tuneable anti cancer gene drug delivery systems

... release of drugs in conventional drug delivery systems (CDDSs) have led to the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery Systems (SDDSs) ... are also done for the co-delivery of anti-cancer drugs together with other substances, including genetic materials [25] , imaging agents or even additional anti-cancer drugs Liposomes, micelles, ... the development of smart nanocarrier-based drug delivery systems, which are also known as Smart Drug Delivery System (SDDSs) SDDSs promise to apply drugs to specific and targeted sites [10]

Ngày tải lên: 15/01/2020, 17:52

... ofinsulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery.In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, NewYork, Chap 13 52 ... RETINAL DEGENERATION—GENETIC MODELS Retinal degeneration leads to impaired function of the photoreceptors andconsequently gradual loss of vision., Many types of degeneration are based on genetic ... retinal degeneration In addition to genetic factors, envir-onmental factors (e.g., light exposure) may lead to retinal degeneration.Macular degeneration is the most common type of retinal degeneration,being

Ngày tải lên: 10/08/2014, 03:20

... polymer-based gene vectors to be thecandidates of choice for pharmacological intervention in many diseases 5 Gene Knockdown Therapy a Antisense Drugs Antisense technology is a novel gene deliverymethod ... patients with metastatic breast cancer J.Clin Oncol., 19(6):1716–1722 165 Schatzlein, A G (2001) Non-viral vectors in cancer gene therapy: principlesand progress Anticancer Drugs, 12(4):275–304 166 ... factor gene delays photoreceptor cell degeneration in RCS rats.Hum Gene Ther., 11(13):1875–1890 149 Farhood, H., Gao, X., and Son, K (1994) Cationic liposome for direct genetransfer in therapy of cancer

Ngày tải lên: 10/08/2014, 03:20

... oligonucleotide therapeutics: drug deliveryand targeting Adv Drug Delivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense godeoxynucleotides Adv Drug Delivery Rev., ... Rojanaskul (1996) Antisense oligonucleotide therapeutics: drug deliveryand targeting Adv Drug Delivery Rev., 18:115–131 153 T M Woolf, D A Melton, and C G B Jennings (1992) Specificity ofantisense oligonucleotides ... specificity.Perspect Drug Discov Design, 4:41–50.165 R M Crooke (1991) In vitro toxicity and pharmacokinetics of antisenseoligonucleotides Anticancer Drug Des., 6:609–646 166 Y Rojanasakul (1996) Antisense

Ngày tải lên: 10/08/2014, 03:20

... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Antiangiogenesis therapy 10 1.2.1 Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular ... eliminating the cancer cells with the potential to shut down the tumor microvasculature and trap the anticancer drug inside the tumor Thus, it was evidenced that antiangiogenesis and anticancer activities

Ngày tải lên: 11/09/2015, 09:58

... for drug delivery systems According to their structural features, the following three types of polymeric membranes are generally important for the design of membrane-reservoir drug delivery systems ... area of drug delivery which is due to the underlying principle that drug delivery technology can bring both commercial and clinical values to healthcare products The innovative drug delivery ... to small molecular drug IBU, the fabrication of controlled drug delivery system for large protein model drug BSA is more complicated, as it involves not only the properties of drug matrix itself

Ngày tải lên: 13/09/2015, 19:46

... nanocarrier-based drug delivery systems for controlled and targeted therapeutic application Chapter 1 provides general information of cancer and cancer treatment strategies The recently cancer treatment ... vehicle to specifically deliver cancer-fighting drugs to tumors We have developed three differ drug delivery systems using PEG and its block copolymer for targeted drug delivery The presence of PEG ... drug.10 Later, Abraxane® was introduced as an albumin-functionalized NP for delivery of taxane without cremphor to enhance drug efficiency.11 Trang 2113 5 Targeted drug delivery systems for cancer

Ngày tải lên: 19/05/2016, 10:45

... topic of drug delivery In the drug delivery topic, the search for subtopics of proteins and genes resulted in 1674 and 284 references, respectively - S C Lee, I K Kwon and K Park, Adv Drug Delivery ... SEMINAR REPORT OF DRUG DELIVERY SYSTEMS Topic: Hydrogels as Drug Delivery Systems Reporter: Nguyen Van Tu Supervisor: Dr Le Thanh Dung Dr Ha Cam ... HOOK INTRODUCTION Various Systems to be applied Attract much attention DDSs Hydrogels: worth concerning Each System possesses particular characteristics DDSs: Drug Delivery Systems SOME FIGURES The

