... 1TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA DEPARTMENT OF ANATOMY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE ... administration results in specific degeneration of about 50%-93% of the dopaminergic neurons in the SNc and more than 99% loss of dopamine in the striatum The schematic drawing of mechanism(s) of ... neurons LBs are intracytoplasmic inclusion bodies composed mainly of neurofilament-like structures that also stain positively for ubiquitin and α-synuclein.Ubiquitin is a protein involved in the degradation
Ngày tải lên: 11/09/2015, 09:05
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... peroxynitrite-mediated tyrosine nitration and inactivation of alpha1-antiproteinase inhibiting peroxynitrite-induced cytotoxicity, intracellular protein nitration and protein oxidation in human neuroblastoma ... levels of Aβ can trigger the changes in tau protein culminating into formation of NFTs It has been shown that protein α-synuclein (core components of lewy body based pathologies, known as synucleinopathies),
Ngày tải lên: 09/09/2015, 08:17
Quality of health care with regard to detection and treatment of mental disorders in patients with coronary heart disease (MenDis-CHD): Study protocol
... population of SHI data SHI data of patients who are inhabitants of Cologne continually insured between 2011 and 2012 and continu-ally insured or deceased in 2013 through 2015 in one of the four ... retirement) The findings of the MenDis-CHD will contribute to an overview of the current state of health care in CHD with the aim of improving and modifying care delivery, so that appropriate interventions ... evidence of cognitive impairment, 26– 20 points: indicative of mild dementia, 19–10 points: in-dicative of moderate dementia, nine points and below: indicative of severe dementia The test-retest reliability
Ngày tải lên: 10/01/2020, 13:03
New ESPGHAN guidelines for the diagnosis of Coeliac Disease in Children and Adolescents pptx
... levels Trang 321 The new guidelines will offer the option of omitting biopsies in selected cases with symptoms suggestive of CD without increasing the risk of misclassification. 2 Preconditions ... n=2,598 Entering Level 1 screening n=2,242 + 22 no full text excluded n=334 Full text Entering Level 2 screening n=247 excluded n=87 Entering Level 3 screening n = 16 publications Included in data ... quality serology including EMA • taking quantitative antibody levels into account • HLA typing • full information to parents/patient on consequences Trang 33ESPGHAN Working Group on Celiac
Ngày tải lên: 22/03/2014, 09:20
Báo cáo nghiên cứu nông nghiệp " Improving the Quality of Diagnosis of Animal Disease in Vietnam " pot
... completed within the two year period from commencement, culminating in a final ‘advanced’ workshop in Ho Chi Minh City, concentrating on diseases nominated by the Vietnam Ministry of Agriculture ... level of staffing by graduate veterinarians, and the official policy is to promote in-service training. However, few veterinarians have any specialist training in diagnostic pathology, making ... really only a beginning Our colleagues in Vietnam will need more help in curriculum development and training in more... addressing Taking the last round of training to the next
Ngày tải lên: 22/06/2014, 13:20
Báo cáo y học: "Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis" pps
... usefulness of aripiprazole in the treatment of the psychotic symptoms in bipolar disorder Methods: A systematic MEDLINE and repository search concerning clinical trials for aripiprazole in bipolar ... (SGAs) gained a position in the treatment of BD [12,13] Their efficacy against acute mania is reported to be inde-pendent of sedation or of their effect on psychotic symp-toms Olanzapine, risperidone, ... Dash indicates missing data. a Not included in the calculation of the pooled measures because of a different study design (fixed dosage). Trang 8In comparison to the baseline scores reported in
Ngày tải lên: 08/08/2014, 23:21
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 1 ppsx
... recognition as a clinical investigator Dr Findling is the principal investigator of a National Institute of Child Health and Human Development contract examining lithium in the treatment of pediatric ... for Clinical Research, and Codirector of the Division of Bipolar Disorders Research at the University of Cincinnati College of Medicine She is also Director, Research Education and Training, Child ... of Medicine in Baltimore, Maryland Dr Barnett has worked on several multisite studies focusing on mood disorders in children and adolescents, including the Treatment of Early Age Mania, the Treatment
