vitamin e and lung cancer prevention

... reviewed the Cochrane Library for relevant articles Concurrently, the reference lists of reviews and retrieved articles were searched manually When the same patient population appeared in several publications, ... For future studies, strict selection of patients, wellmatched controls and larger sample size will be required Moreover, gene-gene and gene-environment interactions should also be considered List ... molecular mechanisms to explain these histology-specific differences in the risk of lung cancer remain unresolved Recent epidemiological and biochemical studies have suggested increased susceptibility

Ngày tải lên: 10/08/2014, 10:21

... different stages of lung cancer development In this study, three genes among the five candidate genes originally selected While the p16 gene methylation has been reported as one of the earliest ... curve, we prepared different ratios of methylated versus unmethylated target sequences by mixing methylated and unmethylated DNA The follow-ing ratios were prepared (methylated/unmethylated): ... Trang 1Open AccessResearch Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients Einstein College of Medicine, Bronx, NY, USA Email: Weiguo Han

Ngày tải lên: 12/08/2014, 14:20

... measurements, the FAs in the pre-pared samples were derivatized as FAMEs and simulta-neously extracted [19] The pulverized pickled soybeans (50  mg) were placed in a 2  mL amber vial, and pen-tadecanoic ... the least significant difference (LSD) test was conducted at the 0.05 probability level to determine the differences between the means among the samples Results and discussion Changes in the ... immersion However, malonyl and acetyl glucoside-types decreased by 17–41% after the pickling process [7] Hitherto, to our knowledge, there has been no com-prehensive report concerning the changes

Ngày tải lên: 29/05/2020, 13:40

... cancers in both men and women, lung cancer causes more deaths than any other cancer [5] Curiously, the association between obesity and lung cancer seems to be different from other cancer types, ... the men in our Fig Dose-response analysis for body mass index and lung cancer risk in never smokers The solid line represents the trend between BMI and lung cancer risk, and the dashed lines represent ... categories Normal weight was defined as 18.5–24.99 kg/m2, which was considered as the reference level When the RRs with 95%Cis were reported by different BMI categories, the estimates for alternative

Ngày tải lên: 24/07/2020, 01:27

... index, Obesity, Overweight, Lung cancer Background Lung cancer is the most common cancer and the leading cause of cancer-related deaths worldwide, with an estimated 1.82 million lung cancer cases ... using the formula: (number of years smoked x mean number of cigarettes smoked per day)/20 In cases, time elapsed was computed as the difference between the age at enrolment and diagnosis, whereas ... BMI and lung cancer disappeared [34, 35] Secondly, preclinical effects of lung cancer and associated weight loss may distort the association between BMI and lung cancer, which is often referred

Ngày tải lên: 24/07/2020, 01:55

... larger matched case-control study de-signed to examine genetic factors and lung cancer risk described in [29], we generated whole-genome DNA Trang 3methylation data for 350 lung cancer cases identifiedduring ... but they were statistically imprecise Similar patterns were ob-served in the 242 case-control pairs where both mem-bers of the case-control pair would have been eligible for lung cancer screening ... samples were collected at visits between 1994 and 1997 The intervention was stopped in 1996 due to higher lung cancer incidence and overall mortality rates in the intervention versus placebo arm

Ngày tải lên: 05/11/2020, 01:42

... men given that we expected few women to have been exposed to asbestos in the workplace We used the same analysis file previ-ously used to evaluate associations between diesel engine exhaust emissions ... of these jobs were pipefitters and boilermakers, and insulators None of the first-order interaction terms between cigarette smoking pack-years and the three measures of asbestos exposure were statistically ... scale For each substance, benchmarks were established and exposures were coded with respect to these benchmarks Non exposure was interpreted as exposure up to background levels found in the general

Ngày tải lên: 05/11/2020, 08:05

... and dead cells were monitored in the presence of 200 nM Sytox Green (Invitrogen) The Sytox method labels the nuclei of dead cells yielding green fluorescence Fluorescence intensities from the ... potently cyto-toxic to neoplastic and normal cells, although newer targeted therapies developed against specific cancer phe-notypes may potentially increase efficacy and decrease toxic side effects ... the presence of Sytox Green for 3 h, and maximal fluorescence inten-sities were taken as 100% Data are represented as a per-centage of dead cells after normalization to total cell number for each

Ngày tải lên: 05/11/2020, 06:41

... transfection experiments with mutant Sp1 (mSp1) decoys were performed as a negative control of interference The experiment was performed in triplicate (E) TAp73 levels were quantified by IMAGEQUANT and ... total extracts from 12 lung cancer cell lines revealed elevated DNp73 levels in these cells (C) Western blot analysis demon-strated an increase in DNp73 in representative squamous cell carcinoma and ... levels were monitored in 12 lung can-cer cell lines, as well as in four representative paired samples of the 26-membered panel of lung cancer patients Figure 5B shows that DMp73 protein expres-sion

Ngày tải lên: 29/03/2014, 09:20

... 10-Acetyl-3,7-dihydroxyphenoxazine (Amplex Red) and monochlorobimane (MCB) were supplied by Molecular Probes (Eugene, OR) Before the experiments, the cells were counted, centrifuged at 5000 g for 30 s and resuspended in Hepes ... by the relatively weak phenotype seen in the knockout mice Caveolae have recently been shown to be involved in MDR However, reports on the effect of caveolins on the development of MDR are controversial: ... increase of the rate of PIRA passive uptake In order to determine an eventual impact of MbCD on the rate of MRP1-mediated efflux of PIRA, experi-ments were performed with energy-depleted resistant