Ngày tải lên: 07/06/2017, 14:46

... result in the drug having low bioavailability, making the preparation of self-microemulsifying drug delivery systems rational Besides, the amine group in the molecular structure of the drug (Fig ... and sev-eral other herbal drugs such as curcumin (Zhang et al., 2012), silymarin (Wu et al., 2006) or baicalein (Liu et al., 2012) Self microemulsifying drug delivery systems (SMEDDS) has been ... determination of the drug release was not quite suitable for SMEDDS In this study, the drug diffusion through dialysis membrane was used for the investigation However, the driving force of drug diffusion

Ngày tải lên: 20/01/2020, 07:31

... increase drug delivery efficacy and reduce side effects, and to improve the drug therapeutic effect by controlling the rate of drug delivery Hydrogel-based contact lenses were used to prepare local drug ... and their potential uses as drug delivery carriers have also been reported in recent research [8 10] Ophthalmic drug delivery via PHEMA contact lenses could improve the delivery efficiency by increasing ... Barriers to glaucoma drug delivery J Glaucoma 17(2):147–156 5 Bengani LC, Hsu KH, Gause S, Chauhan A (2013) Contact lenses as a platform for ocular drug delivery Expert Opin Drug Del 10(11):1483–1496

Ngày tải lên: 29/05/2020, 15:16

... NP composites for drug delivery systems 6 Selected studies on chitosan films for drug delivery systems Chitosan was also used in the preparation of films for drug delivery systems[85e87] Films ... of chitosan composites for drug delivery systems Many studies have been conducted recently using chitosan as a drug delivery biomaterial to treat diseases such as cancer [61], optical diseases ... 127 128 129 130 Trang 33 Drug delivery properties of chitosan3.1 Anionic drug delivery properties When a technique of drug discharge cannot be achieved by using a simple drug dissolution process

Ngày tải lên: 02/11/2022, 11:37

... review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern ... dosage/delivery systems An ideal drug delivery system should pose two important elements: controlled and targeted delivery In this regard, NPs have emerged as the potential and effective drug delivery systems ... tumor therapy Other examples of polymeric NPs for antimicrobial drug delivery are shown in Table 4 Trang 10Table 4 - Polymeric based drug delivery systems Poly (D,L-lactide) (PLA) Nanospheres

Ngày tải lên: 04/12/2022, 15:47

... transdermal drug delivery systems and revealed their implications over the other administration routes PLGA-based transdermal drug delivery systems PLGA-based microneedles for transdermal drug delivery ... routes, including intravenous drug delivery, pulmonary drug delivery, transdermal drug delivery, etc Further to enhance the loading efficiency and specificity of the drug delivery carrier, PLGA surface ... desired drug dosage and the therapeutic window is one of the primary criteria to be considered while designing drug delivery systems (DDS) By employing nanomaterials as a base for drug delivery

Ngày tải lên: 04/12/2022, 15:56

... reached about whether CNTs are the best carriers in anticancer drug delivery systems because there are many other anticancer drug delivery systems based on other nanomaterials, such as cationic ... system Drug delivery targeted to tumor To deliver anticancer drugs into cancer focus is the prerequisite for the drugs to develop their effects However, some drugs cannot arrive or enter cancer ... the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the lymphatic...

Ngày tải lên: 20/06/2014, 22:20

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development ... nanotechnology and biological mimicry to create drug delivery systems that penetrate into 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development articular cartilage tissue...

Ngày tải lên: 25/10/2013, 08:20

... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g ... Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE ... carrier materials incorporated into drug delivery systems 4 DRUG LEAKAGE+ +NON TARGET +METABOLISM /CLEARANCE IB ROUTE OF ADMINISTRATION IDRUG + CARRIER Ic IDRUG IDRUG + CARRIER P + CARRIER +NON...

Ngày tải lên: 28/03/2014, 10:20

... CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ...  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered...

Ngày tải lên: 18/04/2014, 15:37

... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems ... 0‑8493‑9073‑7 (alk paper) Drug delivery systems Nanoparticles I Thassu, Deepak II Deleers, Michel III Pathak, Yashwant IV Series [DNLM: Drug Delivery Systems ‑methods Nanostructures Drug Carriers W1 DR893B...

Ngày tải lên: 04/06/2014, 14:47

... ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery Systems, edited by Alain Rolland and...

Ngày tải lên: 10/08/2014, 00:20

... of drugs (61) Concentrations in retina were lower than those in aqueous for drugs that easily penetrate into the Copyright © 2003 Marcel Dekker, Inc General Considerations in Ocular Drug Delivery ... local drug delivery to the eye generally provides direct access to the site of action and, in most cases, substantially reduces systemic exposure and toxicity, systemic administration of drugs ... (1990) Ocular drug delivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and Drug Delivery...

Ngày tải lên: 10/08/2014, 00:20