what knowledge do we have and what is lacking

... therapy data and reviewed the manuscript LC participated in assembling of the data and reviewed the manuscript BMG and HB reviewed the manuscript TL supervised the study and data assembling and critically ... colonoscopy, endorectal ultrasound (ErUS), magnetic resonance imaging (MRI) of the pelvis and computed tomography (CT) scans of chest, liver and pelvis Staging results were conferred and interdisciplinary ... 16 Local 0 Local + Distant 2 Distant 15 14 * Patients were not included in statistical analysis staged III rectal cancers therefore showed no higher risk of cancer relapse and cancer-related death...

Ngày tải lên: 09/08/2014, 03:21

... drawn from the study [11]: no volume challenge was performed and Bland–Altman analysis revealed unsatisfactory agreement between ∆POP and pulse pressure variation Thus, utility of ∆POP in detecting ... processing on the displayed waveform, the automatic gain incorporated into the pulse oximeter was disengaged in the study conducted by Cannesson and coworkers [11] This allowed the investigators ... source and the photo detector of the pulse oximeter, the ‘pulse’ wave is assumed to be the result of the beat-to-beat changes in stroke volume transmitted to arterial blood In this respect, ∆POP is...

Ngày tải lên: 12/08/2014, 23:20

... go/no-go and ranking decisions Standard documented methods – consistency across a wide range of decisions Dependence on a transport model, showing how people respond to changes in networks and changes ... using monetised, quantitative and qualitative assessment and public accounts Concept of economic welfare, using willingness to pay and other methods for valuing non-market impacts Dominance of ... financial risks, contributions Management: governance, risk management, stakeholders Commercial: procurement, capability, risk allocation Economic: Green Book/WebTAG Cost benefit analysis Strategic...

Ngày tải lên: 27/11/2015, 12:40

... in this crisis, shrink from the service of his country; but he that stands it now, deserves the love and thanks of man and woman Tyranny, like hell, is not easily conquered; yet we have this consolation ... to finish the work we are in, to bind up the nation's wounds; to care for him who shall have borne the battle, and for his widow and orphan—to all which may achieve and cherish a just and lasting ... the triumph What we obtain too cheap, we esteem too lightly; 'tis dearness only that gives everything its value —The Crisis, Number I by Thomas Paine Chapter : What Is Style, and How Do I Get Some?...

Ngày tải lên: 01/11/2013, 16:20

... What Is Micromanagement? And What You Can Do To Avoid It Steve Lemmex, Global Knowledge Instructor, PMP “Fifty percent of the typical employee’s job satisfaction is determined by ... organization What Are the Tell-Tale Signs of a Micromanager? They have a hard time delegating tasks They likely spend more time “telling” staff what to and how to it versus “asking” them what they did and ... seldom praise staff members • Their staff appear frustrated, depressed, and/ or unmotivated • Their staff not take initiative – they have to check with the manager before doing anything • They have...

Ngày tải lên: 24/01/2014, 09:20

... a division of Random House, Inc., New York RANDOM HOUSE and colophon are registered trademarks of Random House, Inc Library of Congress CataloginginPublication Data Duhigg, Charles The power of ... time, the meals we order, what we say to our kids each night, whether we save or spend, how often we exercise, and the way we organize our thoughts and work routines have enormous impacts on our ... from Aristotle to Oprah—spent much of his life trying to understand why habits exist But only in the past two decades have scientists and marketers really begun understanding how habits work—and...

Ngày tải lên: 11/03/2014, 18:09

... exceeding capacity constraints, is known as “potential output” The difference In this article we expand on the above distinction and clarify between actual and potential output is known as the “output ... words, the NRR is the interest rate that is consistent with a situation in which inflation and inflation expectations are stable at the inflation target and the output gap is zero and is expected ... of new disturbances, may be longer It is this other variables in the economy, will actually cause demand longer horizon, which we loosely characterise as the ‘medium and inflation to expand or...

Ngày tải lên: 15/03/2014, 01:20

... scrutinizing old lands and what we might learn from them It would also be helpful to know when shapes  in the distance are new lands and what new discoveries we might make if we were to land there Endnotes ... contrasts between vocal and instrumental music Do these make different kinds of demands upon listeners, composers, performers? The unity of music and text What is this, and how is it established? Ontology ... between music and text, the distinction between structure and content, the controversy between representationalism and expressivism, etc.); (e) problems regarding the understanding of music (what...

Ngày tải lên: 23/03/2014, 13:20

... is more rapid virus clearance and less severe disease Many practical and regulatory issues arise, however, in connection with such a possible partially protective vaccine Perhaps the T cell and ... interferon, which is normally induced by viral infection and in turn induces cellular anti-viral proteins that interfere with viral replication; and we have already mentioned the HA and the NA, and members ... 8:46 This may be possible in the future and progress is being made in identifying conserved amino acid sequences associated with past pandemics [5] but we don’t yet know enough about what determines...

Ngày tải lên: 06/08/2014, 19:20

... adverse events of statins, including rhabdomyolysis and death from rhabdomyolysis [65] The risk of death from rhabdomyolysis is about in 300,000 a year (Figure 4) Risk of cardiac adverse events, including ... risk can be presented in a way that is understood This is especially true when there is a background rate in the population, which we must know or guess, and we then have to apply an imprecise ... risk) We also checked the bibliographies of any relevant studies, risk websites (see [10], for instance) and books, reviews and articles on risk presentation We looked for full journal-published...