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 2 pps
... exam-ining the effects of carbamazapine and other atypical antipsychotics on mIconcentrations in bipolar disorder Choline The Cho peak mainly consists of phosphorylcholine and phorylcholine and ... effect of lithium on norepinephrine may be related tolithium dose and the chronicity of treatment (Ahluwalia & Singhal, 1980) Gamma-Aminobutyric Acid Lowered baseline levels of gamma-aminobutyric ... measurement The authors notedthat using this strategy was useful in determining initial lithium dosing inthis study cohort Trang 20The use of nomogram-based dosing requires being able to accuratelymeasure
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 4 pdf
... Lamotrigine also inhibits serotoninreuptake, suggesting that it might possess antidepressant properties In2003 the FDA approved lamotrigine for the maintenance treatment of polar I disorder in adults ... free-radicalscavenging Zonisamide is protein-bound (40–60%) but does not appear toaffect the protein binding of other drugs Concurrent administration withenzyme-inducing anticonvulsants such as carbamazepine ... was significantly greater in the plus-quetiapine group than in the valproate-plus-placebo group (87% vs.53%) The findings of this study indicate that quetiapine in combinationwith divalproex was
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 6 pps
... although the extent of these findings in youths remains unclear Given the increasingly growing concern with neuropsychological and executive-function defects in predicting later SUD, children ... of ADHD improvement prior to initial manic improve - ment. Treatment with tricyclic antidepressants, in the absence of mood sta - bilization, resulted in a relapse rate of 76% in the visits in ... in adolescence in particular remain unclear Given the prominent genetic influences in both bipolar disorder and ADHD (as individual disorders and perhaps cosegregating), it remains
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 7 docx
... ofmania in families of probands with OCD and in families of probands withbipolar disorder Similarly, an increased incidence of obsessional traits hasbeen reported in the offspring of probands with ... 1986) On the other hand, lamotrigine, in a preliminary RCT, exhibited potential efficacy in the treatment of PTSDsymptoms of reexperiencing, avoidance, and numbing in adults (Hertzberg et al., 1999) ... antipsychotic agents in treating CD with aggressive features Anopen-label pharmacokinetic study by Findling et al (2006) examinedquetiapine in 6- to 12-year-olds with the primary diagnosis of CD The out-come
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 8 docx
... an increase in carbamazepine levels When fluvoxamine and clozapine are Treatment of Bipolar Depression 315 coadministered, the dose of clozapine may need to be decreased because of ... and Treatment of Children and Adolescents at High Risk 303 memory biases in the offspring of parents with bipolar disorder: Indications... paroxetine and fluoxetine inhibit ... risk of causing initial in- somnia, which could be confused with an early symptom of mania. Prob - lematic reactions would then spur discontinuation of the stimulant and a trial of atomoxetine,
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 9 doc
... peripheral insu-lin sensitivity and, consequently, hyperinsulinemia were pivotal to thepathogenesis of PCOS Hopkinson hypothesized that insulin acts in theliver to inhibit the production of insulin-like ... (IGF-1) bindingprotein and SHBG, with the latter leading to an increase in free testoster-one Therefore, according to Hopkinson, insulin resistance not only in-creases the secretion of ovarian ... ofPCOS include an increased LH/FSH ratio and increased insulin and andro-gen concentrations Increased levels of 17-hydroxyprogesterone levels inthecal cells have also been implicated in playing
Ngày tải lên: 11/08/2014, 04:20
TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 10 pps
