/12/2013, 21:15

... motorcycles and automobile are 57.2% and 36.6% on highway number 3; 4.1% and 95.3% on highway number 5; 52.9% and 45.6% on highway number and 58.2% and 39% on highway number 18 Speeding and reckless ... or train Both are slow, and safety conditions not approach U.S standards Local buses and taxis are available in some areas, particularly in the larger cities Safety standards vary widely depending ... program and accident monitoring and evaluation program along three high-risk national road corridors: Highway between Ha Noi and Vinh (281 km) and HCM City and Can Tho City (151 km), and Highway...

Ngày tải lên: 12/12/2013, 23:15

... 49 50 Information and education about Internet safety 50 3.3 Online safety of children and adolescents Safety and security requirements ... States and eight Canadian provinces along with New Zealand, Puerto Rico, Guam, and the Virgin Islands Its mission is to assist its members in “developing, implementing, and enforcing uniform standards ... the design and layout, and Kai Lashley for editing The global survey and this report were prepared and managed by the WHO Global Observatory for eHealth: Misha Kay, Jonathan Santos, and Marina...

Ngày tải lên: 18/02/2014, 00:20

... awareness and prevention of cyberbullying and suicide through education 42 Online Safety and Technology Working Group McGruff.org Internet Safety stories, games, videos and tools Nonprofit for kids and ... prescription for child safety online 10 Online Safety and Technology Working Group Subcommittee on Internet Safety Education To understand how industry, schools, non-profits and government can best ... resolve safety and privacy related problems Resources about parental control tools Safety related games Mobile phone apps Safety tips and guides Law enforcement training Presentations at parent and...

Ngày tải lên: 18/02/2014, 00:20