Ngày tải lên: 09/08/2014, 10:23

... jaw already displays the palatine rugae present in the adult as well as the frenulum and the incisive papilla In most cases the frenulum, which is located between the lip and the incisive papilla, ... [50] The central incisor and canine segments are approximately equal in size and are well marked; they are separated from the smaller lateral incisor segment, which is indistinct and sometimes lies ... maxillary arch dimensions of English, Swiss and Italian normal children at birth and months Are there national differences? In What is cleft lip and palate? A multidisciplinary update; proceedings...

Ngày tải lên: 11/08/2014, 23:22

... dimension • Comparison of non-intubated PT/LBW and term infants' palatal measurements Results and Discussion Seventy-eight articles published between 1940 and 2000 were included in the analysis of descriptions ... descriptions of the palatal morphology and palatal development in preterm and low birthweight infants The majority of the studies were published between 1980 and 1990 Visual descriptions of the palatal ... Part of this review is therefore to contribute a fundamental analysis of methodologies, confounding factors, and outcomes of studies on palatal development of preterm and low birthweight infants...

Ngày tải lên: 11/08/2014, 23:22

... Fundamentally, we have to begin articulating and testing specific hypotheses about why health status and quality of life may be poor post ICU discharge We must subtract the ‘background noise’ of preexisting ... HL69991 and R01 HS/HL11620), AHRQ (R01 HS/HL11620), and NIGMS (R01 GM61992) to determine intermediate and long-term outcomes of critical illness References So how we tease this out? Fundamentally, we ... candidates Yet many of the ICU controls may have similarly suffered profound inflammatory insults, and so some of the potential mechanisms for poor long-term health and quality of life may have...

Ngày tải lên: 12/08/2014, 20:20

... Maggiore and colleagues emphasize the need for prospective randomized controlled studies in the neurotrauma population It is clear that our interventions have potential both for benefit and for ... these limited data are insufficient to mandate changes to standards of care, they provide ethical justification for the examination of these standards in randomized controlled trials Ultimately, ... Critical Care Vol 13 No Zygun However, the small sample size and non-randomized methodology limit the generalizability of these results Importantly, alternatives...

Ngày tải lên: 13/08/2014, 18:22

... [abstract] Crit Care Med 2008, 36:sA68 doi:10.1186/cc9236 Cite this article as: Nasraway SA Jr, Rattan R: Tight glycemic control: what we really know, and what should we expect? Critical Care 2010, 14:198 ... even with handheld glucometers, the less hypoglycemia experienced by patients and the tighter the glycemic control [19] The SPRINT study supports this premise Frequency is crucial, however laborious ... becomes more achievable We can expect that there will be more emphasis on defining hypoglycemia, and in avoiding it with greater rigor We can expect a movement towards insulin-dosing software, as...

Ngày tải lên: 13/08/2014, 21:21

... the risks and benefits LTP is a proper way of handling these patients, but further research is a necessity One of the authors (PKH) is planning further studies to establish the knowledge base and ... GE, and TW designed the study; SF, GE, and PKH reviewed the literature; SF and GE collected and analyzed the data; and SF, GF, PKH, and TW wrote the manuscript All of the authors revised and ... training and written protocols, and this seems to increase confidence How the patient is positioned in LTP differs, and the consequence of this is unknown More research on the utilization and consequences...

Ngày tải lên: 13/08/2014, 23:20

... presentation and the establishment of a low-level chronic disease The first decade of the genomics era has revolutionized our understanding of microbiology, and it is very likely that this process ... plasmids, raises the question of why this genome is so large, as there appears to be no obvious biological reason The genome does not contain a large number of repeated elements, but does have genes ... of a virtual organism, suggested to be a free-living Gram-negative bacterium, with a 2.25 megabase (Mb) genome containing two rRNAs and 45 tRNAs This method appears to be a promising way of assembling...

Ngày tải lên: 14/08/2014, 14:22

... that is true, it is perhaps also too facile As they note, their system does not offer DSS-type warnings about drug-drug interactions, allergies, or toxic doses; however, it does have pull down ... formulary, and IV administration guide Thus, the demarcation between CPOE systems and forms of decision support, which might reduce or influence errors, is seldom the bright line we imagine When ... possible/potential errors If we examine patients’ charts, we may see both prevented and administered errors (There are undoubtedly other, undetected errors.) Berger and Kichak [3] make the critical...

Ngày tải lên: 25/10/2012, 10:39

... the street Conclusion We see a lot of things outside our houses We see a lot of food and drinks near our houses We don’t see many trees near our houses We see dogs, cats and birds near our houses ... We see food and drinks …  On the street   At the party In our school We see many plants and trees In our school On the street In the park...

Ngày tải lên: 22/06/2013, 01:26

... levels are not distinct Dividing comprehension into literal, referential and critical strands is only intended as a guide for teachers when preparing reading assessments Studies have shown that ... third level of comprehension is critical reading whereby ideas and information are evaluated Critical evaluation occurs only after our students have understood the ideas and information that the ... several levels, mastery at any one level is not a prerequisite to comprehension at another level Furthermore, the reading skills for each level or strand cut across ages; they are relevant to...

Ngày tải lên: 06/09/2013, 10:10