... without fasting In addition, the stable glucose finding is also notentirely surprising, as in youngsters with intact pancreatic beta cell reserve,one would not expect to find an initial rise in glucose ... olanzapine, risperidone, or quetiapine for a variety ofpsychiatric indications support the notion that SGA treatment in youthscan lead to insulin resistance after as little as 3 months of treatment(Correll, ... double-blind, placebo-controlled trial of metformin treatment of weight gain associ- random-ated with initiation of atypical antipsychotic therapy in children and adolescents Ameri-can Journal of
Ngày tải lên: 11/08/2014, 04:20
Báo cáo y học: "Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription" pptx
... its in vitro activity profile, we hypothesized that in vivo therapy with LMP-420 would decrease intestinal production of pro-inflammatory cytokines including TNF and thus decrease intestinal inflammation ... 2derived from intestinal microbiota (reviewed in [1,2])that are perpetuated by ongoing exposure to these anti-gens in the intestine A number of pro-inflammatory cytokines and chemokines have been ... then processed and embedded into paraffin The severity of inflammation seen in hematoxylin and eosin-stained sections was scored independently by a pathologist blinded to treatment group Histologic
Ngày tải lên: 11/08/2014, 08:21
Treatment of Osteoarthritic Change in the Hip - part 1 pps
... applica-Springer is a part of applica-Springer Science +Business Media springer.com © Springer 2007 Printed in Japan Typesetting: SNP Best-set Typesetter Ltd., Hong Kong Printing and binding: Shinano, ... Trang 2M Sofue, N Endo (Eds.)Treatment of Osteoarthritic Change in the Hip Joint Preservation or Joint Replacement? Trang 3M Sofue, N Endo (Eds.)Trang 4Muroto Sofue, M.D.Director of Nakajo Central ... treatment of hip disease depends on how we can preserve the natural hip joint and on steps leading to regeneration of the diseased, injured, or destroyed joint Preservation and regeneration treatments
Ngày tải lên: 11/08/2014, 17:20
Treatment of Osteoarthritic Change in the Hip - part 2 ppt
... with the in situ pinning technique, whereas intertrochanteric osteotomy is indicated for moderate to severe cases In patients incapable of walking or suffering from hip joint pain on exertion, ... acetabular shelf occurred in 1 of 6 of cases with a PTA of 30°, in 1 of 3 of cases with a PTA of 60°, and in 1 of 2 of cases with a PTA of 90°, and that this might ... Development of posterior tilting angle (PTA) joint pain developed in 1 patient in whom there was narrowing of the joint space There was a difference in leg length, ranging from 0.5
Ngày tải lên: 11/08/2014, 17:20
Treatment of Osteoarthritic Change in the Hip - part 3 potx
... chronic in 3 joints and chronic in 46 joints The direction of slip was posteroinferior in 48 cases, and 1 was posterosuperior (Table 1) The course of treatment is shown in Table 2 Forty-fi ve hips of ... osteoarthritis in the hip joint With these points in mind, we chose Imhaeuser’s method and treated the patients according to his principles This chapter is the report of the treatment of those patients ... were very satisfying, and this treatment should be continued in the future Key words. Slipping of the femoral capital epiphysis, Aseptic necrosis of the femoral head, In situ pinning, Imhaeuser’s
Ngày tải lên: 11/08/2014, 17:20
Treatment of Osteoarthritic Change in the Hip - part 4 docx
... not often follow instructions to rest We perform in situ pinning in patients with a posterior tilting angle of <30°.However, some studies have shown good results after in situ pinning in patients ... for in situ pinning was the Knewles pin in 2 patients, Kirschner wire (k-wire) with thread in 3, and ACE(R) SCFE screw in 6 For contralateral preven-tive pinning, the Knewles pin was used in 2 ... Schultz WR, Weinstein JN, Weinstein SL (2002) Prophylactic pinning of the eral hip in slipped capital femoral epiphysis: evaluation of long-term outcome for the contralateral hip with use of decision
Ngày tải lên: 11/08/2014, 17:20
Treatment of Osteoarthritic Change in the Hip - part 7 ppsx
... dislocation In: Proceedings of the 4th open scientific meeting of the Hip Society Mosby, St Louis 45 Kuznenko WW, Adiev TM (1977) The translocation of the hip joint in the treatment of secondary ... RB (1961) Innominate osteotomy in the treatment of congenital dislocation and subluxation of the hip J Bone Joint Surg [Br] 43:518–539 35 Sutherland DH, Greenfield R (1977) Double innominate osteotomy ... findings of femoral head harvested from terminal-stage OA a Cross section of the femoral head , capital drop; , original line of the head b Magnification of chondroid plugs at weight-bearing
Ngày tải lên: 11/08/2014, 17:20