Ngày tải lên: 30/03/2014, 09:20

... initially tested in cell lines and tissue specimens representing different steps of lung cancer progression supporting the panel of the tumor suppressor genes selected to be altered in lung cancer In ... are functionally involved in the different steps during tumorigenesis and cancer pro-gression remains to be determined These genes would represent attractive targets for cancer therapy, given ... candidate genes MS-MLPA profiles of lung cancer cell lines The methylation profiles of the 18 genes under study were initially tested in seven cell lines derived from lung tumors of different histopathologic

Ngày tải lên: 18/06/2014, 16:20

... components may be responsible for the differences in cathepsin K, L, and S activity profiles between breast, lung, and cervical tissue and changes to these profiles as the cancer stage increased Ductal ... the most potent mam-malian collagenase, capable of cleaving type I collagen in the native triple helix and in the telopeptide regions while other collagenases can only cleave at either one site ... proteases that are metal dependent endopeptidases impli-cated in cancer development and metastasis [29,30] MMP-2 and -9 are among the most studied members and gelatin zymography identifies their

Ngày tải lên: 18/06/2014, 22:20

... defined the upper lobe in the right lung and the seg-ment 1+2 and 3 in the left lung as the upper lung field, and the rest of the lung as the lower lung field The tumor movement in the lower lung ... consecutive patients were treated for 55 lesions; 42 were stage I non-small cell lung cancer (NSCLC), 10 were metastatic lung cancers, and 3 were local recurrences of NSCLC Tumor movement was measured ... daily life) was observed in 7 patients At 3 years, the cumulative incidence was 17% The rate for stage IA and IB was 17% and 19%, respectively Other adverse events were grade 1 atelectasis seen in

Ngày tải lên: 09/08/2014, 09:22

... Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central ... In the upper volume the esophagus could have been better spared chosing a less steep angle for the oblique beams (e.g 285° and 75° instead of 305° and 55°) However, as the whole upper volume is ... treated only with an elective dose (45 Gy), significant esophageal side effects have not been observed, and the beam angles were optimized with regard to sparing of lung tissues In the lower

Ngày tải lên: 09/08/2014, 10:20

... wake/sleep parameters are stratified by site There were no site differences in prior treatment, cancer stage, and ECOG performance status Patient Therapy All patients received identical chemotherapy ... Actigraphic and subjective sleep data are in agreement when determining activity-sleep patterns and sleep quality/quantity, each of which are severely affected in cancer patients We investigated the relationship ... (% sleep), sleep latency, sleep efficiency, frequency of long sleep episodes (long sleep episodes) Site Differences in Actigraphy Each patient’s baseline sleep/activity cycle was measured prior

Ngày tải lên: 10/08/2014, 09:20

... based on theoretical reasoning Model building with level 1 and level 2 variables Next, level 2 variables were entered stepwise creating random intercepts models. Random intercepts models assume ... component for the level 1 slope were entered to determine whether treatment group assignment accounts for any between- pool variation. Besides coefficient estimates, standard- ized coefficient estimates ... These issues are addressed by the field of implementation research. Implementation research studies the processes and fac- tors that are associated with and lead to the widespread use and the

Ngày tải lên: 10/08/2014, 10:22

... is very poorly understood at this time and represents an interest- ing area of future research. Lung cancer allelotypes have been investigated in detail and have recently identified new regions ... the sensitivity and specificity of this new strategy for early detection. Several therapeutic approaches to cancer have been devel- oped to reduce undesirable expression of gene product or otherwise ... lung cancer and to identify surrogate endpoints for response to chemoprevention strategies. Despite the societal need for the early diagnosis of lung cancer, no role for biomarkers has yet been

Ngày tải lên: 12/08/2014, 18:21

... first grouped benzene, hep- tane, toluene, ethylbenzene, trimethylbenzene with an explained variance of 27.5% (total xylenes were excluded because of their high correlation with ethylbenzene: r>0.95); ... Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and ... the second grouped octane, styrene, pentameth- ylheptane and decane with an explained variance of 20%, and the third grouped pentane, isoprene and methylpen- tane with an explained variance of

Ngày tải lên: 12/08/2014, 18:21

... when they are heterogenous. In the absence of between-study het- erogeneity, the two methods provide identical results. The presence of heterogeneity can result from differ- ences in the selection ... Cochrane Q statistics test is used for the assess- ment of heterogeneity. The fixed effects model is used when the effects are assumed to be homogenous, while the random effects model is used when ... the summary OR and prevalence were essentially based on the random effects model. The meta-analyses were performed on crude ORs, since the adjusted ORs were not comparable because of the inclusion...

Ngày tải lên: 31/10/2012, 14:59

... organized and motivated way. Health systems need to be adapted to meet the needs of the healthy and the sick by developing comprehensive cancer control programmes that seek to prevent, detect early cure ... the onset of some common cancers depend largely on how early they are detected and how well they are treated. Early detection is based on the obser- vation that treatment is more effective when cancer ... smallest in some Western countries where populations are rejecting tobacco and adopting healthier lifestyles. 10.3 million people per year unless we act Men Women Percentage increase in cancer deaths...

Ngày tải lên: 15/02/2014, 05:20